BioDrugs

, Volume 20, Issue 5, pp 271–273

The Pro-Oxidant Activity of High-Dose Vitamin E Supplements in Vivo

  • Philip Pearson
  • Sarah A. Lewis
  • John Britton
  • Ian S. Young
  • Andrew Fogarty
Short Communication

Abstract

Background

A recent meta-analysis has demonstrated that the regular administration of high-dose vitamin E supplements may be associated with increased mortality. The biological mechanism for this effect is uncertain.

Methods

A ferrous oxidation xylenol assay was used to assess plasma oxidation activity levels in samples from a randomized, placebo-controlled, 6-week trial of daily vitamin E supplementation in adults with asthma (n = 72).

Results and conclusion

27% increase in plasma oxidation activity levels was observed in patients receiving vitamin E. We demonstrate a pro-oxidant effect of high-dose vitamin E supplementation that may explain the increase in mortality observed in intervention studies using this nutrient.

Copyright information

© Adis Data Information BV 2006

Authors and Affiliations

  • Philip Pearson
    • 1
  • Sarah A. Lewis
    • 1
  • John Britton
    • 2
  • Ian S. Young
    • 3
  • Andrew Fogarty
    • 2
  1. 1.Division of Respiratory MedicineUniversity of Nottingham, Nottingham City HospitalNottinghamUK
  2. 2.Division of Epidemiology and Public HealthUniversity of Nottingham, Nottingham City Hospital, Clinical Science BuildingNottinghamUK
  3. 3.Queen’s University Belfast, Welcome Research Laboratories, Royal Victoria HospitalBelfastUK

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