Clinical Drug Investigation

, Volume 22, Issue 6, pp 347–354

Effect of Metformin on Blood Pressure

A Study in Obese Non-Diabetic Patients with Hypertension
  • Ilkka Kantola
  • Juha Rouru
  • Kimmo Malminiemi
  • Perttu Arkkila
  • Krista Korhonen
  • Sirpa Rantanen
  • Risto Huupponen
Original Research Article


Objective: To evaluate the effect of metformin on blood pressure and insulin sensitivity in non-diabetic, moderately obese, hypertensive patients.

Patients and methods: An 8-week double-blind, placebo-controlled randomised study with a 4-week placebo run-in period was performed. Euglycaemic hyperinsulinaemic clamp tests and 24-hour ambulatory blood pressure measurements were performed after the 4-week placebo run-in period and after the 8-week double-blind treatment in patients in either the metformin 1500mg a day (n = 11) or corresponding placebo (n = 10) group.

Results: Metformin administration did not decrease either 24-hour ambulatory or office blood pressure when compared with placebo. The office mean systolic/ diastolic (±standard deviation) blood pressures before and after treatments were 153 (±22)/96 (±4)mm Hg and 155 (±14)/94 (+6)mm Hg in the metformin group, and 153 (±30)/97 (± 9)mm Hg and 149 (± 18)/96 (± 9)mm Hg in the placebo group, respectively. Metformin significantly decreased fasting serum glucose concentrations from 5.7 (± 0.9) to 5.2 (± 0.4) mmol/L (p = 0.04), but did not affect the insulin sensitivity of the patients.

Conclusions: Metformin does not appear to have a place in the treatment of hypertension in non-diabetic individuals, at least in those with mild hypertension.


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Copyright information

© Adis International Limited 2002

Authors and Affiliations

  • Ilkka Kantola
    • 1
  • Juha Rouru
    • 2
  • Kimmo Malminiemi
    • 3
  • Perttu Arkkila
    • 4
  • Krista Korhonen
    • 5
  • Sirpa Rantanen
    • 5
  • Risto Huupponen
    • 2
  1. 1.Department of MedicineTurku University Central HospitalTurkuFinland
  2. 2.Department of Pharmacology and Clinical PharmacologyUniversity of TurkuTurkuFinland
  3. 3.Department of MedicineTampere University HospitalTampereFinland
  4. 4.Department of MedicineHelsinki University Central HospitalHelsinkiFinland
  5. 5.Härkätie Health CentreLietoFinland

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