Guidelines for Conducting Pharmaceutical Budget Impact Analyses for Submission to Public Drug Plans in Canada
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Until now, there has been no standardized method of performing and presenting budget impact analyses (BIAs) in Canada. Nevertheless, most drug plan managers have been requiring this economic data to inform drug reimbursement decisions. This paper describes the process used to develop the Canadian BIA Guidelines; describes the Guidelines themselves, including the model template; and compares this guidance with other guidance on BIAs. The intended audience includes those who develop, submit or use BIA models, and drug plan managers who evaluate BIA submissions.
The Patented Medicine Prices Review Board (PMPRB) initiated the development of the Canadian BIA Guidelines on behalf of the National Prescription Drug Utilisation Information System (NPDUIS). The findings and recommendations from a needs assessment with respect to BIA submissions were reviewed to inform guideline development. In addition, a literature review was performed to identify existing BIA guidance. The detailed guidance was developed on this basis, and with the input of the NPDUIS Advisory Committee, including drug plan managers from multiple provinces in Canada and a representative from the Canadian Agency for Drugs and Technologies in Health. A Microsoft® Excel-based interactive model template was designed to support BIA model development. Input regarding the guidelines and model template was sought from each NPDUIS Advisory Committee member to ensure compatibility with existing drug plan needs. Decisions were made by consensus through multiple rounds of review and discussion. Finally, BIA guidance in Canadian provinces and other countries were compared on the basis of multiple criteria.
The BIA guidelines consist of three major sections: Analytic Framework, Inputs and Data Sources, and Reporting Format. The Analytic Framework section contains a discussion of nine general issues surrounding BIAs (model design, analytic perspective, time horizon, target population, costing, scenarios to be compared, the characterisation of uncertainty, discounting, and validation methods). The Inputs and Data Sources section addresses methods for market size estimation, comparator selection, scenario forecasting and drug price estimation. The Reporting Format section describes methods for BIA reporting.
The new Canadian BIA Guidelines represent a significant departure from the limited guidance that was previously available from some of the provinces, because they include specific details of the methods of performing BIAs. The Canadian BIA Guidelines differ from the Principles of Good Research Practice for BIAs developed by the International Society for Pharmacoeconomic and Outcomes Research (ISPOR), which provide more general guidance.
The Canadian BIA Guidelines and template build upon existing guidance to address the specific requirements of each of the participating drug plans in Canada. Both have been endorsed by the NPDUIS Steering Committee and the PMPRB for the standardization of BIA submissions.
KeywordsReference Scenario Drug Plan Budget Impact Analysis Pharmaceutical Benefit Advisory Committee Common Drug Review
The Guidelines for conducting pharmaceutical budget impact analyses for submission to public drug plans in Canada and the supporting Microsoft® Excel-based BIA model template were developed by i3 Innovus under contract after a competitive bidding process, with the Patented Medicines Prices Review Board (PMPRB) for the National Prescription Drug Utilization Information System (NPDUIS). i3 Innovus is a contract research organization that specializes in health economics and outcomes research.
This report was produced with the assistance of the NPDUIS Steering Committee, the membership of which is detailed in the PMPRB BIA Guidelines Report. The NPDUIS Advisory Committee worked with i3 Innovus and the PMPRB to review and comment on the guidelines and template, and these comments were incorporated into the final versions of both products.
i3 Innovus recognizes the contribution of its staff in the development of these guidelines, with special mention going to Amy Lee, PhD, for her contribution to the development of the interactive BIA template. i3 Innovus would also like to acknowledge Bindu Islam, formerly of the PMPRB, for her contribution to this project. i3 Innovus also acknowledges the International Society of Pharmacoeconomics and Outcomes Research (ISPOR) Task Force Good Research Practices — Budget Impact Analysis and its Principles of Good Practice for Budget Impact Analysis Report, which was used to inform the development of this Canadian guidance document. In addition, i3 Innovus would like to express its thanks to Alberta Health and Wellness, Manitoba Health and the Ontario Drug Benefit Program for their BIA templates to inform the development of these guidelines.
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