Clinical Drug Investigation

, Volume 11, Issue 2, pp 90–96 | Cite as

Effect of L-Carnitine on the Limitation of Infarct Size in One-Month Postmyocardial Infarction Cases

A Multicentre, Randomised, Parallel, Placebo-Controlled Trial
  • K. G. C. Jacoba
  • R. F. AbarquezJr
  • G. O. Topacio
  • M. T. Abola
  • V. B. Flores
  • J. M. Sison
  • V. Defensor
  • D. Aliwalas
Clinical Use


On the basis of biochemical, experimental and clinical studies reporting a favourable effect of L-carnitine in acute myocardial ischaemia, the capability of the compound to reduce the extent of necrotic area in patients with a confirmed diagnosis of acute myocardial infarction was evaluated. The effect of L-carnitine was determined using technetium-99m (Tc99m) SPECT (Single Photon Emission Tomography) imaging. L-carnitine was found to significantly increase myocardial viability in treated patients after 8 week’ oral supplementation, in comparison with controls treated with placebo. The data suggest that L-carnitine may have a significant role in the treatment of patients after myocardial infarction.


Acute Myocardial Infarction Carnitine Drug Invest Single Photon Emission Tomography Trimetazidine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Adis International Limited 1996

Authors and Affiliations

  • K. G. C. Jacoba
    • 1
  • R. F. AbarquezJr
    • 1
  • G. O. Topacio
    • 2
  • M. T. Abola
    • 1
  • V. B. Flores
    • 1
  • J. M. Sison
    • 3
  • V. Defensor
    • 2
  • D. Aliwalas
    • 2
  1. 1.Philippine Heart CenterQuezon CityPhilippines
  2. 2.Department of MedicineMedical Center ManilaManilaPhilippines
  3. 3.Medical Corp, Armed Forces of the Philippines Medical CenterQuezon CityPhilippines

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