Systematic review —a tool for the pharmaceutical physician

Original Article

DOI: 10.2165/00124363-200204000-00003

Cite this article as:
Shrewsbury, S.B. International Journal of Pharmaceutical Medicine (2002) 16: 67. doi:10.2165/00124363-200204000-00003


A meta-analysis of nine large clinical studies that had looked at a clinical dilemma, which option to use at ‘Step 3 of the British Guidelines on Asthma Management’, was conducted to attempt to determine the better option for adult asthma. All studies had reported results demonstrating superiority of the addition of a long-acting bronchodilator to inhaled corticosteroid for lung function, but, taken singly, none of the studies had sufficient power to provide conclusive evidence on the relative effect of either treatment option on the incidence of asthma exacerbations. However, a carefully conducted meta-analysis of the nine studies was able to provide a conclusive answer to this question. The work was further developed after abstract presentation and subsequently published. This article argues that the pharmaceutical physician is well placed to use this statistical tool more often, but still judiciously, to look at the benefit (or risk) of drugs in development or on the market, and then to act upon that information appropriately.


asthma exacerbation inhaled corticosteroids long-acting bronchodilator meta-analysis salmeterol 

Copyright information

© Lippincott Williams & Wilkins 2002

Authors and Affiliations

  1. 1.Clinical Development & Medical AffairsGlaxoSmithKlineUSA

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