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Sports Medicine

, Volume 38, Issue 7, pp 579–606 | Cite as

The Effect of Muscle-Damaging Exercise on Blood and Skeletal Muscle Oxidative Stress

Magnitude and Time-Course Considerations
  • Michalis G. NikolaidisEmail author
  • Athanasios Z. Jamurtas
  • Vassilis Paschalis
  • Ioannis G. Fatouros
  • Yiannis Koutedakis
  • Dimitris Kouretas
Review Article

Abstract

The aim of this article is to present the effects of acute muscle-damaging exercise on oxidative stress/damage of animal and human tissues using a quantitative approach and focusing on the time-course of exercise effects. The reviewed studies employed eccentric contractions on a dynamometer or downhill running. The statistical power of each study to detect a 20% or 40% post-exercise change compared with pre-exercise value in each oxidative stress/damage biomarker was calculated. Muscle-damaging exercise can increase free radical levels and augment oxidation of lipids, proteins, glutathione and possibly DNA in the blood. In contrast, the effect of muscle-damaging exercise on concentration of antioxidants in the blood, except for glutathione, was little. Muscle-damaging exercise induces oxidative stress/damage in skeletal muscle, even though this is not fully supported by the original statistical analysis of some studies. In contrast, muscle-damaging exercise does not appear to affect — at least to similar extent as the oxidative stress/ damage markers — the levels of antioxidants in skeletal muscle. Based on the rather limited data available, the oxidative stress response of skeletal muscle to exercise was generally independent of muscle fibre type. Most of the changes in oxidative stress/damage appeared and were sustained for days after muscledamaging exercise. The major part of the delayed oxidative stress/damage production that follows muscle-damaging exercise probably comes from phagocytic cells that are activated and recruited to the site of the initial damage. A point that emerged and potentially explains much of the lack of consensus among studies is the low statistical power of many of them. In summary, muscle-damaging exercise can increase oxidative stress/damage in blood and skeletal muscle of rats and humans that may persist for and/or appear several days after exercise.

Keywords

Reactive Oxygen Species Nitric Oxide Muscle Damage Total Antioxidant Capacity Protein Carbonyl 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors received no sources of funding for the preparation of this review. The authors have no conflicts of interest that are directly relevant to the content of this review.

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Copyright information

© Adis Data Information BV 2008

Authors and Affiliations

  • Michalis G. Nikolaidis
    • 1
    • 2
    • 3
    Email author
  • Athanasios Z. Jamurtas
    • 1
    • 2
  • Vassilis Paschalis
    • 1
    • 2
  • Ioannis G. Fatouros
    • 4
  • Yiannis Koutedakis
    • 1
    • 2
    • 5
  • Dimitris Kouretas
    • 3
  1. 1.Institute of Human Performance and RehabilitationCenter for Research and Technology — ThessalyKariesGreece
  2. 2.Department of Physical Education and Sports ScienceUniversity of ThessalyKariesGreece
  3. 3.Department of Biochemistry and BiotechnologyUniversity of ThessalyGreece
  4. 4.Department of Physical Education and Sports ScienceDemocritus University of ThraceGreece
  5. 5.School of Sport, Performing Arts and LeisureWolverhampton UniversityUK

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