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Amniotic rupture sequence (first report) after in utero exposure: case report

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      Shanske AL.Bilateral oblique facial clefts and extremity anomaly in an infant after intrauterine efavirenz exposure and review of its teratogenic risk. AIDS 26: 1775-1779, No. 14, 10 Sep 2012. Available from: URL: http://dx.doi.org/10.1097/QAD.0b013e328356467a - USA

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    Editorial Comment: A search of AdisBase, Medline and Embase did not reveal any previous case reports of amniotic rupture sequence associated with efavirenz. The WHO ADR database contained 3 reports of amniotic band syndrome associated with efavirenz.

    Key words

    Efavirenz; Neonates; Pregnancy; In-utero-exposure; Fetus; adverse reactions; drug-induced; Teratogenesis

    An event is serious (FDA MedWatch definition) when the patient outcome is: death; life-threatening; hospitalisation; disability; congenital anomaly; requires intervention to prevent permanent impairment or damage; First published case repo

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    Efavirenz. React. Wkly. 1428, 16 (2012). https://doi.org/10.2165/00128415-201214280-00053

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    • Efavirenz
    • Nelfinavir
    • Coloboma
    • Microphthalmia
    • Lacrimal Duct