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2.5 Serum C-Reactive Protein Levels (SCRP) as Predictors of Global and Cardiovascular (CV) Mortality: Validation in the Clinical Practice

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2.5 Serum C-Reactive Protein Levels (SCRP) as Predictors of Global and Cardiovascular (CV) Mortality: Validation in the Clinical Practice

Introduction: High sCRP is considered a non-traditional risk factor for CV morbidity and mortality. Aims of this study were the validation of both the reliability of high sCRP as predictor of global and CV mortality and the associations between sCRP ad other proxies of CV risk.

Methods: We studied the patients admitted to our Renal Unit from 1/1/2000 to 12/31/2001. During the hospital stay the following parameters were assessed: measured creatinine clearance (CrCl), haemoglobin (hb), haematocrit (hct), sCRP (high-sensitive method), serum levels of uric acid (UA), total cholesterol (chol), triglycerides (try) and total proteins (prot). Thus data about the survival of the patients were recorded at the study end date (12/31/2006). Patients with end stage renal disease, sepsis or those taking steroids or NSAIDs were excluded.

Results: We studied 233 patients (46.3% males, 16.3% diabetics, 9% taking statins), aged [mean(SD)] 55.7(18.2) years. Means(SD) of the other parameters were: hb 13.4(1.7) g/dl, hct 39.8(4.3)%, UA 5.3(1.8) mg/dl, prot 6.8(0.6) g/dl, chol 193.8(43.4) mg/dl, try 145.1(107) mg/dl, CrCl 67.5(35) ml/min. Thus the patients were subdivided according to the sCRP quartiles (PLa ClCr and Prot progressively decreased among quartiles. UA significantly correlated with sPCR levels in the whole population Spearman analysis) (R=0,15; P=0,009). The presence of diabetes mellitus or lipid-lowering therpy do not significatly modify these data.

Conclusions: 1) high sCRP does not predict 5-year global and cardiovascular mortality; 2) ClCr and Prot have not been significantly related to hsCRP levels; 3) values of sCRP 7 mg/L have been associated to reduced levels of HGB, HCT, CHOL and high levels of UA; 4) UA has been sifnificantly dorelated to sCRP in the whole population.

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Vernaglione, L., Cristofano, C., Nosella, V. et al. 2.5 Serum C-Reactive Protein Levels (SCRP) as Predictors of Global and Cardiovascular (CV) Mortality: Validation in the Clinical Practice. High Blood Press Cardiovasc Prev 14, 145 (2007). https://doi.org/10.2165/00151642-200714030-00026

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