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Understanding the composition of gene lists that result from high-throughput experiments requires elaborate processing of gene annotation lists. In this article we present GOAT (Gene Ontology Analysis Tool), a tool based on the statistical software ‘R’ for analysing Gene Ontology™ (GO) term enrichment in gene lists. Given a gene list, GOAT calculates the enrichment and statistical significance of every GO term and generates graphical presentations of significantly enriched terms. GOAT works for any organism with a genome-scale GO annotation and allows easy updates of ontologies and annotations.
- 2.Feng W, Wang G, Zeeberg BR, et al. Development of gene ontology tool for biological interpretation of genomic and proteomic data. AMIA Annu Symp Proc 2003, 839Google Scholar
- 7.Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B 1995; 57: 289–300Google Scholar