Drugs

, Volume 69, Issue 13, pp 1761–1776 | Cite as

Fixed-Dose Combinations as Initial Therapy for Hypertension

A Review of Approved Agents and a Guide to Patient Selection
  • Bernard Waeber
  • François Feihl
  • Luis M. Ruilope
Review Article

Abstract

Recent guidelines recommend initiation of antihypertensive therapy with fixed-dose combinations in high-risk patients because such patients usually need two or more blood pressure (BP)-lowering agents in order to normalize their BP. Agents that block the renin-angiotensin system (ACE inhibitors or angiotensin II receptor antagonists [angiotensin receptor blockers; ARBs]) are preferred for the management of hypertension in most patients exhibiting subclinical target organ damage, or established cardiovascular or renal diseases. Unless contraindicated they should be one of the components of fixed-dose combinations, whereas the other component may be either a calcium channel antagonist or a thiazide diuretic. Fixed-dose combinations containing an ACE inhibitor or ARB plus a calcium channel antagonist appear particularly effective in preventing complications of coronary heart disease.

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Copyright information

© Adis Data Information BV 2009

Authors and Affiliations

  • Bernard Waeber
    • 1
  • François Feihl
    • 1
  • Luis M. Ruilope
    • 2
  1. 1.Division of Clinical PathophysiologyCentre Hospitalier Universitaire Vaudois et Université de LausanneLausanneSwitzerland
  2. 2.Hypertension UnitHospital 12 de OctubreMadridSpain

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