, Volume 27, Issue 6, pp 439–450 | Cite as

Cost Effectiveness of Influenza Vaccination in Older Adults

A Critical Review of Economic Evaluations for the 50- to 64-Year Age Group
  • Anthony T. Newall
  • Heath Kelly
  • Stuart Harsley
  • Paul A. Scuffham
Leading Article


Several recent studies have assessed the benefits of extending influenza vaccination programmes, which are currently targeted primarily at those aged over 65 years, to those aged 50–64 years. We identified and reviewed all costeffectiveness studies of influenza vaccination in those aged 50–64 years published before July 2008. While the studies suggest that vaccination in this age-group is likely to be cost effective, these results were dependent on several key assumptions. The estimates of serious outcomes due to influenza and the estimates of vaccine effectiveness (VE) against these outcomes were found to have the most influence on cost effectiveness. However, due to factors including mismatches between the measure of VE and the outcome under consideration, as well as various other data limitations, there is significant uncertainty around these key assumptions that was not well explored. There was a failure in some studies to report fundamental inputs such as discount rates. Overall, there was a general lack of transparency in the studies and, consequently, the conclusions around the cost effectiveness of influenza vaccine in those aged 50–64 years must be interpreted with caution.


Influenza Influenza Vaccine Influenza Vaccination Vaccine Effectiveness Utility Weight 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Anthony Newell has received research grants for investigator-driven research from GlaxoSmithKline Australia. Heath Kelly has received grants and consultancy funds from companies that manufacture influenza vaccines. Stuart Harsley is an employee of CSL Limited and owns shares in the company. Paul Scuffham has no conflicts of interest to declare.


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Copyright information

© Adis Data Information BV 2009

Authors and Affiliations

  • Anthony T. Newall
    • 1
    • 2
  • Heath Kelly
    • 3
    • 4
  • Stuart Harsley
    • 5
  • Paul A. Scuffham
    • 6
  1. 1.School of Public Health and Community MedicineUniversity of New South WalesSydneyAustralia
  2. 2.National Centre for Immunisation Research and Surveillance of Vaccine Preventable DiseasesThe Children’s Hospital at WestmeadWestmeadAustralia
  3. 3.School of Population HealthUniversity of MelbourneMelbourneAustralia
  4. 4.Victorian Infectious Diseases Reference LaboratoryMelbourneAustralia
  5. 5.CSL BiotherapiesParkvilleAustralia
  6. 6.L03 2.43 School of Medicine, Logan CampusGriffith UniversityMeadowbrookAustralia

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