CNS Drugs

, Volume 22, Issue 12, pp 1005–1019

Neurotrophic Factors in Neurodegenerative Disorders

Potential for Therapy
  • Fabio Fumagalli
  • Raffaella Molteni
  • Francesca Calabrese
  • Paola Francesca Maj
  • Giorgio Racagni
  • Marco Andrea Riva
Review Article

DOI: 10.2165/0023210-200822120-00004

Cite this article as:
Fumagalli, F., Molteni, R., Calabrese, F. et al. CNS Drugs (2008) 22: 1005. doi:10.2165/0023210-200822120-00004

Abstract

Finding an effective therapy to treat chronic neurodegenerative disorders still represents an unmet and elusive goal, mainly because so many pathogenic variables come into play in these diseases. Recent emphasis has been placed on the role of neurotrophic factors in the aetiology of such disorders because of their role in the survival of different cell phenotypes under various adverse conditions, including neurodegeneration.

This review summarizes the current status and the efforts to treat neurodegenerative disorders by the exogenous administration of neurotrophic factors in an attempt to replenish trophic supply, the paucity of which may contribute to the development of the illness. Although promising results have been seen in animal models, this approach still meets disparate and often insurmountable problems in clinical settings, presumably related to the unique nature of the human being.

Copyright information

© Adis Data Information BV 2008

Authors and Affiliations

  • Fabio Fumagalli
    • 1
  • Raffaella Molteni
    • 1
  • Francesca Calabrese
    • 1
  • Paola Francesca Maj
    • 1
  • Giorgio Racagni
    • 1
    • 2
  • Marco Andrea Riva
    • 1
  1. 1.Department of Pharmacological Sciences, Center of NeuropharmacologyUniversity of MilanMilanItaly
  2. 2.I.R.C.C.S. San Giovanni di Dio-FatebenefratelliBresciaItaly

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