Transdermal drug delivery has ideal properties in the elderly
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The transdermal route of drug delivery has many advantages over other routes; some of these advantages are particularly applicable to the elderly population.
Transdermal route ideal for drug delivery
Despite its barrier function, many drugs can pass through the skin. Transdermal drug-delivery systems, therefore, have been developed. Passive-diffusion transdermal systems are available as reservoir or matrix types (figure 1). The reservoir system utilizes a membrane to control the drug release rate and, therefore, the drug is released constantly. Matrix systems are limited by the rate of the drug’s skin penetration, and can be classified as simple matrix (the drug is manufactured in a polymer layer that controls drug delivery), drug-in-adhesive system (has the advantage of being thin and flexible) or multilayer matrix (superposition of layers with varying drug concentrations create a concentration gradient).
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