BioDrugs

, Volume 20, Issue 6, pp 351–356

BioMEMS Sensor Systems for Bacterial Infection Detection

Progress and Potential
Technology

Abstract

The spread of drug-resistant bacteria represents a growing worldwide health problem. The most efficient way to fight drug-resistant bacteria is to detect their colonies, identify their type, monitor their growth, and destroy them before they reach the human body. A gravimetric biomedical micro-electro-mechanical sensor (BioMEMS) system operating in the pico-gram range (10−12 g/cm2) has been proposed for detecting growth of drug-resistant bacterial colonies. The sensor is based on a MEMS metal-coated thin piezoelectric membrane resonator. A combination of shear horizontal surface acoustic (SHSAW), Bleustein-Gulyaev, skimming and ‘leaky’ waves, generated in the resonator, are highly sensitive to mass, density, viscoelastic, and electrochemical changes at the resonator/bacteria interface. Measuring resonant frequency shifts of the composite resonator provides information about the mass and type of the bacterium colony growing on the resonator.

References

  1. 1.
    Victorian Government’s Department of Human Services [online]. Available from URL: http://www.health.vic.gov.au [Accessed 2006 Oct 16]
  2. 2.
    Sauerbrey GZ. Verwendung von Schwingquarzen zur wãgung düimer schichten und zur mikrowagung. Z Phys 1959; 155: 206–22CrossRefGoogle Scholar
  3. 3.
    Wohltjen H, Dessy R. Surface acoustic wave probe for chemical analysis. Anal Chem 1979; 51: 1458–75CrossRefGoogle Scholar
  4. 4.
    Martin SJ, Frye GC, Cernosek RW, et al. Microtextured resonators for measuring liquid properties [abstract no. 229]. Presented at the 1994 Solid-State Sensor and Actuator Workshop; 1994 Jun 13–16; Hilton Head Island (SC)Google Scholar
  5. 5.
    Martin SJ, Frye GC, Senturia SD. Dynamics and response of polymer-coated surface acoustic wave devices: effects of viscoelastic properties and film resonance. Anal Chem 1994; 66: 2201–19CrossRefGoogle Scholar
  6. 6.
    Ivanov D, Yelon A. Chemical sensitivity of the thickness-shear-mode quartz-resonator nanobalance. J Electrochem Soc 1996; 143: 2835–41CrossRefGoogle Scholar
  7. 7.
    Ivanov D, Yelon A. Limits to the applicationof the quartz-crystal resonator as gravimetric instrument. In: Leddy J, Wightman RM, editors. New directions in electroanalytical chemistry: proceedings volume. Pennington (NJ): The Electrochemical Society, Inc., 1995: 110–9Google Scholar
  8. 8.
    Auld BA. Acoustic fields and waves in solids. New York: John Wiley and Sons, 1973Google Scholar
  9. 9.
    Dieulesaint E, Royer D. Elastic waves in solids: application to signal processing [in French]. Paris: Masson et Cie, 1974Google Scholar
  10. 10.
    Gulyaev YV. Review of shear surface acoustic waves in solids. IEEE T Ultrason Ferr 1998; 45: 935–8CrossRefGoogle Scholar
  11. 11.
    Farneil GW, Adler EL. Elastic wave propagation in thin layers. In: Mason WP, Thurston RN, editors. Physical acoustics. Vol. IX. New York: Academic Press, 1972: 51Google Scholar
  12. 12.
    White RM, Wicher PJ, Wenzel SW, et al. Plate-mode ultrasonic oscillator sensors. IEEE T Ultrason Ferr 1987; 34(2): 162–71CrossRefGoogle Scholar

Copyright information

© Adis Data Information BV 2006

Authors and Affiliations

  1. 1.Microelectronics Fabrication CenterNew Jersey Institute of TechnologyNewark R200USA

Personalised recommendations