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Pazopanib

In Advanced Renal Cell Carcinoma

Abstract

Pazopanib is an orally administered, multi-tyrosine kinase inhibitor that interrupts tumor growth in renal cell carcinoma.

In a randomized, double-blind, placebo-controlled, multinational trial in patients with locally advanced or metastatic renal cell carcinoma, the median progression-free survival (PFS) of patients who were treated with pazopanib 800 mg once daily was significantly longer than that of placebo recipients (9.2 vs 4.2 months; hazard ratio 0.46 [95% CI 0.34, 0.62]).

In prespecified analyses in treatment-naive and cytokine-pretreated patients, grouped according to prior treatment history, age, sex, Memorial Sloan-Kettering Cancer Center risk category, and Eastern Cooperative Oncology Group performance status, median PFS was significantly longer in pazopanib than placebo recipients in all subgroups.

Pazopanib recipients also had a significantly higher overall response rate than placebo recipients; in pazopanib recipients, the median time to response was 11.9 weeks and the median duration of response was 58.7 weeks.

Oral pazopanib had an acceptable tolerability profile in patients with advanced renal cell carcinoma. Adverse events were common in pazopanib and placebo recipients and were mostly of mild to moderate severity.

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Acknowledgments and Disclosures

The manuscript was reviewed by: N. Agarwal, Division of Hematology and Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA; R. Iacovelli, Oncology Unit, Department of Radiology, Oncology and Human Pathology, “Sapienza” University of Rome, Rome, Italy; A.A.M. van der Veldt, Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, the Netherlands.

The preparation of this review was not supported by any external funding. During the peer review process, the manufacturer of the agent under review was offered an opportunity to comment on this article. Changes resulting from any comments received were made on the basis of scientific and editorial merit.

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Correspondence to Mark Sanford.

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Sanford, M., Keating, G.M. Pazopanib. BioDrugs 24, 279–286 (2010). https://doi.org/10.2165/11205480-000000000-00000

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Keywords

  • Renal Cell Carcinoma
  • Sorafenib
  • Sunitinib
  • Placebo Recipient
  • Objective Response Rate