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BioDrugs

, Volume 19, Issue 6, pp 347–354 | Cite as

Strategies of Tumor Immune Evasion

  • Barbara SeligerEmail author
Novel Therapeutic Strategies

Abstract

During the last decade, increased understanding of the molecular mechanisms responsible for immune activation to protect against challenges by tumor cells has revolutionized the field of immunotherapy research. It has been demonstrated that the dysfunction of the host’s immune system represents one of the major mechanisms by which tumors evade immunosurveillance. This is due, for example, to T cell anergy, the existence of regulatory T cells, and systemic defects of dendritic cells derived from tumor patients. In addition, escape from immunosurveillance can also be linked to tumor-related factors, including secretion of immunosuppressive cytokines, resistance to apoptosis, and deficient expression of immunomodulatory molecules and major histocompatibility complex (MHC) class I antigens possibly due to immunoselection. Both host- and tumor-related mechanisms can lead to a failure to mount a proper anti-tumor-specific immune response, and these are frequently key factors in limiting the success of cancer immunotherapy.

Keywords

Major Histocompatibility Complex Natural Killer Cell Human Leukocyte Antigen Major Histocompatibility Complex Class Treg Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

I would like to thank Liis Pellenen and Claudia Stoerr for excellent secretarial help. The work was partially supported by a grant from the Mildred Scheel Stiftung (Project No. 10-1712).

The author has no potential conflicts of interest that are directly relevant to the contents of this article.

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© Adis Data Information BV 2005

Authors and Affiliations

  1. 1.Institute of Medical ImmunologyMartin Luther University Halle-WittenbergHalleGermany

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