Clinical Drug Investigation

, Volume 17, Issue 1, pp 1–8 | Cite as

Evaluation of Ibuprofen vs Paracetamol Analgesic Activity Using a Sore Throat Pain Model

  • F. Boureau
  • F. Pelen
  • F. Verriere
  • A. Paliwoda
  • R. Manfredi
  • M. Farhan
  • R. Wall
Clinical Use

Abstract

Objective: To validate a slightly modified sore throat pain model by comparing the analgesic efficacy of ibuprofen with that of paracetamol.

Design: A double-blind, double-dummy study was conducted.

Setting: Nineteen primary care centres in France.

Patients: Adults consulting their general practitioner with acute sore throat of a maximum of two days’ duration.

Interventions: Patients (n = 113) with acute pain associated with tonsillo-pharyngitis randomly received either 400mg ibuprofen or 1000mg paracetamol. The study design included repeated administration up to 48 hours to assess tolerability.

Main Outcome Measures: At hourly intervals for 6 hours after the first dose of treatment, the patients evaluated pain intensity on swallowing, difficulty in swallowing and global pain relief according to visual analogue scales.

Results: Ibuprofen 400mg was significantly more effective than paracetamol 1000mg in all three ratings, at all time-points for pain intensity and difficulty in swallowing, and from two hours onwards for pain relief. There were no serious adverse effects and no statistically significant difference in the incidence of adverse events in the two treatment groups.

Conclusions: Sore throat pain provided a sensitive model to assess the analgesic efficacy of class I analgesics and discriminated between the analgesic efficacy of ibuprofen and paracetamol. Sore throat is a very common complaint and practising physicians should consider ibuprofen as an effective alternative to paracetamol in the treatment of sore throat pain. The sore throat model should be considered by researchers as a sensitive assay of analgesic activity.

Keywords

Adis International Limited Ibuprofen Paracetamol Sore Throat Analgesic Efficacy 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Schachtel BP. Sore throat pain. In: Portenoy MM, Laska E, editors. Advances in pain research and therapy. Vol 18. New York: Raven Press Ltd, 1991; 393–407Google Scholar
  2. 2.
    Schachtel BP, Thoden WR. A placebo-controlled model for assaying systemic analgesics in children. Clin Pharmacol Ther 1993; 5: 593–601CrossRefGoogle Scholar
  3. 3.
    Bertin L, Pons G, d’Athis P, et al. Randomised, double-blind, multicentre, controlled trial of ibuprofen versus acetaminophen (paracetamol) and placebo for treatment of symptoms of tonsillitis and pharyngitis in children. J Pediatr 1991; 119: 811–4PubMedCrossRefGoogle Scholar
  4. 4.
    Schachtel BP, Fillingim JM, Beiter DJ, et al. Subjective and objective features of sore throat. Arch Intern Med 1984; 144: 497–500PubMedCrossRefGoogle Scholar
  5. 5.
    Schachtel BP, Fillingim JM, Lane AC, et al. Caffeine as an analgesic adjuvant: a double-blind study comparing aspirin 800mg with caffeine 64mg to aspirin 800mg and placebo in patients with sore throat. Arch Intern Med 1991; 151: 733–7PubMedCrossRefGoogle Scholar
  6. 6.
    Schachtel BP, Fillingim JM, Beiter DJ, et al. Rating scales for analgesics in sore throat. Clin Pharmacol Ther 1984; 36: 151–6PubMedCrossRefGoogle Scholar
  7. 7.
    Schachtel BP, Fillingim JM, Thoden WR, et al. Sore throat pain in the evaluation of mild analgesics. Clin Pharmacol Ther 1988; 44: 704–11PubMedCrossRefGoogle Scholar
  8. 8.
    Cooper SA, Beaver WT. A model to evaluate mild analgesics in oral surgery outpatients. Clin Pharmacol Ther 1976; 20: 241–50PubMedGoogle Scholar
  9. 9.
    Cooper SA. Five studies on ibuprofen for postsurgical dental pain. Am J Med 1984; 77 Suppl.: 70–7PubMedCrossRefGoogle Scholar

Copyright information

© Adis International Limited 1999

Authors and Affiliations

  • F. Boureau
    • 1
  • F. Pelen
    • 2
  • F. Verriere
    • 2
  • A. Paliwoda
    • 3
  • R. Manfredi
    • 3
  • M. Farhan
    • 4
  • R. Wall
    • 4
  1. 1.Hôpital Saint-AntoineCentre d’Evaluation et de Traitement de la DouleurParisFrance
  2. 2.Boots HealthcareCourbevoieFrance
  3. 3.Phoenix International FranceLe Kremlin BicêtreFrance
  4. 4.Boots Healthcare InternationalNottinghamUK

Personalised recommendations