Comparative Effects of Doxazosin and Carvedilol on Clinical Status and Left Ventricular Function in Hypertensive Patients with Mild Heart Failure

  • Fabio Zacà
  • Alberto Benassi
  • Roberto Bolzani
  • Italo Ghidoni
  • Giuseppina Santese
  • Antonietta Schipani
  • Cosimo Stefanio
Original Research Article

DOI: 10.2165/00151642-200512010-00006

Cite this article as:
Zacà, F., Benassi, A., Bolzani, R. et al. High Blood Press Cardiovasc Prev (2005) 12: 37. doi:10.2165/00151642-200512010-00006
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Abstract

Introduction: β-Blockers have been shown to be effective in the treatment of both arterial hypertension and heart failure. However, slow titration of β-blockers over several weeks and rigorous supervision are essential to minimise antiadrenergic adverse effects in patients with heart failure. α1-Blockers are well tolerated and effectively lower blood pressure by reducing peripheral resistance.

Patients and methods: This study assessed changes in left ventricular function and quality of life in hypertensive patients with mild heart failure treated with enalapril and furosemide combined with a β-blocker with peripheral vasodilating activity (carvedilol) or an α-blocker (doxazosin), over a 1-year period. Sixty patients aged 45–65 years with untreated essential arterial hypertension and mild heart failure were randomised to receive enalapril + furosemide in combination with carvedilol or doxazosin.

Results: In the carvedilol compared with the doxazosin group, ejection fraction diminished significantly (38% vs 42%, p < 0.05) and quality of life worsened significantly (Minnesota Living Heart Failure score 54 vs 47, p < 0.05) during the first 3 weeks of treatment. Ejection fraction and quality of life had significantly improved from baseline in both groups by 12 months.

Conclusion: Doxazosin in combination antihypertensive therapy rapidly improves clinical status and haemodynamics in hypertensive patients with mild heart failure by reducing afterload. After 1 year, doxazosin and carvedilol improve clinical and haemodynamic parameters.

Copyright information

© Adis Data Information BV 2005

Authors and Affiliations

  • Fabio Zacà
    • 1
  • Alberto Benassi
    • 1
  • Roberto Bolzani
    • 2
  • Italo Ghidoni
    • 2
  • Giuseppina Santese
    • 1
  • Antonietta Schipani
    • 1
  • Cosimo Stefanio
    • 1
  1. 1.Dipartimento di Cardiologia Medico-ChirurgicaHesperia HospitalModenaItaly
  2. 2.Dipartimento di PsicologiaUniversity of BolognaBolognaItaly

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