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Opinion and Evidence in Cardiovascular Therapeutics

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    Notes

    1. 1.

      Inpharma Weekly provides rapid alerts to news on drugs and drug therapy. Summarizing information selected from over 1600 biomedical journals, this newsletter is produced by Adis International Limited and is available in a variety of formats. Please contact your nearest Adis office for subscription details.

    2. 2.

      Normalized diastolic BP was defined as a BP of <90mm Hg.

    3. 3.

      The maximum infusion rate for abciximab was 10 μg/min.

    4. 4.

      Abciximab and tirofiban were initially administered as IV boluses of 0.25 mg/kg and 10 μg/kg, respectively. All patients received aspirin 250 to 500mg within 24 hours of surgery and 75 to 325 mg/day thereafter.

    5. 5.

      Costs (1999 values) included those related to additional events and procedures, hospitalization and physicians’ services.

    6. 6.

      Normal blood cholesterol levels were defined as LDL-cholesterol levels of <3 mmol/L or total cholesterol of <5 mmol/L at baseline.

    7. 7.

      Costs included those for drug acquisition, hospitalization, physician services, laboratory services and complications.

    8. 8.

      The trials included the Evaluation of Xemilofiban in Controlling Thrombotic Events (EXCITE), Orbofiban in Patients with Unstable Angina (OPUS), Sibrafiban versus aspirin to Yield Maximum Protection from ischemic Heart events post-acute cOroNary sYndromes (SYMPHONY), and 2nd SYMPHONY.

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    Opinion and Evidence in Cardiovascular Therapeutics. Am J Cordiovosc Drugs 2, 345–353 (2002). https://doi.org/10.2165/00129784-200202050-00009

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    Keywords

    • Clopidogrel
    • Abciximab
    • Levosimendan
    • Irbesartan
    • Bivalirudin