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Understanding the composition of gene lists that result from high-throughput experiments requires elaborate processing of gene annotation lists. In this article we present GOAT (Gene Ontology Analysis Tool), a tool based on the statistical software ‘R’ for analysing Gene Ontology™ (GO) term enrichment in gene lists. Given a gene list, GOAT calculates the enrichment and statistical significance of every GO term and generates graphical presentations of significantly enriched terms. GOAT works for any organism with a genome-scale GO annotation and allows easy updates of ontologies and annotations.
KeywordsGene Ontology Gene List Annotation Data Term Enrichment Annotation File
This work was supported by grant no. P01 HD39691 from the National Institute of Health, National Institute of Child Health and Human Development (NIH-NICHD).
The authors have no conflicts of interest that are directly relevant to the content of this article.
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