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Sports Medicine

, Volume 34, Issue 6, pp 363–369 | Cite as

Exercise and Prostate Cancer

  • Dorothea C. Torti
  • Gordon O. Matheson
Review Article

Abstract

Prostate cancer is a leading cause of cancer morbidity and mortality in men. In addition to improved treatments, strategies to reduce disease risk are urgently required. This review summarises the literature that examines the association between exercise and prostate cancer risk. Between 1989 and 2001, 13 cohort studies were conducted in the US and internationally. Of these, nine showed an association between exercise and decreased prostate cancer risk. Five of 11 case-control studies conducted between 1988 and 2002 reported an association between decreased risk of prostate cancer and high activity levels. Considering all studies performed between 1976 and 2002, 16 out of 27 studies reported reduced risk in men who were most active; in nine out of 16 studies the reduction in risk was statistically significant. Average risk reduction ranged from 10–30%. In aggregate, this evidence suggests a probable link between increased physical exercise and decreased prostate cancer risk. The ability of exercise to modulate hormone levels, prevent obesity, enhance immune function and reduce oxidative stress have all been postulated as mechanisms that may underlie the protective effect of exercise. Exercise may also be of benefit in men undergoing treatment for prostate cancer. Overall, study design and control of potential confounding factors varied greatly among studies, possibly contributing to the variation in results. Epidemiological studies that are better controlled, larger in scale and more carefully designed may help to more fully clarify the relationship between exercise and prostate cancer. In addition, intervention trials that test whether exercise programmes can reduce prostate cancer risk are currently underway to rigorously test the ability of exercise to reduce prostate cancer incidence.

Keywords

Prostate Cancer Androgen Deprivation Therapy Prostate Cancer Risk Bone Mineral Loss Colecalciferol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

No sources of funding were used to assist in the preparation of this review. The authors have no conflicts of interest that are directly relevant to the content of this review.

References

  1. 1.
    Greenlee RT, Hill-Harmon MB, Murray T, et al. Cancer statistics, 2001. CA Cancer J Clin 2001; 51: 15–36PubMedCrossRefGoogle Scholar
  2. 2.
    Friedenreich CM, Thune I. A review of physical activity and prostate cancer risk. Cancer Cases Control 2001; 12: 461–75CrossRefGoogle Scholar
  3. 3.
    Brawley OW, Parnes H. Prostate cancer prevention trials in the USA. Eur J Cancer 2000; 36: 1312–5PubMedCrossRefGoogle Scholar
  4. 4.
    Erikssen G. Physical fitness and changes in mortality: the survival of the fittest. Sports Med 2001; 31: 571–6PubMedCrossRefGoogle Scholar
  5. 5.
    Exercise and the prostate: can you run away from trouble? Harvard Men’s Health Watch 2001 May; 5(10): 1–3Google Scholar
  6. 6.
    Friedenreich CM. Physical activity and cancer prevention: from observational to intervention research. Cancer Epidemiol Biomarkers Prev 2001; 10: 287–301PubMedGoogle Scholar
  7. 7.
    Polednak AP. College athletics, body size, and cancer mortality. Cancer 1976; 38: 382–7PubMedCrossRefGoogle Scholar
  8. 8.
    Paffenbarger RS, Hyde RT, Wing AL. Physical activity and incidence of cancer in diverse populations: a preliminary report. Am J Clin Nutr 1987; 45: 312–7PubMedGoogle Scholar
  9. 9.
    Severson RK, Nomura AMY, Grove JS, et al. A prospective analysis of physical activity and cancer. Am J Epidemiol 1989; 130: 522–9PubMedGoogle Scholar
  10. 10.
    Lee I-M, Paffenbarger RS. Physical activity and its relation to cancer risk: a prospective study of college alumni. Med Sci Sports Exerc 1994; 26: 831–7PubMedGoogle Scholar
  11. 11.
    Thune I, Lund E. Physical activity and the risk of prostate and testicular cancer: a cohort study of 53,000 Norwegian men. Cancer Causes Control 1994; 5: 549–56PubMedCrossRefGoogle Scholar
  12. 12.
    Hsing AW, McLaughlin JK, Zheng W, et al. Occupation, physical activity, and risk of prostate cancer in Shanghai, People’s Republic of China. Cancer Causes Control 1994; 5: 136–40PubMedCrossRefGoogle Scholar
  13. 13.
    Steenland K, Nowlin S, Palu S. Cancer incidence in the National Health and Nutrition Survey I, follow-up data: diabetes, cholesterol, pulse and physical activity. Cancer Epidemiol Biomarker Prev 1995; 4: 807–11Google Scholar
  14. 14.
    Oliveria SA, Kohl HW, Trichopoulos D, et al. The association between cardiorespiratory fitness and prostate cancer. Med Sci Sports Exerc 1996; 28: 97–104PubMedGoogle Scholar
  15. 15.
    Cerhan JR, Torner JC, Lynch CF, et al. Association of smoking, body mass, and physical activity with risk of prostate cancer in the Iowa 65+ Rural Health Study (United States). Cancer Causes Control 1997; 8: 229–38PubMedCrossRefGoogle Scholar
  16. 16.
    Hartman TJ, Albanes D, Tautalahti M, et al. Physical activity and prostate cancer in the Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study (Finland). Cancer Causes Control 1998; 9: 11–8PubMedCrossRefGoogle Scholar
  17. 17.
    Giovannucci E, Leitzmann M, Spiegelman D, et al. A prospective study of physical activity and prostate cancer in male health professionals. Cancer Res 1998; 58: 5117–22PubMedGoogle Scholar
  18. 18.
    Liu S, Lee I-M, Linson P, et al. A prospective study of physical activity and risk of prostate cancer in US physicians. Int J Epidemiol 2000; 29: 29–35PubMedCrossRefGoogle Scholar
  19. 19.
    Lund Nilsen TI, Johnsen R, Vatten LJ. Socio-economic and lifestyle factors associated with risk of prostate cancer. Br J Cancer 2000; 82: 1358–63PubMedCrossRefGoogle Scholar
  20. 20.
    Clarke G, Whittemore AS. Prostate cancer risk in relation to anthropometry and physical activity: the national health and nutrition examination survey I, epidemiological follow-up study. Cancer Epidemiol Biomarkers Prev 2000; 9: 875–81PubMedGoogle Scholar
  21. 21.
    Wannamethee SG, Shaper AG, Walker M. Physical activity and risk of cancer in middle-aged men. Br J Cancer 2001; 85: 1311–6PubMedCrossRefGoogle Scholar
  22. 22.
    Yu H, Harris RE, Wynder EL. Case-control study of prostate cancer and socioeconomic factors. Prostate 1988; 13: 317–25PubMedCrossRefGoogle Scholar
  23. 23.
    Brownson RC, Chang JC, Davis JR, et al. Physical activity on the job and cancer in Missouri. Am J Public Health 1991; 81: 639–42PubMedCrossRefGoogle Scholar
  24. 24.
    Le Marchand L, Kolonel LN, Yoshizawa CN. Lifetime occupational physical activity and prostate cancer risk. Am J Epidemiol 1991; 133: 103–11PubMedGoogle Scholar
  25. 25.
    West DW, Slattery ML, Robison LM, et al. Adult dietary intake and prostate cancer risk in Utah: a case-control study with special emphasis on aggressive tumors. Cancer Causes Control 1991; 2: 85–94PubMedCrossRefGoogle Scholar
  26. 26.
    Dosemeci M, Hayes RB, Vetter R, et al. Occupational physical activity, socioeconomic status, and risks of 15 cancer sites in Turkey. Cancer Causes Control 1993; 4: 313–21PubMedCrossRefGoogle Scholar
  27. 27.
    Anderson S-O, Anderson S-O, Baron J, Wolk A, et al. Early life risk factors for prostate cancer: a population-based case-control study in Sweden. Cancer Epidemiol Biomarkers Prev 1995; 4: 187–92Google Scholar
  28. 28.
    Whittemore AS, Kolonel LN, Wu AH, et al. Prostate cancer in relation to diet, physical activity, and body size in blacks, whites, and Asians in the United States and Canada. J Natl Cancer Inst 1995; 87: 652–61PubMedCrossRefGoogle Scholar
  29. 29.
    Sung JFC, Lin RS, Pu Y-S, et al. Risk factors for prostate carcinoma in Taiwan: a case-control study in a Chinese population. Cancer 1999; 86: 484–91PubMedCrossRefGoogle Scholar
  30. 30.
    Villeneuve PJ, Johnson KC, Kreiger N, et al. Risk factors for prostate cancer: results from the Canadian National Enhanced Cancer Surveillance System. Cancer Causes Control 1999; 10: 355–67PubMedCrossRefGoogle Scholar
  31. 31.
    Bairati I, Larouche R, Meyer F, et al. Lifetime occupational physical activity and incidental prostate cancer. Cancer Causes Control 2000; 11: 759–64PubMedCrossRefGoogle Scholar
  32. 32.
    Lacey JV, Deng J, Dosemeci M, et al. Prostate cancer, benign prostatic hyperplasia and physical activity in Shanghai China. Int J Epidemiol 2001; 30: 341–9PubMedCrossRefGoogle Scholar
  33. 33.
    Vena JE, Graham S, Zielezny M, et al. Occupational exercise and risk of cancer. Am J Clin Nutr 1987; 45: 318–27PubMedGoogle Scholar
  34. 34.
    Albanes D, Blair A, Taylor PR. Physical activity and risk of cancer in the NHANES 1 population. Am J Public Health 1989; 79: 744–50PubMedCrossRefGoogle Scholar
  35. 35.
    Lee I-M, Paffenbarger RS, Hsieh C-C. Physical activity and risk of prostatic cancer among college alumni. Am J Epidemiol 1992; 135: 169–79PubMedGoogle Scholar
  36. 36.
    Paffenbarger Jr RS, Lee I-M, Wong AL. The influence of physical activity on the incidence of site-specific cancers in college alumni. In: Jacobs MM, editor. Exercise, fat, and cancer. New York: Plenum Press, 1992: 7–15CrossRefGoogle Scholar
  37. 37.
    Ilic M, Vlajinac H, Marinkovic J. Case-control study of risk factors for prostate cancer. Br J Cancer 1996; 74: 1682–6PubMedCrossRefGoogle Scholar
  38. 38.
    Whittemore AS, Paffenbarger RS, Anderson K, et al. Early precursors of site-specific cancers in college men and women. J Natl Cancer Inst 1985; 74: 43–51PubMedGoogle Scholar
  39. 39.
    Wynder EL, Laakso K, Sotarauta M, et al. Metabolic epidemiology of prostatic cancer. Prostate 1984; 5: 47–53PubMedCrossRefGoogle Scholar
  40. 40.
    Wheeler GD, Wall SR, Beicastro AN, et al. Reduced serum testosterone and prolactin levels in male distance runners. JAMA 1984; 252: 514–6PubMedCrossRefGoogle Scholar
  41. 41.
    Hackney AC, Sinning WE, Bruot BC. Reproductive hormonal profiles of endurance-trained and untrained males. Med Sci Sports Exerc 1988; 20: 60–5PubMedCrossRefGoogle Scholar
  42. 42.
    Neiman DC, Pedersen BK. Exercise and immune function: recent developments. Sports Med 1999; 27: 73–80CrossRefGoogle Scholar
  43. 43.
    Daniell HW, Dunn SR, Ferguson DW, et al. Progressive osteoporosis during androgen deprivation therapy for prostate cancer. J Urol 2000; 163: 181–6PubMedCrossRefGoogle Scholar
  44. 44.
    Daniell HW. Osteoporosis due to androgen deprivation therapy in men with prostate cancer. Urology 2001; 58Suppl. 2A: 101–7PubMedCrossRefGoogle Scholar
  45. 45.
    Ross RW, Small EJ. Osteoporosis in men treated with androgen deprivation therapy for prostate cancer. J Urol 2002; 167: 1952–6PubMedCrossRefGoogle Scholar
  46. 46.
    Hamalainen EK, Aldercreutz H, Puska P, et al. Decrease of serum total and free testosterone during a low-fat high-fibre diet. J Steroid Biochem 1983; 18: 369–70PubMedCrossRefGoogle Scholar
  47. 47.
    McTiernan A, Ulrich CM, Yancey D, et al. The Physical Activity for Total Health (PATH) study: rationale and design. Med Sci Sports Exerc 1999; 31: 1307–12PubMedCrossRefGoogle Scholar
  48. 48.
    McTiernan A. Intervention studies in exercise and cancer prevention. Med Sci Sports Exerc 2003; 35: 1841–5PubMedCrossRefGoogle Scholar
  49. 49.
    Ornish DM, Lee KL, Fair WR, et al. Dietary trial in prostate cancer: early experience and implications for clinical trial design. Urology 2001; 57Suppl. 4A: 200–1PubMedCrossRefGoogle Scholar

Copyright information

© Adis Data Information BV 2004

Authors and Affiliations

  1. 1.Program in Human Biology, School of Humanities and SciencesStanford UniversityStanfordUSA
  2. 2.Division of Sports Medicine, Department of Orthopedic Surgery, School of MedicineStanford UniversityStanfordUSA

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