American Journal of Cardiovascular Drugs

, Volume 8, Issue 6, pp 373–418 | Cite as

Statin Adverse Effects

A Review of the Literature and Evidence for a Mitochondrial Mechanism
  • Beatrice A. GolombEmail author
  • Marcella A. Evans
Review Article


HMG-CoA reductase inhibitors (statins) are a widely used class of drug, and like all medications, have potential for adverse effects (AEs). Here we review the statin AE literature, first focusing on muscle AEs as the most reported problem both in the literature and by patients. Evidence regarding the statin muscle AE mechanism, dose effect, drug interactions, and genetic predisposition is examined. We hypothesize, and provide evidence, that the demonstrated mitochondrial mechanisms for muscle AEs have implications to other nonmuscle AEs in patients treated with statins. In meta-analyses of randomized controlled trials (RCTs), muscle AEs are more frequent with statins than with placebo. A number of manifestations of muscle AEs have been reported, with rhabdomyolysis the most feared. AEs are dose dependent, and risk is amplified by drug interactions that functionally increase statin potency, often through inhibition of the cytochrome P450 3A4 system. An array of additional risk factors for statin AEs are those that amplify (or reflect) mitochondrial or metabolic vulnerability, such as metabolic syndrome factors, thyroid disease, and genetic mutations linked to mitochondrial dysfunction. Converging evidence supports a mitochondrial foundation for muscle AEs associated with statins, and both theoretical and empirical considerations suggest that mitochondrial dysfunction may also underlie many nonmuscle statin AEs. Evidence from RCTs and studies of other designs indicates existence of additional statin-associated AEs, such as cognitive loss, neuropathy, pancreatic and hepatic dysfunction, and sexual dysfunction. Physician awareness of statin AEs is reportedly low even for the AEs most widely reported by patients. Awareness and vigilance for AEs should be maintained to enable informed treatment decisions, treatment modification if appropriate, improved quality of patient care, and reduced patient morbidity.



The authors have no conflicts of interest to report. Work that contributed to this paper was funded by a Robert Wood Johnson Generalist Physician Faculty Scholar award to Dr Golomb. The study sponsor did not participate in study design; in the collection, analysis, or interpretation of data; in the writing of this report; or in the decision to submit this paper for publication. The authors would like to thank Hanh Nguyen and Jersey Neilson for kind assistance securing articles; and Sabrina Koperski for excellent editorial and administrative assistance.


  1. 1.
    IMS Health. US top ten products by prescriptions [online]. Available from URL:,2779,1343-1343-144004,00.html [Accessed 2001 Apr 19].
  2. 2.
    IMS HEALTH, National Prescription Audit PlusTM, 2002. IMS Health. Lipitor leads the way in 2003 [online]. Available from URL:[Accessed 2005 May 23].
  3. 3.
    IMS Health. IMS global insights. IMS Retail Drug Monitor 2007 Dec [online]. Available from URL:,3148,64576068_63872702_70260998_83746585,00.html [Accessed 2008 May 2].
  4. 4.
    Davidson MH. Safety profiles for the HMG-CoA reductase inhibitors: treatment and trust. Drugs 2001; 61(2): 197–206.PubMedCrossRefGoogle Scholar
  5. 5.
    Smith SCJ. Bridging the treatment gap. Am J Cardiol 2000; 85(12 A): 3–7E.CrossRefGoogle Scholar
  6. 6.
    Bernini F, Poli A, Paoletti R. Safety of HMG-CoA reductase inhibitors: focus on atorvastatin. Cardiovasc Drugs Ther 2001; 15(3): 211–8.PubMedCrossRefGoogle Scholar
  7. 7.
    Criqui MH, Golomb BA. Low and lowered cholesterol and total mortality. J Am Coll Cardiol 2004 Sep 1; 44(5): 1009–10.PubMedCrossRefGoogle Scholar
  8. 8.
    Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994 Nov 19; 344(8934): 1383–9.Google Scholar
  9. 9.
    Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels: the Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group [see comments]. N Engl J Med 1998; 339 (19): 1349–57.Google Scholar
  10. 10.
    Buhaescu I, Izzedine H. Mevalonate pathway: a review of clinical and therapeutical implications. Clin Biochem 2007 Jun; 40(9–10): 575–84.PubMedCrossRefGoogle Scholar
  11. 11.
    Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature 1990 Feb 1; 343(6257): 425–30.PubMedCrossRefGoogle Scholar
  12. 12.
    Mach F. Statins as immunomodulatory agents. Circulation 2004 Jun 1; 109(21 Suppl. 1): II15–7.PubMedGoogle Scholar
  13. 13.
    Keyhani J, Keyhani E. Mevalonic acid as a precursor of the alkyl sidechain of heme a of cytochrome c oxidase in yeast Saccharomyces cerevisiae. FEBS Lett 1978 Sep 15; 93(2): 271–4.PubMedCrossRefGoogle Scholar
  14. 14.
    Mol MJ, Stalenhoef AF, Stuyt PM, et al. Effects of inhibition of cholesterol synthesis by simvastatin on the production of adrenocortical steroid hormones and ACTH. Clin Endocrinol (Oxf) 1989 Dec; 31(6): 679–89.CrossRefGoogle Scholar
  15. 15.
    Hyyppa MT, Kronholm E, Virtanen A, et al. Does simvastatin affect mood and steroid hormone levels in hypercholesterolemic men? A randomized double-blind trial. Psychoneuroendocrinology 2003 Feb; 28(2): 181–94.PubMedCrossRefGoogle Scholar
  16. 16.
    Cimino M, Gelosa P, Gianella A, et al. Statins: multiple mechanisms of action in the ischemic brain. Neuroscientist 2007 Jun; 13(3): 208–13.PubMedCrossRefGoogle Scholar
  17. 17.
    Harris JI, Hibbeln JR, Mackey RH, et al. Statin treatment alters serum n-3 and n-6 fatty acids in hypercholesterolemic patients. Prostaglandins Leukot Essent Fatty Acids 2004 Oct; 71(4): 263–9.PubMedCrossRefGoogle Scholar
  18. 18.
    Maritz FJ. Efficacy and dangers of statin therapy. Cardiovasc J S Afr 2002 Jul–Aug; 13(4): 200–3.PubMedGoogle Scholar
  19. 19.
    Talbert RL. Safety issues with statin therapy. J Am Pharm Assoc (Wash DC) 2006 Jul–Aug; 46(4): 479–88.CrossRefGoogle Scholar
  20. 20.
    Mortensen SA, Leth A, Agner E, et al. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997; 18 Suppl.: S137–44.PubMedCrossRefGoogle Scholar
  21. 21.
    Rundek T, Naini A, Sacco R, et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol 2004 Jun; 61(6): 889–92.PubMedCrossRefGoogle Scholar
  22. 22.
    De Pinieux G, Chariot P, Ammi-Said M, et al. Lipid-lowering drugs and mitochondrial function: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol 1996; 42(3): 333–7.PubMedCrossRefGoogle Scholar
  23. 23.
    Mahoney DJ, Parise G, Tarnopolsky MA. Nutritional and exercise-based therapies in the treatment of mitochondrial disease. Curr Opin Clin Nutr Metab Care 2002 Nov; 5(6): 619–29.PubMedCrossRefGoogle Scholar
  24. 24.
    Rosenfeldt FL, Pepe S, Linnane A, et al. Coenzyme Q10 protects the aging heart against stress: studies in rats, human tissues, and patients. Ann N Y Acad Sci 2002 Apr; 959: 355–9, discussion 463–5.PubMedCrossRefGoogle Scholar
  25. 25.
    Barbiroli B, Frassineti C, Martinelli P, et al. Coenzyme Q10 improves mitochondrial respiration in patients with mitochondrial cytopathies: an in vivo study on brain and skeletal muscle by phosphorous magnetic resonance spectroscopy. Cell Mol Biol (Noisy-le-grand) 1997 Jul; 43(5): 741–9.Google Scholar
  26. 26.
    Scott RS, Lintott CJ, Wilson MJ. Simvastatin and side effects. NZ Med J 1991; 104(924): 493–5.Google Scholar
  27. 27.
    Wierzbicki AS, Lumb PJ, Semra Y, et al. Atorvastatin compared with simvastatin-based therapies in the management of severe familial hyperlipidaemias. QJM 1999 Jul; 92(7): 387–94.PubMedCrossRefGoogle Scholar
  28. 28.
    McClure DL, Valuck RJ, Glanz M, et al. Systematic review and meta-analysis of clinically relevant adverse events from HMG CoA reductase inhibitor trials worldwide from 1982 to present. Pharmacoepidemiol Drug Saf 2007 Feb; 16(2): 132–43.PubMedCrossRefGoogle Scholar
  29. 29.
    McDermott MM, Guralnik JM, Greenland P, et al. Statin use and leg functioning in patients with and without lower-extremity peripheral arterial disease. Circulation 2003 Feb 11; 107(5): 757–61.PubMedCrossRefGoogle Scholar
  30. 30.
    Arnaud C, Mach F. Pleiotropic effects of statins in atherosclerosis: role on endothelial function, inflammation and immunomodulation. Arch Mal Coeur Vaiss 2005 Jun; 98(6): 661–6.PubMedGoogle Scholar
  31. 31.
    Phillips PS, Haas RH, Bannykh S, et al. Statin-associated myopathy with normal creatine kinase levels. Ann Intern Med 2002 Oct 1; 137(7): 581–5.PubMedGoogle Scholar
  32. 32.
    Troseid M, Henriksen OA, Lindal S. Statin-associated myopathy with normal creatine kinase levels: case report from a Norwegian family. APMIS 2005 Sep; 113(9): 635–7.PubMedCrossRefGoogle Scholar
  33. 33.
    Sinzinger H. Statin-induced myositis migrans. Wien Klin Wochenschr 2002 Nov 30; 114(21–22): 943–4.PubMedGoogle Scholar
  34. 34.
    Bruckert E, Hayem G, Dejager S, et al. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients: the PRIMO study. Cardiovasc Drugs Ther 2005 Dec; 19(6): 403–14.PubMedCrossRefGoogle Scholar
  35. 35.
    Franc S, Bruckert E, Giral P, et al. Rhabdomyolysis in patients with preexisting myopathy, treated with antilipemic agents [in French]. Presse Med 1997 Dec 6; 26(38): 1855–8.PubMedGoogle Scholar
  36. 36.
    Hosein S. Warnings issued in Canada and the European Union about lipid drug. CATIE News, 2004 Jun 28 [online] Available from URL: [Accessed 2005 Jan 15].
  37. 37.
    Golomb B, Yang E, Denenberg J, et al. Statin-associated muscle adverse effects. Circulation 2003 Mar 5; 107: e7028–9.Google Scholar
  38. 38.
    Mancuso CE, Tanzi MG, Gabay M. Paradoxical reactions to benzodiazepines: literature review and treatment options. Pharmacotherapy 2004 Sep; 24(9): 1177–85.PubMedCrossRefGoogle Scholar
  39. 39.
    Gutierrez MA, Roper JM, Hahn P. Paradoxical reactions to benzodiazepines. Am J Nurs 2001 Jul; 101(7): 34–9, quiz 9–40.PubMedCrossRefGoogle Scholar
  40. 40.
    Tanquary J, Masand P. Paradoxical reaction to buspirone augmentation of fluoxetine. J Clin Psychopharmacol 1990 Oct; 10(5): 377.PubMedCrossRefGoogle Scholar
  41. 41.
    Stewart JT. Paradoxical aggressive effect of propranolol in a patient with Huntington’s disease. J Clin Psychiatry 1987 Sep; 48(9): 385–6.PubMedGoogle Scholar
  42. 42.
    Short TG, Forrest P, Galletly DC. Paradoxical reactions to benzodiazepines: a genetically determined phenomenon? Anaesth Intensive Care 1987 Aug; 15(3): 330–1.PubMedGoogle Scholar
  43. 43.
    Warren SE, Ebert E, Swerdlin AH, et al. Clonidine and propranolol paradoxical hypertension. Arch Intern Med 1979 Feb; 139(2): 253.PubMedCrossRefGoogle Scholar
  44. 44.
    Lion JR, Azcarate CL, Koepke HH. 'Paradoxical rage reactions’ during psychotropic medication. Dis Nerv Syst 1975 Oct; 36(10): 557–8.PubMedGoogle Scholar
  45. 45.
    Blum I, Atsmon A, Steiner M, et al. Paradoxical rise in blood pressure during propranolol treatment. BMJ 1975 Dec 13; 4(5997): 623.PubMedCrossRefGoogle Scholar
  46. 46.
    Mitani H, Egashira K, Ohashi N, et al. Preservation of endothelial function by the HMG-CoA reductase inhibitor fluvastatin through its lipid-lowering independent antioxidant properties in atherosclerotic rabbits. Pharmacology 2003 Jul; 68(3): 121–30.PubMedCrossRefGoogle Scholar
  47. 47.
    Carneado J, Alvarez de Sotomayo M, Perez-Guerrero C, et al. Simvastatin improves endothelial function in spontaneously hypertensive rats through a super-oxide dismutase mediated antioxidant effect. J Hypertens 2002 Mar; 20(3): 429–37.PubMedCrossRefGoogle Scholar
  48. 48.
    Vaughan CJ, Delanty N. Neuroprotective properties of statins in cerebral ischemia and stroke. Stroke 1999 Sep; 30(9): 1969–73.PubMedCrossRefGoogle Scholar
  49. 49.
    Sugiyama M, Ohashi M, Takase H, et al. Effects of atorvastatin on inflammation and oxidative stress. Heart Vessels 2005 Jul; 20(4): 133–6.PubMedCrossRefGoogle Scholar
  50. 50.
    Himmelfarb J. Linking oxidative stress and inflammation in kidney disease: which is the chicken and which is the egg? Semin Dial 2004 Nov–Dec; 17(6): 449–54.PubMedCrossRefGoogle Scholar
  51. 51.
    Sinzinger H, Chehne F, Lupattelli G. Oxidation injury in patients receiving HMG-CoA reductase inhibitors: occurrence in patients without enzyme elevation or myopathy. Drug Saf 2002; 25(12): 877–83.PubMedCrossRefGoogle Scholar
  52. 52.
    Sinzinger H, Lupattelli G, Chehne F. Increased lipid peroxidation in a patient with CK-elevation and muscle pain during statin therapy. Atherosclerosis 2000 Nov; 153(1): 255–6.PubMedCrossRefGoogle Scholar
  53. 53.
    Sinzinger H, Lupattelli G, Chehne F, et al. Isoprostane 8-epi-PGF2alpha is frequently increased in patients with muscle pain and/or CK-elevation after HMG-Co-enzyme-A-reductase inhibitor therapy. J Clin Pharm Ther 2001 Aug; 26(4): 303–10.PubMedCrossRefGoogle Scholar
  54. 54.
    Arnaiz JA, Carne X, Riba N, et al. The use of evidence in pharmacovigilance: case reports as the reference source for drug withdrawals. Eur J Clin Pharmacol 2001 Apr; 57(1): 89–91.PubMedCrossRefGoogle Scholar
  55. 55.
    Goldman SA, Kennedy DL. MedWatch: FDA’s Medical Products Reporting Program. Postgrad Med 1998 Mar; 103(3): 13–6.PubMedCrossRefGoogle Scholar
  56. 56.
    Rossi AC, Knapp DE. Discovery of new adverse drug reactions: a review of the Food and Drug Administration’s spontaneous reporting system. JAMA 1984 Aug 24–31; 252(8): 1030–3.PubMedCrossRefGoogle Scholar
  57. 57.
    McNeil JJ, Grabsch EA, McDonald MM. Postmarketing surveillance: strengths and limitations: the flucloxacillin-dicloxacillin story. Med J Aust 1999; 170(6): 270–3.PubMedGoogle Scholar
  58. 58.
    Sinzinger H, O’Grady J. Professional athletes suffering from familial hypercholesterolaemia rarely tolerate statin treatment because of muscular problems. Br J Clin Pharmacol 2004 Apr; 57(4): 525–8.PubMedCrossRefGoogle Scholar
  59. 59.
    Eagles CJ, Kendall MJ. The effects of combined treatment with beta 1-selective receptor antagonists and lipid-lowering drugs on fat metabolism and measures of fatigue during moderate intensity exercise: a placebo-controlled study in healthy subjects. Br J Clin Pharmacol 1997 Mar; 43(3): 291–300.PubMedCrossRefGoogle Scholar
  60. 60.
    Seachrist JL, Loi CM, Evans MG, et al. Roles of exercise and pharmacokinetics in cerivastatin-induced skeletal muscle toxicity. Toxicol Sci 2005 Dec; 88(2): 551–61.PubMedCrossRefGoogle Scholar
  61. 61.
    Thompson PD, Zmuda JM, Domalik LJ, et al. Lovastatin increases exerciseinduced skeletal muscle injury. Metabolism 1997 Oct; 46(10): 1206–10.PubMedCrossRefGoogle Scholar
  62. 62.
    Urso ML, Clarkson PM, Hittel D, et al. Changes in ubiquitin proteasome pathway gene expression in skeletal muscle with exercise and statins. Arterioscler Thromb Vasc Biol 2005 Dec; 25(12): 2560–6.PubMedCrossRefGoogle Scholar
  63. 63.
    Fauchais AL, Iba Ba J, Maurage P, et al. Polymyositis induced or associated with lipid-lowering drugs: five cases [in French]. Rev Med Interne 2004 Apr; 25(4): 294–8.PubMedCrossRefGoogle Scholar
  64. 64.
    Giordano N, Senesi M, Mattii G, et al. Polymyositis associated with simvastatin [letter]. Lancet 1997; 349(9065): 1600–1.PubMedCrossRefGoogle Scholar
  65. 65.
    Hill C, Zeitz C, Kirkham B. Dermatomyositis with lung involvement in a patient treated with simvastatin. Aust NZ J Med 1995; 25: 745–6.CrossRefGoogle Scholar
  66. 66.
    Khattak FH, Morris IM, Branford WA. Simvastatin-associated dermatomyositis [letter]. Br J Rheumatol 1994; 33(2): 199.PubMedCrossRefGoogle Scholar
  67. 67.
    Noel B, Cerottini JP, Panizzon RG. Atorvastatin-induced dermatomyositis. Am J Med 2001 Jun 1; 110(8): 670–1.PubMedCrossRefGoogle Scholar
  68. 68.
    Riesco-Eizaguirre G, Arpa-Gutierrez FJ, Gutierrez M, et al. Severe polymyositis with simvastatin use [in Spanish]. Rev Neurol 2003 Nov 16–30; 37(10): 934–6.PubMedGoogle Scholar
  69. 69.
    Rodriguez-Garcia JL, Serrano Commino M. Lovastatin-associated dermatomyositis [letter]. Postgrad Med J 1996; 72(853): 694.PubMedCrossRefGoogle Scholar
  70. 70.
    Schalke BB, Schmidt B, Toyka K, et al. Pravastatin-associated inflammatory myopathy [letter]. N Engl J Med 1992; 327(9): 649–50.PubMedGoogle Scholar
  71. 71.
    Takagi A, Shiio Y. Pravastatin-associated polymyositis, a case report [in Japanese]. Rinsho Shinkeigaku 2004 Jan; 44(1): 25–7.PubMedGoogle Scholar
  72. 72.
    Thual N, Penven K, Chevallier JM, et al. Fluvastatin-induced dermatomyositis [in French]. Ann Dermatol Venereol 2005 Dec; 132(12 Pt 1): 996–9.PubMedCrossRefGoogle Scholar
  73. 73.
    Vasconcelos OM, Campbell WW. Dermatomyositis-like syndrome and HMG-CoA reductase inhibitor (statin) intake. Muscle Nerve 2004 Dec; 30(6): 803–7.PubMedCrossRefGoogle Scholar
  74. 74.
    Zuech P, Pauwels C, Duthoit C, et al. Pravastatin-induced dermatomyositis [in French]. Rev Med Interne 2005 Nov; 26(11): 897–902.PubMedCrossRefGoogle Scholar
  75. 75.
    Scalvini T, Marocolo D, Cerudelli B, et al. Pravastatin-associated myopathy: report of a case. Recenti Prog Med 1995; 86(5): 198–200.PubMedGoogle Scholar
  76. 76.
    Witko-Sarsat V, Nguyen Khoa T, Jungers P, et al. Advanced oxidation protein products: oxidative stress markers and mediators of inflammation in uremia. Adv Nephrol Necker Hosp 1998; 28: 321–41.PubMedGoogle Scholar
  77. 77.
    Collins LV, Hajizadeh S, Holme E, et al. Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses. J Leukoc Biol 2004 Jun; 75(6): 995–1000.PubMedCrossRefGoogle Scholar
  78. 78.
    Cartwright MS, Jeffery DR, Nuss GR, et al. Statin-associated exacerbation of myasthenia gravis. Neurology 2004 Dec 14; 63(11): 2188.PubMedCrossRefGoogle Scholar
  79. 79.
    Franc S, Dejager S, Bruckert E, et al. A comprehensive description of muscle symptoms associated with lipid-lowering drugs. Cardiovasc Drugs Ther 2003; 17(5–6): 459–65.PubMedCrossRefGoogle Scholar
  80. 80.
    Soininen K, Niemi M, Kilkki E, et al. Muscle symptoms associated with statins: a series of twenty patients. Basic Clin Pharmacol Toxicol 2006; 98(1): 51–4.PubMedCrossRefGoogle Scholar
  81. 81.
    Eriksson M, Angelin B, Sjoberg S. Risk for fatal statin-induced rhabdomyolysis as a consequence of misinterpretation of ‘evidence-based medicine'. J Intern Med 2005 Mar; 257(3): 313–4.PubMedCrossRefGoogle Scholar
  82. 82.
    Ozdemir O, Boran M, Gökçe V, et al. A case with severe rhabdomyolysis and renal failure associated with cerivastatin-gemfibrozil combination therapy: a case report. Angiology 2000; 51(8): 695–7.PubMedGoogle Scholar
  83. 83.
    Staffa JA, Chang J, Green L. Cerivastatin and reports of fatal rhabdomyolysis. New Engl J Med 2002; 346(7): 539–40.PubMedCrossRefGoogle Scholar
  84. 84.
    Weise WJ, Possidente CJ. Fatal rhabdomyolysis associated with simvastatin in a renal transplant patient. Am J Med 2000 Mar; 108(4): 351–2.PubMedCrossRefGoogle Scholar
  85. 85.
    Scheen AJ. Fatal rhabdomyolysis caused by cerivastatin [in French]. Rev Med Liege 2001 Aug; 56(8): 592–4.PubMedGoogle Scholar
  86. 86.
    Hare CB, Vu MP, Grunfeld C, et al. Simvastatin-nelfinavir interaction implicated in rhabdomyolysis and death. Clin Infect Dis 2002 Nov 15; 35(10): e111–2.PubMedCrossRefGoogle Scholar
  87. 87.
    Federman DG, Hussain F, Walters AB. Fatal rhabdomyolysis caused by lipid-lowering therapy. South Med J 2001 Oct; 94(10): 1023–6.PubMedGoogle Scholar
  88. 88.
    Gladding P, Pilmore H, Edwards C. Potentially fatal interaction between diltiazem and statins. Ann Intern Med 2004 Apr 20; 140(8): W31.PubMedGoogle Scholar
  89. 89.
    Kahri J, Valkonen M, Backlund T, et al. Rhabdomyolysis in a patient receiving atorvastatin and fluconazole. Eur J Clin Pharmacol 2005 Feb; 60(12): 905–7.PubMedCrossRefGoogle Scholar
  90. 90.
    Jamil S, Iqbal P. Rhabdomyolysis induced by a single dose of a statin. Heart 2004 Jan; 90(1): e3.PubMedCrossRefGoogle Scholar
  91. 91.
    Al Shohaib S. Simvastatin-induced rhabdomyolysis in a patient with chronic renal failure. Am J Nephrol 2000; 20(3): 212–3.PubMedCrossRefGoogle Scholar
  92. 92.
    Jose J, Saravu K, Shastry BA. Atorvastatin-induced early-onset rhabdomyolysis in a patient with nephrotic syndrome. Am J Health Syst Pharm 2007 Apr 1; 64(7): 726–9.PubMedCrossRefGoogle Scholar
  93. 93.
    Archambeaud-Mouveroux F, Lopez S, Combes C, et al. Rhabdomyolysis induced by fenofibrate monotherapy [in French]. Rev Med Interne 2006 Jul; 27(7): 573–4.PubMedCrossRefGoogle Scholar
  94. 94.
    Antons KA, Williams CD, Baker SK, et al. Clinical perspectives of statin-induced rhabdomyolysis. Am J Med 2006 May; 119(5): 400–9.PubMedCrossRefGoogle Scholar
  95. 95.
    Schindler C, Thorns M, Matschke K, et al. Asymptomatic statin-induced rhabdomyolysis after long-term therapy with the hydrophilic drug pravastatin. Clin Ther 2007 Jan; 29(1): 172–6.PubMedCrossRefGoogle Scholar
  96. 96.
    Sreenarasimhaiah J, Shiels P, Lisker-Melman M. Multiorgan failure induced by atorvastatin. Am J Med 2002 Sep; 113(4): 348–9.PubMedCrossRefGoogle Scholar
  97. 97.
    Akoglu H, Yilmaz R, Kirkpantur A, et al. Combined organ failure with combination antihyperlipidemic treatment: a case of hepatic injury and acute renal failure. Ann Pharmacother 2007 Jan; 41(1): 143.PubMedGoogle Scholar
  98. 98.
    Kogan AD, Orenstein S. Lovastatin-induced acute rhabdomyolysis. Postgrad Med J 1990; 66(774): 294–6.PubMedCrossRefGoogle Scholar
  99. 99.
    Sirvent AE, Cabezuelo JB, Enriquez R, et al. Rhabdomyolysis and anuric kidney failure induced by the treatment with a gemfibrozil-cerivastatin combination [in Spanish]. Nefrologia 2001 Sep–Oct; 21(5): 497–500.PubMedGoogle Scholar
  100. 100.
    Chu PH, Chen WJ, Chiang CW, et al. Rhabdomyolysis, acute renal failure and hepatopathy induced by lovastatin monotherapy. Jpn Heart J 1997; 38(4): 541–5.PubMedCrossRefGoogle Scholar
  101. 101.
    Bravo JJ, Novoa D, Romero R, et al. Cerivastatin and acute kidney failure caused by rhabdomyolysis [in Spanish]. Nefrologia 2001 Sep–Oct; 21(5): 509.PubMedGoogle Scholar
  102. 102.
    Corpier CL, Jones PH, Suki WN, et al. Rhabdomyolysis and renal injury with lovastatin use: report of two cases in cardiac transplant recipients. JAMA 1988 Jul 8; 260(2): 239–41.PubMedCrossRefGoogle Scholar
  103. 103.
    Fernandez Zatarain G, Navarro V, Garcia H, et al. Rhabdomyolysis and acute renal failure associated with lovastatin. Nephron 1994; 66(4): 483–4.PubMedCrossRefGoogle Scholar
  104. 104.
    Knoll RW, Ciafone R, Galen M. Rhabdomyolysis and renal failure secondary to combination therapy of hyperlipidemia with lovastatin and gemfibozil. Conn Med 1993 Sep; 57(9): 593–4.PubMedGoogle Scholar
  105. 105.
    Abdul-Ghaffar NU, el-Sonbaty MR. Pancreatitis and rhabdomyolysis associated with lovastatin-gemfibrozil therapy. J Clin Gastroenterol 1995; 21(4): 340–1.PubMedCrossRefGoogle Scholar
  106. 106.
    Bielecki JW, Schraner C, Briner V, et al. Rhabdomyolysis and cholestatic hepatitis under treatment with simvastatin and chlorzoxazone [in German]. Schweiz Med Wochenschr 1999; 129(13): 514–8.PubMedGoogle Scholar
  107. 107.
    Stein CA, Goel S, Ghavamian R. Hepatitis and rhabdomyolysis in a patient with hormone refractory prostate cancer on ketoconazole and concurrent lovastatin therapy. Invest New Drugs 2007 Jun; 25(3): 277–8.PubMedCrossRefGoogle Scholar
  108. 108.
    Ricaurte B, Guirguis A, Taylor HC, et al. Simvastatin-amiodarone interaction resulting in rhabdomyolysis, azotemia, and possible hepatotoxicity. Ann Pharmacother 2006 Apr; 40(4): 753–7.PubMedCrossRefGoogle Scholar
  109. 109.
    Su M, Hoffman RS, Flomenbaum M. Cerivastatin and gemfibrozil-induced cardiac rhabdomyolysis. Am J Forensic Med Pathol 2002 Sep; 23(3): 305–6.PubMedCrossRefGoogle Scholar
  110. 110.
    Ireland JH, Eggert CH, Arendt CJ, et al. Rhabdomyolysis with cardiac involvement and acute renal failure in a patient taking rosuvastatin and fenofibrate. Ann Intern Med 2005 Jun 7; 142(11): 949–50.PubMedGoogle Scholar
  111. 111.
    Dromer C, Vedrenne C, Billey T, et al. Rhabdomyolysis due to simvastin: apropos of a case with review of the literature [in French]. Rev Rhum Mal Osteoartic 1992 Apr; 59(4): 281–3.PubMedGoogle Scholar
  112. 112.
    Chariot P, Abadia R, Agnus D, et al. Simvastatin-induced rhabdomyolysis followed by a MELAS syndrome. Am J Med 1993 Jan; 94(1): 109–10.PubMedCrossRefGoogle Scholar
  113. 113.
    Dobkin BH. Underappreciated statin-induced myopathic weakness causes disability. Neurorehabil Neural Repair 2005 Sep; 19(3): 259–63.PubMedCrossRefGoogle Scholar
  114. 114.
    Sinzinger H, Schmid P, O’Grady J. Two different types of exercise-induced muscle pain without myopathy and CK-elevation during HMG-Co-enzyme-A-reductase inhibitor treatment. Atherosclerosis 1999 Apr; 143(2): 459–60.PubMedCrossRefGoogle Scholar
  115. 115.
    Pearce PZ. Statin-induced myopathy in a competitive amateur cyclist. Curr Sports Med Rep 2008; 7(3): 149–51.PubMedGoogle Scholar
  116. 116.
    Thompson PD, Nugent AM, Herbert PN. Increases in creatine kinase after exercise in patients treated with HMG Co-A reductase inhibitors. JAMA 1990 Dec 19; 264(23): 2992.PubMedCrossRefGoogle Scholar
  117. 117.
    Andreu AL, Tanji K, Bruno C, et al. Exercise intolerance due to a nonsense mutation in the mtDNA ND4 gene. Ann Neurol 1999 Jun; 45(6): 820–3.PubMedCrossRefGoogle Scholar
  118. 118.
    DiMauro S. Exercise intolerance and the mitochondrial respiratory chain. Ital J Neurol Sci 1999 Dec; 20(6): 387–93.PubMedGoogle Scholar
  119. 119.
    DiMauro S, Andreu AL. Mutations in mitochondrial DNA as a cause of exercise intolerance. Ann Med 2001 Oct; 33(7): 472–6.PubMedCrossRefGoogle Scholar
  120. 120.
    Haller RG, Lewis SF, Estabrook RW, et al. Exercise intolerance, lactic acidosis, and abnormal cardiopulmonary regulation in exercise associated with adult skeletal muscle cytochrome c oxidase deficiency. J Clin Invest 1989 Jul; 84(1): 155–61.PubMedCrossRefGoogle Scholar
  121. 121.
    Nishigaki Y, Bonilla E, Shanske S, et al. Exercise-induced muscle “burning”, fatigue, and hyper-CKemia: mtDNA T10010C mutation in tRNA(gly). Neurology 2002 Apr 23; 58(8): 1282–5.PubMedCrossRefGoogle Scholar
  122. 122.
    Taivassalo T, Jensen TD, Kennaway N, et al. The spectrum of exercise tolerance in mitochondrial myopathies: a study of 40 patients. Brain 2003 Feb; 126(Pt 2): 413–23.PubMedCrossRefGoogle Scholar
  123. 123.
    Hooper RG, Thomas AR, Kearl RA. Mitochondrial enzyme deficiency causing exercise limitation in normal-appearing adults. Chest 1995 Feb; 107(2): 317–22.PubMedCrossRefGoogle Scholar
  124. 124.
    Engel WK. Reversible ocular myasthenia gravis or mitochondrial myopathy from statins? Lancet 2003 Jan 4; 361(9351): 85–6.PubMedCrossRefGoogle Scholar
  125. 125.
    Windler E. Should lipid-lowering agents be prescribed in myasthenia? [in German]. Dtsch Med Wochenschr 1996 Jan 19; 121(3): 80.PubMedGoogle Scholar
  126. 126.
    Li L, Shou Y, Borowitz JL, et al. Reactive oxygen species mediate pyridostigmine-induced neuronal apoptosis: involvement of muscarinic and NMDA receptors. Toxicol Appl Pharmacol 2001 Nov 15; 177(1): 17–25.PubMedCrossRefGoogle Scholar
  127. 127.
    Milatovic D, Gupta RC, Aschner M. Anticholinesterase toxicity and oxidative stress. Sci World J 2006; 6: 295–310.CrossRefGoogle Scholar
  128. 128.
    Marchiori PE, Levy JA, Carvalho-Alegro MS, et al. Mitochondrial dysfunction in myasthenia gravis: report of a case. Arq Neuropsiquiat 1989 Sep; 47(3): 355–8.PubMedGoogle Scholar
  129. 129.
    Baker SK, Tarnopolsky MA. Sporadic rippling muscle disease unmasked by simvastatin. Muscle Nerve 2006 Oct; 34(4): 478–81.PubMedCrossRefGoogle Scholar
  130. 130.
    Rajabally YA, Varakantam V, Abbott RJ. Disorder resembling Guillain-Barre syndrome on initiation of statin therapy. Muscle Nerve 2004 Nov; 30(5): 663–6.PubMedCrossRefGoogle Scholar
  131. 131.
    Daghfous R, El Aidli S, Gheni R, et al. Drug tendon disorders [in French]. Tunis Med 2005 May; 83(5): 253–7.PubMedGoogle Scholar
  132. 132.
    Chazerain P, Hayem G, Hamza S, et al. Four cases of tendinopathy in patients on statin therapy. Joint Bone Spine 2001 Oct; 68(5): 430–3.PubMedCrossRefGoogle Scholar
  133. 133.
    Pullatt RC, Gadarla MR, Karas RH, et al. Tendon rupture associated with simvastatin/ezetimibe therapy. Am J Cardiol 2007 Jul 1; 100(1): 152–3.PubMedCrossRefGoogle Scholar
  134. 134.
    Movahed MR, Samsamsharaiat SA. Reproducible tendinitis-like symptoms related to statin therapy. J Clin Rheumatol 2006 Dec; 12(6): 320–1.PubMedCrossRefGoogle Scholar
  135. 135.
    Franc S, Dejager S, Bruckert E, et al. A comprehensive description of muscle symptoms associated with lipid-lowering drugs. Cardiovasc Drugs Ther 2003 Sep–Nov; 17(5–6): 459–65.PubMedCrossRefGoogle Scholar
  136. 136.
    Medicines Adverse Reactions Committee of the New Zealand Medicines and Medical Services Safety Authority. Adverse Reaction Reporting and IMMP. Minutes of the 114th Medicines Adverse Reactions Committee Meeting. 3.2.2 Statins and tendonopathy. 2003 June 26 [online]. Available from URL: [Accessed 2007 Jan 10].
  137. 137.
    Marie I, Delafenetre H, Massy N, et al. Tendinous disorders attributed to statins: a study on ninety-six spontaneous reports in the period 1990–2005 and review of the literature. Arthritis Rheum 2008; 59(3): 367–72.PubMedCrossRefGoogle Scholar
  138. 138.
    Ouedraogo G, Morliere P, Santus R, et al. Damage to mitochondria of cultured human skin fibroblasts photosensitized by fluoroquinolones. J Photochem Photobiol B 2000 Oct; 58(1): 20–5.PubMedCrossRefGoogle Scholar
  139. 139.
    Lawrence JW, Claire DC, Weissig V, et al. Delayed cytotoxicity and cleavage of mitochondrial DNA in ciprofloxacin-treated mammalian cells. Mol Pharmacol 1996 Nov; 50(5): 1178–88.PubMedGoogle Scholar
  140. 140.
    Pouzaud F, Dutot M, Martin C, et al. Age-dependent effects on redox status, oxidative stress, mitochondrial activity and toxicity induced by fluoroquinolones on primary cultures of rabbit tendon cells. Comp Biochem Physiol C Toxicol Pharmacol 2006 Jun; 143(2): 232–41.PubMedCrossRefGoogle Scholar
  141. 141.
    Guis S, Jouglard J, Kozak-Ribbens G, et al. Malignant hyperthermia susceptibility revealed by myalgia and rhabdomyolysis during fluoroquinolone treatment. J Rheumatol 2001 Jun; 28(6): 1405–6.PubMedGoogle Scholar
  142. 142.
    Guis S, Bendahan D, Kozak-Ribbens G, et al. Investigation of fluoroquinoloneinduced myalgia using (31)P magnetic resonance spectroscopy and in vitro contracture tests. Arthritis Rheum 2002 Mar; 46(3): 774–8.PubMedCrossRefGoogle Scholar
  143. 143.
    Petitjeans F, Nadaud J, Perez JP, et al. A case of rhabdomyolysis with fatal outcome after a treatment with levofloxacin. Eur J Clin Pharmacol 2003 Dec; 59(10): 779–80.PubMedCrossRefGoogle Scholar
  144. 144.
    Harada K, Tsuruoka S, Fujimura A. Shoulder stiffness: a common adverse effect of HMG-CoA reductase inhibitors in women? Intern Med 2001; 40(8): 817–8.PubMedCrossRefGoogle Scholar
  145. 145.
    Edwards IR, Star K, Kiuru A. Statins, neuromuscular degenerative disease and an amyotrophic lateral sclerosis-like syndrome: an analysis of individual case safety reports from vigibase. Drug Saf 2007; 30(6): 515–25.PubMedCrossRefGoogle Scholar
  146. 146.
    Golomb BA, Kwon EK, Koperski S, et al. Amyotrophic lateral sclerosis-like conditions arising in association with cholesterol-lowering drugs: hypothesized role for oxidative stress and mitochondrial Injury. Drug Safety. In press.Google Scholar
  147. 147.
    Boltan DD, Lachar W, Khetan A, et al. Fatal and widespread skeletal myopathy confirmed morphologically years after initiation of simvastatin therapy. Am J Cardiol 2007; 99(8): 1171–6.PubMedCrossRefGoogle Scholar
  148. 148.
    Prabhala A, Garg R, Dandona P. Severe myopathy associated with vitamin D deficiency in western New York. Arch Intern Med 2000; 160(8): 1199–203.PubMedCrossRefGoogle Scholar
  149. 149.
    Dupuis L, Gonzalez de Aguilar JL, Echaniz-Laguna A, et al. Mitochondrial dysfunction in amyotrophic lateral sclerosis also affects skeletal muscle. Muscle Nerve 2006; 34(2): 253–4.PubMedCrossRefGoogle Scholar
  150. 150.
    Krasnianski A, Deschauer M, Neudecker S, et al. Mitochondrial changes in skeletal muscle in amyotrophic lateral sclerosis and other neurogenic atrophies. Brain 2005; 128(Pt 8): 1870–6.PubMedCrossRefGoogle Scholar
  151. 151.
    Soraru G, Vergani L, Fedrizzi L, et al. Activities of mitochondrial complexes correlate with nNOS amount in muscle from ALS patients. Neuropathol Appl Neurobiol 2007; 33(2): 204–11.PubMedCrossRefGoogle Scholar
  152. 152.
    Vielhaber S, Kunz D, Winkler K, et al. Mitochondrial DNA abnormalities in skeletal muscle of patients with sporadic amyotrophic lateral sclerosis. Brain 2000; 123(Pt 7): 1339–48.PubMedCrossRefGoogle Scholar
  153. 153.
    Wiedemann FR, Winkler K, Kuznetsov AV, et al. Impairment of mitochondrial function in skeletal muscle of patients with amyotrophic lateral sclerosis. J Neurol Sci 1998; 156(1): 65–72.PubMedCrossRefGoogle Scholar
  154. 154.
    Walker JL, Smith GH, Gaston MS, et al. Spontaneous compartment syndrome in association with simvastatin-induced myositis. Emerg Med J 2008; 25(5): 305–6.PubMedCrossRefGoogle Scholar
  155. 155.
    Ramdass MJ, Singh G, Andrews B. Simvastatin-induced bilateral leg compartment syndrome and myonecrosis associated with hypothyroidism. Postgrad Med J 2007; 83(977): 152–3.PubMedCrossRefGoogle Scholar
  156. 156.
    Vladutiu GD, Simmons Z, Isackson PJ, et al. Genetic risk factors associated with lipid-lowering drug-induced myopathies. Muscle Nerve 2006 Aug; 34(2): 153–62.PubMedCrossRefGoogle Scholar
  157. 157.
    Phillips CT, Gray NL, Puhek LM, et al. Cardiopulmonary function is abnormal after statin-induced rhabdomyolysis and myositis [abstract]. J Am Coll Cardiol 2004; 43 Suppl. A: 16a.CrossRefGoogle Scholar
  158. 158.
    Phillips CT, Gray NL, Puhek LM, et al. Basal respiratory exchange ratio is altered with statin use in normals [abstract]. J Am Coll Cardiol 2004; 43 Suppl. A: 233a.CrossRefGoogle Scholar
  159. 159.
    Phillips PS, Phillips CT, Sullivan MJ, et al. Statin myotoxicity is associated with changes in the cardiopulmonary function. Atherosclerosis 2004 Nov; 177(1): 183–8.PubMedCrossRefGoogle Scholar
  160. 160.
    Tsivgoulis G, Spengos K, Karandreas N, et al. Presymptomatic neuromuscular disorders disclosed following statin treatment. Arch Intern Med 2006 Jul 24; 166(14): 1519–24.PubMedCrossRefGoogle Scholar
  161. 161.
    Livingstone C, Al Riyami S, Wilkins P, et al. McArdle’s disease diagnosed following statin-induced myositis. Ann Clin Biochem 2004 Jul; 41(Pt 4): 338–40.PubMedCrossRefGoogle Scholar
  162. 162.
    Voermans NC, Lammens M, Wevers RA, et al. Statin-disclosed acid maltase deficiency. J Intern Med 2005 Aug; 258(2): 196–7.PubMedCrossRefGoogle Scholar
  163. 163.
    England JD, Walsh JC, Stewart P, et al. Mitochondrial myopathy developing on treatment with the HMG CoA reductase inhibitors: simvastatin and pravastatin [letter]. Aust NZ J Med 1995; 25(4): 374–5.CrossRefGoogle Scholar
  164. 164.
    Ronaldson KJ, O’Shea JM, Boyd IW. Risk factors for rhabdomyolysis with simvastatin and atorvastatin. Drug Saf 2006; 29(11): 1061–7.PubMedCrossRefGoogle Scholar
  165. 165.
    Tenenbaum A, Fisman EZ, Motro M. Rhabdomyolysis and lipid-lowering drugs. JAMA 2005 Mar 23; 293(12): 1448.PubMedCrossRefGoogle Scholar
  166. 166.
    Phillips PS. How common is rhabdomyolysis in patients receiving lipid-lowering therapy? Nat Clin Pract Cardiovasc Med 2005 Mar; 2(3): 130–1.PubMedCrossRefGoogle Scholar
  167. 167.
    Ardati A, Stolley P, Knapp DE, et al. Statin-associated rhabdomyolysis. Pharmacoepidemiol Drug Saf 2005 Apr; 14(4): 287.PubMedCrossRefGoogle Scholar
  168. 168.
    Cziraky MJ, Willey VJ, McKenney JM, et al. Statin safety: an assessment using an administrative claims database. Am J Cardiol 2006 Apr 17; 97(8A): 61C–8C.PubMedCrossRefGoogle Scholar
  169. 169.
    Graham DJ, Staffa JA, Shatin D, et al. Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs. JAMA 2004 Dec 1; 292(21): 2585–90.PubMedCrossRefGoogle Scholar
  170. 170.
    Andrejak M, Gras V, Caron J. Severe muscle disorders associated with statins: analysis of cases notified in France up to the end of February 2002 and data concerning the risk profile of cerivastatin [in French]. Therapie 2005 May–Jun; 60(3): 299–304.PubMedCrossRefGoogle Scholar
  171. 171.
    Prueksaritanont T, Tang C, Qiu Y, et al. Effects of fibrates on metabolism of statins in human hepatocytes. Drug Metab Dispos 2002 Nov; 30(11): 1280–7.PubMedCrossRefGoogle Scholar
  172. 172.
    Prueksaritanont T, Zhao JJ, Ma B, et al. Mechanistic studies on metabolic interactions between gemfibrozil and statins. J Pharmacol Exp Ther 2002 Jun; 301(3): 1042–51.PubMedCrossRefGoogle Scholar
  173. 173.
    Kanathur N, Mathai MG, Byrd RP, et al. Simvastatin-diltiazem drug interaction resulting in rhabdomyolysis and hepatitis. Tenn Med 2001 Sep; 94(9): 339–41.PubMedGoogle Scholar
  174. 174.
    Alsheikh-Ali AA, Karas RH. Adverse events with concomitant amiodarone and statin therapy. Prev Cardiol 2005 Spring; 8(2): 95–7.PubMedCrossRefGoogle Scholar
  175. 175.
    Sun D, Fernandes G. Lovastatin inhibits bone marrow-derived dendritic cell maturation and upregulates proinflammatory cytokine production. Cell Immunol 2003 May; 223(1): 52–62.PubMedCrossRefGoogle Scholar
  176. 176.
    Silva MA, Swanson AC, Gandhi PJ, et al. Statin-related adverse events: a meta-analysis. Clin Ther 2006 Jan; 28(1): 26–35.PubMedCrossRefGoogle Scholar
  177. 177.
    Silva M, Matthews ML, Jarvis C, et al. Meta-analysis of drug-induced adverse events associated with intensive-dose statin therapy. Clin Ther 2007 Feb; 29(2): 253–60.PubMedCrossRefGoogle Scholar
  178. 178.
    Kashani A, Phillips CO, Foody JM, et al. Risks associated with statin therapy: a systematic overview of randomized clinical trials. Circulation 2006 Dec 19; 114(25): 2788–97.PubMedCrossRefGoogle Scholar
  179. 179.
    Dale KM, Henyan NN, Coleman CI, et al. Does more aggressive statin therapy increase muscle and liver risk? [abstract no. 981–193]. J Am Coll Cardiol 2006 Feb 21; 47(4 Suppl. A): 335A.Google Scholar
  180. 180.
    Prueksaritanont T, Subramanian R, Fang X, et al. Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization. Drug Metab Dispos 2002 May; 30(5): 505–12.PubMedCrossRefGoogle Scholar
  181. 181.
    Food and Drug Administration. FDA Public Health Advisory on Crestor (rosuvastatin) [online]. Available from URL: [Accessed 2005 Mar 2].
  182. 182.
    Alsheikh-Ali AA, Maddukuri PV, Han H, et al. Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trials. J Am Coll Cardiol 2007 Jul 31; 50(5): 409–18.PubMedCrossRefGoogle Scholar
  183. 183.
    Sasaki J, Iwashita M, Kono S. Statins: beneficial or adverse for glucose metabolism. J Atheroscler Thromb 2006 Jun; 13(3): 123–9.PubMedCrossRefGoogle Scholar
  184. 184.
    Raskin P, Ganda OP, Willard D, et al. Efficacy and safety of pravastatin in the treatment of type I or type II diabetes mellitus and hypercholesterolemia. Am J Med 1995; 99: 362–9.PubMedCrossRefGoogle Scholar
  185. 185.
    Sabatine MS, Cannon CP. High-dose atorvastatin associated with worse glycemic control: A PROVE-IT TIMI 22 substudy. Circulation 2004; 100 Suppl. III: 834.Google Scholar
  186. 186.
    Lennernas H, Fager G. Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors: similarities and differences. Clin Pharmacokinet 1997; 32(5): 403–25.PubMedCrossRefGoogle Scholar
  187. 187.
    Omkumar RV, Gaikwad AS, Ramasarma T. Feedback-type inhibition of activity of 3-hydroxy-3-methylglutaryl coenzyme a reductase by ubiquinone. Biochem Biophys Res Commun 1992 May 15; 184(3): 1280–7.PubMedCrossRefGoogle Scholar
  188. 188.
    Kumar A, Kaur H, Kumar S, et al. Atorvastatin alone/ in combination with coenzyme Q10 in 103 cases of heart failure (HF) due to ischemic cardiomyopathy (ICM). Fourth Conference of the International Coenzyme Q10 Association; 2005 Apr 14–17; Los Angeles (CA).Google Scholar
  189. 189.
    Scranton RE, Cantillon C, Gagnon D, et al. Occurrences of rhabdomyolysis or myositis among statin users in a Veteran Affairs population [abstract]. Presented at the American Heart Association Council on Epidemiology and Prevention Meeting; 2004 Mar; San Francisco (CA). Circulation 2004; 109(6): P154.Google Scholar
  190. 190.
    Link E, Parish S, Armitage J, et al. SLCO1B1 variants and statin-induced myopathy: a genomewide study. N Engl J Med 2008; 359(8): 789–99.PubMedCrossRefGoogle Scholar
  191. 191.
    Ridker PM, Danielson E, Fonseca FA, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 2008; 359: 2195–207.PubMedCrossRefGoogle Scholar
  192. 192.
    Steinberg D. Thematic review series: the pathogenesis of atherosclerosis: an interpretive history of the cholesterol controversy. Part I. J Lipid Res 2004 Sep; 45(9): 1583–93.PubMedCrossRefGoogle Scholar
  193. 193.
    Stein E. The lower the better? Reviewing the evidence for more aggressive cholesterol reduction and goal attainment. Atheroscler Suppl 2002 Apr; 2(4): 19–23.PubMedCrossRefGoogle Scholar
  194. 194.
    O’Keefe Jr JH, Cordain L, Harris WH, et al. Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal. J Am Coll Cardiol 2004 Jun 2; 43(11): 2142–6.PubMedCrossRefGoogle Scholar
  195. 195.
    Afilalo J, Majdan AA, Eisenberg MJ. Intensive statin therapy in acute coronary syndromes and stable coronary heart disease: a comparative meta-analysis of randomised controlled trials. Heart 2007 Aug; 93(8): 914–21.PubMedCrossRefGoogle Scholar
  196. 196.
    Jones PH, Davidson MH. Reporting rate of rhabdomyolysis with fenofibrate + statin versus gemfibrozil + any statin. Am J Cardiol 2005 Jan 1; 95(1): 120–2.PubMedCrossRefGoogle Scholar
  197. 197.
    Myopathy and rhabdomyolysis with lovastatin taken with gemfibrozil [letter]. JAMA 1990; 264 (23): 2991–2.Google Scholar
  198. 198.
    Pierce LR, Wysowski DK, Gross TP. Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy [see comments]. JAMA 1990; 264(1): 71–5.PubMedCrossRefGoogle Scholar
  199. 199.
    Duell PB, Connor WE, Illingworth DR. Rhabdomyolysis after taking atorvastatin with gemfibrozil. Am J Cardiol 1998; 81(3): 368–9.PubMedCrossRefGoogle Scholar
  200. 200.
    Tal A, Rajeshawari M, Isley W. Rhabdomyolysis associated with simvastatin-gemfibrozil therapy. South Med J 1997; 90(5): 546–7.PubMedCrossRefGoogle Scholar
  201. 201.
    Alexandridis G, Pappas GA, Elisaf MS. Rhabdomyolysis due to combination therapy with cerivastatin and gemfibrozil [letter]. Am J Med 2000; 109(3): 261–2.PubMedCrossRefGoogle Scholar
  202. 202.
    Bermingham RP, Whitsitt TB, Smart ML, et al. Rhabdomyolysis in a patient receiving the combination of cerivastatin and gemfibrozil. Am J Health Syst Pharm 2000; 57(5): 461–4.PubMedGoogle Scholar
  203. 203.
    Marais GE, Larson KK. Rhabdomyolysis and acute renal failure induced by combination lovastatin and gemfibrozil therapy. Ann Intern Med 1990 Feb 1; 112(3): 228–30.PubMedGoogle Scholar
  204. 204.
    Maxa JL, Melton LB, Ogu CC, et al. Rhabdomyolysis after concomitant use of cyclosporine, simvastatin, gemfibrozil, and itraconazole. Ann Pharmacother 2002 May; 36(5): 820–3.PubMedCrossRefGoogle Scholar
  205. 205.
    van Puijenbroek EP, Du Buf-Vereijken PW, Spooren PF, et al. Possible increased risk of rhabdomyolysis during concomitant use of simvastatin and gemfibrozil. J Intern Med 1996 Dec; 240(6): 403–4.PubMedCrossRefGoogle Scholar
  206. 206.
    Hyman DJ, Henry A, Taylor A. Severe rhabdomyolysis related to cerivastatin without gemfibrozil. Ann Intern Med 2002 Jul 2; 137(1): 74.PubMedGoogle Scholar
  207. 207.
    Carretero MM, Manrique CA, Callol JA. Rhabdomyolysis associated with cerivastatin plus gemfibrozil combined regimen. Br J Gen Pract 2002 Mar; 52(476): 235–6.Google Scholar
  208. 208.
    Roca B, Calvo B, Monferrer R. Severe rhabdomyolysis and cerivastatin-gemfibrozil combination therapy. Ann Pharmacother 2002 Apr; 36(4): 730–1.PubMedCrossRefGoogle Scholar
  209. 209.
    Bosch Rovira T, Llompart Pou JA, Forteza-Rey J. Rhabdomyolysis associated with combined treatment of cerivastatin and gemfibrozil [in Spanish]. Rev Clin Esp 2001 Dec; 201(12): 731–2.PubMedGoogle Scholar
  210. 210.
    Hendriks F, Kooman JP, van der Sande FM. Massive rhabdomyolysis and life threatening hyperkalaemia in a patient with the combination of cerivastatin and gemfibrozil. Nephrol Dial Transplant 2001 Dec; 16(12): 2418–9.PubMedCrossRefGoogle Scholar
  211. 211.
    Bruno-Joyce J, Dugas JM, MacCausland OE. Cerivastatin and gemfibrozil-associated rhabdomyolysis. Ann Pharmacother 2001 Sep; 35(9): 1016–9.PubMedCrossRefGoogle Scholar
  212. 212.
    de Arriba Mendez JJ, Gomez Merino E, Saez Barcelona JA, et al. Severe rhabdomyolysis associated with cerivastatin and gemfibrozil [in Spanish]. Med Clin (Barc) 2001 Sep 15; 117(7): 278–9.Google Scholar
  213. 213.
    Vasconez Espinosa F, Gomez Rodrigue N, Martin Joven A, et al. Rhabdomyolysis complicated with acute renal insufficiency in a patient treated with gemfibrozil and cerivastatin [in Spanish]. Rev Clin Esp 2001 Apr; 201(4): 228–9.PubMedGoogle Scholar
  214. 214.
    Tomlinson B, Lan IW. Combination therapy with cerivastatin and gemfibrozil causing rhabdomyolysis: is the interaction predictable? Am J Med 2001 Jun 1; 110(8): 669–70.PubMedCrossRefGoogle Scholar
  215. 215.
    Mastroianni CM, d’Ettorre G, Forcina G, et al. Rhabdomyolysis after cerivastatin-gemfibrozil therapy in an HIV-infected patient with protease inhibitor-related hyperlipidemia. AIDS 2001 Apr 13; 15(6): 820–1.PubMedCrossRefGoogle Scholar
  216. 216.
    Pogson GW, Kindred LH, Carper BG. Rhabdomyolysis and renal failure associated with cerivastatin-gemfibrozil combination therapy. Am J Cardiol 1999 Apr 1; 83(7): 1146.PubMedCrossRefGoogle Scholar
  217. 217.
    Kind AH, Zakowski LJ, McBride PE. Rhabdomyolysis from the combination of a statin and gemfibrozil: an uncommon but serious adverse reaction. WMJ 2002; 101(7): 53–6.PubMedGoogle Scholar
  218. 218.
    Marsa Carretero M, Alos Manrique C, Valles Callol JC. Rhabdomyolysis associated with cerivastatin plus gemfibrozil combined regimen. Br J Gen Pract 2002 Mar; 52(476): 235–6.PubMedGoogle Scholar
  219. 219.
    SantaCruz PL, Gonzalez A, Leon ME, et al. Rhabdomyolysis, acute renal failure and use of cerivastatin combined with gemfibrozil: new evidence [in Spanish]. Nefrologia 2002; 22(3): 301–2.PubMedGoogle Scholar
  220. 220.
    Chang JT, Staffa JA, Parks M, et al. Rhabdomyolysis with HMG-CoA reductase inhibitors and gemfibrozil combination therapy. Pharmacoepidemiol Drug Saf 2004 Jul; 13(7): 417–26.PubMedCrossRefGoogle Scholar
  221. 221.
    Lau TK, Leachman DR, Lufschanowski R. Severe rhabdomyolysis associated with the cerivastin-gemfibrozil combination therapy: report of a case. Tex Heart Inst J 2001; 28(2): 142–5.PubMedGoogle Scholar
  222. 222.
    Farswan M, Rathod SP, Upaganlawar AB, et al. Protective effect of coenzyme Q10 in simvastatin and gemfibrozil induced rhabdomyolysis in rats. Indian J Exp Biol 2005 Oct; 43(10): 845–8.PubMedGoogle Scholar
  223. 223.
    Gouton M. Hypothyroidism, hypocholesteremic agents and rhabdomyolysis [in French]. Arch Mal Coeur Vaiss 1993 Dec; 86(12): 1761–4.PubMedGoogle Scholar
  224. 224.
    Chrysanthopoulos C, Kounis N. Rhabdomyolysis due to combined treatment with lovastatin and cholestyramine. BMJ (Clinical Research Ed) 1992; 304(6836): 1225.CrossRefGoogle Scholar
  225. 225.
    Reaven P, Witztum JL. Lovastatin, nicotinic acid, and rhabdomyolysis. Ann Intern Med 1988 Oct 1; 109(7): 597–8.PubMedGoogle Scholar
  226. 226.
    Piedra Leon M, Garcia Unzueta MT, Otero Martinez M, et al. Rhabdomyolysis associated to combined ezetimibe-statin treatment [in Spanish]. Rev Clin Esp 2007 Sep; 207(8): 425–6.PubMedCrossRefGoogle Scholar
  227. 227.
    Omar MA, Wilson JP. FDA adverse event reports on statin-associated rhabdomyolysis. Ann Pharmacother 2002 Feb; 36(2): 288–95.PubMedCrossRefGoogle Scholar
  228. 228.
    Glueck CJ, Oakes N, Speirs J, et al. Gemfibrozil-lovastatin therapy for primary hyperlipoproteinemias. Am J Cardiol 1992; 70(1): 1–9.PubMedCrossRefGoogle Scholar
  229. 229.
    Plotkin E, Bernheim J, Ben-Chetrit S, et al. Influenza vaccine: a possible trigger of rhabdomyolysis induced acute renal failure due to the combined use of cerivastatin and bezafibrate. Nephrol Dial Transplant 2000 May; 15(5): 740–1.PubMedCrossRefGoogle Scholar
  230. 230.
    Jacob SS, Jacob S, Williams C, et al. Simvastatin, fenofibrate, and rhabdomyolysis. Diabetes Care 2005 May; 28(5): 1258.PubMedCrossRefGoogle Scholar
  231. 231.
    Sorokin AV, Duncan B, Panetta R, et al. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006 Sep 1; 98(5): 705–6.PubMedCrossRefGoogle Scholar
  232. 232.
    Weffald LA, Flach LA. Myopathy associated with atorvastatin-ezetimibe combination therapy. Pharmacotherapy 2007 Feb; 27(2): 309–11.PubMedCrossRefGoogle Scholar
  233. 233.
    Omar MA, Wilson JP, Cox TS. Rhabdomyolysis and HMG-CoA reductase inhibitors. Ann Pharmacother 2001 Sep; 35(9): 1096–107.PubMedCrossRefGoogle Scholar
  234. 234.
    Molden E, Andersson KS. Simvastatin-associated rhabdomyolysis after coadministration of macrolide antibiotics in two patients. Pharmacotherapy 2007 Apr; 27(4): 603–7.PubMedCrossRefGoogle Scholar
  235. 235.
    Molden E, Andersson KS, Jacobsen D. Interactions between statins and macrolide antibiotics [in Norwegian]. Tidsskr Nor Laegeforen 2007 Jun 14; 127(12): 1660–1.PubMedGoogle Scholar
  236. 236.
    Spach DH, Bauwens JE, Clark CD, et al. Rhabdomyolysis associated with lovastatin and erythromycin use. West J Med 1991 Feb; 154(2): 213–5.PubMedGoogle Scholar
  237. 237.
    Grunden JW, Fisher KA. Lovastatin-induced rhabdomyolysis possibly associated with clarithromycin and azithromycin. Ann Pharmacother 1997; 31(7–8): 859–63.PubMedGoogle Scholar
  238. 238.
    Lee AJ, Maddix DS. Rhabdomyolysis secondary to a drug interaction between simvastatin and clarithromycin. Ann Pharmacother 2001; 35(1): 26–31.PubMedCrossRefGoogle Scholar
  239. 239.
    Sipe BE, Jones RJ, Bokhart GH. Rhabdomyolysis causing AV blockade due to possible atorvastatin, esomeprazole, and clarithromycin interaction. Ann Pharmacother 2003 Jun; 37(6): 808–11.PubMedCrossRefGoogle Scholar
  240. 240.
    Trieu J, Emmett L, Perera C, et al. Rhabdomyolysis resulting from interaction of simvastatin and clarithromycin demonstrated by Tc-99m MDP scintigraphy. Clin Nucl Med 2004 Dec; 29(12): 803–4.PubMedCrossRefGoogle Scholar
  241. 241.
    Kahri AJ, Valkonen MM, Vuoristo MK, et al. Rhabdomyolysis associated with concomitant use of simvastatin and clarithromycin. Ann Pharmacother 2004 Apr; 38(4): 719.PubMedGoogle Scholar
  242. 242.
    Huynh T, Cordato D, Yang F, et al. HMG CoA reductase-inhibitor-related myopathy and the influence of drug interactions. Intern Med J 2002 Sep–Oct; 32(9–10): 486–90.PubMedCrossRefGoogle Scholar
  243. 243.
    Gilad R, Lampl Y. Rhabdomyolysis induced by simvastatin and ketoconazole treatment. Clin Neuropharmacol 1999; 22(5): 295–7.PubMedGoogle Scholar
  244. 244.
    Itakura H, Vaughn D, Haller DG, et al. Rhabdomyolysis from cytochrome p-450 interaction of ketoconazole and simvastatin in prostate cancer. J Urol 2003 Feb; 169(2): 613.PubMedCrossRefGoogle Scholar
  245. 245.
    Akram K, Rao S, Parker M. A lesson for everyone in drug-drug interactions. Int J Cardiol 2007 May 16; 118(1): e19–20.PubMedCrossRefGoogle Scholar
  246. 246.
    Lees RS, Lees AM. Rhabdomyolysis from the coadministration of lovastatin and the antifungal agent itraconazole. N Engl J Med 1995 Sep 7; 333(10): 664–5.PubMedCrossRefGoogle Scholar
  247. 247.
    Vlahakos DV, Manginas A, Chilidou D, et al. Itraconazole-induced rhabdomyolysis and acute renal failure in a heart transplant recipient treated with simvastatin and cyclosporine. Transplantation 2002 Jun 27; 73(12): 1962–4.PubMedCrossRefGoogle Scholar
  248. 248.
    Horn M. Coadministration of itraconazole with hypolipidemic agents may induce rhabdomyolysis in healthy individuals. Arch Dermatol 1996 Oct; 132(10): 1254.PubMedCrossRefGoogle Scholar
  249. 249.
    Shaukat A, Benekli M, Vladutiu GD, et al. Simvastatin-fluconazole causing rhabdomyolysis. Ann Pharmacother 2003 Jul–Aug; 37(7–8): 1032–5.PubMedCrossRefGoogle Scholar
  250. 250.
    Moro H, Tsukada H, Tanuma A, et al. Rhabdomyolysis after simvastatin therapy in an HIV-infected patient with chronic renal failure. AIDS Patient Care STDS 2004 Dec; 18(12): 687–90.PubMedCrossRefGoogle Scholar
  251. 251.
    Rodriguez JA, Crespo-Leiro MG, Paniagua MJ, et al. Rhabdomyolysis in heart transplant patients on HMG-CoA reductase inhibitors and cyclosporine. Transplant Proc 1999 Sep; 31(6): 2522–3.PubMedCrossRefGoogle Scholar
  252. 252.
    Hermida Lazcano I, Revillo Pinilla P, Nerin Sanchez C, et al. Rhabdomyolysis in a patient treated with lovastatin and cyclosporine [in Spanish]. An Med Interna 1997 Sep; 14(9): 488.PubMedGoogle Scholar
  253. 253.
    Meier C, Stey C, Brack T, et al. Rhabdomyolysis in patients treated with simvastatin and cyclosporin: role of the hepatic cytochrome P450 enzyme system activity [in German]. Schweiz Med Wochenschr 1995 Jul 11; 125(27–28): 1342–6.PubMedGoogle Scholar
  254. 254.
    Mora C, Rodriguez ML, Navarro JF. Cerivastatin-induced rhabdomyolysis in a renal transplant on cyclosporin. Transplantation 2001 Aug 15; 72(3): 551.PubMedCrossRefGoogle Scholar
  255. 255.
    Gumprecht J, Zychma MJ, Grzeszczak W, et al. Simvastatin-induced rhabdomyolysis in a CsA-treated renal transplant recipient. Med Sci Monit 2003 Sep; 9(9): CS89–91.PubMedGoogle Scholar
  256. 256.
    Peces R, Pobes A. Rhabdomyolysis associated with concurrent use of simvastatin and diltiazem. Nephron 2001 Sep; 89(1): 117–8.PubMedCrossRefGoogle Scholar
  257. 257.
    Chiffoleau A, Trochu JN, Veyrac G, et al. Rhabdomyolysis in cardiac transplant recipient due to verapamil interaction with simvastatin and cyclosporin treatment [in French]. Therapie 2003 Mar–Apr; 58(2): 168–70.PubMedCrossRefGoogle Scholar
  258. 258.
    Wombolt DG, Jackson A, Punn R, et al. Case report: rhabdomyolysis induced by mibefradil in a patient treated with cyclosporine and simvastatin. J Clin Pharmacol 1999 Mar; 39(3): 310–2.PubMedGoogle Scholar
  259. 259.
    Schmassmann-Suhijar D, Bullingham R, Gasser R, et al. Rhabdomyolysis due to interaction of simvastatin with mibefradil. Lancet 1998 Jun 27; 351(9120): 1929–30.PubMedCrossRefGoogle Scholar
  260. 260.
    Giner V, Munoz R, Redon J. Risperidone and severe cerivastatin-induced rhabdomyolysis. J Intern Med 2002 Feb; 251(2): 177–8.PubMedCrossRefGoogle Scholar
  261. 261.
    Webber MA, Mahmud W, Lightfoot JD, et al. Rhabdomyolysis and compartment syndrome with coadministration of risperidone and simvastatin. J Psychopharmacol 2004 Sep; 18(3): 432–4.PubMedCrossRefGoogle Scholar
  262. 262.
    Patier JL, Ferrere F, Moreno-Cobo MA, et al. [Rhabdomyolysis caused by the association of simvastatin and risperidone]. Med Clin (Barc) 2007; 129(11): 439.CrossRefGoogle Scholar
  263. 263.
    Shelton PS, Barnett FL, Krick SE. Hyperventilation associated with quetiapine. Ann Pharmacother 2000 Mar; 34(3): 335–7.PubMedCrossRefGoogle Scholar
  264. 264.
    Prior TI, Chue PS, Tibbo P, et al. Drug metabolism and atypical antipsychotics. Eur Neuropsychopharmacol 1999 Jun; 9(4): 301–9.PubMedCrossRefGoogle Scholar
  265. 265.
    Burkhardt C, Kelly JP, Lim YH, et al. Neuroleptic medications inhibit complex I of the electron transport chain. Ann Neurol 1993 May; 33(5): 512–7.PubMedCrossRefGoogle Scholar
  266. 266.
    Aguilar Garcia MD, Garmendia Leiza JR, Cuende Melero JI, et al. Rhabdomyolysis in neuroleptics: are we talking of neuroleptic malignant syndrome? [in Spanish]. Aten Primaria 2003 Jun 15; 32(1): 66–7.PubMedCrossRefGoogle Scholar
  267. 267.
    Baumgart U, Schmid R, Spiessl H. Olanzapine-induced acute rhabdomyolysis: a case report. Pharmacopsychiatry 2005 Jan; 38(1): 36–7.PubMedCrossRefGoogle Scholar
  268. 268.
    Himmerich H, Ehrlinger M, Hackenberg M, et al. Possible case of quetiapineinduced rhabdomyolysis in a patient with depression treated with fluoxetine. J Clin Psychopharmacol 2006 Dec; 26(6): 676–7.PubMedCrossRefGoogle Scholar
  269. 269.
    Melli G, Chaudhry V, Cornblath DR. Rhabdomyolysis: an evaluation of 475 hospitalized patients. Medicine (Baltimore) 2005 Nov; 84(6): 377–85.CrossRefGoogle Scholar
  270. 270.
    Meltzer HY, Cola PA, Parsa M. Marked elevations of serum creatine kinase activity associated with antipsychotic drug treatment. Neuropsychopharmacology 1996 Oct; 15(4): 395–405.PubMedCrossRefGoogle Scholar
  271. 271.
    Pezza M, Busiello L, Palmese S, et al. Rhabdomyolysis associated with respiratory infection in chronic psychiatric patients during neuroleptic treatment [in Italian]. Minerva Anestesiol 2003 Jun; 69(6): 591–6.PubMedGoogle Scholar
  272. 272.
    Rosebraugh CJ, Flockhart DA, Yasuda SU, et al. Olanzapine-induced rhabdomyolysis. Ann Pharmacother 2001 Sep; 35(9): 1020–3.PubMedCrossRefGoogle Scholar
  273. 273.
    Shuster J. Olanzapine and rhabdomyolysis. Nursing 2000 Sep; 30(9): 87.PubMedGoogle Scholar
  274. 274.
    Smith RP, Puckett BN, Crawford J, et al. Quetiapine overdose and severe rhabdomyolysis. J Clin Psychopharmacol 2004 Jun; 24(3): 343.PubMedCrossRefGoogle Scholar
  275. 275.
    Waring WS, Wrate J, Bateman DN. Olanzapine overdose is associated with acute muscle toxicity. Hum Exp Toxicol 2006 Dec; 25(12): 735–40.PubMedCrossRefGoogle Scholar
  276. 276.
    Yang SH, McNeely MJ. Rhabdomyolysis, pancreatitis, and hyperglycemia with ziprasidone. Am J Psychiatry 2002 Aug; 159(8): 1435.PubMedCrossRefGoogle Scholar
  277. 277.
    Zink M, Knopf U, Argiriou S, et al. A case of pulmonary thromboembolism and rhabdomyolysis during therapy with mirtazapine and risperidone. J Clin Psychiatry 2006 May; 67(5): 835.PubMedCrossRefGoogle Scholar
  278. 278.
    Ben-Shachar D. Mitochondrial dysfunction in schizophrenia: a possible linkage to dopamine. J Neurochem 2002 Dec; 83(6): 1241–51.PubMedCrossRefGoogle Scholar
  279. 279.
    Roten L, Schoenenberger RA, Krahenbuhl S, et al. Rhabdomyolysis in association with simvastatin and amiodarone. Ann Pharmacother 2004 Jun; 38(6): 978–81.PubMedCrossRefGoogle Scholar
  280. 280.
    de Denus S, Spinler SA. Amiodarone’s role in simvastatin-associated rhabdomyolysis. Am J Health Syst Pharm 2003 Sep 1; 60(17): 1791.PubMedGoogle Scholar
  281. 281.
    Schmidt GA, Hoehns JD, Purcell JL, et al. Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin, amiodarone, and atazanavir. J Am Board Fam Med 2007; 20(4): 411–6.PubMedCrossRefGoogle Scholar
  282. 282.
    Varbiro G, Toth A, Tapodi A, et al. Concentration dependent mitochondrial effect of amiodarone. Biochem Pharmacol 2003 Apr 1; 65(7): 1115–28.PubMedCrossRefGoogle Scholar
  283. 283.
    Yasuda SU, Sausville EA, Hutchins JB, et al. Amiodarone-induced lymphocyte toxicity and mitochondrial function. J Cardiovasc Pharmacol 1996 Jul; 28(1): 94–100.PubMedCrossRefGoogle Scholar
  284. 284.
    Fromenty B, Fisch C, Berson A, et al. Dual effect of amiodarone on mitochondrial respiration: initial protonophoric uncoupling effect followed by inhibition of the respiratory chain at the levels of complex I and complex II. J Pharmacol Exp Ther 1990 Dec; 255(3): 1377–84.PubMedGoogle Scholar
  285. 285.
    Ribeiro SM, Campello AP, Nascimento AJ, et al. Effect of amiodarone (AMD) on the antioxidant enzymes, lipid peroxidation and mitochondrial metabolism. Cell BiochemFunct 1997 Sep; 15(3): 145–52.Google Scholar
  286. 286.
    Card JW, Racz WJ, Brien JF, et al. Attenuation of amiodarone-induced pulmonary fibrosis by vitamin E is associated with suppression of transforming growth factor-beta1 gene expression but not prevention of mitochondrial dysfunction. J Pharmacol Exp Ther 2003 Jan; 304(1): 277–83.PubMedCrossRefGoogle Scholar
  287. 287.
    Bolt MW, Card JW, Racz WJ, et al. Disruption of mitochondrial function and cellular ATP levels by amiodarone and N-desethylamiodarone in initiation of amiodarone-induced pulmonary cytotoxicity. J Pharmacol Exp Ther 2001 Sep; 298(3): 1280–9.PubMedGoogle Scholar
  288. 288.
    Golomb BA, Evans MA. Potential link between HMG-CoA reductase inhibitor (statin) use and interstitial lung disease. Med J Aust 2007 Aug 20; 187(4): 253.PubMedGoogle Scholar
  289. 289.
    Aboulafia DM, Johnston R. Simvastatin-induced rhabdomyolysis in an HIV-infected patient with coronary artery disease. AIDS Patient Care STDS 2000 Jan; 14(1): 13–8.PubMedCrossRefGoogle Scholar
  290. 290.
    Cheng CH, Miller C, Lowe C, et al. Rhabdomyolysis due to probable interaction between simvastatin and ritonavir. Am J Health Syst Pharm 2002 Apr 15; 59(8): 728–30.PubMedGoogle Scholar
  291. 291.
    Nerurkar PV, Pearson L, Frank JE, et al. Highly active antiretroviral therapy (HAART)-associated lactic acidosis: in vitro effects of combination of nucleoside analogues and protease inhibitors on mitochondrial function and lactic acid production. Cell Mol Biol (Noisy-le-grand) 2003 Dec; 49(8): 1205–11.Google Scholar
  292. 292.
    Sternfel T, Schmid M, Tischleder A, et al. The influence of HIV infection and antiretroviral therapy on the mitochondrial membrane potential of peripheral mononuclear cells. Antivir Ther 2007; 12(5): 769–78.Google Scholar
  293. 293.
    Lopez S, Miro O, Martinez E, et al. Mitochondrial effects of antiretroviral therapies in asymptomatic patients. Antivir Ther 2004 Feb; 9(1): 47–55.PubMedGoogle Scholar
  294. 294.
    ter Hofstede HJ, Burger DM, Koopmans PP. Antiretroviral therapy in HIV patients: aspects of metabolic complications and mitochondrial toxicity. Neth J Med 2003 Dec; 61(12): 393–403.PubMedGoogle Scholar
  295. 295.
    Walker UA, Bauerle J, Laguno M, et al. Depletion of mitochondrial DNA in liver under antiretroviral therapy with didanosine, stavudine, or zalcitabine. Hepatology 2004 Feb; 39(2): 311–7.PubMedCrossRefGoogle Scholar
  296. 296.
    Montaner JS, Cote HC, Harris M, et al. Mitochondrial toxicity in the era of HAART: evaluating venous lactate and peripheral blood mitochondrial DNA in HIV-infected patients taking antiretroviral therapy. J Acquir Immune Defic Syndr 2003 Sep; 34 Suppl. 1: S85–90.PubMedCrossRefGoogle Scholar
  297. 297.
    Vittecoq D, Jardel C, Barthelemy C, et al. Mitochondrial damage associated with long-term antiretroviral treatment: associated alteration or causal disorder? J Acquir Immune Defic Syndr 2002 Nov 1; 31(3): 299–308.PubMedCrossRefGoogle Scholar
  298. 298.
    Brinkman K, Kakuda TN. Mitochondrial toxicity of nucleoside analogue reverse transcriptase inhibitors: a looming obstacle for long-term antiretroviral therapy? Curr Opin Infect Dis 2000 Feb; 13(1): 5–11.PubMedCrossRefGoogle Scholar
  299. 299.
    Brinkman K, Smeitink JA, Romijn JA, et al. Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy. Lancet 1999 Sep 25; 354(9184): 1112–5.PubMedCrossRefGoogle Scholar
  300. 300.
    Benveniste O, Longuet P, Duval X, et al. Two episodes of acute renal failure, rhabdomyolysis, and severe hepatitis in an AIDS patient successively treated with ritonavir and indinavir. Clin Infect Dis 1999 May; 28(5): 1180–1.PubMedCrossRefGoogle Scholar
  301. 301.
    Garg H, Blumenthal R. HIV gp41-induced apoptosis is mediated by caspase-3-dependent mitochondrial depolarization, which is inhibited by HIV protease inhibitor nelfinavir. J Leukoc Biol 2006 Feb; 79(2): 351–62.PubMedCrossRefGoogle Scholar
  302. 302.
    Piliero PJ. Interaction between ritonavir and statins. Am J Med 2002 Apr 15; 112(6): 510–1.PubMedCrossRefGoogle Scholar
  303. 303.
    Jacobson RH, Wang P, Glueck CJ. Myositis and rhabdomyolysis associated with concurrent use of simvastatin and nefazodone [letter]. JAMA 1997; 277(4): 296–7.PubMedCrossRefGoogle Scholar
  304. 304.
    Thompson M, Samuels S. Rhabdomyolysis with simvastatin and nefazodone. Am J Psychiatry 2002 Sep; 159(9): 1607.PubMedCrossRefGoogle Scholar
  305. 305.
    Karnik NS, Maldonado JR. Antidepressant and statin interactions: a review and case report of simvastatin and nefazodone-induced rhabdomyolysis and transaminitis. Psychosomatics 2005 Nov–Dec; 46(6): 565–8.PubMedCrossRefGoogle Scholar
  306. 306.
    Skrabal MZ, Stading JA, Monaghan MS. Rhabdomyolysis associated with simvastatin-nefazodone therapy. South Med J 2003 Oct; 96(10): 1034–5.PubMedCrossRefGoogle Scholar
  307. 307.
    Gutierrez CA. Sildenafil-simvastatin interaction: possible cause of rhabdomyolysis? Am Fam Physician 2001 Feb 15; 63(4): 636–7.PubMedGoogle Scholar
  308. 308.
    Mogyorosi A, Bradley B, Showalter A, et al. Rhabdomyolysis and acute renal failure due to combination therapy with simvastatin and warfarin. J Intern Med 1999 Dec; 246(6): 599–602.PubMedCrossRefGoogle Scholar
  309. 309.
    Bhatia V. Massive rhabdomyolysis with simvastatin precipitated by amoxicillin. J Postgrad Med 2004 Jul–Sep; 50(3): 234–5.PubMedGoogle Scholar
  310. 310.
    Andreou ER, Ledger S. Potential drug interaction between simvastatin and danazol causing rhabdomyolysis. Can J Clin Pharmacol 2003 Winter; 10(4): 172–4.PubMedGoogle Scholar
  311. 311.
    Baker SK, Goodwin S, Sur M, et al. Cytoskeletal myotoxicity from simvastatin and colchicine. Muscle Nerve 2004 Dec; 30(6): 799–802.PubMedCrossRefGoogle Scholar
  312. 312.
    Atasoyu EM, Evrenkaya TR, Solmazgul E. Possible colchicine rhabdomyolysis in a fluvastatin-treated patient. Ann Pharmacother 2005 Jul–Aug; 39(7–8): 1368–9.PubMedGoogle Scholar
  313. 313.
    Hsu WC, Chen WH, Chang MT, et al. Colchicine-induced acute myopathy in a patient with concomitant use of simvastatin. Clin Neuropharmacol 2002 Sep–Oct; 25(5): 266–8.PubMedCrossRefGoogle Scholar
  314. 314.
    Justiniano M, Dold S, Espinoza LR. Rapid onset of muscle weakness (rhabdomyolysis) associated with the combined use of simvastatin and colchicine. J Clin Rheumatol 2007; 13(5): 266–8.PubMedCrossRefGoogle Scholar
  315. 315.
    Alsheikh-Ali AA, Karas RH. Adverse events with concomitant use of simvastatin or atorvastatin and thiazolidinediones. Am J Cardiol 2004 Jun 1; 93(11): 1417–8.PubMedCrossRefGoogle Scholar
  316. 316.
    Veeraputhiran M, Sundermeyer M. Rhabdomyolysis resulting from pharmacologic interaction between erlotinib and simvastatin. Clin Lung Cancer 2008; 9(4): 232–4.PubMedCrossRefGoogle Scholar
  317. 317.
    Prueksaritanont T, Vega JM, Zhao J, et al. Interactions between simvastatin and troglitazone or pioglitazone in healthy subjects. J Clin Pharmacol 2001 May; 41(5): 573–81.PubMedCrossRefGoogle Scholar
  318. 318.
    Nadanaciva S, Dykens JA, Bernal A, et al. Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration. Toxicol Appl Pharmacol 2007 Sep 15; 223(3): 277–87.PubMedCrossRefGoogle Scholar
  319. 319.
    Neuvonen PJ, Niemi M, Backman JT. Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther 2006 Dec; 80(6): 565–81.PubMedCrossRefGoogle Scholar
  320. 320.
    Hippius M, Farker K, Helble S, et al. Assessment of ADRs associated with lipid-lowering agents recorded in the Department of Internal Medicine, University Hospital, Jena. Int J Clin Pharmacol Ther 2002 Mar; 40(3): 97–101.PubMedGoogle Scholar
  321. 321.
    Gruer PJ, Vega JM, Mercuri MF, et al. Concomitant use of cytochrome P450 3A4 inhibitors and simvastatin. Am J Cardiol 1999; 84(7): 811–5.PubMedCrossRefGoogle Scholar
  322. 322.
    Molden E, Westergren T. Interaction risk with statin switch [in Norwegian]. Tidsskr Nor Laegeforen 2007 Feb 15; 127(4): 428–31.PubMedGoogle Scholar
  323. 323.
    Kantola T, Kivisto KT, Neuvonen PJ. Erythromycin and verapamil considerably increase serum simvastatin and simvastatin acid concentrations. Clin Pharmacol Ther 1998 Aug; 64(2): 177–82.PubMedCrossRefGoogle Scholar
  324. 324.
    Dreier JP, Endres M. Statin-associated rhabdomyolysis triggered by grapefruit consumption. Neurology 2004 Feb 24; 62(4): 670.PubMedCrossRefGoogle Scholar
  325. 325.
    Christopher-Stine L. Statin myopathy: an update. Curr Opin Rheumatol 2006 Nov; 18(6): 647–53.PubMedGoogle Scholar
  326. 326.
    Davidson MH, Robinson JG. Safety of aggressive lipid management. J Am Coll Cardiol 2007 May 1; 49(17): 1753–62.PubMedCrossRefGoogle Scholar
  327. 327.
    Lilja JJ, Kivisto KT, Neuvonen PJ. Grapefruit juice-simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors. Clin Pharmacol Ther 1998 Nov; 64(5): 477–83.PubMedCrossRefGoogle Scholar
  328. 328.
    Beaird SL. HMG-CoA reductase inhibitors: assessing differences in drug interactions and safety profiles. J Am Pharm Assoc (Wash) 2000 Sep–Oct; 40(5): 637–44.Google Scholar
  329. 329.
    Abbott A. Special section on human genetics: with your genes? Take one of these, three times a day. Nature 2003; 425: 760–2.PubMedCrossRefGoogle Scholar
  330. 330.
    Schmitz G, Langmann T. Pharmacogenomics of cholesterol-lowering therapy. Vascul Pharmacol 2006 Feb; 44(2): 75–89.PubMedCrossRefGoogle Scholar
  331. 331.
    Takane H, Miyata M, Burioka N, et al. Pharmacogenetic determinants of variability in lipid-lowering response to pravastatin therapy. J Hum Genet 2006; 51(9): 822–6.PubMedCrossRefGoogle Scholar
  332. 332.
    Vermes A, Vermes I. Genetic polymorphisms in cytochrome P450 enzymes: effect on efficacy and tolerability of HMG-CoA reductase inhibitors. Am J Cardiovasc Drugs 2004; 4(4): 247–55.PubMedCrossRefGoogle Scholar
  333. 333.
    Tiwari A, Bansal V, Chugh A, et al. Statins and myotoxicity: a therapeutic limitation. Expert Opin Drug Saf 2006 Sep; 5(5): 651–66.PubMedCrossRefGoogle Scholar
  334. 334.
    Kordas K, Phillips P, Golomb B. Clinical characteristics of 1053 patients with statin-associated muscle complaints. Arterioscler Thromb Vasc Biol 2004 May 1, 2004; 24(5): e51–136.Google Scholar
  335. 335.
    Golomb B, Evans M. Risk factors for rhabdomyolysis with simvastatin and atorvastatin. Drug Saf 2006; 29(12): 1191.PubMedCrossRefGoogle Scholar
  336. 336.
    Chapplain JM, Beillot J, Begue JM, et al. Mitochondrial abnormalities in HIV-infected lipoatrophic patients treated with antiretroviral agents. J Acquir Immune Defic Syndr 2004 Dec 1; 37(4): 1477–88.PubMedCrossRefGoogle Scholar
  337. 337.
    Gerschenson M, Brinkman K. Mitochondrial dysfunction in AIDS and its treatment. Mitochondrion 2004 Sep; 4(5–6): 763–77.PubMedCrossRefGoogle Scholar
  338. 338.
    Pasternak RC, SmithJr SC, Bairey-Merz CN, et al. ACC/AHA/NHLBI clinical advisory on the use and safety of statins. Stroke 2002 Sep; 33(9): 2337–41.PubMedCrossRefGoogle Scholar
  339. 339.
    Rosenberg AD, Neuwirth MG, Kagen LJ, et al. Intraoperative rhabdomyolysis in a patient receiving pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitor. Anesth Analg 1995; 81(5): 1089–91.PubMedGoogle Scholar
  340. 340.
    Wilhelmi M, Winterhalter M, Fischer S, et al. Massive postoperative rhabdomyolysis following combined CABG/abdominal aortic replacement: a possible association with HMG-CoA reductase inhibitors. Cardiovasc Drugs Ther 2002 Sep; 16(5): 471–5.PubMedCrossRefGoogle Scholar
  341. 341.
    GottoJr AM. Safety and statin therapy: reconsidering the risks and benefits. Arch Intern Med 2003 Mar 24; 163(6): 657–9.PubMedCrossRefGoogle Scholar
  342. 342.
    Sewright KA, Clarkson PM, Thompson PD. Statin myopathy: incidence, risk factors, and pathophysiology. Curr Atheroscler Rep 2007; 9(5): 389–96.PubMedCrossRefGoogle Scholar
  343. 343.
    Sinzinger H, Oguogho A. Variable influence of statins on isoprostanes in hyperlipidemia. Adv Exp Med Biol 2003; 525: 209–12.PubMedCrossRefGoogle Scholar
  344. 344.
    Judy WV, Stogsdill WW, Folkers K. Myocardial preservation by therapy with coenzyme Q10 during heart surgery. Clin Investig 1993; 71(8 Suppl.): S155–61.PubMedGoogle Scholar
  345. 345.
    Matsushima T, Sueda T, Matsuura Y, et al. Protection by coenzyme Q10 of canine myocardial reperfusion injury after preservation. J Thorac Cardiovasc Surg 1992 May; 103(5): 945–51.PubMedGoogle Scholar
  346. 346.
    Chello M, Mastroroberto P, Romano R, et al. Protection by coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting. Ann Thorac Surg 1994 Nov; 58(5): 1427–32.PubMedCrossRefGoogle Scholar
  347. 347.
    Crestanello JA, Doliba NM, Babsky AM, et al. Effect of coenzyme Q10 supplementation on mitochondrial function after myocardial ischemia reperfusion. J Surg Res 2002 Feb; 102(2): 221–8.PubMedCrossRefGoogle Scholar
  348. 348.
    Satoh K, Ichihara K. Lipophilic HMG-CoA reductase inhibitors increase myocardial stunning in dogs. J Cardiovasc Pharmacol 2000 Feb; 35(2): 256–62.PubMedCrossRefGoogle Scholar
  349. 349.
    Biccard BM, Sear JW, Foex P. Statin therapy: a potentially useful peri-operative intervention in patients with cardiovascular disease. Anaesthesia 2005 Nov; 60(11): 1106–14.PubMedCrossRefGoogle Scholar
  350. 350.
    Biccard BM, Sear JW, Foex P. The pharmaco-economics of peri-operative statin therapy. Anaesthesia 2005 Nov; 60(11): 1059–63.PubMedCrossRefGoogle Scholar
  351. 351.
    Pasceri V, Patti G, Nusca A, et al. Randomized trial of atorvastatin for reduction of myocardial damage during coronary intervention: results from the ARMYDA (Atorvastatin for Reduction of MYocardial Damage during Angioplasty) study. Circulation 2004 Aug 10; 110(6): 674–8.PubMedCrossRefGoogle Scholar
  352. 352.
    Finsterer J, Zuntner G. Rhabdomyolysis from simvastatin triggered by infection and muscle exertion. South Med J 2005 Aug; 98(8): 827–9.PubMedCrossRefGoogle Scholar
  353. 353.
    Wong WM, Wai-Hung Shek T, Chan KH, et al. Rhabdomyolysis triggered by cytomegalovirus infection in a heart transplant patient on concomitant cyclosporine and atorvastatin therapy. J Gastroenterol Hepatol 2004 Aug; 19(8): 952–3.PubMedCrossRefGoogle Scholar
  354. 354.
    Hamilton-Craig I. Statin-associated myopathy. Med J Aust 2001 Nov 5; 175(9): 486–9.PubMedGoogle Scholar
  355. 355.
    Mahboobi SK, Shohat EZ, Jellinek SP, et al. Systemic infections can decrease the threshold of statin-induced muscle injury. South Med J 2006 Apr; 99(4): 403–4.PubMedCrossRefGoogle Scholar
  356. 356.
    Almog Y. Statins, inflammation, and sepsis: hypothesis. Chest 2003 Aug; 124(2): 740–3.PubMedCrossRefGoogle Scholar
  357. 357.
    Golomb BA, Evans MA. Re: Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease. Neurology 2008; 70(24): 2349; author reply 2349–50.PubMedCrossRefGoogle Scholar
  358. 358.
    Golomb BA, Jaworski BA. Statins and dementia. Arch Neurol 2001; 58: 1169–70.PubMedCrossRefGoogle Scholar
  359. 359.
    Unnikrishnan D, Satish B. Exertion-induced rhabdomyolysis in a patient on statin therapy. Nephrol Dial Transplant 2005 Jan; 20(1): 244.PubMedCrossRefGoogle Scholar
  360. 360.
    Davidson MH. Controversy surrounding the safety of cerivastatin. Expert Opin Drug Saf 2002 Sep; 1(3): 207–12.PubMedCrossRefGoogle Scholar
  361. 361.
    Schech S, Graham D, Staffa J, et al. Risk factors for statin-associated rhabdomyolysis. Pharmacoepidemiol Drug Saf 2007; 16(3): 352–8.PubMedCrossRefGoogle Scholar
  362. 362.
    Egger SS, Ratz Bravo AE, Hess L, et al. Age-related differences in the prevalence of potential drug-drug interactions in ambulatory dyslipidaemic patients treated with statins. Drugs Aging 2007; 24(5): 429–40.PubMedCrossRefGoogle Scholar
  363. 363.
    Lenaz G, D’Aurelio M, Merlo Pich M, et al. Mitochondrial bioenergetics in aging. Biochim Biophys Acta 2000 Aug 15; 1459(2–3): 397–404.PubMedGoogle Scholar
  364. 364.
    Pennisi E. Aging research: do mitochondrial mutations dim the fire of life? Science 1999 Oct 22; 286(5440): 664.PubMedCrossRefGoogle Scholar
  365. 365.
    Crestor®: rosuvastatin calcium [product insert]. Wilmington (DE): AstraZeneca Pharmaceuticals LP, 2007.Google Scholar
  366. 366.
    Downs JR, Clearfield M, Weis S, et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study [see comments]. JAMA 1998; 279(20): 1615–22.PubMedCrossRefGoogle Scholar
  367. 367.
    Dale KM, Coleman CI, Shah SA, et al. Impact of gender on statin efficacy. Curr Med Res Opin 2007 Mar; 23(3): 565–74.PubMedCrossRefGoogle Scholar
  368. 368.
    Nakajima K. Sex-related differences in response of plasma lipids to simvastatin: the Saitama Postmenopausal Lipid Intervention Study. S-POLIS Group. Clin Ther 1999 Dec; 21(12): 2047–57.PubMedCrossRefGoogle Scholar
  369. 369.
    Schieszer J. Adverse vaccine reactions twice as likely to occur in women. Intern Med World Rep 2003 Jun 5: 25.Google Scholar
  370. 370.
    Dobs AS, Schrott H, Davidson MH, et al. Effects of high-dose simvastatin on adrenal and gonadal steroidogenesis in men with hypercholesterolemia. Metabolism 2000 Sep; 49(9): 1234–8.PubMedCrossRefGoogle Scholar
  371. 371.
    Rangwala SM, Li X, Lindsley L, et al. Estrogen-related receptor alpha is essential for the expression of antioxidant protection genes and mitochondrial function. Biochem Biophys Res Commun 2007 May 25; 357(1): 231–6.PubMedCrossRefGoogle Scholar
  372. 372.
    Biesenbach G, Janko O, Stuby U, et al. Terminal myoglobinuric renal failure in lovastatin therapy with pre-existing chronic renal insufficiency [in German]. Wien Klin Wochenschr 1996; 108(11): 334–7.PubMedGoogle Scholar
  373. 373.
    Chalasani N. Statins and hepatotoxicity: focus on patients with fatty liver. Hepatology 2005 Apr; 41(4): 690–5.PubMedCrossRefGoogle Scholar
  374. 374.
    Begriche K, Igoudjil A, Pessayre D, et al. Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. Mitochondrion 2006 Feb; 6(1): 1–28.PubMedCrossRefGoogle Scholar
  375. 375.
    Fromenty B, Robin MA, Igoudjil A, et al. The ins and outs of mitochondrial dysfunction in NASH. Diabetes Metab 2004 Apr; 30(2): 121–38.PubMedCrossRefGoogle Scholar
  376. 376.
    Berson A, De Beco V, Letteron P, et al. Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes. Gastroenterology 1998 Apr; 114(4): 764–74.PubMedCrossRefGoogle Scholar
  377. 377.
    Hoek JB, Cahill A, Pastorino JG. Alcohol and mitochondria: a dysfunctional relationship. Gastroenterology 2002 Jun; 122(7): 2049–63.PubMedCrossRefGoogle Scholar
  378. 378.
    Sun F, Cui J, Gavras H, et al. A novel class of tests for the detection of mitochondrial DNA-mutation involvement in diseases. Am J Hum Genet 2003 Jun; 72(6): 1515–26.PubMedCrossRefGoogle Scholar
  379. 379.
    Marzoa-Rivas R, Crespo-Leiro MG, Paniagua-Marin MJ, et al. Safety of statins when response is carefully monitored: a study of 336 heart recipients. Transplant Proc 2005 Nov; 37(9): 4071–3.PubMedCrossRefGoogle Scholar
  380. 380.
    Alberici LC, Oliveira HC, Bighetti EJ, et al. Hypertriglyceridemia increases mitochondrial resting respiration and susceptibility to permeability transition. J Bioenerg Biomembr 2003 Oct; 35(5): 451–7.PubMedCrossRefGoogle Scholar
  381. 381.
    Tokinaga K, Oeda T, Suzuki Y, et al. HMG-CoA reductase inhibitors (statins) might cause high elevations of creatine phosphokinase (CK) in patients with unnoticed hypothyroidism. Endocr J 2006 Jun; 53(3): 401–5.PubMedCrossRefGoogle Scholar
  382. 382.
    Rodriguez Framil M, Martinez Rey C, Alende Sixto MR, et al. Hypothyroidism and lovastatin-induced myositis [in Spanish]. An Med Interna 2005 May; 22(5): 252–3.PubMedGoogle Scholar
  383. 383.
    Bar SL, Holmes DT, Frohlich J. Asymptomatic hypothyroidism and statin-induced myopathy. Can Fam Physician 2007; 53(3): 428–31.PubMedGoogle Scholar
  384. 384.
    Park IR, Mount DB, Himms-Hagen J. Role of T3 in thermogenic and trophic responses of brown adipose tissue to cold. AmJPhysiol 1989 Jul; 257(1 Pt 1): E81–7.Google Scholar
  385. 385.
    Martinez B, del Hoyo P, Martin MA, et al. Thyroid hormone regulates oxidative phosphorylation in the cerebral cortex and striatum of neonatal rats. J Neurochem 2001 Sep; 78(5): 1054–63.PubMedCrossRefGoogle Scholar
  386. 386.
    Schonfeld P, Wieckowski MR, Wojtczak L. Thyroid hormone-induced expression of the ADP/ATP carrier and its effect on fatty acid-induced uncoupling of oxidative phosphorylation. FEBS Lett 1997 Oct 13; 416(1): 19–22.PubMedCrossRefGoogle Scholar
  387. 387.
    Li R, Luciakova K, Zaid A, et al. Thyroid hormone activates transcription from the promoter regions of some human nuclear-encoded genes of the oxidative phosphorylation system. Mol Cell Endocrinol 1997 Apr 4; 128(1–2): 69–75.PubMedCrossRefGoogle Scholar
  388. 388.
    Iossa S, Barletta A, Liverini G. The effect of thyroid state and cold exposure on rat liver oxidative phosphorylation. Mol Cell Endocrinol 1991 Jan; 75(1): 15–8.PubMedCrossRefGoogle Scholar
  389. 389.
    Verhoeven AJ, Kamer P, Groen AK, et al. Effects of thyroid hormone on mitochondrial oxidative phosphorylation. Biochem J 1985 Feb 15; 226(1): 183–92.PubMedGoogle Scholar
  390. 390.
    Holness M, Crespo-Armas A, Mowbray J. The influence of thyroid hormone on the degree of control of oxidative phosphorylation exerted by the adenine nucleotide translocator. FEBS Lett 1984 Nov 19; 177(2): 231–5.PubMedCrossRefGoogle Scholar
  391. 391.
    Kiernan TJ, Rochford M, McDermott JH. Simvastatin induced rhabdomyolysis and an important clinical link with hypothyroidism. Int J Cardiol 2007; 119(3): 374–6.PubMedCrossRefGoogle Scholar
  392. 392.
    Kisch E, Segall HS. Interaction between simvastatin and L-thyroxine. Ann Intern Med 2005; 143(7): 547.PubMedGoogle Scholar
  393. 393.
    Cohen BH, Gold DR. Mitochondrial cytopathy in adults: what we know so far. Cleve Clin J Med 2001; 68(7): 625–6: 629–42.PubMedCrossRefGoogle Scholar
  394. 394.
    Franco MC, Arciuch VG, Peralta JG, et al. Hypothyroid phenotype is contributed by mitochondrial complex I inactivation due to translocated neuronal nitricoxide synthase. J Biol Chem 2006; 281(8): 4779–86.PubMedCrossRefGoogle Scholar
  395. 395.
    Lorenzoni PJ, Silvado CE, Scola RH, et al. McArdle disease with rhabdomyolysis induced by rosuvastatin: case report. Arq Neuropsiquiatr 2007 Sep; 65(3B): 834–7.PubMedCrossRefGoogle Scholar
  396. 396.
    Freedman DB, Housley D. Gitelman’s syndrome presenting as intolerance to statin therapy. Ann Clin Biochem 2005 May; 42(Pt 3): 232–3.PubMedCrossRefGoogle Scholar
  397. 397.
    Rosenmund A, Brand B, Straub PW. Hyperlactataemia, hyperkalemia and heart block in acute iron overload: the fatal role of the hepatic iron-incorporation rate in rats on ferric citrate infusions. Eur J Clin Invest 1988 Feb; 18(1): 69–74.PubMedCrossRefGoogle Scholar
  398. 398.
    Edelman S, Witztum JL. Hyperkalemia during treatment with HMG-CoA reductase inhibitor. N Engl J Med 1989 May 4; 320(18): 1219–20.PubMedGoogle Scholar
  399. 399.
    Oh J, Ban MR, Miskie BA, et al. Genetic determinants of statin intolerance. Lipids Health Dis 2007; 6: 7.PubMedCrossRefGoogle Scholar
  400. 400.
    Frudakis TN, Thomas MJ, Ginjupalli SN, et al. CYP2D6*4 polymorphism is associated with statin-induced muscle effects. Pharmacogenet Genomics 2007; 17(9): 695–707.PubMedCrossRefGoogle Scholar
  401. 401.
    Mulder AB, van Lijf HJ, Bon MA, et al. Association of polymorphism in the cytochrome CYP2D6 and the efficacy and tolerability of simvastatin. Clin Pharmacol Ther 2001; 70(6): 546–51.PubMedCrossRefGoogle Scholar
  402. 402.
    Zuccaro P, Mombelli G, Calabresi L, et al. Tolerability of statins is not linked to CYP450 polymorphisms, but reduced CYP2D6 metabolism improves cholesteraemic response to simvastatin and fluvastatin. Pharmacol Res 2007; 55(4): 310–7.PubMedCrossRefGoogle Scholar
  403. 403.
    Di Giovanni S, Mirabella M, Spinazzola A, et al. Coenzyme Q10 reverses pathological phenotype and reduces apoptosis in familial CoQ10 deficiency. Neurology 2001; 57(3): 515–8.PubMedCrossRefGoogle Scholar
  404. 404.
    Fiegenbaum M, da Silveira FR, Van der Sand CR, et al. The role of common variants of ABCB1, CYP3A4, and CYP3A5 genes in lipid-lowering efficacy and safety of simvastatin treatment. Clin Pharmacol Ther 2005; 78: 551–8.PubMedCrossRefGoogle Scholar
  405. 405.
    Ruano G, Thompson PD, Windemuth A, et al. Physiogenomic association of statinrelated myalgia to serotonin receptors. Muscle Nerve 2007; 36(3): 329–35.PubMedCrossRefGoogle Scholar
  406. 406.
    Gambelli S, Dotti MT, Malandrini A, et al. Mitochondrial alterations in muscle biopsies of patients on statin therapy. J Submicrosc Cytol Pathol 2004 Jan; 36(1): 85–9.PubMedGoogle Scholar
  407. 407.
    Meyer RA, Slade JM, Towse TF, et al. Elevated muscle phosphodiesterase in 31P-NMR spectra of patients on statins. Proc Intl Soc Mag Reson Med 2005; 13: 2036.Google Scholar
  408. 408.
    Schick BA, Laaksonen R, Frohlich JJ, et al. Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin. Clin Pharmacol Ther 2007 May; 81(5): 650–3.PubMedCrossRefGoogle Scholar
  409. 409.
    Guis S, Figarella-Branger D, Mattei JP, et al. In vivo and in vitro characterization of skeletal muscle metabolism in patients with statin-induced adverse effects. Arthritis Rheum 2006 Aug 15; 55(4): 551–7.PubMedCrossRefGoogle Scholar
  410. 410.
    Paiva H, Thelen KM, Van Coster R, et al. High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial. Clin Pharmacol Ther 2005 Jul; 78(1): 60–8.PubMedCrossRefGoogle Scholar
  411. 411.
    Thomas JE, Lee N, Thompson PD. Statins provoking MELAS syndrome: a case report. Eur Neurol 2007; 57(4): 232–5.PubMedCrossRefGoogle Scholar
  412. 412.
    Neale R, Reynolds TM, Saweirs W. Statin precipitated lactic acidosis? J Clin Pathol 2004 Sep; 57(9): 989–90.PubMedCrossRefGoogle Scholar
  413. 413.
    Goli AK, Goli SA, ByrdJr RP, et al. Simvastatin-induced lactic acidosis: a rare adverse reaction? Clin Pharmacol Ther 2002 Oct; 72(4): 461–4.PubMedCrossRefGoogle Scholar
  414. 414.
    Diaczok BJ, Shali R. Statins unmasking a mitochondrial myopathy: a case report and proposed mechanism of disease. South Med J 2003 Mar; 96(3): 318–20.PubMedCrossRefGoogle Scholar
  415. 415.
    Lenaz G, Bovina C, D’Aurelio M, et al. Role of mitochondria in oxidative stress and aging. Ann N Y Acad Sci 2002 Apr; 959: 199–213.PubMedCrossRefGoogle Scholar
  416. 416.
    Papucci L, Schiavone N, Witort E, et al. Coenzyme q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property. J Biol Chem 2003 Jul 25; 278(30): 28220–8.PubMedCrossRefGoogle Scholar
  417. 417.
    Menke T, Gille G, Reber F, et al. Coenzyme Q10 reduces the toxicity of rotenone in neuronal cultures by preserving the mitochondrial membrane potential. Biofactors 2003; 18(1–4): 65–72.PubMedCrossRefGoogle Scholar
  418. 418.
    Yamamura T, Otani H, Nakao Y, et al. Dual involvement of coenzyme Q10 in redox signaling and inhibition of death signaling in the rat heart mitochondria. Antioxid Redox Signal 2001 Feb; 3(1): 103–12.PubMedCrossRefGoogle Scholar
  419. 419.
    Manoukian AA, Bhagavan NV, Hayashi T, et al. Rhabdomyolysis secondary to lovastatin therapy. Clin Chem 1990 Dec; 36(12): 2145–7.PubMedGoogle Scholar
  420. 420.
    Wolters M, Hahn A. Plasma ubiquinone status and response to six-month supplementation combined with multivitamins in healthy elderly women: results of a randomized, double-blind, placebo-controlled study. Int J Vitam Nutr Res 2003 May; 73(3): 207–14.PubMedCrossRefGoogle Scholar
  421. 421.
    Singh RB, Niaz MA, Sindberg CD, et al. Effect of oral coenzyme Q10 dosages on serum Q10 and MDA levels among healthy men. Fourth Conference of the International Coenzyme Q10 Association; 2005 Apr 14–17; Los Angeles (CA).Google Scholar
  422. 422.
    Niklowitz P, Menke T, Wiesel T, et al. Coenzyme Q10 in plasma and erythrocytes: comparison of antioxidant levels in healthy probands after oral supplementation and in patients suffering from sickle cell anemia. Clin Chim Acta 2002 Dec; 326(1–2): 155–61.PubMedCrossRefGoogle Scholar
  423. 423.
    Barbiroli B, Lotti S, Lodi R. Improved brain and muscle mitochondrial respiration with CoQ: an in vivo study by 31P-MR spectroscopy in patients with mitochondrial cytopathies. Biofactors 1999; 9(2–4): 253–60.PubMedCrossRefGoogle Scholar
  424. 424.
    Satoh K, Nakai T, Ichihara K. Influence of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on mitochondrial respiration in rat liver during ischemia. Eur J Pharmacol 1994 Aug 3; 270(4): 365–9.PubMedGoogle Scholar
  425. 425.
    Satoh K, Yamato A, Nakai T, et al. Effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on mitochondrial respiration in ischaemic dog hearts. Br J Pharmacol 1995 Sep; 116(2): 1894–8.PubMedCrossRefGoogle Scholar
  426. 426.
    Sugiyama S. HMG CoA reductase inhibitor accelerates aging effect on diaphragm mitochondrial respiratory function in rats. Biochem Mol Biol Int 1998 Dec; 46(5): 923–31.PubMedGoogle Scholar
  427. 427.
    Diebold BA, Bhagavan NV, Guillory RJ. Influences of lovastatin administration on the respiratory burst of leukocytes and the phosphorylation potential of mitochondria in guinea pigs. Biochim Biophys Acta 1994 Jul 6; 1200(2): 100–8.PubMedCrossRefGoogle Scholar
  428. 428.
    Velho JA, Okanobo H, Degasperi GR, et al. Statins induce calcium-dependent mitochondrial permeability transition. Toxicology 2006 Feb 15; 219(1–3): 124–32.PubMedCrossRefGoogle Scholar
  429. 429.
    Sobreira C, Hirano M, Shanske S, et al. Mitochondrial encephalomyopathy with coenzyme Q10 deficiency. Neurology 1997; 48(5): 1238–43.PubMedCrossRefGoogle Scholar
  430. 430.
    De Vivo DC, Di Mauro S. Mitochondrial defects of brain and muscle. Biol Neonate 1990; 58 Suppl. 1: 54–69.PubMedGoogle Scholar
  431. 431.
    Wong PW, Dillard TA, Kroenke K. Multiple organ toxicity from addition of erythromycin to long-term lovastatin therapy. South Med J 1998 Feb; 91(2): 202–5.PubMedCrossRefGoogle Scholar
  432. 432.
    Golomb BA, McGraw JJ, Evans MA, et al. Physician response to patient reports of adverse drug effects: implications for patient-targeted adverse effect surveillance. Drug Saf 2007; 30(8): 669–75.PubMedCrossRefGoogle Scholar
  433. 433.
    Sastre J, Pallardo FV, Vina J. The role of mitochondrial oxidative stress in aging. Free Radic Biol Med 2003 Jul 1; 35(1): 1–8.PubMedCrossRefGoogle Scholar
  434. 434.
    Linnane AW, Zhang C, Yarovaya N, et al. Human aging and global function of coenzyme Q10. Ann N Y Acad Sci 2002 Apr; 959: 396–411.PubMedCrossRefGoogle Scholar
  435. 435.
    Kopsidas G, Kovalenko SA, Heffernan DR, et al. Tissue mitochondrial DNA changes: a stochastic system. Ann N Y Acad Sci 2000 Jun; 908: 226–43.PubMedCrossRefGoogle Scholar
  436. 436.
    Ozawa T. Mitochondrial DNA mutations associated with aging and degenerative diseases. Exp Gerontol 1995 May–Aug; 30(3–4): 269–90.PubMedCrossRefGoogle Scholar
  437. 437.
    De Flora S, Izzotti A, Randerath K, et al. DNA adducts and chronic degenerative disease: pathogenetic relevance and implications in preventive medicine. Mutat Res 1996 Dec; 366(3): 197–238.PubMedCrossRefGoogle Scholar
  438. 438.
    Shulman RG, Rothman DL, Behar KL, et al. Energetic basis of brain activity: implications for neuroimaging. Trends Neurosci 2004 Aug; 27(8): 489–95.PubMedCrossRefGoogle Scholar
  439. 439.
    Fehm HL, Kern W, Peters A. The selfish brain: competition for energy resources. Prog Brain Res 2006; 153: 129–40.PubMedCrossRefGoogle Scholar
  440. 440.
    Ogasahara S, Engel AG, Frens D, et al. Muscle coenzyme Q deficiency in familial mitochondrial encephalomyopathy. Proc Natl Acad Sci U S A 1989 Apr; 86(7): 2379–82.PubMedCrossRefGoogle Scholar
  441. 441.
    Boitier E, Degoul F, Desguerre I, et al. A case of mitochondrial encephalomyopathy associated with a muscle coenzyme Q10 deficiency. J Neurol Sci 1998; 156(1): 41–6.PubMedCrossRefGoogle Scholar
  442. 442.
    Gaist D, Jeppesen U, Andersen M, et al. Statins and risk of polyneuropathy: a case-control study. Neurology 2002 May 14; 58(9): 1333–7.PubMedCrossRefGoogle Scholar
  443. 443.
    Golomb BA, Kane T, Dimsdale JE. Severe irritability associated with statin cholesterol-lowering drugs. QJM 2004 Apr; 97(4): 229–35.PubMedCrossRefGoogle Scholar
  444. 444.
    Buajordet I, Madsen S, Olsen H. Statins: the pattern of adverse effects with emphasis on mental reactions: data from a national and an international database [in Norwegian]. Tidsskr Nor Laegeforen 1997; 117(22): 3210–3.PubMedGoogle Scholar
  445. 445.
    Duits N, Bos FM. Psychiatric disorders with use of simvastatin [in Dutch]. Ned Tijdschr Geneesd 1993; 137(26): 1312–5.Google Scholar
  446. 446.
    Lechleitner M, Hoppichler F, Konwalinka G, et al. Depressive symptoms in hypercholesterolaemic patients treated with pravastatin [letter]. Lancet 1992; 340(8824): 910.PubMedCrossRefGoogle Scholar
  447. 447.
    Golomb BA, Kwon EK, Criqui MH, et al. Simvastatin but not pravastatin affects sleep: findings from the UCSD Statin Study. Circulation 2007; 116: II–847.Google Scholar
  448. 448.
    Coskun E, Ulusal G, Bulut N, et al. Mitochondrial neurogastrointestinal encephalomyopathy. Turk J Gastroenterol 2005 Sep; 16(3): 163–6.PubMedGoogle Scholar
  449. 449.
    Suzuki Y, Taniyama M, Hata T, et al. Sleep-wake dysrhythm in mitochondrial diabetes mellitus. Diabetes Res Clin Pract 1997 Feb; 35(1): 61–2.PubMedCrossRefGoogle Scholar
  450. 450.
    Tatsumi C, Takahashi M, Yorifuji S, et al. Mitochondrial encephalomyopathy with sleep apnea. Eur Neurol 1988; 28(2): 64–9.PubMedCrossRefGoogle Scholar
  451. 451.
    Sherratt EJ, Thomas AW, Alcolado JC. Mitochondrial DNA defects: a widening clinical spectrum of disorders. Clin Sci (Lond) 1997 Mar; 92(3): 225–35.Google Scholar
  452. 452.
    Kagawa Y. Molecular genetics of mitochondria and diabetes [in Japanese]. Nippon Rinsho 1994 Oct; 52(10): 2599–605.PubMedGoogle Scholar
  453. 453.
    Petersen KF, Befroy D, Dufour S, et al. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 2003 May 16; 300(5622): 1140–2.PubMedCrossRefGoogle Scholar
  454. 454.
    Lamson DW, Plaza SM. Mitochondrial factors in the pathogenesis of diabetes: a hypothesis for treatment. Altern Med Rev 2002 Apr; 7(2): 94–111.PubMedGoogle Scholar
  455. 455.
    Campos Y, Garcia A, Eiris J, et al. Mitochondrial myopathy, cardiomyopathy and psychiatric illness in a Spanish family harbouring the mtDNA 3303C > T mutation. J Inherit Metab Dis 2001 Nov; 24(6): 685–7.PubMedCrossRefGoogle Scholar
  456. 456.
    Odawara M. Mitochondrial gene abnormalities as a cause of psychiatric diseases. Nucleic Acids Res Suppl 2002; 2: 253–254.PubMedCrossRefGoogle Scholar
  457. 457.
    Hara K, Yamamoto M, Anegawa T, et al. Mitochondrial encephalomyopathy associated with parkinsonism and a point mutation in the mitochondrial tRNA(Leu)(UUR)) gene [in Japanese]. Rinsho Shinkeigaku 1994 Apr; 34(4): 361–5.PubMedGoogle Scholar
  458. 458.
    Muldoon MF, Barger SD, Ryan CM, et al. Effects of lovastatin on cognitive function and psychological well-being. Am J Med 2000; 108(7): 538–46.PubMedCrossRefGoogle Scholar
  459. 459.
    Muldoon MF, Ryan CM, Sereika SM, et al. Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults. Am J Med 2004 Dec 1; 117(11): 823–9.PubMedCrossRefGoogle Scholar
  460. 460.
    Shepherd J, Blauw GJ, Murphy MB, et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet 2002 Nov 23; 360(9346): 1623–30.PubMedCrossRefGoogle Scholar
  461. 461.
    Collins R, Armitage J, Parish S, et al. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002; 360(9326): 7–22.CrossRefGoogle Scholar
  462. 462.
    Golomb BA, Dimsdale JE, White HL, et al. Do low dose statins affect cognition? Results of the UCSD Statin Study. Circulation 2006; 114(18): II–289.Google Scholar
  463. 463.
    Sparks DL, Sabbagh M, Connor D, et al. Statin therapy in Alzheimer’s disease. Acta Neurol Scand Suppl 2006; 185: 78–86.PubMedCrossRefGoogle Scholar
  464. 464.
    Simons M, Schwarzler F, Lutjohann D, et al. Treatment with simvastatin in normocholesterolemic patients with Alzheimer’s disease: a 26-week randomized, placebo-controlled, double-blind trial. Ann Neurol 2002 Sep; 52(3): 346–50.PubMedCrossRefGoogle Scholar
  465. 465.
    Padala KP, Padala PR, Potter JF. Simvastatin-induced decline in cognition. Ann Pharmacother 2006 Oct; 40(10): 1880–3.PubMedCrossRefGoogle Scholar
  466. 466.
    Galatti L, Polimeni G, Salvo F, et al. Short-term memory loss associated with rosuvastatin. Pharmacotherapy 2006 Aug; 26(8): 1190–2.PubMedCrossRefGoogle Scholar
  467. 467.
    Tatley M, Savage R. Psychiatric adverse reactions with statins, fibrates and ezetimibe: implications for the use of lipid-lowering agents. Drug Saf 2007; 30(3): 195–201.PubMedCrossRefGoogle Scholar
  468. 468.
    King DS, Jones EW, Wofford MR, et al. Cognitive impairment associated with atorvastatin [abstract no. 36]. Pharmacotherapy 2001; 21: 371.Google Scholar
  469. 469.
    King DS, Wilburn AJ, Wofford MR, et al. Cognitive impairment associated with atorvastatin and simvastatin. Pharmacotherapy 2003 Dec; 23(12): 1663–7.PubMedCrossRefGoogle Scholar
  470. 470.
    Orsi A, Sherman O, Woldeselassie Z. Simvastatin-associated memory loss. Pharmacotherapy 2001; 21(6): 767–9.PubMedCrossRefGoogle Scholar
  471. 471.
    Wagstaff LR, Mitton MW, Arvik BM, et al. Statin-associated memory loss: analysis of 60 case reports and review of the literature. Pharmacotherapy 2003 Jul; 23(7): 871–80.PubMedCrossRefGoogle Scholar
  472. 472.
    Mathew JP, Grocott HP, McCurdy JR, et al. Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass. J Cardiothorac Vasc Anesth 2005 Jun; 19(3): 294–9.PubMedCrossRefGoogle Scholar
  473. 473.
    Bonovas S, Sitaras NM. Does pravastatin promote cancer in elderly patients? A meta-analysis. CMAJ 2007 Feb 27; 176(5): 649–54.PubMedCrossRefGoogle Scholar
  474. 474.
    Caldwell SH, Hespenheide EE, von Borstel RW. Myositis, microvesicular hepatitis, and progression to cirrhosis from troglitazone added to simvastatin. Dig Dis Sci 2001; 46(2): 376–8.PubMedCrossRefGoogle Scholar
  475. 475.
    Wolters LM, Van Buuren HR. Rosuvastatin-associated hepatitis with autoimmune features. Eur J Gastroenterol Hepatol 2005 May; 17(5): 589–90.PubMedCrossRefGoogle Scholar
  476. 476.
    Ballare M, Campanini M, Catania E, et al. Acute cholestatic hepatitis during simvastatin administration. Recenti Prog Med 1991; 82(4): 233–5.PubMedGoogle Scholar
  477. 477.
    Bruguera M, Joya P, Rodés J. Hepatitis associated with treatment with lovastatin: presentation of 2 cases. Gastroenterol Hepatol 1998; 21(3): 127–8.PubMedGoogle Scholar
  478. 478.
    Raveh D, Arnon R, Israeli A, et al. Lovastatin-induced hepatitis. Isr J Med Sci 1992 Feb; 28(2): 101–2.PubMedGoogle Scholar
  479. 479.
    Feydy P, Bogomoletz WV. A case of hepatitis caused by simvastatin [in French]. Gastroenterol Clin Biol 1991; 15(1): 94–5.PubMedGoogle Scholar
  480. 480.
    Gavilan Carrasco JC, Bermúdez Recio F, Salgado Ordóñez F, et al. Hepatitis due to lovastatin. Med Clin (Barc) 1996; 107(14): 557–8.Google Scholar
  481. 481.
    Hartleb M, Rymarczyk G, Januszewski K. Acute cholestatic hepatitis associated with pravastatin. Am Jgastroenterol 1999; 94(5): 1388–90.CrossRefGoogle Scholar
  482. 482.
    Solomon DH, Avorn J. Coxibs, science, and the public trust. Arch Intern Med 2005 Jan 24; 165(2): 158–60.PubMedCrossRefGoogle Scholar
  483. 483.
    Stilley CS, Sereika S, Muldoon MF, et al. Psychological and cognitive function: predictors of adherence with cholesterol lowering treatment. Ann Behav Med 2004 Apr; 27(2): 117–24.PubMedCrossRefGoogle Scholar
  484. 484.
    Bruckert E, Simonetta C, Giral P. Compliance with fluvastatin treatment characterization of the noncompliant population within a population of 3845 patients with hyperlipidemia: CREOLE Study Team. J Clin Epidemiol 1999 Jun; 52(6): 589–94.PubMedCrossRefGoogle Scholar
  485. 485.
    Evans MA, Golomb BA. Statin associated cognitive problems reported by 171 subjects. Pharmacotherapy. In press.Google Scholar
  486. 486.
    Golomb BA. Cholesterol and violence: is there a connection? Ann Intern Med 1998; 128: 478–87.PubMedGoogle Scholar
  487. 487.
    Golomb BA, Tenkanen L, Alikoski T, et al. Insulin sensitivity markers: predictors of accidents and suicides in Helsinki Heart Study screenees. J Clin Epidemiol 2002 Aug; 55(8): 767–73.PubMedCrossRefGoogle Scholar
  488. 488.
    Klaassen T, Riedel WJ, Deutz NE, et al. Mood congruent memory bias induced by tryptophan depletion. Psychol Med 2002 Jan; 32(1): 167–72.PubMedCrossRefGoogle Scholar
  489. 489.
    Partonen T. Vitamin D and serotonin in winter. Med Hypotheses 1998 Sep; 51(3): 267–8.PubMedCrossRefGoogle Scholar
  490. 490.
    Morris MC, Evans DA, Tangney CC, et al. Fish consumption and cognitive decline with age in a large community study. Arch Neurol 2005 Dec; 62(12): 1849–53.PubMedCrossRefGoogle Scholar
  491. 491.
    Dale KM, Coleman CI, Henyan NN, et al. Statins and cancer risk: a meta-analysis. JAMA 2006 Jan 4; 295(1): 74–80.PubMedCrossRefGoogle Scholar
  492. 492.
    Browning DR, Martin RM. Statins and risk of cancer: a systematic review and metaanalysis. Int J Cancer 2007 Feb 15; 120(4): 833–43.PubMedCrossRefGoogle Scholar
  493. 493.
    Huchzermeyer H, Munzenmaier R. Lovastatin-induced acute cholestatic hepatitis [in German]. Dtsch Med Wochenschr 1995; 120(8): 252–6.PubMedCrossRefGoogle Scholar
  494. 494.
    Jimenez-Alonso J, Osorio JM, Gutiérrez-Cabello F, et al. Atorvastatin-induced cholestatic hepatitis in a young woman with systemic lupus erythematosus: Grupo Lupus Virgen de las Nieves [letter]. Arch Intern Med 1999; 159(15): 1811–2.PubMedCrossRefGoogle Scholar
  495. 495.
    Nakad A, Bataille L, Hamoir V, et al. Atorvastatin-induced acute hepatitis with absence of cross-toxicity with simvastatin [letter]. Lancet 1999; 353(9166): 1763–4.PubMedCrossRefGoogle Scholar
  496. 496.
    Roblin X, Becot F, Piquemal A, et al. Simvastatin-induced hepatitis [letter; in French]. Gastroenterol Clin Biol 1992; 16(1): 101.PubMedGoogle Scholar
  497. 497.
    Heuer T, Gerards H, Pauw M, et al. Toxic liver damage caused by HMG-CoA reductase inhibitor [in German]. Med Klin (Munich) 2000 Nov 15; 95(11): 642–4.CrossRefGoogle Scholar
  498. 498.
    Grimbert S, Pessayre D, Degott C, et al. Acute hepatitis induced by HMG-CoA reductase inhibitor, lovastatin. Dig Dis Sci 1994 Sep; 39(9): 2032–3.PubMedCrossRefGoogle Scholar
  499. 499.
    Graziadei IW, Obermoser GE, Sepp NT, et al. Drug-induced lupus-like syndrome associated with severe autoimmune hepatitis. Lupus 2003; 12(5): 409–12.PubMedCrossRefGoogle Scholar
  500. 500.
    Ballare M, Campanini M, Airoldi G, et al. Hepatotoxicity of hydroxy-methyl-glutaryl-coenzyme A reductase inhibitors. Minerva Gastroenterol Dietol 1992 Jan-Mar; 38(1): 41–4.PubMedGoogle Scholar
  501. 501.
    Punthakee Z, Scully LJ, Guindi MM, et al. Liver fibrosis attributed to lipid lowering medications: two cases. J Intern Med 2001 Sep; 250(3): 249–54.PubMedCrossRefGoogle Scholar
  502. 502.
    Cokca F, Ozkan S, Nergisoglu G, et al. Statin toxicity: a situation that mimics viral hepatitis. Int J Clin Pharmacol Ther 2005 Nov; 43(11): 543–5.PubMedGoogle Scholar
  503. 503.
    Pelli N, Setti M. Atorvastatin as a trigger of autoimmune hepatitis. J Hepatol 2004 Apr; 40(4): 716.PubMedCrossRefGoogle Scholar
  504. 504.
    Pelli N, Setti M, Ceppa P, et al. Autoimmune hepatitis revealed by atorvastatin. Eur J Gastroenterol Hepatol 2003 Aug; 15(8): 921–4.PubMedCrossRefGoogle Scholar
  505. 505.
    Ridruejo E, Mando OG. Acute cholestatic hepatitis after reinitiating treatment with atorvastatin. J Hepatol 2002 Jul; 37(1): 165–6.PubMedCrossRefGoogle Scholar
  506. 506.
    Torres M, Sobrino J, Asensio C, et al. Acute cholestatic hepatitis induced by cerivastatin [in Spanish]. Med Clin (Barc) 2002 May 18; 118(18): 717.Google Scholar
  507. 507.
    van Heyningen C. Drug-induced acute autoimmune hepatitis during combination therapy with atorvastatin and ezetimibe. Ann Clin Biochem 2005 Sep; 42(Pt 5): 402–4.PubMedCrossRefGoogle Scholar
  508. 508.
    Yoshikawa T, Furukawa Y, Wakamatsu Y, et al. The protection of coenzyme Q10 against carbon tetrachloride hepatotoxicity. Gastroenterol Jpn 1981; 16(3): 281–5.PubMedGoogle Scholar
  509. 509.
    Dujovne CA. Side effects of statins: hepatitis versus ‘transaminiti’-myositis versus ‘CPKiti’. Am J Cardiol 2002 Jun 15; 89(12): 1411–3.PubMedCrossRefGoogle Scholar
  510. 510.
    Ashar U, Desai D, Bhaduri A. Flutamide-induced hepatotoxicity with possible potentiation by simvastatin. J Assoc Physicians India 2003 Jan; 51: 75–7.PubMedGoogle Scholar
  511. 511.
    Koornstra JJ, Ottervanger JP, Fehmers MC, et al. Clinically manifest liver lesions during use of simvastatin [in Dutch]. Ned Tijdschr Geneeskd 1996 Apr 13; 140(15): 846–8.PubMedGoogle Scholar
  512. 512.
    Kinnman N, Hultcrantz R. Lipid lowering medication and hepatotoxicity. J Intern Med 2001 Sep; 250(3): 183–5.PubMedCrossRefGoogle Scholar
  513. 513.
    Amarenco P, Bogousslavsky J, Callahan 3rd A, et al. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med 2006 Aug 10; 355(6): 549–59.PubMedCrossRefGoogle Scholar
  514. 514.
    Goldstein LB, Amarenco P, Szarek M, et al. Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels study. Neurology 2008; 70(24 Pt 2): 2364–70.PubMedCrossRefGoogle Scholar
  515. 515.
    Vrecer M, Turk S, Drinovec J, et al. Use of statins in primary and secondary prevention of coronary heart disease and ischemic stroke: meta-analysis of randomized trials. Int J Clin Pharmacol Ther 2003 Dec; 41(12): 567–77.PubMedGoogle Scholar
  516. 516.
    Byington RP, Davis BR, Plehn JF, et al. Reduction of stroke events with pravastatin: the Prospective Pravastatin Pooling (PPP) Project. Circulation 2001 Jan 23; 103(3): 387–92.PubMedCrossRefGoogle Scholar
  517. 517.
    Warshafsky S, Packard D, Marks SJ, et al. Efficacy of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors for prevention of stroke. J Gen Intern Med 1999 Dec; 14(12): 763–74.PubMedCrossRefGoogle Scholar
  518. 518.
    Neaton J, Blackburn H, Jacobs D, et al. Serum cholesterol level and mortality findings for men screened in the multiple risk factor intervention trial. Arch Intern Med 1992; 152: 1490–500.PubMedCrossRefGoogle Scholar
  519. 519.
    Okumura K, Iseki K, Wakugami K, et al. Low serum cholesterol as a risk factor for hemorrhagic stroke in men: a community-based mass screening in Okinawa, Japan. Jpn Circ J 1999 Jan; 63(1): 53–8.PubMedCrossRefGoogle Scholar
  520. 520.
    Iribarren C, Jacobs DR, Sadler M, et al. Low total serum cholesterol and intracerebral hemorrhagic stroke: is the association confined to elderly men? The Kaiser Permanente Medical Care Program. Stroke 1996 Nov; 27(11): 1993–8.PubMedCrossRefGoogle Scholar
  521. 521.
    Woo D, Kissela BM, Khoury JC, et al. Hypercholesterolemia, HMG-CoA reductase inhibitors, and risk of intracerebral hemorrhage: a case-control study. Stroke 2004 Jun; 35(6): 1360–4.PubMedCrossRefGoogle Scholar
  522. 522.
    Frick MH, Elo O, Haapa K, et al. Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N Engl J Med 1987 Nov 12; 317(20): 1237–45.PubMedCrossRefGoogle Scholar
  523. 523.
    Okopien B, Krysiak R, Herman ZS. Effect of monthly atorvastatin treatment on hemostasis. Int J Clin Pharmacol Ther 2004 Nov; 42(11): 589–93.PubMedGoogle Scholar
  524. 524.
    Libby P, Aikawa M. Mechanisms of plaque stabilization with statins. Am J Cardiol 2003 Feb 20; 91(4A): 4B–8B.PubMedCrossRefGoogle Scholar
  525. 525.
    Gaddam V, Li DY, Mehta JL. Anti-thrombotic effects of atorvastatin: an effect unrelated to lipid lowering. J Cardiovasc Pharmacol Ther 2002 Oct; 7(4): 247–53.PubMedCrossRefGoogle Scholar
  526. 526.
    Puccetti L, Pasqui AL, Pastorelli M, et al. Time-dependent effect of statins on platelet function in hypercholesterolaemia. Eur J Clin Invest 2002 Dec; 32(12): 901–8.PubMedCrossRefGoogle Scholar
  527. 527.
    Ohmura C, Watada H, Hirose T, et al. Acute onset and worsening of diabetes concurrent with administration of statins. Endocr J 2005 Jun; 52(3): 369–72.PubMedCrossRefGoogle Scholar
  528. 528.
    Prasad GV, Kim SJ, Huang M, et al. Reduced incidence of new-onset diabetes mellitus after renal transplantation with 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors (statins). Am J Transplant 2004 Nov; 4(11): 1897–903.PubMedCrossRefGoogle Scholar
  529. 529.
    Sinzinger H, Mayr F, Schmid P, et al. Sleep disturbance and appetite loss after lovastatin. Lancet 1994 Apr 16; 343(8903): 973.PubMedCrossRefGoogle Scholar
  530. 530.
    Black DM, Lamkin G, Olivera EH, et al. Sleep disturbance and HMG CoA reductase inhibitors [letter]. JAMA 1990; 264(9): 1105.PubMedCrossRefGoogle Scholar
  531. 531.
    Allain P, Cailleux A. [Insomnia, lovastatin and isoprene]. Therapie 1990; 45(1): 47–8.PubMedGoogle Scholar
  532. 532.
    Tobert JA. Lovastatin-associated sleep and mood disturbances. Am J Med 1995; 99(1): 108–9.PubMedCrossRefGoogle Scholar
  533. 533.
    Rosenson RS, Goranson NL. Lovastatin-associated sleep and mood disturbances. Am J Med 1993; 95(5): 548–9.PubMedCrossRefGoogle Scholar
  534. 534.
    Boriani G, Biffi M, Strocchi E, et al. Nightmares and sleep disturbances with simvastatin and metoprolol. Ann Pharmacother 2001 Oct; 35(10): 1292.PubMedCrossRefGoogle Scholar
  535. 535.
    Gregoor PJ. Atorvastatin may cause nightmares. BMJ 2006; 332(7547): 950.PubMedCrossRefGoogle Scholar
  536. 536.
    Malini PL, Ambrosioni E, De Divitiis O, et al. Simvastatin versus pravastatin: efficacy and tolerability in patients with primary hypercholesterolemia. Clin Ther 1991; 13(4): 500–10.PubMedGoogle Scholar
  537. 537.
    Chung N, Cho SY, Choi DH, et al. STATT: a titrate-to-goal study of simvastatin in Asian patients with coronary heart disease. Simvastatin Treats Asians to Target. Clin Ther 2001; 23(6): 858–70.PubMedCrossRefGoogle Scholar
  538. 538.
    Lovastatin 5-year safety and efficacy study. Lovastatin study groups I through IV. Arch Intern Med 1993; 153(9): 1079–87.CrossRefGoogle Scholar
  539. 539.
    Vgontzas AN, Kales A, Bixler EO, et al. Effects of lovastatin and pravastatin on sleep efficiency and sleep stages. Clin Pharmacol Ther 1991; 50(6): 730–7.PubMedCrossRefGoogle Scholar
  540. 540.
    Pascual-Cruz M, Chimenos-Kustner E, Garcia-Vicente JA, et al. Adverse side effects of statins in the oral cavity. Med Oral Patol Oral Cir Bucal 2008; 13(2): E98–E101.PubMedGoogle Scholar
  541. 541.
    Abellan-Miralles I, Sanchez-Perez RM, Perez-Carmona N, et al. Multiple mononeuropathy associated to treatment with pravastatin [in Spanish]. Rev Neurol 2006 Dec 1–15; 43(11): 659–61.PubMedGoogle Scholar
  542. 542.
    Palmucci L, Doriguzzi C, Orsi L, et al. Neuropathy secondary to vitamin E deficiency in acquired intestinal malabsorption. Ital J Neurol Sci 1988 Dec; 9(6): 599–602.PubMedCrossRefGoogle Scholar
  543. 543.
    McCarron MO, Russell AJ, Metcalfe RA, et al. Chronic vitamin E deficiency causing spinocerebellar degeneration, peripheral neuropathy, and centro-cecal scotomata. Nutrition 1999 Mar; 15(3): 217–9.PubMedCrossRefGoogle Scholar
  544. 544.
    Traber MG, Sokol RJ, Ringel SP, et al. Lack of tocopherol in peripheral nerves of vitamin E-deficient patients with peripheral neuropathy. N Engl J Med 1987 Jul 30; 317(5): 262–5.PubMedCrossRefGoogle Scholar
  545. 545.
    Sokol RJ, Butler-Simon N, Heubi JE, et al. Vitamin E deficiency neuropathy in children with fat malabsorption: studies in cystic fibrosis and chronic cholestasis. Ann N Y Acad Sci 1989; 570: 156–69.PubMedCrossRefGoogle Scholar
  546. 546.
    Pezeshkpour G, Krarup C, Buchthal F, et al. Peripheral neuropathy in mitochondrial disease. J Neurol Sci 1987 Feb; 77(2–3): 285–304.PubMedCrossRefGoogle Scholar
  547. 547.
    Chu CC, Huang CC, Fang W, et al. Peripheral neuropathy in mitochondrial encephalomyopathies. Eur Neurol 1997; 37(2): 110–5.PubMedCrossRefGoogle Scholar
  548. 548.
    Halkin A, Lossos IS, Mevorach D. HMG-CoA reductase inhibitor-induced impotence [letter]. Ann Pharmacother 1996; 30(2): 192.PubMedGoogle Scholar
  549. 549.
    Boyd IW. Comment: HMG-CoA reductase inhibitor-induced impotence [letter]. Ann Pharmacother 1996; 30(10): 1199.PubMedGoogle Scholar
  550. 550.
    Jackson G. Simvastatin and impotence. BMJ 1997; 315: 31.CrossRefGoogle Scholar
  551. 551.
    Bruckert E, Giral P, Heshmati HM, et al. Men treated with hypolipidaemic drugs complain more frequently of erectile dysfunction. J Clin Pharm Ther 1996; 21: 89–94.PubMedCrossRefGoogle Scholar
  552. 552.
    Adverse Drug Reactions Advisory Committee. Simvastatin and adverse endocrine effects in men. Aust Adv Drug React Bull 1995; 14(3): 10.Google Scholar
  553. 553.
    Rizvi K, Hampson JP, Harvey JN. Do lipid-lowering drugs cause erectile dysfunction? A systematic review. Fam Pract 2002 Feb; 19(1): 95–8.PubMedCrossRefGoogle Scholar
  554. 554.
    Pia Iglesias G, Fernandez Fernandez FJ, Ameneiros Lago E, et al. HMG-CoA reductase inhibitors and sexual dysfunction [Spanish]. An Med Interna 2001 Mar; 18(3): 171.PubMedGoogle Scholar
  555. 555.
    Carvajal A, Macias D, Sainz M, et al. HMG CoA reductase inhibitors and impotence: two case series from the Spanish and French drug monitoring systems. Drug Saf 2006; 29(2): 143–9.PubMedCrossRefGoogle Scholar
  556. 556.
    Solomon H, Samarasinghe YP, Feher MD, et al. Erectile dysfunction and statin treatment in high cardiovascular risk patients. Int J Clin Pract 2006 Feb; 60(2): 141–5.PubMedCrossRefGoogle Scholar
  557. 557.
    Blanker MH, Verhagen AP. Lipid-lowering drugs and erectile dysfunction. Fam Pract 2002 Oct; 19(5): 567.PubMedCrossRefGoogle Scholar
  558. 558.
    de Graaf L, Brouwers AH, Diemont WL. Is decreased libido associated with the use of HMG-CoA-reductase inhibitors? Br J Clin Pharmacol 2004 Sep; 58(3): 326–8.PubMedCrossRefGoogle Scholar
  559. 559.
    Hildebrand RD, Hepperlen TW. Lovastatin and hypospermia [letter]. Ann Intern Med 1990; 112(7): 549–50.PubMedGoogle Scholar
  560. 560.
    Niederberger C. Atorvastatin and male infertility: is there a link? J Androl 2005 Jan–Feb; 26(1): 12.PubMedGoogle Scholar
  561. 561.
    Azzarito C, Boiardi L, Vergoni W, et al. Testicular function in hypercholesterolemic male patients during prolonged simvastatin treatment. Horm Metab Res 1996; 28(4): 193–8.PubMedCrossRefGoogle Scholar
  562. 562.
    Andreis PG, Cavallini L, Mazzocchi G, et al. Effects of prolonged administration of lovastatin, an inhibitor of cholesterol synthesis, on the morphology and function of rat Leydig cells. Exp Clin Endocrinol 1990; 96(1): 15–24.PubMedGoogle Scholar
  563. 563.
    Chen CM, Huang CC. Gonadal dysfunction in mitochondrial encephalomyopathies. Eur Neurol 1995; 35(5): 281–6.PubMedCrossRefGoogle Scholar
  564. 564.
    Pollack PS, Shields KE, Burnett DM, et al. Pregnancy outcomes after maternal exposure to simvastatin and lovastatin. Birth Defects Res A Clin Mol Teratol 2005 Nov; 73(11): 888–96.PubMedCrossRefGoogle Scholar
  565. 565.
    Gibb H, Scialli AR. Statin drugs and congenital anomalies. Am J Med Genet A 2005 Jun 1; 135(2): 230–1.PubMedGoogle Scholar
  566. 566.
    Edison RJ, Muenke M. Mechanistic and epidemiologic considerations in the evaluation of adverse birth outcomes following gestational exposure to statins. Am J Med Genet 2004 Dec 15; 131A(3): 287–98.CrossRefGoogle Scholar
  567. 567.
    Edison RJ, Muenke M. Central nervous system and limb anomalies in case reports of first-trimester statin exposure. N Engl J Med 2004 Apr 8; 350(15): 1579–82.PubMedCrossRefGoogle Scholar
  568. 568.
    Edison RJ, Muenke M. Gestational exposure to lovastatin followed by cardiac malformation misclassified as holoprosencephaly. N Engl J Med 2005 Jun 30; 352(26): 2759.PubMedCrossRefGoogle Scholar
  569. 569.
    Ghidini A, Sicherer S, Willner J. Congenital abnormalities (VATER) in baby born to mother using lovastatin. Lancet 1992 Jun 6; 339(8806): 1416–7.PubMedCrossRefGoogle Scholar
  570. 570.
    Statins: beware during pregnancy. Prescrire Int 2006 Feb; 15 (81): 18–9.Google Scholar
  571. 571.
    Adverse Drug Reactions Advisory Committee (ADRAC). Statins and peripheral neuropathy. Aust Adverse Drug React Bull 2005 Apr; 24(2): 6.Google Scholar
  572. 572.
    Ahmad S. Lovastatin and peripheral neuropathy [letter]. Am Heart J 1995; 130(6): 1321.PubMedCrossRefGoogle Scholar
  573. 573.
    Backes JM, Howard PA. Association of HMG-CoA reductase inhibitors with neuropathy. Ann Pharmacother 2003 Feb; 37(2): 274–8.PubMedCrossRefGoogle Scholar
  574. 574.
    Chong PH, Boskovich A, Stevkovic N, et al. Statin-associated peripheral neuropathy: review of the literature. Pharmacotherapy 2004 Sep; 24(9): 1194–203.PubMedCrossRefGoogle Scholar
  575. 575.
    Corrao G, Zambon A, Bertu L, et al. Lipid lowering drugs prescription and the risk of peripheral neuropathy: an exploratory case-control study using automated databases. J Epidemiol Community Health 2004 Dec; 58(12): 1047–51.PubMedCrossRefGoogle Scholar
  576. 576.
    Donaghy M. Assessing the risk of drug-induced neurologic disorders: statins and neuropathy. Neurology 2002 May 14; 58(9): 1321–2.PubMedCrossRefGoogle Scholar
  577. 577.
    Gaist D, Garcia Rodriguez LA, Huerta C, et al. Are users of lipid-lowering drugs at increased risk of peripheral neuropathy? Eur J Clin Pharmacol 2001 Mar; 56(12): 931–3.PubMedCrossRefGoogle Scholar
  578. 578.
    Jeppesen U, Gaist D, Smith T, et al. Statins and peripheral neuropathy. Eur J Clin Pharmacol 1999; 54(11): 835–8.PubMedCrossRefGoogle Scholar
  579. 579.
    Jacobs MB. HMG-CoA reducase inhibitor therapy and peripheral neuropathy [letter]. Ann Intern Med 1994; 120: 970.PubMedGoogle Scholar
  580. 580.
    Lo YL, Leoh TH, Loh LM, et al. Statin therapy and small fibre neuropathy: a serial electrophysiological study. J Neurol Sci 2003 Apr 15; 208(1–2): 105–8.PubMedCrossRefGoogle Scholar
  581. 581.
    Phan T, McLeod JG, Pollard JD, et al. Peripheral neuropathy associated with simvastatin. J Neurol Neurosurg Psychiatry 1995; 58(5): 625–8.PubMedCrossRefGoogle Scholar
  582. 582.
    Silverberg C. Atorvastatin-induced polyneuropathy. Ann Intern Med 2003 Nov 4; 139(9): 792–3.PubMedGoogle Scholar
  583. 583.
    Vaughan TB, Bell DS. Statin neuropathy masquerading as diabetic autoimmune polyneuropathy. Diabetes Care 2005 Aug; 28(8): 2082.PubMedCrossRefGoogle Scholar
  584. 584.
    Weimer LH. Medication-induced peripheral neuropathy. Curr Neurol Neurosci Rep 2003 Jan; 3(1): 86–92.PubMedCrossRefGoogle Scholar
  585. 585.
    Ziajka PE, Wehmeier T. Peripheral neuropathy and lipid-lowering therapy. South Med J 1998; 91(7): 667–8.PubMedCrossRefGoogle Scholar
  586. 586.
    Scola RH, Trentin AP, Germiniani FM, et al. Simvastatin-induced mononeuropathy multiplex: case report. Arq Neuropsiquiatr 2004 Jun; 62(2B): 540–2.PubMedCrossRefGoogle Scholar
  587. 587.
    Iannaccone ST, Sokol RJ. Vitamin E deficiency in neuropathy of abetalipoproteinemia. Neurology 1986 Jul; 36(7): 1009.PubMedCrossRefGoogle Scholar
  588. 588.
    Hegele RA, Angel A. Arrest of neuropathy and myopathy in abetalipoproteinemia with high-dose vitamin E therapy. Can Med Assoc J 1985 Jan 1; 132(1): 41–4.PubMedGoogle Scholar
  589. 589.
    Wichman A, Buchthal F, Pezeshkpour GH, et al. Peripheral neuropathy in abetalipoproteinemia. Neurology 1985 Sep; 35(9): 1279–89.PubMedCrossRefGoogle Scholar
  590. 590.
    Miller RG, Davis CJ, Illingworth DR, et al. The neuropathy of abetalipoproteinemia. Neurology 1980 Dec; 30(12): 1286–91.PubMedCrossRefGoogle Scholar
  591. 591.
    Tackmann W, Herdemerten S. Neurological symptoms in a-beta-lipoproteinemia (author’s transl) [in German]. Fortschr Neurol Psychiatr Grenzgeb 1979 Jan; 47(1): 24–35.PubMedGoogle Scholar
  592. 592.
    Smals AG, Weusten JJ, Benraad TJ, et al. The HMG-CoA reductase inhibitor simvastatin suppresses human testicular testosterone synthesis in vitro by a selective inhibitory effect on 17-ketosteroid-oxidoreductase enzyme activity. J Steroid Biochem Mol Biol 1991 Apr; 38(4): 465–8.PubMedCrossRefGoogle Scholar
  593. 593.
    Azadzoi KM, Schulman RN, Aviram M, et al. Oxidative stress in arteriogenic erectile dysfunction: prophylactic role of antioxidants. J Urol 2005 Jul; 174(1): 386–93.PubMedCrossRefGoogle Scholar
  594. 594.
    von Keutz E, Schluter G. Preclinical safety evaluation of cerivastatin, a novel HMG-CoA reductase inhibitor. Am J Cardiol 1998; 82(4B): 11–17J.CrossRefGoogle Scholar
  595. 595.
    Dogru MT, Basar MM, Simsek A, et al. Effects of statin treatment on serum sex steroids levels and autonomic and erectile function. Urology 2008; 71(4): 703–7.PubMedCrossRefGoogle Scholar
  596. 596.
    Herrmann HC, Levine LA, Macaluso Jr J, et al. Can atorvastatin improve the response to sildenafil in men with erectile dysfunction not initially responsive to sildenafil? Hypothesis and pilot trial results. J Sex Med 2006 Mar; 3(2): 303–8.PubMedCrossRefGoogle Scholar
  597. 597.
    Castro MM, Rizzi E, Rascado RR, et al. Atorvastatin enhances sildenafil-induced vasodilation through nitric oxide-mediated mechanisms. Eur J Pharmacol 2004 Sep 13; 498(1–3): 189–94.PubMedCrossRefGoogle Scholar
  598. 598.
    Saltzman EA, Guay AT, Jacobson J. Improvement in erectile function in men with organic erectile dysfunction by correction of elevated cholesterol levels: a clinical observation. J Urol 2004 Jul; 172(1): 255–8.PubMedCrossRefGoogle Scholar
  599. 599.
    Morita H, Saito Y, Ohashi N, et al. Fluvastatin ameliorates the hyperhomocysteinemia-induced endothelial dysfunction: the antioxidative properties of fluvastatin. Circ J 2005 Apr; 69(4): 475–80.PubMedCrossRefGoogle Scholar
  600. 600.
    Haendeler J, Hoffmann J, Zeiher AM, et al. Antioxidant effects of statins via S-nitrosylation and activation of thioredoxin in endothelial cells: a novel vas-culoprotective function of statins. Circulation 2004 Aug 17; 110(7): 856–61.PubMedCrossRefGoogle Scholar
  601. 601.
    Grosser N, Hemmerle A, Berndt G, et al. The antioxidant defense protein heme oxygenase 1 is a novel target for statins in endothelial cells. Free Radic Biol Med 2004 Dec 15; 37(12): 2064–71.PubMedCrossRefGoogle Scholar
  602. 602.
    Aerts J, Karmochkine M, Raguin G. Gynecomastia due to pravastatin [in French]. Presse Med 1999 Apr 17; 28(15): 787.PubMedGoogle Scholar
  603. 603.
    Hammons KB, Edwards RF, Rice WY. Golf-inhibiting gynecomastia associated with atorvastatin therapy. Pharmacotherapy 2006 Aug; 26(8): 1165–8.PubMedCrossRefGoogle Scholar
  604. 604.
    Oteri A, Catania MA, Travaglini R, et al. Gynecomastia possibly induced by rosuvastatin. Pharmacotherapy 2008; 28(4): 549–51.PubMedCrossRefGoogle Scholar
  605. 605.
    Fischereder M, Grab C, Anthuber M, et al. Gynaecomastia following solid organ transplantation. Transplant Proc 2002; 34(6): 2227–8.PubMedCrossRefGoogle Scholar
  606. 606.
    Linnebur SA, Hiatt WH. Probable statin-induced testicular pain. Ann Pharmacother 2007 Jan; 41(1): 138–42.PubMedGoogle Scholar
  607. 607.
    van Zyl-Smit R, Firth JC, Duffield M, et al. Renal tubular toxicity of HMG-CoA reductase inhibitors. Nephrol Dial Transplant 2004 Dec; 19(12): 3176–9.PubMedCrossRefGoogle Scholar
  608. 608.
    Deslypere JP, Delanghe J, Vermeulen A. Proteinuria as complication of simvastatin treatment. Lancet 1990 Dec 8; 336(8728): 1453.PubMedCrossRefGoogle Scholar
  609. 609.
    Castro JG, Gutierrez L. Rhabdomyolysis with acute renal failure probably related to the interaction of atorvastatin and delavirdine. Am J Med 2002 Apr 15; 112(6): 505.PubMedCrossRefGoogle Scholar
  610. 610.
    Bakri R, Wang J, Wierzbicki AS, et al. Cerivastatin monotherapy-induced muscle weakness, rhabdomyolysis and acute renal failure. Int J Cardiol 2003 Sep; 91(1): 107–9.PubMedCrossRefGoogle Scholar
  611. 611.
    Oldemeyer JB, Lund RJ, Koch M, et al. Rhabdomyolysis and acute renal failure after changing statin-fibrate combinations. Cardiology 2000; 94(2): 127–8.PubMedCrossRefGoogle Scholar
  612. 612.
    de Alava E, Sola JJ, Lozano MD, et al. Rhabdomyolysis and acute renal failure in a heart transplant recipient treated with hypolipemiants. Nephron 1994; 66(2): 242–3.PubMedCrossRefGoogle Scholar
  613. 613.
    Kusus M, Stapleton DD, Lertora JJ, et al. Rhabdomyolysis and acute renal failure in a cardiac transplant recipient due to multiple drug interactions. Am J Med Sci 2000 Dec; 320(6): 394–7.PubMedCrossRefGoogle Scholar
  614. 614.
    Khanal S, Attallah N, Smith DE, et al. Statin therapy reduces contrast-induced nephropathy: an analysis of contemporary percutaneous interventions. Am J Med 2005 Aug; 118(8): 843–9.PubMedCrossRefGoogle Scholar
  615. 615.
    Sandhu S, Wiebe N, Fried LF, et al. Statins for improving renal outcomes: a metaanalysis. J Am Soc Nephrol 2006 Jul; 17(7): 2006–16.PubMedCrossRefGoogle Scholar
  616. 616.
    Douglas K, O’Malley PG, Jackson JL. Meta-analysis: the effect of statins on albuminuria. Ann Intern Med 2006 Jul 18; 145(2): 117–24.PubMedGoogle Scholar
  617. 617.
    Vidt DG, Cressman MD, Harris S, et al. Rosuvastatin-induced arrest in progression of renal disease. Cardiology 2004; 102(1): 52–60.PubMedCrossRefGoogle Scholar
  618. 618.
    Kaplan J, Shively C, Fontenot D, et al. Demonstration of an association among dietary cholesterol, central serotonergic activity, and social behavior in monkeys. Psychosom Med 1994; 56: 479–84.PubMedGoogle Scholar
  619. 619.
    Kaplan JR, Manuck SB. The effects of fat and cholesterol on aggressive behavior in monkeys. Psychosomatic Med 1990; 52: 226–7.Google Scholar
  620. 620.
    Golomb BA, Stattin H, Mednick S. Low cholesterol and violent crime. J Psychiatr Res 2000 Jul–Oct; 34(4–5): 301–9.PubMedCrossRefGoogle Scholar
  621. 621.
    Virkkunen M. Serum cholesterol in antisocial personality. Neuropsychobiology 1979; 5: 27–30.PubMedCrossRefGoogle Scholar
  622. 622.
    Virkkunen M. Serum cholesterol levels in homicidal offenders: a low cholesterol level is connected with a habitually violent tendency under the influence of alcohol. Neuropsychobiology 1983; 10: 65–9.PubMedCrossRefGoogle Scholar
  623. 623.
    Virkkunen M, Penttinen H. Serum cholesterol in aggressive conduct disorder: a preliminary study. Biol Psychiat 1984; 19(3): 435–9.PubMedGoogle Scholar
  624. 624.
    Hillbrand M, Foster H. Serum cholesterol levels and severity of aggression. Psychol Rep 1993; 72(1): 270.PubMedCrossRefGoogle Scholar
  625. 625.
    Hillbrand M, Spitz R, Foster H. Serum cholesterol and aggression in hospitalized male forensic patients. J Behav Med 1995; 18(1): 33–43.PubMedCrossRefGoogle Scholar
  626. 626.
    Spitz R, Hillbrand M, Foster HJ. Serum cholesterol levels and frequency of aggression. Psychol Rep 1994; 74(2): 622.PubMedCrossRefGoogle Scholar
  627. 627.
    Mufti R, Balon R, Arfken C. Low cholesterol and violence. Psychiatr Serv 1998; 49(2): 221–4.PubMedGoogle Scholar
  628. 628.
    Repo-Tiihonen E, Halonen P, Tiihonen J, et al. Total serum cholesterol level, violent criminal offences, suicidal behavior, mortality and the appearance of conduct disorder in Finnish male criminal offenders with antisocial personality disorder. Eur Arch Psychiatry Clin Neurosci 2002 Feb; 252(1): 8–11.PubMedGoogle Scholar
  629. 629.
    Chakrabarti N, Sinha VK. A study of serum lipid profile and serum apolipoproteins A1 and B in Indian male violent criminal offenders. Crim Behav Ment Health 2006; 16(3): 177–82.PubMedCrossRefGoogle Scholar
  630. 630.
    Muldoon M, Manuck S, Matthews K. Lowering cholesterol concentrations and mortality: a review of primary prevention trials. BMJ 1990; 301: 309–14.PubMedCrossRefGoogle Scholar
  631. 631.
    Muldoon M, Rossouw J, Manuck S, et al. Low or lowered cholesterol and risk of death from suicide and trauma. Metabolism 1993; 42(9 Suppl. 1): 45–56.PubMedCrossRefGoogle Scholar
  632. 632.
    Muldoon MF, Manuck SB, Mendelsohn AB, et al. Cholesterol reduction and non-illness mortality: meta-analysis of randomised clinical trials. BMJ 2001; 322(7277): 11–5.PubMedCrossRefGoogle Scholar
  633. 633.
    Adonaylo VN, Oteiza PI. Lead intoxication: antioxidant defenses and oxidative damage in rat brain. Toxicology 1999; 135(2–3): 77–85.PubMedCrossRefGoogle Scholar
  634. 634.
    Ahamed M, Fareed M, Kumar A, et al. Oxidative stress and neurological disorders in relation to blood lead levels in children. Redox Rep 2008; 13(3): 117–22.PubMedCrossRefGoogle Scholar
  635. 635.
    Ahamed M, Siddiqui MK. Low level lead exposure and oxidative stress: current opinions. Clin Chim Acta 2007; 383(1–2): 57–64.PubMedCrossRefGoogle Scholar
  636. 636.
    Marlowe M, Errera J. Low lead levels and behavior problems in children. Behav Disord 1982; 7(3): 163–72.Google Scholar
  637. 637.
    Pihl R, Ervin F. Lead and cadmium levels in violent criminals. Psychol Rep 1990; 66(3 Pt 1): 839–44.PubMedCrossRefGoogle Scholar
  638. 638.
    Stohs SJ, Bagchi D, Hassoun E, et al. Oxidative mechanisms in the toxicity of chromium and cadmium ions. J Environ Pathol Toxicol Oncol 2000; 19(3): 201–13.PubMedGoogle Scholar
  639. 639.
    Valko M, Morris H, Cronin MT. Metals, toxicity and oxidative stress. Curr Med Chem 2005; 12(10): 1161–208.PubMedCrossRefGoogle Scholar
  640. 640.
    Wolf MB, Baynes JW. Cadmium and mercury cause an oxidative stress-induced endothelial dysfunction. Biometals 2007 Feb; 20(1): 73–81.PubMedCrossRefGoogle Scholar
  641. 641.
    Devinsky O, Kernan J, Bear DM. Aggressive behavior following exposure to cholinesterase inhibitors. J Neuropsychiatry Clin Neurosci 1992; 4(2): 189–94.PubMedGoogle Scholar
  642. 642.
    Stallones L, Beseler C. Pesticide illness, farm practices, and neurological symptoms among farm residents in Colorado. Environ Res 2002; 90(2): 89–97.PubMedCrossRefGoogle Scholar
  643. 643.
    Ramanathan L, Gulyani S, Nienhuis R, et al. Sleep deprivation decreases super-oxide dismutase activity in rat hippocampus and brainstem. Neuroreport 2002; 13(11): 1387–90.PubMedCrossRefGoogle Scholar
  644. 644.
    Schulze G. Sleep protects excitatory cortical circuits against oxidative damage. Med Hypotheses 2004; 63(2): 203–7.PubMedCrossRefGoogle Scholar
  645. 645.
    Brylewski J, Wiggs L. Sleep problems and daytime challenging behaviour in a community-based sample of adults with intellectual disability. J Intellect Disabil Res 1999; 43(Pt 6): 504–12.PubMedCrossRefGoogle Scholar
  646. 646.
    Flemons WW, Tsai W. Quality of life consequences of sleep-disordered breathing. J Allergy Clin Immunol 1997; 99(2): S750–6.PubMedCrossRefGoogle Scholar
  647. 647.
    Haugli L, Skogstad A, Hellesoy OH. Health, sleep, and mood perceptions reported by airline crews flying short and long hauls. Aviat Space Environ Med 1994; 65(1): 27–34.PubMedGoogle Scholar
  648. 648.
    Golomb BA, Dimsdale JE, Evans MA, et al. Effects of statins on aggression differ by gender: results of a double blind placebo controlled trial. Circulation 2008; 117(11) Suppl.: e268–9.Google Scholar
  649. 649.
    Volatron AC, Belleguic C, Polard E, et al. Simvastatin-induced chylothorax [in French]. Rev Mal Respir 2003 Apr; 20(2 Pt 1): 291–3.PubMedGoogle Scholar
  650. 650.
    Yoshioka S, Mukae H, Ishii H, et al. A case of drug-induced pneumonia possibly associated with simvastatin [in Japanese]. Nihon Kokyuki Gakkai Zasshi 2005 Oct; 43(10): 600–4.PubMedGoogle Scholar
  651. 651.
    De Groot REB, Willems LNA, Dijkman JH. Interstitial lung disease with pleural effusion caused by simvastatin. J Internal Med 1996; 239: 361–3.PubMedCrossRefGoogle Scholar
  652. 652.
    Veyrac G, Cellerin L, Jolliet P. A case of interstitial lung disease with atorvastatin (Tahor) and a review of the literature about these effects observed under statins [in French]. Therapie 2006 Jan–Feb; 61(1): 57–67.PubMedCrossRefGoogle Scholar
  653. 653.
    Walker T, McCaffery J, Steinfort C. Potential link between HMG-CoA reductase inhibitor (statin) use and interstitial lung disease. Med J Aust 2007 Jan 15; 186(2): 91–4.PubMedGoogle Scholar
  654. 654.
    Lantuejoul S, Brambilla E, Brambilla C, et al. Statin-induced fibrotic nonspecific interstitial pneumonia. Eur Respir J 2002 Mar; 19(3): 577–80.PubMedCrossRefGoogle Scholar
  655. 655.
    Kalomenidis I, Papiris S, Loukides S. Bilateral pleural effusions associated with pravastatin sodium treatment. Eur Respir J 2007; 30(5): 1022.PubMedCrossRefGoogle Scholar
  656. 656.
    Roncato-Saberan M, Hustache-Mathieu L, Hoen B. Eosinophilic pleural effusion caused by simvastatin after 13 years of exposure. Eur J Intern Med 2006; 17(6): 450.PubMedCrossRefGoogle Scholar
  657. 657.
    Liscoet-Loheac N, Andre N, Couturaud F, et al. Hypersensitivity pneumonitis in a patient taking pravastatin [in French]. Rev Mal Respir 2001 Sep; 18(4 Pt 1): 426–8.PubMedGoogle Scholar
  658. 658.
    Liebhaber MI, Wright RS, Gelberg HJ, et al. Polymyalgia, hypersensitivity pneumonitis and other reactions in patients receiving HMG-CoA reductase inhibitors: a report of ten cases. Chest 1999; 115(3): 886–9.PubMedCrossRefGoogle Scholar
  659. 659.
    Silver MA, Langsjoen PH, Szabo S, et al. Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction. Am J Cardiol 2004 Nov 15; 94(10): 1306–10.PubMedCrossRefGoogle Scholar
  660. 660.
    Morisco C, Trimarco B, Condorelli M. Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study. Clin Investig 1993; 71(8 Suppl.): S134–6.PubMedGoogle Scholar
  661. 661.
    Langsjoen PH, Folkers K. Isolated diastolic dysfunction of the myocardium and its response to CoQ10 treatment. Clin Investig 1993; 71(8 Suppl.): S140–4.PubMedGoogle Scholar
  662. 662.
    Sola S, Mir MQ, Lerakis S, et al. Atorvastatin improves left ventricular systolic function and serum markers of inflammation in nonischemic heart failure. J Am Coll Cardiol 2006 Jan 17; 47(2): 332–7.PubMedCrossRefGoogle Scholar
  663. 663.
    Laufs U, Wassmann S, Schackmann S, et al. Beneficial effects of statins in patients with non-ischemic heart failure. Z Kardiol 2004 Feb; 93(2): 103–8.PubMedCrossRefGoogle Scholar
  664. 664.
    Akahane T, Mizushige K, Nishio H, et al. Atrial fibrillation induced by simvastatin treatment in a 61-year-old man. Heart Vessels 2003 Jul; 18(3): 157–9.PubMedCrossRefGoogle Scholar
  665. 665.
    Fujioka T, Sakamoto Y, Mimura G. Clinical study of cardiac arrhythmias using a 24-hour continuous electrocardiographic recorder (5th report): antiarrhythmic action of coenzyme Q10 in diabetics. Tohoku J Exp Med 1983 Dec; 141 Suppl.: 453–63.PubMedCrossRefGoogle Scholar
  666. 666.
    Baggio E, Gandini R, Plancher AC, et al., on behalf of the CoQ10 Drug Surveillance Investigators. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. Mol Aspects Med 1994; 15(Suppl. 1): s287–94.PubMedCrossRefGoogle Scholar
  667. 667.
    Lin PH, Lee SH, Su CP, et al. Oxidative damage to mitochondrial DNA in atrial muscle of patients with atrial fibrillation. Free Radic Biol Med 2003 Nov 15; 35(10): 1310–8.PubMedCrossRefGoogle Scholar
  668. 668.
    Ohmae M, Rabkin SW. Hyperkalemia-induced bundle branch block and complete heart block. Clin Cardiol 1981 Jan; 4(1): 43–6.PubMedCrossRefGoogle Scholar
  669. 669.
    Guzman SV, DeleonJr AC, West JW, et al. Cardiac effects of isoproterenol, norepinephrine and epinephrine in complete A–V heart block during experimental acidosis and hyperkalemia. Circ Res 1959 Jul; 7(4): 666–72.PubMedCrossRefGoogle Scholar
  670. 670.
    Annoura M, Ogawa M, Kumagai K, et al. Cholesterol paradox in patients with paroxysmal atrial fibrillation. Cardiology 1999; 92(1): 21–7.PubMedCrossRefGoogle Scholar
  671. 671.
    Korantzopoulos P, Galaris D, Papaioannides D, et al. C-reactive protein and oxidative stress in atrial fibrillation. Int J Cardiol 2003 Mar; 88(1): 103–4.PubMedCrossRefGoogle Scholar
  672. 672.
    Korantzopoulos P, Kolettis T, Siogas K, et al. Atrial fibrillation and electrical remodeling: the potential role of inflammation and oxidative stress. Med Sci Monit 2003 Sep 9; (9): RA225–9.PubMedGoogle Scholar
  673. 673.
    Korantzopoulos P, Kolettis TM, Goudevenos JA. The anti-inflammatory and antioxidant effects of long-chain n-3 fatty acids or oil-rich fish may favorably affect atrial remodeling in atrial fibrillation. Med Hypotheses 2005; 64(6): 1245–6.PubMedCrossRefGoogle Scholar
  674. 674.
    Korantzopoulos P, Kolettis TM, Kountouris E, et al. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation. Int J Cardiol 2005 Jul 10; 102(2): 321–6.PubMedCrossRefGoogle Scholar
  675. 675.
    Korantzopoulos P, Kountouris E, Kolettis T, et al. Anti-inflammatory and antioxidant actions of statins may favorably affect atrial remodeling in atrial fibrillation. Am J Cardiol 2004 May 1; 93(9): 1200.PubMedCrossRefGoogle Scholar
  676. 676.
    Patti G, Chello M, Candura D, et al. Randomized trial of atorvastatin for reduction of postoperative atrial fibrillation in patients undergoing cardiac surgery: results of the ARMYDA-3 (Atorvastatin for Reduction of MYocardial Dysrhythmia After cardiac surgery) study. Circulation 2006 Oct 3; 114(14): 1455–61.PubMedCrossRefGoogle Scholar
  677. 677.
    Judy WV, Stogsdill WW, Judy JS. CoQ10 in the management of low energy and delayed development in children with Praeder-Willi syndrome [abstract]. Proceedings of the Third Conference of the International Coenzyme Q10 Association; 2002 Nov 22–4; London, 34–5.Google Scholar
  678. 678.
    Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 1999; 13: 203–308.PubMedCrossRefGoogle Scholar
  679. 679.
    Muller T, Kuhn W, Pohlau D, et al. Parkinsonism unmasked by lovastatin. Ann Neurol 1995 May; 37(5): 685–6.PubMedCrossRefGoogle Scholar
  680. 680.
    Beal MF. Coenzyme Q10 as a possible treatment for neurodegenerative diseases. Free Radic Res 2002 Apr; 36(4): 455–60.PubMedCrossRefGoogle Scholar
  681. 681.
    Beal MF. Therapeutic effects of coenzyme Q10 in neurodegenerative diseases. Methods Enzymol 2004; 382: 473–87.PubMedCrossRefGoogle Scholar
  682. 682.
    Beal MF, Henshaw DR, Jenkins BG, et al. Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate. Ann Neurol 1994 Dec; 36(6): 882–8.PubMedCrossRefGoogle Scholar
  683. 683.
    Shults CW, Oakes D, Kieburtz K, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 2002 Oct; 59(10): 1541–50.PubMedCrossRefGoogle Scholar
  684. 684.
    Huang X, Chen H, Miller WC, et al. Lower low-density lipoprotein cholesterol levels are associated with Parkinson’s disease. Mov Disord 2007 Feb 15; 22(3): 377–81.PubMedCrossRefGoogle Scholar
  685. 685.
    Dupuis L, Corcia P, Fergani A, et al. Dyslipidemia is a protective factor in amyotrophic lateral sclerosis. Neurology 2008 Mar 25; 70(13): 1004–9.PubMedCrossRefGoogle Scholar
  686. 686.
    Oranje WA, Sels JP, Rondas-Colbers GJ, et al. Effect of atorvastatin on LDL oxidation and antioxidants in normocholesterolemic type 2 diabetic patients. Clin Chim Acta 2001 Sep 25; 311(2): 91–4.PubMedCrossRefGoogle Scholar
  687. 687.
    Finsterer J. Parkinson syndrome as a manifestation of mitochondriopathy. Acta Neurol Scand 2002 May; 105(5): 384–9.PubMedCrossRefGoogle Scholar
  688. 688.
    Sohmiya M, Tanaka M, Tak NW, et al. Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson’s disease. J Neurol Sci 2004 Aug 30; 223(2): 161–6.PubMedCrossRefGoogle Scholar
  689. 689.
    Sudha K, Rao AV, Rao S, et al. Free radical toxicity and antioxidants in Parkinson’s disease. Neurol India 2003 Mar; 51(1): 60–2.PubMedGoogle Scholar
  690. 690.
    Ciccone CD. Free-radical toxicity and antioxidant medications in Parkinson’s disease. Phys Ther 1998 Mar; 78(3): 313–9.PubMedGoogle Scholar
  691. 691.
    Hill CF, Schwartz LM, Thompson PD, et al. Effects of statin treatment and supplemental Co Q10 on C2C12 myotubes: 2436. Med Sci Sports Exerc 2005 May 2005; 37(5 Suppl.): S466–S7.Google Scholar
  692. 692.
    Jick H, Zornberg GL, Jick SS, et al. Statins and the risk of dementia. Lancet 2000 Nov 11; 356(9242): 1627–31.PubMedCrossRefGoogle Scholar
  693. 693.
    Wolozin B, Kellman W, Ruosseau P, et al. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch Neurol 2000 Oct; 57(10): 1439–43.PubMedCrossRefGoogle Scholar
  694. 694.
    Wolozin B, Wang SW, Li NC, et al. Simvastatin is associated with a reduced incidence of dementia and Parkinson’s disease. BMC Med 2007 Jul 19; 5(1): 20.PubMedCrossRefGoogle Scholar
  695. 695.
    LeBlanc ES, Janowsky J, Chan BK, et al. Hormone replacement therapy and cognition: systematic review and meta-analysis. JAMA 2001 Mar 21; 285(11): 1489–99.PubMedCrossRefGoogle Scholar
  696. 696.
    Shumaker SA, Legault C, Rapp SR, et al. Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women’s Health Initiative Memory Study. A randomized controlled trial. JAMA 2003 May 28; 289(20): 2651–62.PubMedCrossRefGoogle Scholar
  697. 697.
    Rapp SR, Espeland MA, Shumaker SA, et al. Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women’s Health Initiative Memory Study. A randomized controlled trial. JAMA 2003 May 28; 289(20): 2663–72.PubMedCrossRefGoogle Scholar
  698. 698.
    Expert Panel on Detection Evaluation, and Treatment of High Blood Cholesterol in Adults. Third report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Executive Sumary [online]. Available from URL: [Accessed 2008 Sep 29].
  699. 699.
    Li G, Larson EB, Sonnen JA, et al. Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease. Neurology 2007 Aug 28; 69(9): 878–85.PubMedCrossRefGoogle Scholar
  700. 700.
    Ahmad S. Lovastatin-induced lupus erythematosus [see comments]. Arch Intern Med 1991; 151(8): 1667–8.PubMedCrossRefGoogle Scholar
  701. 701.
    Ahmad A, Fletcher MT, Roy TM. Simvastatin-induced lupus-like syndrome. Tennessee Med 2000; 93(1): 21–2.Google Scholar
  702. 702.
    Alla V, Abraham J, Siddiqui J, et al. Autoimmune hepatitis triggered by statins. J Clin Gastroenterol 2006 Sep; 40(8): 757–61.PubMedCrossRefGoogle Scholar
  703. 703.
    Bannwarth B, Miremont G, Papapietro PM. Lupuslike syndrome associated with simvastatin. Arch Intern Med 1992 May; 152(5): 1093.PubMedCrossRefGoogle Scholar
  704. 704.
    Castiella A, Fernandez J, Zapata E. Autoimmune hepatitis after treatment with fluvastatin. Liver Int 2007 May; 27(4): 592.PubMedCrossRefGoogle Scholar
  705. 705.
    Hanson J, Bossingham D. Lupus-like syndrome associated with simvastatin. Lancet 1998 Sep 26; 352(9133): 1070.PubMedCrossRefGoogle Scholar
  706. 706.
    Jimenez-Alonso J, Jaimez L, Sabio JM, et al. Atorvastatin-induced reversible positive antinuclear antibodies. Am J Med 2002 Mar; 112(4): 329–30.PubMedCrossRefGoogle Scholar
  707. 707.
    Khosla R, Butman AN, Hammer DF. Simvastatin-induced lupus erythematosus. Southern Med J 1998; 91(9): 873–4.PubMedCrossRefGoogle Scholar
  708. 708.
    Konig C, Eickert A, Scharfetter-Kochanek K, et al. Linear IgA bullous dermatosis induced by atorvastatin. J Am Acad Dermatol 2001 Apr; 44(4): 689–92.PubMedCrossRefGoogle Scholar
  709. 709.
    Noel B. Autoimmune diseases and statins [in French]. Ann Dermatol Venereol 2006 Mar; 133(3): 276–8.PubMedCrossRefGoogle Scholar
  710. 710.
    Noel B. Lupus erythematosus and other autoimmune diseases related to statin therapy: a systematic review. J Eur Acad Dermatol Venereol 2007 Jan; 21(1): 17–24.PubMedCrossRefGoogle Scholar
  711. 711.
    Noel B. Autoimmune disease and other potential side-effects of statins. Lancet 2004 Jun 12; 363(9425): 2000.PubMedCrossRefGoogle Scholar
  712. 712.
    Noel B, Panizzon RG. Lupus-like syndrome associated with statin therapy. Dermatology 2004; 208(3): 276–7.PubMedCrossRefGoogle Scholar
  713. 713.
    Rudski L, Rabinovitch MA, Danoff D. Systemic immune reactions to HMG-CoA reductase inhibitors: report of 4 cases and review of the literature. Medicine (Baltimore) 1998 Nov; 77(6): 378–83.CrossRefGoogle Scholar
  714. 714.
    Schmutz JL, Barbaud A, Trechot P. Statins and lupus erythematosus [in French]. Ann Dermatol Venereol 2006 Jan; 133(1): 98.PubMedCrossRefGoogle Scholar
  715. 715.
    Sridhar MK, Abdulla A. Fatal lupus-like syndrome and ARDS induced by fluvastatin. Lancet 1998 Jul 11; 352(9122): 114.PubMedCrossRefGoogle Scholar
  716. 716.
    Suchak R, Benson K, Swale V. Statin-induced Ro/SSa-positive subacute cutaneous lupus erythematosus. Clin Exp Dermatol 2007; 32(5): 589–91.PubMedCrossRefGoogle Scholar
  717. 717.
    Kamen DL, Cooper GS, Bouali H, et al. Vitamin D deficiency in systemic lupus erythematosus. Autoimmun Rev 2006 Feb; 5(2): 114–7.PubMedCrossRefGoogle Scholar
  718. 718.
    Cantorna MT. Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease. Prog Biophys Mol Biol 2006 Sep; 92(1): 60–4.PubMedCrossRefGoogle Scholar
  719. 719.
    Mark BL, Carson JA. Vitamin D and autoimmune disease: implications for practice from the multiple sclerosis literature. J Am Diet Assoc 2006 Mar; 106(3): 418–24.PubMedCrossRefGoogle Scholar
  720. 720.
    Ponsonby AL, Lucas RM, Van der Mei IA. UVR, vitamin D and three autoimmune diseases: multiple sclerosis, type 1 diabetes, rheumatoid arthritis. Photochem Photobiol 2005 Nov–Dec; 81(6): 1267–75.PubMedCrossRefGoogle Scholar
  721. 721.
    van Amerongen BM, Dijkstra CD, Lips P, et al. Multiple sclerosis and vitamin D: an update. Eur J Clin Nutr 2004 Aug; 58(8): 1095–109.CrossRefGoogle Scholar
  722. 722.
    Luong K, Nguyen LT, Nguyen DN. The role of vitamin D in protecting type 1 diabetes mellitus. Diabetes Metab Res Rev 2005 Jul–Aug; 21(4): 338–46.PubMedCrossRefGoogle Scholar
  723. 723.
    Mathieu C, Badenhoop K. Vitamin D and type 1 diabetes mellitus: state of the art. Trends Endocrinol Metab 2005 Aug; 16(6): 261–6.PubMedCrossRefGoogle Scholar
  724. 724.
    Brown SJ. The role of vitamin D in multiple sclerosis. Ann Pharmacother 2006 Jun; 40(6): 1158–61.PubMedCrossRefGoogle Scholar
  725. 725.
    Holick MF. Vitamin D: important for prevention of osteoporosis, cardiovascular heart disease, type 1 diabetes, autoimmune diseases, and some cancers. South Med J 2005 Oct; 98(10): 1024–7.PubMedCrossRefGoogle Scholar
  726. 726.
    Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004 Dec; 80(6 Suppl.): 1678–1688.Google Scholar
  727. 727.
    Griffin MD, Xing N, Kumar R. Vitamin D and its analogs as regulators of immune activation and antigen presentation. Annu Rev Nutr 2003; 23: 117–45.PubMedCrossRefGoogle Scholar
  728. 728.
    Zella JB, DeLuca HF. Vitamin D and autoimmune diabetes. J Cell Biochem 2003 Feb 1; 88(2): 216–22.PubMedCrossRefGoogle Scholar
  729. 729.
    Adorini L. Immunomodulatory effects of vitamin D receptor ligands in autoimmune diseases. Int Immunopharmacol 2002 Jun; 2(7): 1017–28.PubMedCrossRefGoogle Scholar
  730. 730.
    Neuhaus O, Stuve O, Zamvil SS, et al. Evaluation of HMG-CoA reductase inhibitors for multiple sclerosis: opportunities and obstacles. CNS Drugs 2005; 19(10): 833–41.PubMedCrossRefGoogle Scholar
  731. 731.
    Johnson JL, Loomis IB. A case of simvastatin-associated pancreatitis and review of statin-associated pancreatitis. Pharmacotherapy 2006 Mar; 26(3): 414–22.PubMedCrossRefGoogle Scholar
  732. 732.
    Tysk C, Al-Eryani AY, Shawabkeh AA. Acute pancreatitis induced by fluvastatin therapy. J Clin Gastroenterol 2002 Nov–Dec; 35(5): 406–8.PubMedCrossRefGoogle Scholar
  733. 733.
    Singh S, Nautiyal A, Dolan JG. Recurrent acute pancreatitis possibly induced by atorvastatin and rosuvastatin: is statin induced pancreatitis a class effect? JOP 2004 Nov; 5(6): 502–4.PubMedGoogle Scholar
  734. 734.
    Singh S. Drug induced pancreatitis might be a class effect of statin drugs. JOP 2005 Jul; 6(4): 380.PubMedGoogle Scholar
  735. 735.
    Ramdani M, Schmitt AM, Liautard J, et al. Simvastatin-induced acute pancreatitis: two cases [in French]. Gastroenterol Clin Biol 1991; 15(12): 986.PubMedGoogle Scholar
  736. 736.
    Pezzilli R, Ceciliato R, Corinaldesi R, et al. Acute pancreatitis due to simvastatin therapy: increased severity after rechallenge. Dig Liver Dis 2004 Sep; 36(9): 639–40.PubMedCrossRefGoogle Scholar
  737. 737.
    Miltiadous G, Anthopoulou A, Elisaf M. Acute pancreatitis possibly associated with combined salicylate and atorvastatin therapy. JOP 2003 Jan; 4(1): 20–1.PubMedGoogle Scholar
  738. 738.
    McDonald KB, Garber BG, Perreault MM. Pancreatitis associated with simvastatin plus fenofibrate. Ann Pharmacother 2002 Feb; 36(2): 275–9.PubMedCrossRefGoogle Scholar
  739. 739.
    Lons T, Chousterman M. Simvastatin: a new drug responsible for acute pancreatitis? [in French]. Gastroenterol Clin Biol 1991; 15(1): 93–4.PubMedGoogle Scholar
  740. 740.
    Kanbay M, Sekuk H, Yilmaz U, et al. Acute pancreatitis associated with combined lisinopril and atorvastatin therapy. Dig Dis 2005; 23(1): 92–4.PubMedCrossRefGoogle Scholar
  741. 741.
    Grahit Vidosa V, Aviles Ciguela S, Ribas Batllori A, et al. Acute pancreatitis due to lipid-lowering drugs [in Spanish]. Aten Primaria 2005 May 15; 35(8): 437–8.PubMedCrossRefGoogle Scholar
  742. 742.
    Couderc M, Blanc P, Rouillon JM, et al. A new case of simvastatin-induced acute pancreatitis [in French]. Gastroenterol Clin Biol 1991; 15(12): 986–7.PubMedGoogle Scholar
  743. 743.
    Becker C, Hvalic C, Delmore G, et al. Recurrent acute pancreatitis during pravastatin-therapy [in German]. Schweiz Rundsch Med Prax 2006 Jan 25; 95(4): 111–6.Google Scholar
  744. 744.
    Anagnostopoulos GK, Tsiakos S, Margantinis G, et al. Acute pancreatitis due to pravastatin therapy. JOP 2003 May; 4(3): 129–32.PubMedGoogle Scholar
  745. 745.
    Belaiche G, Ley G, Slama JL. [Acute pancreatitis associated with atorvastatine therapy]. Gastroenterol Clin Biol 2000; 24(4): 471–2.PubMedGoogle Scholar
  746. 746.
    Singh S, Loke YK. Statins and pancreatitis: a systematic review of observational studies and spontaneous case reports. Drug Saf 2006; 29(12): 1123–32.PubMedCrossRefGoogle Scholar
  747. 747.
    Tsigrelis C, Pitchumoni CS. Pravastatin: a potential cause for acute pancreatitis. World J Gastroenterol 2006 Nov 21; 12(43): 7055–7.PubMedGoogle Scholar
  748. 748.
    Thisted H, Jacobsen J, Munk EM, et al. Statins and the risk of acute pancreatitis: a population-based case-control study. Aliment Pharmacol Ther 2006 Jan 1; 23(1): 185–90.PubMedCrossRefGoogle Scholar
  749. 749.
    Verny C, Amati-Bonneau P, Letournel F, et al. Mitochondrial DNA A3243G mutation involved in familial diabetes, chronic intestinal pseudo-obstruction and recurrent pancreatitis. Diabetes Metab. Epub 2008 Oct 25.Google Scholar
  750. 750.
    Singh L, Bakshi DK, Majumdar S, et al. Mitochondrial dysfunction and apoptosis of acinar cells in chronic pancreatitis. J Gastroenterol 2008; 43(6): 473–83.PubMedCrossRefGoogle Scholar
  751. 751.
    Odinokova IV, Sung KF, Mareninova OA, et al. Mitochondrial mechanisms of death responses in pancreatitis. J Gastroenterol Hepatol 2008; 23 Suppl. 1: S25–30.PubMedCrossRefGoogle Scholar
  752. 752.
    Mukherjee R, Criddle DN, Gukvoskaya A, et al. Mitochondrial injury in pancreatitis. Cell Calcium 2008; 44(1): 14–23.PubMedCrossRefGoogle Scholar
  753. 753.
    Finsterer J. Recurrent pancreatitis as a manifestation of multisystem mitochondrial disorder. Minerva Gastroenterol Dietol 2007; 53(3): 285–9.PubMedGoogle Scholar
  754. 754.
    Finsterer J. Pancreatitis as a manifestation of mitochondrial disorder. Am J Med Genet A 2007; 143(6): 632–3.PubMedGoogle Scholar
  755. 755.
    Debray FG, Drouin E, Herzog D, et al. Recurrent pancreatitis in mitochondrial cytopathy. Am J Med Genet A 2006; 140(21): 2330–5.PubMedGoogle Scholar
  756. 756.
    Toyono M, Nakano K, Kiuchi M, et al. A case of MERRF associated with chronic pancreatitis. Neuromuscul Disord 2001; 11(3): 300–4.PubMedCrossRefGoogle Scholar
  757. 757.
    Spreckelsen U, Kirchhoff R, Haacke H. Cholestatic jaundice during lovastatin medication [in German]. Dtsch Med Wochenschr 1991 May 10; 116(19): 739–40.PubMedCrossRefGoogle Scholar
  758. 758.
    Yoshida EM, Levin A. Lovastatin and cholestasis. CMAJ 1993 Feb 1; 148(3): 374.PubMedGoogle Scholar
  759. 759.
    Tuteja S, Pyrsopoulos NT, Wolowich WR, et al. Simvastatin-ezetimibe-induced hepatic failure necessitating liver transplantation. Pharmacotherapy 2008; 28(9): 1188–93.PubMedCrossRefGoogle Scholar
  760. 760.
    Holme SA, Pearse AD, Anstey AV. Chronic actinic dermatitis secondary to simvastatin. Photodermatol Photoimmunol Photomed 2002 Dec; 18(6): 313–4.PubMedCrossRefGoogle Scholar
  761. 761.
    Granados MT, de la Torre C, Cruces MJ, et al. Chronic actinic dermatitis due to simvastatin. Contact Dermatitis 1998 May; 38(5): 294–5.PubMedCrossRefGoogle Scholar
  762. 762.
    Oskay T, Kutluay L. Acute generalized exanthematous pustulosis induced by simvastatin. Clin Exp Dermatol 2003 Sep; 28(5): 558–9.PubMedCrossRefGoogle Scholar
  763. 763.
    Segal AS. Alopecia associated with atorvastatin. Am J Med 2002 Aug 1; 113(2): 171.PubMedCrossRefGoogle Scholar
  764. 764.
    Lee TH. By the way, doctor: my hair has been thinning out for the past decade or so, but since my doctor started me on Lipitor (atorvastatin) a few months ago for high cholesterol, I swear it’s been falling out much faster. My doctor discounts the possibility, but I looked in the Physicians’ desk reference (PDR) and alopecia is listed under “adverse reactions.” What do you think? Harv Health Lett 2000 Jul; 25(9): 8.Google Scholar
  765. 765.
    Robb-Nicholson C. Recently, I heard on a TV show that anticholesterol drugs can cause hair loss. I’ve been taking Zocorfor about 18 months now, and in the past 6 months I’ve noticed hair loss from the top and sides of my head. Is this common? Will my hair regrow once I stop taking the drug? Harv Womens Health Watch 1998 Jan; 5(5): 8.Google Scholar
  766. 766.
    Hampson JP, Smith D, Cowell R, et al. Hypotension and eosinophilia with atorvastatin. Pharm World Sci 2005 Aug; 27(4): 279–80.PubMedCrossRefGoogle Scholar
  767. 767.
    Mehregan DR, Mehregan DA, Pakideh S. Cheilitis due to treatment with simvastatin. Cutis 1998; 62(4): 197–8.PubMedGoogle Scholar
  768. 768.
    Peramiquel L, Serra E, Dalmau J, et al. Occupational contact dermatitis from simvastatin. Contact Dermatitis 2005 May; 52(5): 286–7.PubMedCrossRefGoogle Scholar
  769. 769.
    Field S, Bourke B, Hazelwood E, et al. Simvastatin: occupational contact dermatitis. Contact Dermatitis 2007; 57(4): 282–3.PubMedCrossRefGoogle Scholar
  770. 770.
    Adcock BB, Hornsby LB, Jenkins K. Dermographism: an adverse effect of atorvastatin. J Am Board Fam Pract 2001 Mar–Apr; 14(2): 148–51.PubMedGoogle Scholar
  771. 771.
    de Boer EM, Bruynzeel DP. Allergy to pravastatin. Contact Dermatitis 1994; 30(4): 238.PubMedCrossRefGoogle Scholar
  772. 772.
    Krasovec M, Elsner P, Burg G. Generalized eczematous skin rash possibly due to HMG-CoA reductase inhibitors. Dermatology 1993; 186(4): 248–52.PubMedCrossRefGoogle Scholar
  773. 773.
    Proksch E. Antilipemic drug-induced skin manifestations [in German]. Hautarzt 1995 Feb; 46(2): 76–80.PubMedCrossRefGoogle Scholar
  774. 774.
    DeGiovanni C, Chard M, Woollons A. Eosinophilic fasciitis secondary to treatment with atorvastatin. Clin Exp Dermatol 2006 Jan; 31(1): 131–2.PubMedCrossRefGoogle Scholar
  775. 775.
    Williams ML, Feingold KR, Grubauer G, et al. Ichthyosis induced by cholesterollowering drugs: implications for epidermal cholesterol homeostasis. Arch Dermatol 1987 Nov; 123(11): 1535–8.PubMedCrossRefGoogle Scholar
  776. 776.
    Sparsa A, Boulinguez S, Le Brun V, et al. Acquired ichthyosis with pravastatin. J Eur Acad Dermatol Venereol 2007 Apr; 21(4): 549–50.PubMedGoogle Scholar
  777. 777.
    Stoebner PE, Michot C, Ligeron C, et al. Simvastatin-induced lichen planus pemphigoides [in French]. Ann Dermatol Venereol 2003 Feb; 130(2 Pt 1): 187–90.PubMedGoogle Scholar
  778. 778.
    Roger D, Rolle F, Labrousse F, et al. Simvastatin-induced lichenoid drug eruption. Clin Exp Dermatol 1994 Jan; 19(1): 88–9.PubMedCrossRefGoogle Scholar
  779. 779.
    Keough GC, Richardson TT, Grabski WJ. Pravastatin-induced lichenoid drug eruption. Cutis 1998; 61(2): 98–100.PubMedGoogle Scholar
  780. 780.
    Sebok B, Toth M, Anga B, et al. Lichenoid drug eruption with HMG-CoA reductase inhibitors (fluvastatin and lovastatin). Acta Derm Venereol 2004; 84(3): 229–30.PubMedCrossRefGoogle Scholar
  781. 781.
    Pua VS, Scolyer RA, Barnetson RS. Pravastatin-induced lichenoid drug eruption. Australas J Dermatol 2006 Feb; 47(1): 57–9.PubMedCrossRefGoogle Scholar
  782. 782.
    Marguery MC, Chouini-Lalanne N, Drugeon C, et al. UV-B phototoxic effects induced by atorvastatin. Arch Dermatol 2006 Aug; 142(8): 1082–4.PubMedGoogle Scholar
  783. 783.
    Morimoto K, Kawada A, Hiruma M, et al. Photosensitivity to simvastatin with an unusual response to photopatch and photo tests. Contact Dermatitis 1995; 33(4): 274.PubMedCrossRefGoogle Scholar
  784. 784.
    Abadir R, Liebmann J. Radiation reaction recall following simvastatin therapy: a new observation. Clin Oncol (R Coll Radiol) 1995; 7(5): 325–6.CrossRefGoogle Scholar
  785. 785.
    Feldmann R, Mainetti C, Saurat JH. Skin lesions due to treatment with simvastatin (Zocor). Dermatology 1993; 186(4): 272.PubMedCrossRefGoogle Scholar
  786. 786.
    Pfeiffer CM, Kazenoff S, Rothberg HD. Toxic epidermal necrolysis from atorvastatin. JAMA 1998 May 27; 279(20): 1613–4.PubMedCrossRefGoogle Scholar
  787. 787.
    Anliker MD, Wuthrich B. Chronic urticaria to atorvastatin. Allergy 2002 Apr; 57(4): 366.PubMedCrossRefGoogle Scholar
  788. 788.
    Proksch E, Feingold KR, Elias PM. Epidermal HMG CoA reductase activity in essential fatty acid deficiency: barrier requirements rather than eicosanoid generation regulate cholesterol synthesis. J Invest Dermatol 1992 Aug; 99(2): 216–20.PubMedCrossRefGoogle Scholar
  789. 789.
    Feingold KR, Man MQ, Menon GK, et al. Cholesterol synthesis is required for cutaneous barrier function in mice. J Clin Invest 1990 Nov; 86(5): 1738–45.PubMedCrossRefGoogle Scholar
  790. 790.
    Mao-Qiang M, Feingold KR, Elias PM. Inhibition of cholesterol and sphingolipid synthesis causes paradoxical effects on permeability barrier homeostasis. J Invest Dermatol 1993 Aug; 101(2): 185–90.PubMedCrossRefGoogle Scholar
  791. 791.
    Haratake A, Ikenaga K, Katoh N, et al. Topical mevalonic acid stimulates de novo cholesterol synthesis and epidermal permeability barrier homeostasis in aged mice. J Invest Dermatol 2000 Feb 114(2): 247–52.PubMedCrossRefGoogle Scholar
  792. 792.
    Ramsing D, Agner E, Malinowski J, et al. Effect of systemic treatment with cholesterol-lowering drugs on the skin barrier function in humans [in French]. Acta Derm Venereol 1995 May; 75(3): 198–201.PubMedGoogle Scholar
  793. 793.
    Namazi MR. Statins: novel additions to the dermatologic arsenal? Exp Dermatol 2004 Jun; 13(6): 337–9.PubMedCrossRefGoogle Scholar
  794. 794.
    Noel M, Gagne C, Bergeron J, et al. Positive pleiotropic effects of HMG-CoA reductase inhibitor on vitiligo. Lipids Health Dis 2004 May 10; 3: 7.PubMedCrossRefGoogle Scholar
  795. 795.
    Bousquet E, Amar J, Salvador M, et al. Cataract and simvastatin: case report [letter; in French]. Therapie 1998; 53(5): 505–7.PubMedGoogle Scholar
  796. 796.
    Laties AM, Keates EU, Taylor HR, et al. The human lens after 48 weeks of treatment with lovastatin [letter]. N Engl J Med 1990; 323(10): 683–4.PubMedCrossRefGoogle Scholar
  797. 797.
    Langer J. Drug against high cholesterol can affect vision [in Danish]. Sygeplejersken 1991 Jan 23; 91(4): 13.PubMedGoogle Scholar
  798. 798.
    Negevesky GJ, Kolsky MP, Laureno R, et al. Reversible atorvastatin-associated external ophthalmoplegia, anti-acetylcholine receptor antibodies, and ataxia. Arch Ophthalmol 2000 Mar; 118(3): 427–8.PubMedGoogle Scholar
  799. 799.
    Fraunfelder FW, Richards AB. Diplopia, blepharoptosis, and ophthalmoplegia and 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitor use. Ophthalmology. Epub 2008 Oct 17.Google Scholar
  800. 800.
    Schlienger RG, Haefeli WE, Jick H, et al. Risk of cataract in patients treated with statins. Arch Intern Med 2001 Sep 10; 161(16): 2021–6.PubMedCrossRefGoogle Scholar
  801. 801.
    Smeeth L, Hubbard R, Fletcher AE. Cataract and the use of statins: a case-control study. QJM 2003 May; 96(5): 337–43.PubMedCrossRefGoogle Scholar
  802. 802.
    Behrens-Baumann W, Morawietz A, Thiery J, et al. Ocular side effects of the lipid-lowering drug simvastatin? A one year follow-up. Lens Eye Toxic Res 1989; 6(1–2): 331–7.PubMedGoogle Scholar
  803. 803.
    Hutnik CM, Nichols BD. Cataracts in systemic diseases and syndromes. Curr Opin Ophthalmol 1999 Feb; 10(1): 22–8.PubMedCrossRefGoogle Scholar
  804. 804.
    Taylor A, Jacques PF, Epstein EM. Relations among aging, antioxidant status, and cataract. Am J Clin Nutr 1995 Dec; 62(6 Suppl.): 1439–47.Google Scholar
  805. 805.
    Smeeth L, Hubbard R, Fletcher AE. Cataract and the use of statins: a case-control study. QJM 2003; 96(5): 337–43.PubMedCrossRefGoogle Scholar
  806. 806.
    Klein BE, Klein R, Lee KE, et al. Statin use and incident nuclear cataract. JAMA 2006; 295(23): 2752–8.PubMedCrossRefGoogle Scholar
  807. 807.
    Feher J, Kovacs B, Kovacs I, et al. Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10. Ophthalmologica 2005 May–Jun; 219(3): 154–66.PubMedCrossRefGoogle Scholar
  808. 808.
    Dunlop IS, Dunlop P. Reversible ophthalmoplegia in CPEO. Aust N Z J Ophthalmol 1995 Aug; 23(3): 231–4.PubMedCrossRefGoogle Scholar
  809. 809.
    Shoffner JM, Lott MT, Voljavec AS, et al. Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip-replication model and metabolic therapy. Proc Natl Acad Sci U S A 1989 Oct; 86(20): 7952–6.PubMedCrossRefGoogle Scholar
  810. 810.
    Wallace DC. Mitochondrial DNA mutations in diseases of energy metabolism. J Bioenerg Biomembr 1994 Jun; 26(3): 241–50.PubMedCrossRefGoogle Scholar
  811. 811.
    Nonaka I. Mitochondrial diseases. Curr Opin Neurol Neurosurg 1992 Oct; 5(5): 622–32.PubMedGoogle Scholar
  812. 812.
    Nakagawa M, Kaminishi Y, Isashiki Y, et al. Familial mitochondrial encephalomyopathy with deaf-mutism, ophthalmoplegia and leukodystrophy. Acta Neurol Scand 1995 Jul; 92(1): 102–8.PubMedCrossRefGoogle Scholar
  813. 813.
    Barboni P, Savini G, Plazzi G, et al. Ocular findings in mitochondrial neurogastrointestinal encephalomyopathy: a case report. Graefes Arch Clin Exp Ophthalmol 2004 Oct; 242(10): 878–80.PubMedCrossRefGoogle Scholar
  814. 814.
    Tomasi LG. Reversibility of human myopathy caused by vitamin E deficiency. Neurology 1979 Aug; 29(8): 1182–6.PubMedCrossRefGoogle Scholar
  815. 815.
    Weber R, Raschka C, Bonzel T. Toxic drug-induced hyposmia with lovastatin. Laryngorhinootologie [in German] 1992 Sep; 71(9): 483–4.CrossRefGoogle Scholar
  816. 816.
    Rock CL, Thornquist MD, Kristal AR, et al. Demographic, dietary and lifestyle factors differentially explain variability in serum carotenoids and fat-soluble vitamins: baseline results from the sentinel site of the Olestra Post-Marketing Surveillance Study. J Nutr 1999 Apr; 129(4): 855–64.PubMedGoogle Scholar
  817. 817.
    Duncan RB, Briggs M. Treatment of uncomplicated anosmia by vitamin A. Arch Otolaryngol 1962 Feb; 75: 116–24.PubMedCrossRefGoogle Scholar
  818. 818.
    Toth J, Temmel AF. Drug therapy for disturbances of smelling [in German]. Laryngorhinootologie 2004 Feb; 83(2): 124–34.PubMedCrossRefGoogle Scholar
  819. 819.
    Henkin RI, Smith FR. Hyposmia in acute viral hepatitis. Lancet 1971 Apr 24; 1(7704): 823–6.PubMedCrossRefGoogle Scholar
  820. 820.
    Fraunfelder FW. Ocular hemorrhage possibly the result of HMG-CoA reductase inhibitors. J Ocul Pharmacol Ther 2004 Apr; 20(2): 179–82.PubMedCrossRefGoogle Scholar
  821. 821.
    Groneberg DA, Barkhuizen A, Jeha T. Simvastatin-induced thrombocytopenia. Am J Hematol