American Journal of Clinical Dermatology

, Volume 11, Issue 1, pp 1–10

The Role of Toll-Like Receptors in Host Defenses and Their Relevance to Dermatologic Diseases

  • Dorothea Terhorst
  • Behnam Naderi Kalali
  • Markus Ollert
  • Johannes Ring
  • Martin Mempel
Leading Article Toll-Like Receptors in Dermatologic Diseases

Abstract

The family of toll-like receptors (TLRs) plays a central role in the cutaneous immune defense system. To date, different TLRs have been found on several major cell populations of the skin, such as keratinocytes, fibroblasts, antigen-presenting cells, and melanocytes.

Activation of TLRs leads, via different intracellular signaling pathways, to the production of pro-inflammatory stimuli, and is considered a danger signal that should transform the skin in to the functional state of defense. However, TLRs have also been implicated in tissue homeostasis and renewal.

Within the group of TLRs, two types have been identified: surface-expressed TLRs, which are predominantly active against bacterial cell wall compounds; and intracellular receptors, which preferentially recognize virus-associated pattern molecules. In addition, surface-expressed receptors trigger phagocytotic and maturation signals, while the intracellular TLRs lead to the induction of antiviral genes.

Our review aims to outline the importance of TLRs in the pathogenesis of numerous skin diseases and the potential of TLR agonists as a treatment option for various skin diseases.

Copyright information

© Adis Data Information BV 2010

Authors and Affiliations

  • Dorothea Terhorst
    • 1
  • Behnam Naderi Kalali
    • 2
    • 3
  • Markus Ollert
    • 2
    • 3
  • Johannes Ring
    • 2
    • 4
  • Martin Mempel
    • 2
    • 3
    • 4
  1. 1.Department of Dermatology and AllergySkin Cancer Center Charité, Charité-Universitätsmedizin BerlinBerlinGermany
  2. 2.Department of Dermatology and AllergyBiederstein, Technische Universität MünchenMunichGermany
  3. 3.Clinical Research Division of Molecular and Clinical AllergotoxicologyTechnische Universität MünchenMunichGermany
  4. 4.Division of Environmental Dermatology and AllergyHelmholtz Center Munich/Technische Universität MünchenMunichGermany

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