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Drugs in R & D

, Volume 4, Issue 1, pp 1–18 | Cite as

Immunosuppressive and Anti-Inflammatory Mechanisms of Triptolide, the Principal Active Diterpenoid from the Chinese Medicinal Herb Tripterygium wilfordii Hook. f.

  • Daoming Qiu
  • Peter N. KaoEmail author
Review Article

Abstract

Extracts of Tripterygium wilfordii hook. f. (leigong teng, Thundergod vine) are effective in traditional Chinese medicine for treatment of immune inflammatory diseases including rheumatoid arthritis, systemic lupus erythematosus, nephritis and asthma. Characterisation of the terpenoids present in extracts of Tripterygium identified triptolide, a diterpenoid triepoxide, as responsible for most of the immunosuppressive, anti-inflammatory and antiproliferative effects observed in vitro. Triptolide inhibits lymphocyte activation and T-cell expression of interleukin-2 at the level of transcription. In all cell types examined, triptolide inhibits nuclear factor-κB transcriptional activation at a unique step in the nucleus after binding to DNA. Further characterisation of the molecular mechanisms of triptolide action will serve to elucidate pathways of immune system regulation.

Keywords

Cyclosporin Tacrolimus Pulmonary Arterial Hypertension Triptolide Primary Pulmonary Hypertension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

Dr Kao has received consultant fees from Pharmagenesis (Palo Alto, CA, USA). The research findings described have been supported by NIH grants AI39624 and HL62588, and by industrial grants from Pharmagenesis to PNK.

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© Adis International Limited 2003

Authors and Affiliations

  1. 1.Division of Pulmonary and Critical Care MedicineStanford University Medical CenterStanfordUSA

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