Clinical Drug Investigation

, Volume 22, Supplement 2, pp 1–11

Pharmacology of Desloratadine

Special Characteristics
Review Article

DOI: 10.2165/00044011-200222002-00001

Cite this article as:
DuBuske, L.M. Clin. Drug Investig. (2002) 22(Suppl 2): 1. doi:10.2165/00044011-200222002-00001


Desloratadine is a new, nonsedating H1 receptor antagonist, which has been shown to have good tolerability and to be effective in the treatment of seasonal allergic rhinitis, perennial allergic rhinitis and chronic idiopathic urticaria. The pharmacological profile of desloratadine exhibits particular advantages compared with other antihistamines in terms of binding and occupancy of the human H1 receptor and its pharmacokinetics. This review describes aspects of these pharmacological properties, focusing on H1 receptor antagonism by desloratadine, its predictable pharmacokinetics when administered with food and common medications, and its lack of effect on important drug transport molecules, such as P-glycoprotein and organic anion transport polypeptide.

Copyright information

© Adis International Limited 2002

Authors and Affiliations

  1. 1.Immunology Research Institute of New EnglandGardnerUSA

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