Abstract
We report a typical case of hematidrosis in a Chinese girl who had experienced frequent bleeding episodes for more than 3 years. During hospitalization, spontaneous bleeding from her intact skin was witnessed by our staff on more than 20 occasions. Characteristically, bloody droplets from the intact skin contained all blood components. Histopathologic examination showed some inconspicuous abnormalities, with normal sweat gland structure containing no blood, and bloody exudate also came from some areas that do not contain sweat glands.Webelieve that the blood was mixed with a sweat-like fluid, rather than real sweat. The patient’s bleeding problem was dramatically resolved by treatment with propranolol. We suggest that sympathetic nerve activation might play a role in these events, and that β-adrenoceptor antagonists might be an effective treatment for this disorder.
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References
Holoubek JE, Holoubek AB. Blood, sweat and fear: a classification of hematidrosis. J Med 1996; 27: 115–33
Griffith JR. Isolated areolar apocrine chromhidrosis. Pediatrics 2005; 115: 239–41
Wyrick K, Crungun T, Russ B, et al. Atypical chromhidrosis: a case report of orange sweat. Cutis 2008; 81: 161–70
Carvalho AC, Machado-Pinto J, Nogueira GC, et al. Hematidrosis: a case report and review of the literature. Int J Dermatol 2008; 47: 1058–9
de Moerloose P, Levrat E, Fontana P, et al. Diagnosis of mild bleeding disorders. Swiss Med Wkly 2009; 139: 327–32
Manonukul J, Wisuthsarewong W, Chantorn R, et al. Hematidrosis: a pathologic process or stigmata: a case report with comprehensive histopathologic and immunoperoxidase studies. Am J Dermatopathol 2008; 30: 135–9
Zhang FK, Zheng YL, Liu JH, et al. Clinical and laboratory study of a case of hematidrosis. Zhonghua Xue Ye Xue Za Zhi 2004; 25: 147–50
Jacobsen TN, Converse Jr RL, Victor RG. Contrasting effects of propranolol on sympathetic nerve activity and vascular resistance during orthostatic stress. Circulation 1992; 85: 1072–6
Acknowledgments
This case report was supported by a grant from the Natural Science Foundation of China (30770917). The authors have no conflicts of interest that are directly relevant to the content of this case report.
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Wang, Z., Yu, Z., Su, J. et al. A Case of Hematidrosis Successfully Treated with Propranolol. Am J Clin Dermatol 11, 440–443 (2010). https://doi.org/10.2165/11531690-000000000-00000
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DOI: https://doi.org/10.2165/11531690-000000000-00000