A Perspective on Progress in Pharmacogenomics
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The goal of pharmacogenetics/pharmacogenomics is to individualize drug therapy via non-invasive DNA profiling. This is clearly not a simple matter, and a degree of skepticism is justified; achievement of this goal has indeed been slower than predicted. Nonetheless, there are specific areas where (at least partial) pharmacogenomic profiling is nearing clinical utility.
The review by Nebert et al. in this issue analyzes the many pitfalls of the much-hyped field of pharmacogenomics. As Steven Jones from University College, London, once said in a radio interview, the four letters of the genetic code are H, Y, P and E, and this review comes from this end of the spectrum of views about the field. The authors are uncritically pessimistic about the future clinical applications of pharmacogenomics.
Perhaps the message has become confused regarding what is pharmacogenetics versus what is pharmacogenomics. Is there a difference? Whatever the semantics, there are two components. One is using...
KeywordsClozapine Cholesteryl Ester Transfer Protein Anticoagulation Clinic CYP2C9 Gene Clozapine Response
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