Sports Medicine

, Volume 39, Issue 12, pp 1033–1054 | Cite as

Bovine Colostrum Supplementation and Exercise Performance

Potential Mechanisms
  • Cecilia M. Shing
  • Denise C. Hunter
  • Lesley M. Stevenson
Review Article

Abstract

Bovine colostrum (BC) is rich in immune, growth and antimicrobial factors, which promote tissue growth and the development of the digestive tract and immune function in neonatal calves. Although the value of BC to human adults is not well understood, supplementation with BC is becoming increasingly popular in trained athletes to promote exercise performance. The combined presence of insulin-like growth factors (IGF), transforming growth factors, immunoglobulins, cytokines, lactoferrin and lysozyme, in addition to hormones such as growth hormone, gonadotrophin-releasing hormone, luteinizing hormone-releasing hormone and glucocorticoids, would suggest that BC might improve immune function, gastrointestinal integrity and the neuroendocrine system, parameters that may be compromised as a result of intensive training. A review of studies investigating the influence of BC supplementation on exercise performance suggests that BC supplementation is most effective during periods of high-intensity training and recovery from high-intensity training, possibly as a result of increased plasma IGF-1, improved intramuscular buffering capacity, increases in lean body mass and increases in salivary IgA. However, there are contradicting data for most parameters that have been considered to date, suggesting that small improvements across a range of parameters might contribute to improved performance and recovery, although this cannot be concluded with certainty because the various doses and length of supplementation with BC in different studies prevent direct comparison of results. Future research on the influence of BC on sports performance will only be of value if the dose and length of supplementation of a well-defined BC product is standardized across studies, and the bioavailability of the active constituents in BC is determined.

References

  1. 1.
    Uruakpa FO, Ismond MAH, Akobundu ENT. Colostrum and its benefits: a review. Nutr Res 2002; 22: 755–67Google Scholar
  2. 2.
    Korhonen H, Marnila P, Gill HS. Milk immunoglobulins and complement factors. Br J Nutr 2000; 84 Suppl. 1: S75–80Google Scholar
  3. 3.
    Hagiwara K, Kataoka S, Yamanaka H, et al. Detection of cytokines in bovine colostrum. Vet Immunol Immunopathol 2000; 76: 183–90PubMedGoogle Scholar
  4. 4.
    Mandalapu P, Pabst HF, Paetkau V. A novel immunosuppressive factor in human colostrum. Cell Immunol 1995; 162: 178–84PubMedGoogle Scholar
  5. 5.
    Ginjala V, Pakkanen R. Determination of transforming growth factor-beta 1 (TGF-beta 1) and insulin-like growth factor (IGF-1) in bovine colostrum samples. J Immunoassay 1998; 19: 195–207PubMedGoogle Scholar
  6. 6.
    Blattler U, Hammon HM, Morel C, et al. Feeding colostrum, its composition and feeding duration variably modify proliferation and morphology of the intestine and digestive enzyme activities of neonatal calves. J Nutr 2001; 131: 1256–63PubMedGoogle Scholar
  7. 7.
    Mach JP, Pahud JJ. Secretory IgA: a major immunoglobulin in most bovine external secretions. J Immunol 1971; 106: 552–63PubMedGoogle Scholar
  8. 8.
    Suga M, Ando M, Tanaka F, et al. Triggering effects of opsonized-IgG antibody on the superoxide release in the phagosome and phagosome-lysosome fusion by pulmonary alveolar macrophages in rabbits. J Clin Lab Immunol 1990; 33: 55–9PubMedGoogle Scholar
  9. 9.
    Togo S, Shimokawa T, Fukuchi Y, et al. Alternative splicing of myeloid IgA Fc receptor (Fc alpha R, CD89) transcripts in inflammatory responses. FEBS Lett 2003; 535: 205–9PubMedGoogle Scholar
  10. 10.
    Pakkanen R, Aalto J. Growth factors and antimicrobial factors of bovine colostrum. Int Dairy J 1997; 7: 285–97Google Scholar
  11. 11.
    Francis GL, Upton FM, Ballard FJ, et al. Insulin-like growth factors 1 and 2 in bovine colostrums: sequences and biological activities compared with those of a potent truncated form. Biochem J 1988; 251: 95–103PubMedGoogle Scholar
  12. 12.
    Fryburg DA, Jahn LA, Hill SA, et al. Insulin and insulinlike growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms. J Clin Invest 1995; 96: 1722–9PubMedGoogle Scholar
  13. 13.
    Froesch ER, Hussain MA, Schmid C, et al. Insulin-like growth factor I: physiology, metabolic effects and clinical uses. Diabetes Metab Rev 1996; 12: 195–215PubMedGoogle Scholar
  14. 14.
    Wong WM, Wright NA. Epidermal growth factor, epidermal growth factor receptors, intestinal growth, and adaptation. J Parenter Enteral Nutr 1999; 23 (5 Suppl.): S83–8Google Scholar
  15. 15.
    Amarant T, Fridkin M, Koch Y. Luteinizing hormonereleasing hormone and thyrotropin-releasing hormone in human and bovine milk. Eur J Biochem 1982; 127: 647–50PubMedGoogle Scholar
  16. 16.
    Gopal PK, Gill HS. Oligosaccharides and glycoconjugates in bovinemilk and colostrum. Br J Nutr 2000; 84 Suppl. 1: S69–74Google Scholar
  17. 17.
    Ceciliani F, Pocacqua V, Provasi E, et al. Identification of the bovine alpha1-acid glycoprotein in colostrum and milk. Vet Res 2005; 36: 735–46PubMedGoogle Scholar
  18. 18.
    van Hooijdonk AC, Kussendrager KD, Steijns JM. In vivo antimicrobial and antiviral activity of components in bovine milk and colostrum involved in non-specific defence. Br J Nutr 2000; 84 Suppl. 1: S127–34Google Scholar
  19. 19.
    Floren CH, Chinenye S, Elfstrand L, et al. ColoPlus, a new product based on bovine colostrum, alleviates HIVassociated diarrhoea. Scand J Gastroenterol 2006; 41: 682–6PubMedGoogle Scholar
  20. 20.
    Kim JW, Jeon WK, Yun JW, et al. Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats. Asia Pac J Clin Nutr 2005; 14: 103–7PubMedGoogle Scholar
  21. 21.
    Playford RJ, Floyd DN, Macdonald CE, et al. Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. Gut 1999; 44: 653–8PubMedGoogle Scholar
  22. 22.
    Playford RJ, MacDonald CE, Calnan DP, et al. Coadministration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability. Clin Sci (Lond) 2001; 100: 627–33PubMedGoogle Scholar
  23. 23.
    Patel K, Rana R. Pedimune in recurrent respiratory infection and diarrhea: the Indian experience. The PRIDE study. Indian J Pediatr 2006; 73: 585–91Google Scholar
  24. 24.
    Brinkworth GD, Buckley JD. Concentrated bovine colostrum protein supplementation reduces the incidence of self-reported symptoms of upper respiratory tract infection in adult males. Eur J Nutr 2003; 42: 228–32PubMedGoogle Scholar
  25. 25.
    McGuire TC, Pfeiffer NE, Weikel JM, et al. Failure of colostral immunoglobulin transfer in calves dying from infectious disease. J Am Vet Med Assoc 1976; 169: 713–8PubMedGoogle Scholar
  26. 26.
    Rea DE, Tyler JW, Hancock DD, et al. Prediction of calf mortality by use of tests for passive transfer of colostral immunoglobulin. J Am Vet Med Assoc 1996; 208: 2047–9PubMedGoogle Scholar
  27. 27.
    Brignole TJ, Stott GH. Effect of suckling followed by bottle feeding colostrum on immunoglobulin absorption and calf survival. J Dairy Sci 1980; 63: 451–6PubMedGoogle Scholar
  28. 28.
    Walker-Smith JA, Phillips AD, Walford N, et al. Intravenous epidermal growth factor/urogastrone increases small-intestinal cell proliferation in congenital microvillous atrophy. Lancet 1985; 2: 1239–40PubMedGoogle Scholar
  29. 29.
    Steeb CB, Shoubridge CA, Tivey DR, et al. Systemic infusion of IGF-I or LR(3)IGF-I stimulates visceral organ growth and proliferation of gut tissues in suckling rats. Am J Physiol 1997; 272: G522–33Google Scholar
  30. 30.
    Khan Z, Macdonald C, Wicks AC, et al. Use of the ‘nutriceutical’, bovine colostrum, for the treatment of distal colitis: results from an initial study. Aliment Pharmacol Ther 2002; 16: 1917–22PubMedGoogle Scholar
  31. 31.
    Playford RJ, Woodman AC, Clark P, et al. Effect of luminal growth factor preservation on intestinal growth. Lancet 1993; 341: 843–8PubMedGoogle Scholar
  32. 32.
    Kim JW, Jeon WK, Kim EJ. Combined effects of bovine colostrum and glutamine in diclofenac-induced bacterial translocation in rat. Clin Nutr 2005; 24: 785–93PubMedGoogle Scholar
  33. 33.
    Brinkworth GD, Buckley JD. Bovine colostrum supplementation does not affect nutrient absorptive capacity in healthy young men. Nutr Res 2003; 23: 1619–29Google Scholar
  34. 34.
    Salmon H. The mammary gland and neonate mucosal immunity. Vet Immunol Immunopathol 1999; 72: 143–55PubMedGoogle Scholar
  35. 35.
    Quigley JD, Strohbehn RE, Kost CJ, et al. Formulation of colostrum supplements, colostrum replacers and acquisition of passive immunity in neonatal calves. J Dairy Sci 2001; 84: 2059–65PubMedGoogle Scholar
  36. 36.
    Stott GH, Marx DB, Menefee BE, et al. Colostral immunoglobulin transfer in calves: I. Period of absorption. J Dairy Sci 1979; 62: 1632–8PubMedGoogle Scholar
  37. 37.
    Ontsouka CE, Sauter SN, Blum JW, et al. Effects of colostrum feeding and dexamethasone treatment on mRNA levels of insulin-like growth factors (IGF)-I and -II, IGF binding proteins-2 and -3, and on receptors for growth hormone, IGF-I, IGF-II, and insulin in the gastrointestinal tract of neonatal calves. Domest Anim Endocrinol 2004; 26: 155–75PubMedGoogle Scholar
  38. 38.
    Yamanaka H, Hagiwara K, Kirisawa R, et al. Proinflammatory cytokines in bovine colostrum potentiate the mitogenic response of peripheral blood mononuclear cells from newborn calves through IL-2 and CD25 expression. Microbiol Immunol 2003; 47: 461–8PubMedGoogle Scholar
  39. 39.
    Elfstrand L, Lindmark-Mansson H, Oaulsson M, et al. Immunoglobulins, growth factors and growth hormone in bovine colostrum and the effects of processing. Int Dairy J 2002; 12: 879–87Google Scholar
  40. 40.
    Boudry C, Buldgena A, Portetelleb D, et al. Effect of bovine colostrum supplementation on cytokine mRNA expression in weaned piglets. Livestock Sci 2007; 108: 295–8Google Scholar
  41. 41.
    Shing CM, Peake J, Suzuki K, et al. Bovine colostrum modulates cytokine production in human peripheral blood mononuclear cells stimulated with lipopolysaccharide and phytohemagglutinin. J Int Cyt Res 2007; 27: 835–9Google Scholar
  42. 42.
    Jeukendrup AE, Vet-Joop K, Sturk A, et al. Relationship between gastro-intestinal complaints and endotoxaemia, cytokine release and the acute-phase reaction during and after a long-distance triathlon in highly trained men. Clin Sci (Lond) 2000; 98: 47–55PubMedGoogle Scholar
  43. 43.
    Gleeson M. Mucosal immune responses and risk of respiratory illness in elite athletes. Exerc Immunol Rev 2000; 6: 5–42PubMedGoogle Scholar
  44. 44.
    Shing CM, Peake J, Suzuki K, et al. Effects of bovine colostrum supplementation on immune variables in highly trained cyclists. J Appl Physiol 2007; 102: 1113–22PubMedGoogle Scholar
  45. 45.
    Talukder MJ, Takeuchi T, Harada E. Receptor-mediated transport of lactoferrin into the cerebrospinal fluid via plasma in young calves. J Vet Med Sci 2003; 65: 957–64PubMedGoogle Scholar
  46. 46.
    Talukder MJ, Takeuchi T, Harada E. Transport of colostral macromolecules into the cerebrospinal fluid via plasma in newborn calves. J Dairy Sci 2002; 85: 514–24PubMedGoogle Scholar
  47. 47.
    Watkins LR, Maier SF. The pain of being sick: implications of immune-to-brain communication for understanding pain. Annu Rev Psychol 2000; 51: 29–57PubMedGoogle Scholar
  48. 48.
    Maso F, Lac G, Filaire E, et al. Salivary testosterone and cortisol in rugby players: correlation with psychological overtraining items. Br J Sports Med 2004; 38: 260–3PubMedGoogle Scholar
  49. 49.
    Marshall-Gradisnik SM, Sample R, O’Leary L, et al. Improvements in health and psychological indicators in healthy males after eight-week bovine colostrum powder supplementation [abstract]. Aust J Dairy Technol 2003; 58: 197Google Scholar
  50. 50.
    Filaire E, Legrand B, Lac G, et al. Training of elite cyclists: effects on mood state and selected hormonal responses. J Sports Sci 2004; 22: 1025–33PubMedGoogle Scholar
  51. 51.
    Odland L, Wallin S, Walum E. Lipid peroxidation and activities of tyrosine aminotransferase and glutamine synthetase in hepatoma and glioma cells grown in bovine colostrum-supplemented medium. In Vitro Cell Dev Biol 1986; 22: 259–62PubMedGoogle Scholar
  52. 52.
    Przybylska J, Albera E, Kankofer M. Antioxidants in bovine colostrum. Reprod Domest Anim 2007; 42: 402–9PubMedGoogle Scholar
  53. 53.
    Korhonen BH. Antimicrobial factors in bovine colsotrum. J Sci Agric Soc Finland 1977; 49: 434–47Google Scholar
  54. 54.
    Torre C, Jeusette I, Serra M, et al. Bovine colostrum increases proliferation of canine skin fibroblasts. J Nutr 2006; 136: 2058–60Google Scholar
  55. 55.
    Sporn MB, Roberts AB, Shull JH, et al. Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo. Science 1983; 219: 1329–31PubMedGoogle Scholar
  56. 56.
    Mero A, Miikkulainen H, Riski J, et al. Effects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, and saliva IgA during training. J Appl Physiol 1997; 83: 1144–51PubMedGoogle Scholar
  57. 57.
    Hofman Z, Smeets R, Verlaan G, et al. The effect of bovine colostrum supplementation on exercise performance in elite field hockey players. Int J Sport Nutr Exerc Metab 2002; 12: 461–9PubMedGoogle Scholar
  58. 58.
    Buckley JD, Brinkworth GD, Abbott MJ. Effect of bovine colostrum on anaerobic exercise performance and plasma insulin-like growth factor I. J Sports Sci 2003; 21: 577–88PubMedGoogle Scholar
  59. 59.
    Leppäluoto J, Rasi S, Martikkala V, et al. Bovine colostrum supplementation enhances physical performance on maximal exercise tests. 2000 Pre-Olympic Congress Sports Medicine and Physical Education International Congress on Sport Science; 2000 Sep 7–13: Brisbane (QLD)Google Scholar
  60. 60.
    Coombes JS, Conacher M, Austen SK, et al. Dose effects of oral bovine colostrum on physical work capacity in cyclists. Med Sci Sports Exerc 2002; 34: 1184–8PubMedGoogle Scholar
  61. 61.
    Buckley JD, Abbott MJ, Brinkworth GD, et al. Bovine colostrum supplementation during endurance running training improves recovery, but not performance. J Sci Med Sport 2002; 5: 65–79PubMedGoogle Scholar
  62. 62.
    Kerksick C, Kreider R, Rasmussen C, et al. Effects of bovine colostrum supplementation on training adaptations II: performance [abstract]. FASEB J 2001; 15: LB315Google Scholar
  63. 63.
    Antonio J, Sanders MS, Van Gammeren D. The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women. Nutrition 2001; 17: 243–7PubMedGoogle Scholar
  64. 64.
    Fry A, Schilling B, Chiu L, et al. Muscle fibre and performance adaptations to resistance exercise with MyoVive, colostrum or casein and whey supplementation. Res Sports Med 2003; 11: 109–27Google Scholar
  65. 65.
    Kreider R, Rasmussen C, Kerksick C, et al. Effects of bovine colostrum supplementation on training adaptations: I. Body composition [abstract]. FASEB J 2001; 15: LB316Google Scholar
  66. 66.
    Hoffman JR, Kang J, Ratamess NA, et al. Biochemical and hormonal responses during an intercollegiate football season. Med Sci Sports Exerc 2005; 37: 1237–41PubMedGoogle Scholar
  67. 67.
    Brinkworth GD, Buckley JD, Bourdon PC, et al. Oral bovine colostrum supplementation enhances buffer capacity but not rowing performance in elite female rowers. Int J Sport Nutr Exerc Metab 2002; 12: 349–65PubMedGoogle Scholar
  68. 68.
    Mero A, Nykänen T, Rasi S, et al. IGF-1, IGFBP-3, growth hormone and testosterone in male and female athletes during bovine colostrum supplementation [abstract]. Med Sci Sports Exerc 2002; 35: s299Google Scholar
  69. 69.
    O’Leary L. Assessment of anaerobic performance in healthy males after an eight week concentrated bovine colostrum supplementation. Australian Conference of Science and Medicine in Sport; 2003 Oct 25-28: Canberra (ACT)Google Scholar
  70. 70.
    Brinkworth GD, Buckley JD, Slavotinek JP, et al. Effect of bovine colostrum supplementation on the composition of resistance trained and untrained limbs in healthy young men. Eur J Appl Physiol 2004; 91 (1): 53–60PubMedGoogle Scholar
  71. 71.
    Brinkworth GD, Buckley JD. Bovine colostrum supplementation does not affect plasma buffer capacity or haemoglobin content in elite female rowers. Eur J Appl Physiol 2004; 91: 353–6PubMedGoogle Scholar
  72. 72.
    Sample R, O’Leary L, Myers S, et al. Bovine colostrum supplementation and its effect on muscle histology, strength, performance and body composition in the elderly [abstract]. J Sci Med Sport 2004; 7: S16Google Scholar
  73. 73.
    Mero A, Nykanen T, Keinanen O, et al. Protein metabolism and strength performance after bovine colostrum supplementation. Amino Acids 2005; 28: 327–35PubMedGoogle Scholar
  74. 74.
    Crooks C, Wall C, Cross M, et al. The effect of bovine colostrum supplementation on salivary IgA in distance runners. Int J Sport Nutr Exerc Metab 2006; 16: 47–64PubMedGoogle Scholar
  75. 75.
    Shing CM, Jenkins DG, Stevenson L, et al. The influence of bovine colostrum supplementation on exercise performance in highly-trained cyclists. Br J Sports Med 2006; 40: 797–801PubMedGoogle Scholar
  76. 76.
    Kuhne S, Hammon HM, Bruckmaier RM, et al. Growth performance, metabolic and endocrine traits, and absorptive capacity in neonatal calves fed either colostrum or milk replacer at two levels. J Anim Sci 2000; 78: 609–20PubMedGoogle Scholar
  77. 77.
    Hammon H, Blum JW. The somatotropic axis in neonatal calves can be modulated by nutrition, growth hormone, and Long-R3-IGF-I. Am J Physiol 1997; 273: E130–8Google Scholar
  78. 78.
    Sacheck JM, Ohtsuka A, McLary SC, et al. IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1. Am J Physiol Endocrinol Metab 2004; 287: E591–601Google Scholar
  79. 79.
    Malisoux L, Francaux M, Nielens H, et al. Calcium sensitivity of human single muscle fibers following plyometric training. Med Sci Sports Exerc 2006; 38: 1901–8PubMedGoogle Scholar
  80. 80.
    Mero A, Kahkonen J, Nykanen T, et al. IGF-I, IgA, and IgG responses to bovine colostrum supplementation during training. J Appl Physiol 2002; 93: 732–9PubMedGoogle Scholar
  81. 81.
    Kimura T, Murakawa Y, Ohno M, et al. Gastrointestinal absorption of recombinant human insulin-like growth factor-1 in rats. J Pharmacol Exp Ther 1997; 283: 611–8PubMedGoogle Scholar
  82. 82.
    Kuipers H, van Breda E, Verlaan G, et al. Effects of oral bovine colostrum supplementation on serum insulin-like growth factor-I levels. Nutrition 2002; 18: 566–7PubMedGoogle Scholar
  83. 83.
    Nemet D, Pontello AM, Rose-Gottron C, et al. Cytokines and growth factors during and after a wrestling season in adolescent boys. Med Sci Sports Exerc 2004; 36: 794–800PubMedGoogle Scholar
  84. 84.
    Steimer KS, Packard R, Holden D, et al. The serum-free growth of cultured cells in bovine colostrum and in milk obtained later in the lactation period. J Cell Physiol 1981; 109: 223–34PubMedGoogle Scholar
  85. 85.
    Donath MY, Jenni R, Brunner HP, et al. Cardiovascular and metabolic effects of insulin-like growth factor I at rest and during exercise in humans. J Clin Endocrinol Metab 1996; 81: 4089–94PubMedGoogle Scholar
  86. 86.
    Hussain MA, Schmitz O, Mengel A, et al. Comparison of the effects of growth hormone and insulin-like growth factor I on substrate oxidation and on insulin sensitivity in growth hormone-deficient humans. J Clin Invest 1994; 94: 1126–33PubMedGoogle Scholar
  87. 87.
    Buckley J, Abbott M, Martin S, et al. Effects of an oral bovine colostrum supplement (intact TM) on running performance. Australian Conference of Science and Medicine in Sport; 1998 Oct 13–16; Adelaide (SA)Google Scholar
  88. 88.
    Hammon HM, Sauter SN, Reist M, et al. Dexamethasone and colostrum feeding affect hepatic gluconeogenic enzymes differently in neonatal calves. J Anim Sci 2003; 81: 3095–106PubMedGoogle Scholar
  89. 89.
    Hawley JA, Palmer GS, Noakes TD. Effects of 3 days of carbohydrate supplementation on muscle glycogen content and utilisation during a 1-h cycling performance. Eur J Appl Physiol Occup Physiol 1997; 75: 407–12PubMedGoogle Scholar
  90. 90.
    Kavouras SA, Troup JP, Berning JR. The influence of low versus high carbohydrate diet on a 45-min strenuous cycling exercise. Int J Sport Nutr Exerc Metab 2004; 14: 62–72PubMedGoogle Scholar
  91. 91.
    McInerney P, Lessard SJ, Burke LM, et al. Failure to repeatedly supercompensate muscle glycogen stores in highly trained men. Med Sci Sports Exerc 2005; 37: 404–11PubMedGoogle Scholar
  92. 92.
    Karlsson J, Saltin B. Diet, muscle glycogen, and endurance performance. J Appl Physiol 1971; 31: 203–6PubMedGoogle Scholar
  93. 93.
    Rauprich AB, Hammon HM, Blum JW. Influence of feeding different amounts of first colostrum on metabolic, endocrine, and health status and on growth performance in neonatal calves. J Anim Sci 2000; 78: 896–908PubMedGoogle Scholar
  94. 94.
    Nieman DC. Is infection risk linked to exercise workload? Med Sci Sports Exerc 2000; 32: S406–11Google Scholar
  95. 95.
    Atlaoui D, Duclos M, Gouarne C, et al. The 24-h urinary cortisol/cortisone ratio for monitoring training in elite swimmers. Med Sci Sports Exerc 2004; 36: 218–24PubMedGoogle Scholar
  96. 96.
    Halson SL, Bridge MW, Meeusen R, et al. Time course of performance changes and fatigue markers during intensified training in trained cyclists. J Appl Physiol 2002; 93: 947–56PubMedGoogle Scholar
  97. 97.
    Halson SL, Lancaster GI, Jeukendrup AE, et al. Immunological responses to overreaching in cyclists. Med Sci Sports Exerc 2003; 35: 854–61PubMedGoogle Scholar
  98. 98.
    Fitzgerald L. Overtraining increases the susceptibility to infection. Int J Sports Med 1991; 12 Suppl. 1: S5–8Google Scholar
  99. 99.
    Gleeson M. Assessing immune function changes in exercise and diet intervention studies. Curr Opin Clin Nutr Metab Care 2005; 8: 511–5PubMedGoogle Scholar
  100. 100.
    McKune AJ, Smith LL, Semple SJ, et al. Immunoglobulin responses to a repeated bout of downhill running. Br J Sports Med 2006 Oct; 40: 844–9PubMedGoogle Scholar
  101. 101.
    McKune AJ, Smith LL, Semple SJ, et al. Influence of ultraendurance exercise on immunoglobulin isotypes and subclasses. Br J Sports Med 2005; 39: 665–70PubMedGoogle Scholar
  102. 102.
    McKune AJ, Smith LL, Semple SJ, et al. Changes in mucosal and humoral atopic-related markers and immunoglobulins in elite cyclists participating in the Vuelta a Espana. Int J Sports Med 2006; 27: 560–6PubMedGoogle Scholar
  103. 103.
    Biron CA. Cytokines in the generation of immune responses to, and resolution of, virus infection. Curr Opin Immunol 1994; 6: 530–8PubMedGoogle Scholar
  104. 104.
    Sethi SK, Bianco A, Allen JT, et al. Interferon-gamma (IFN-gamma) down-regulates the rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) on human airway epithelial cells. Clin Exp Immunol 1997; 110: 362–9PubMedGoogle Scholar
  105. 105.
    Bachert C, van Kempen MJ, Hopken K, et al. Elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemokines in naturally acquired upper respiratory tract infections. Eur Arch Otorhinolaryngol 2001; 258: 406–12PubMedGoogle Scholar
  106. 106.
    Carmichael MD, Davis JM, Murphy EA, et al. Role of brain IL-beta on fatigue following exercise-induced muscle damage. Am J Physiol Regul Integr Comp Physiol 2006; 291 (5): R1344–8Google Scholar
  107. 107.
    Lakier Smith L. Overtraining, excessive exercise, and altered immunity: is this a T helper-1 versus T helper-2 lymphocyte response? Sports Med 2003; 33: 347–64PubMedGoogle Scholar
  108. 108.
    Lambert GP, Broussard LJ, Mason BL, et al. Gastrointestinal permeability during exercise: effects of aspirin and energy-containing beverages. J Appl Physiol 2001; 90: 2075–80PubMedGoogle Scholar
  109. 109.
    Prosser C, Stelwagen K, Cummins R, et al. Reduction in heat-induced gastrointestinal hyperpermeability in rats by bovine colostrum and goat milk powders. J Appl Physiol 2004; 96: 650–4PubMedGoogle Scholar
  110. 110.
    Lim CL, Wilson G, Brown L, et al. Pre-existing inflammatory state compromises heat tolerance in rats exposed to heat stress. Am J Physiol Regul Integr Comp Physiol 2007; 292: R186–94Google Scholar
  111. 111.
    Buckley JD, Brinkworth GD, Southcott E, et al. Bovine colostrum and whey protein supplementation during running training increase intestinal permeability [abstract]. Asia Pac J Clin Nutr 2004; 13: S81Google Scholar
  112. 112.
    Caradonna L, Amati L, Magrone T, et al. Enteric bacteria, lipopolysaccharides and related cytokines in inflammatory bowel disease: biological and clinical significance. J Endotoxin Res 2000; 6: 205–14PubMedGoogle Scholar
  113. 113.
    Spiekermann GM, Finn PW, Ward ES, et al. Receptormediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung. J Exp Med 2002; 196: 303–10PubMedGoogle Scholar
  114. 114.
    Roos N, Mahe S, Benamouzig R, et al. 15N-labeled immunoglobulins from bovine colostrum are partially resistant to digestion in human intestine. J Nutr 1995; 125: 1238–44PubMedGoogle Scholar
  115. 115.
    Davis PF, Greenhill NS, Rowan AM, et al. The safety of New Zealand bovine colostrum: nutritional and physiological evaluation in rats. Food Chem Toxicol 2007; 45: 229–36PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2009

Authors and Affiliations

  • Cecilia M. Shing
    • 1
  • Denise C. Hunter
    • 2
  • Lesley M. Stevenson
    • 2
  1. 1.School of Human Life SciencesUniversity of TasmaniaLauncestonAustralia
  2. 2.Centre for Phytochemistry and PharmacologySouthern Cross UniversityLismoreAustralia

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