American Journal of Cancer

, Volume 2, Issue 3, pp 211–221

Metastatic Soft Tissue Sarcoma in Adults

Prognosis and Treatment Options
  • Ole S. Nielsen
  • Jean-Yves Blay
  • Ian R. Judson
  • Martine van Glabbeke
  • Jaap Verweij
  • Allan T. van Oosterom
  • EORTC Soft Tissue and Bone Sarcoma Group
Review Article

Abstract

In the present paper the treatment of advanced and metastatic soft tissue sarcoma is reviewed with the primary emphasis on chemotherapy. One of the major advances in the treatment of soft tissue sarcomas is their treatment by multidisciplinary teams in specialized centers. Despite optimal local treatment of the primary tumor, disseminated disease will develop in many patients. Consequently, chemotherapy has been extensively studied but, unfortunately, the responsiveness of these tumors to chemotherapy has been disappointingly low. Doxorubicin and ifosfamide appear to be the most effective drugs — the latter with a somewhat higher toxicity at effective dosages. Other drugs with some first line activity are dacarbazine, liposomal doxorubicin and possibly trabectedin (ET-743). Imatinib is very effective in gastrointestinal stromal tumors (GIST) where it is now the treatment of choice. The combination of doxorubicin and ifosfamide increases the response rate without affecting overall survival. For these reasons, single agent doxorubicin is, in many centers, considered the standard treatment for advanced soft tissue sarcoma, and combination chemotherapy should be reserved for special subgroups of patients such as young patients with chemosensitive tumors. Chemotherapy for patients with advanced and metastatic soft tissue sarcoma is inadequate at present and new drugs are desperately needed. Fortunately, exciting new drugs are under development and hopefully they will improve the treatment of patients with this disease.

Copyright information

© Adis Data Information BV 2003

Authors and Affiliations

  • Ole S. Nielsen
    • 1
    • 7
  • Jean-Yves Blay
    • 2
  • Ian R. Judson
    • 3
  • Martine van Glabbeke
    • 4
  • Jaap Verweij
    • 5
  • Allan T. van Oosterom
    • 6
  • EORTC Soft Tissue and Bone Sarcoma Group
  1. 1.Aarhus University HospitalAarhusDenmark
  2. 2.Unite Cytokines et CancersCentre Leon BerardLyonFrance
  3. 3.Royal Marsden NHS TrustLondonUK
  4. 4.EORTC Data CenterBrusselsBelgium
  5. 5.Rotterdam Cancer Institute (Dr. Daniel den Hoed Kliniek) and University HospitalRotterdamThe Netherlands
  6. 6.UZ GasthuisbergLeuvenBelgium
  7. 7.Department of OncologyAarhus University HospitalAarhus CDenmark

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