For a long time, lead has been linked to cardiovascular effects, especially hypertension. Therefore, looking at this problem from another viewpoint would be beneficial. Lead toxicity is a prevalent health hazard in both developed and developing countries and the mechanisms proposed for both lead-induced and essential hypertension looks the same. This has driven some to suggest lead as the principle cause of essential hypertension. Despite these opinions, no policy has been taken to manage essential hypertension from this point of view. However, recent data suggest that the chelating agents that are used already in treating lead toxicity have therapeutic effects regarding hypertensive cases. The effects of chelators appear to be beyond merely decreasing blood lead level. Therefore, it seems an attractive approach to try chelators as the first step in managing hypertensive patients before starting a chronic course of conventional antihypertensives.
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Salama, M. Lead and Hypertension. High Blood Press Cardiovasc Prev 16, 83–85 (2009). https://doi.org/10.2165/11316960-000000000-00000
- arterial hypertension
- antihypertensive therapy