Drugs & Therapy Perspectives

, Volume 24, Issue 12, pp 25–26 | Cite as

Transdermal drug delivery has ideal properties in the elderly

Practical Issues and Updates

The transdermal route of drug delivery has many advantages over other routes; some of these advantages are particularly applicable to the elderly population.

Transdermal route ideal for drug delivery

Despite its barrier function, many drugs can pass through the skin.[1] Transdermal drug-delivery systems, therefore, have been developed. Passive-diffusion transdermal systems are available as reservoir or matrix types (figure 1). The reservoir system utilizes a membrane to control the drug release rate and, therefore, the drug is released constantly.[1] Matrix systems are limited by the rate of the drug’s skin penetration, and can be classified as simple matrix (the drug is manufactured in a polymer layer that controls drug delivery), drug-in-adhesive system (has the advantage of being thin and flexible) or multilayer matrix (superposition of layers with varying drug concentrations create a concentration gradient).[1]


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© Adis Data Information BV 2008

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