10.16 Inflammation as a Mediator of the Link Between Mild to Moderate Renal Insufficiency and Endothelial Dysfunction in Essential Hypertension.
Introduction and methods: The relationship among inflammation (plasma high-sensitivity C-reactive protein [CRP]), endothelial function (maximal haemodynamic response to acetylcholine [ACh] in the forearm), and renal function (serum creatinine and GFR [Modification of Diet in Renal Disease formula]) was investigated in 264 never-treated individuals with uncomplicated essential hypertension and serum creatinine within the normal range.
Results: Multiple regression models of endothelial function were constructed in sequence including Framingham risk factors as well as renal function (creatinine and GFR) and plasma CRP. The inclusion of serum creatinine and GFR into a model based on Framingham risk factors added highly significant (P<0,001).
Conclusions: In individuals with untreated, uncomplicated essential hypertension, multivariate modelling indicated that inflammation is a crucial mechanism mediating the endothelial-renal function link. The pro-atherogenic potential of inflammation associated with subtle impairment in renal function may contribute to the cardiovascular risk of essential hypertension.
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Tripepi, G., Maio, R., Mallamaci, F. et al. 10.16 Inflammation as a Mediator of the Link Between Mild to Moderate Renal Insufficiency and Endothelial Dysfunction in Essential Hypertension. High Blood Press Cardiovasc Prev 14, 145 (2007). https://doi.org/10.2165/00151642-200714030-00182