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CNS Drugs

, Volume 16, Issue 10, pp 653–662 | Cite as

Pharmacotherapy for Treating Tobacco Dependence

What is the Ideal Duration of Therapy?
  • Tammy Harris SimsEmail author
  • Michael C. Fiore
Current Opinion

Abstract

Various forms of nicotine replacement therapy and bupropion have been found to be efficacious and well tolerated for treating patients dependent on tobacco. However, the currently recommended duration of treatment with pharmacotherapy may be insufficient for some smokers to achieve sustained abstinence from tobacco. Extending the use of pharmacotherapy beyond the recommended timeframe may be an effective strategy for helping tobacco users achieve abstinence and for preventing relapse to tobacco use, especially among those who are highly dependent and those who are concerned about body weight gain following cessation.

Several studies have reported on long-term use of various pharmacotherapies. These studies have demonstrated that such long-term use is not harmful. Moreover, compared with continued smoking, long-term use of pharmacotherapy exposes patients to relatively small amounts of nicotine and none of the cancer-causing chemicals found in cigarettes and other tobacco products. However, more research is needed to further clarify questions regarding the ideal duration of therapy. Two questions have yet to be answered: In what populations of smokers is long-term therapy an effective strategy for achieving abstinence and preventing relapse? Does wider availability of nicotine replacement therapy lead to initiation of nicotine addiction by children and others not using tobacco products? Also, as with all medications, additional documentation of the safety of prolonged use of pharmacotherapy is important.

The aim of this review is to present the current evidence supporting the notion that long-term therapy for treating tobacco dependence may be appropriately considered for some tobacco users.

Keywords

Nicotine Smoking Cessation Bupropion Withdrawal Symptom Nicotine Replacement Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

This research was supported in part by the National Cancer Institute P50-CA84724 centre grant and minority supplements.

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Copyright information

© Adis International Limited 2002

Authors and Affiliations

  1. 1.Department of PediatricsUniversity of Wisconsin Medical School, Center for Tobacco Research and InterventionMadisonUSA
  2. 2.Division of General Internal Medicine, Department of Medicine, Center for Tobacco Research and InterventionUniversity of Wisconsin Medical SchoolMadisonUSA

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