CNS Drugs

, Volume 16, Issue 8, pp 517–526 | Cite as

Intermittent Explosive Disorder

Epidemiology, Diagnosis and Management
  • Rene L. Olvera
Therapy in Practice


Intermittent explosive disorder (IED) is characterised by discrete episodes of aggressive impulses that result in serious assaultive acts towards people or destruction of property. IED causes severe impairments in daily function. The diagnosis of IED should be made only after a thorough medical work-up. A structured or semi-structured diagnostic interview is helpful to ensure that comorbid and pre-existing conditions are considered.

There is a lack of controlled trials of agents for the treatment of patients with IED, but there is evidence that mood stabilisers, antipsychotics, β-blockers, α2-agonists, phenytoin and antidepressants may be useful. Behavioural interventions may be valuable as part of the overall treatment of IED


Personality Disorder Oppositional Defiant Disorder Conduct Disorder Guanfacine Borderline Personality Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Adis International Limited 2002

Authors and Affiliations

  1. 1.Division of Child and Adolescent PsychiatryThe University of Texas Health Science Center at San AntonioSan AntonioUSA

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