BioDrugs

, Volume 15, Issue 8, pp 491–500 | Cite as

Co-Stimulatory Blockade and Tolerance Induction in Transplantation

Leading Article

Abstract

Recipients of organ and tissue transplants require lifelong immunosuppression to prevent rejection. Better understanding of the processes culminating in allograft rejection has led to novel approaches to modulating the immune response. Co-stimulatory signals between antigen-presenting and -responding cells are essential for a normal alloimmune response, and blockade of these pathways during initial graft-host interaction may be used to ameliorate or prevent a destructive response from proceeding. A large number of experimental studies now support this concept, and early clinical trials have been initiated. Despite some early difficulties and many unanswered questions, co-stimulatory blockade has major potential as a future immune-modulating mechanism for use in clinical transplantation.

Notes

Acknowledgements

This work was supported in part by grants from the Health Research Council (HRC) of New Zealand and the Auckland Medical Research Foundation (AMRF).

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© Adis International Limited 2001

Authors and Affiliations

  1. 1.The New Zealand Liver Transplant UnitAuckland District Health BoardAucklandNew Zealand

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