American Journal of Cardiovascular Drugs

, Volume 12, Issue 1, pp 49–56

Ezetimibe/Simvastatin: A Guide to its Clinical Use in Hypercholesterolemia

Adis Drug Clinical Q&A


Ezetimibe/simvastatin therapy combines two lipid-lowering compounds with complementary mechanisms of action, thereby blocking the two sources of plasma cholesterol and improving lipid profiles. Ezetimibe/simvastatin is an effective and generally well tolerated adjunct to dietary therapy for markedly reducing lowdensity lipoprotein cholesterol (LDL-C) levels and improving other lipid parameters across diverse patient populations. Dual treatment with ezetimibe/simvastatin is more effective than monotherapy with an HMG-CoA reductase inhibitor (statin), and the addition of ezetimibe to current statin therapy is more effective than doubling the statin dose.

Copyright information

© Adis Data Information BV 2012

Authors and Affiliations

  1. 1.Adis, a Wolters Kluwer BusinessMairangi Bay, North Shore 0754 AucklandNew Zealand

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