American Journal of Cardiovascular Drugs

, Volume 6, Issue 3, pp 139–147 | Cite as

The Effect of Antihypertensive Agents on New-Onset Diabetes Mellitus

Time to Amend the Guidelines?
  • Tonje Amb AksnesEmail author
  • Sverre Erik Kjeldsen
  • Giuseppe Mancia
Current Opinion


Recent large hypertension trials have shown great differences in incidence of new-onset diabetes mellitus among patients receiving different antihypertensive drug therapies. The incidence of diabetes is unchanged or increased by the use of thiazide diuretics and β-adrenoceptor antagonists (β-blockers) and unchanged or decreased by ACE inhibitors, calcium channel blockers (CCBs), and angiotensin II type 1 receptor antagonists (angiotensin receptor blockers). Recent results from ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) showed superiority of the ‘new’ combination of CCBs and ACE inhibitors over the ‘old’ or ‘conventional’ combination of β-blockers and diuretics. In this review, the results from some of the large hypertension trials are discussed, and the hypotheses on how different antihypertensive drug regimens can affect glucose homeostasis are considered. The question now is whether the results from these recent trials should affect the choice of antihypertensive treatment, particularly for special groups. However, the key goal is still to reduce BP, and this usually requires combinations of drugs.


Impaired Glucose Tolerance Valsartan Telmisartan Thiazide Diuretic Nateglinide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



SE Kjelsen has received honoraria from AstraZeneca, Bayer, Boehringer Ingelheim, Menarini, Merck & Co., Novartis, Pharmacia, Pfizer, and Sankyo; a grant from Merck & Co.; and royalties from Gylendal (Oslo, Norway) and Blood Pressure (Gottenburg, Sweden).

G Mancia has provided consultancies for drug companies producing all major antihypertensive drugs and has received honoraria for participation in scientific meetings sponsored by drug companies with subtypes of drugs (ACE inhibitors, ARBs, diuretics, calcium antagonists, β-blockers).

No sources of funding were used to assist in the conducting of this review.


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Copyright information

© Adis Data Information BV 2006

Authors and Affiliations

  • Tonje Amb Aksnes
    • 1
    Email author
  • Sverre Erik Kjeldsen
    • 1
  • Giuseppe Mancia
    • 2
  1. 1.Department of CardiologyUllevaal University HospitalOsloNorway
  2. 2.Clinica Medica, Ospedale S GerardoUniversita di Milano-BicoccaMonzaItaly

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