Sports Medicine

, Volume 32, Issue 15, pp 987–1004

Growth Hormone Release During Acute and Chronic Aerobic and Resistance Exercise

Recent Findings
  • Laurie Wideman
  • Judy Y. Weltman
  • Mark L. Hartman
  • Johannes D. Veldhuis
  • Arthur Weltman
Review Article

Abstract

Exercise is a potent physiological stimulus for growth hormone (GH) secretion, and both aerobic and resistance exercise result in significant, acute increases in GH secretion. Contrary to previous suggestions that exercise-induced GH release requires that a ’threshold’ intensity be attained, recent research from our laboratory has shown that regardless of age or gender, there is a linear relationship between the magnitude of the acute increase in GH release and exercise intensity. The magnitude of GH release is greater in young women than in young men and is reduced by 4-7-fold in older individuals compared with younger individuals. Following the increase in GH secretion associated with a bout of aerobic exercise, GH release transiently decreases. As a result, 24-hour integrated GH concentrations are not usually elevated by a single bout of exercise. However, repeated bouts of aerobic exercise within a 24-hour period result in increased 24-hour integrated GH concentrations.

Because the GH response to acute resistance exercise is dependent on the work-rest interval and the load and frequency of the resistance exercise used, the ability to equate intensity across different resistance exercise protocols is desirable. This has proved to be a difficult task. Problems with maintaining patent intravenous catheters have resulted in a lack of studies investigating alterations in acute and 24-hour GH pulsatile secretion in response to resistance exercise. However, research using varied resistance protocols and sampling techniques has reported acute increases in GH release similar to those observed with aerobic exercise.

In young women, chronic aerobic training at an intensity greater than the lactate threshold resulted in a 2-fold increase in 24-hour GH release. The time line of adaptation and the mechanism(s) by which this training effect occurs are still elusive. Unfortunately, there are few studies investigating the effects of chronic resistance training on 24-hour GH release.

The decrease in GH secretion observed in individuals who are older or have obesity is associated with many deleterious health effects, although a cause and effect relationship has not been established. While exercise interventions may not restore GH secretion to levels observed in young, healthy individuals, exercise is a robust stimulus of GH secretion. The combination of exercise and administration of oral GH secret agogues may result in greater GH secretion than exercise alone in individuals who are older or have obesity. Whether such interventions would result in favourable clinical outcomes remains to be established.

References

  1. 1.
    Giustina A, Veldhuis JD. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev 1998; 19 (6): 717–97PubMedGoogle Scholar
  2. 2.
    Hartman ML. Physiological regulators of growth hormone secretion. In: Juul A, Jorgensen JOL, editors. Growth hormone in adults. 2nd ed. Cambridge: Cambridge University Press, 2000: 3–53Google Scholar
  3. 3.
    Kojima M, Hiroshi H, Date Y, et al. Ghrelin is a growth-hormone releasing acylated peptide fromstomach. Nature 1999; 402: 656–60PubMedGoogle Scholar
  4. 4.
    Baumann G. Growth hormone heterogeneity: genes, isohormones, variants and binding proteins. Endocr Rev 1991; 12 (4): 424–49PubMedGoogle Scholar
  5. 5.
    Lewis UJ, Sinha YN, Lewis GP. Structure and properties of members of the hGH family: a review. Endocr J 2000; 47: S1–8Google Scholar
  6. 6.
    Strasburger CJ. Methods in determining growth hormone concentrations: an immunofunctional assay. Pediatrics 1999; 104: 1024–8PubMedGoogle Scholar
  7. 7.
    Ebdrup L, Fisker S, Sorensen HH, et al. Variety in growth hormone determinations due to use of different immunoassays and to the interference of growth hormone-binding protein. Horm Res 1999; 51 (1 Suppl.): 20–6PubMedGoogle Scholar
  8. 8.
    Greenspan FS, Li CH, Simpson ME, et al. Bioassay of hypophyseal growth hormone: the tibial test. Endocrinology 1949; 45: 455–63PubMedGoogle Scholar
  9. 9.
    McCall GE, Goulet C, Grindeland RE, et al. Bed rest suppresses bioassay able growth hormone release in response to muscle activity. J Appl Physiol 1997; 83: 2086–90PubMedGoogle Scholar
  10. 10.
    Strasburger CJ, Wu Z, Pflaum C-D, et al. Immunofunctional assay of human growth hormone (hGH) in serum: a possible consensus for quantitative hGH measurement. J Clin Endocrinol Metab 1996; 81: 2613–20PubMedGoogle Scholar
  11. 11.
    Ikeda M, Wada M, Fujita Y, et al. A novel bioassay based on human growth hormone (hGH) receptor mediated cell proliferation: measurement of 20k-hGH and its modified forms. Growth Horm IGF Res 2000; 10: 248–55PubMedGoogle Scholar
  12. 12.
    McCall GE, Grindeland RE, Roy RR, et al. Muscle afferent activity modulates bioassayable growth hormone in human plasma. J Appl Physiol 2000; 89: 1137–41PubMedGoogle Scholar
  13. 13.
    Wallace JD, Cuneo RC, Bidlingmaier M, et al. The response of molecular isoforms of growth hormone to acute exercise in trained adult males. J Clin Endocrinol Metab 2001; 86: 200–6PubMedGoogle Scholar
  14. 14.
    Hymer WC, Kraemer WJ, Nindl BC, et al. Characteristics of circulating growth hormone in women after acute heavy resistance exercise. Am J Physiol Endocrinol Metab 2001; 281: E878–87Google Scholar
  15. 15.
    Binnerts A, Duerenberg P, Swart GR, et al. Body composition in growth hormone deficient adults. Am J Clin Nutr 1992; 55: 918–23PubMedGoogle Scholar
  16. 16.
    Rosen T, Bengtsson BA. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 1990; 336: 285–8PubMedGoogle Scholar
  17. 17.
    Cuneo RC, Salomon F, Wiles CM, et al. Growth hormone treatment in growth hormone-deficient adults: II, effects on exercise performance. J Appl Physiol 1991; 70 (2): 695–700PubMedGoogle Scholar
  18. 18.
    Johansson JO, Fowelin J, Landin K, et al. Growth hormone deficient adults are insulin resistant. Metabolism 1995; 44: 434–7Google Scholar
  19. 19.
    O’Neal D, Few FL, Sikaris K, et al. Low-density lipoprotein particle size in hypopituitary adults receiving conventional hormone replacement therapy. J Clin Endocrinol Metab 1996; 81: 2448–54PubMedGoogle Scholar
  20. 20.
    Russell-Jones DL, Watts GF, Weissberger A, et al. The effect of GH replacement on serum lipids, lipoproteins, apolipoproteins and cholesterol precursors in adult GHD patients. Clin Endocrinol (Oxf) 1994; 41 (3): 345–50Google Scholar
  21. 21.
    Evans LM, Davies JS, Anderson RA, et al. The effect of GH replacement therapy on endothelial function and oxidative stress in adult growth hormone deficiency. Eur J Endocrinol 2000; 142: 254–62PubMedGoogle Scholar
  22. 22.
    Silverman BL, Friedlander JR. Is growth hormone good for the heart? J Pediatr 1997; 131: S70–4Google Scholar
  23. 23.
    Jorgensen JO, Pedersen SA, Thuesen L, et al. Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1989; I (8649): 1221–5Google Scholar
  24. 24.
    Salomon F, Cuneo RC, Hesp R, et al. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med 1989; 321 (26): 1797–803PubMedGoogle Scholar
  25. 25.
    Bengtsson B-A, Eden S, Lonn L, et al. Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. J Clin Endocrinol Metab 1993; 76: 309–17PubMedGoogle Scholar
  26. 26.
    Baum H, Biller B, Finkelstein J, et al. Effects of physiologic growth hormone therapy on bone density and body composition in patients with adult-onset growth hormone deficiency. Ann Intern Med 1996; 125: 883–90PubMedGoogle Scholar
  27. 27.
    Attanasio AF, Lamberts SWJ, Matranga AMC, et al. Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment: Adult Growth Hormone Deficiency Study Group. J Clin Endocrinol Metab 1997; 82 (1): 82–8PubMedGoogle Scholar
  28. 28.
    Cuneo RC, Salomon F, Wiles CM, et al. Growth hormone treatment in growth hormone-deficient adults: I, effects on muscle mass and strength. J Appl Physiol 1991; 70 (2): 688–94PubMedGoogle Scholar
  29. 29.
    Nass R, Huber RM, Klauss V, et al. Effect of growth hormone (hGH) replacement therapy on physical work capacity and cardiac and pulmonary function in patients with hGH deficiency acquired in adulthood. J Clin Endocrinol Metab 1995; 80: 552–7PubMedGoogle Scholar
  30. 30.
    Gullestad L, Birkeland K, Bjonerheim R, et al. Exercise capacity and hormonal response in adults with childhood onset growth hormone deficiency during long-term somatropin treatment. Growth Horm IGF Res 1998; 8: 377–84PubMedGoogle Scholar
  31. 31.
    Woodhouse LJ, Asa SL, Thomas SG, et al. Measures of submaximal aerobic performance evaluate and predict functional response to growth hormone (GH) treatment in GH-deficient adults. J Clin Endocrinol Metab 1999; 84: 4570–7PubMedGoogle Scholar
  32. 32.
    Cittadini A, Cuocolo A, Merola B, et al. Impaired cardiac performance in GH-deficient adults and its improvement after GH replacement. Am J Physiol 1994; 267: E219–25Google Scholar
  33. 33.
    Colao A, di Somma C, Pivonello R, et al. The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: a 12-month prospective study. J Clin Endocrinol Metab 2002; 87 (3): 1088–93PubMedGoogle Scholar
  34. 34.
    Johannsson G, Grimby G, Sunnerhagen KS, et al. Two years of growth hormone (GH) treatment increase isometric and isokinetic muscle strength in GH-deficient adults. J Clin Endocrinol Metab 1997; 82 (9): 2877–84PubMedGoogle Scholar
  35. 35.
    Rodriguez-Arnao J, Jabbar A, Fulcher K, et al. Effects of growth hormone replacement on physical performance and body composition in GH deficient adults. Clin Endocrinol 1999; 51: 53–60Google Scholar
  36. 36.
    Koranyi J, Svensson J, Gotherstrom G, et al. Baseline characteristics and the effects of five years of GH replacement therapy in adults with GH deficiency of childhood or adulthood onset: a comparative, prospective study. J Clin Endocrinol Metab 2001; 86: 4693–9PubMedGoogle Scholar
  37. 37.
    Carroll PV, Christ ER, Bengtsson BA, et al. Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. J Clin Endocrinol Metab 1998; 83: 382–95PubMedGoogle Scholar
  38. 38.
    Simpson H, Savine R, Sönksen P, et al. Growth hormone replacement therapy for adults: into the new millennium. Growth Horm IGF Res 2002; 12: 1–33PubMedGoogle Scholar
  39. 39.
    Rudman D, Kutner MH, Rogers CM, et al. Impaired growth hormone secretion in the adult population. J Clin Invest 1981; 67: 1361–9PubMedGoogle Scholar
  40. 40.
    Zadik Z, Chalew SA, McCarter RJ, et al. The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. J Clin EndocrinolMetab 1985; 60: 513–6PubMedGoogle Scholar
  41. 41.
    Iranmanesh A, Lizarralde G, Veldhuis JD. Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrinol Metab 1991; 73: 1081–8PubMedGoogle Scholar
  42. 42.
    Veldhuis JD, Iranmenesh A, Ho KKY, et al. Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man. J Clin Endocrinol Metab 1991; 72: 51–9PubMedGoogle Scholar
  43. 43.
    Veldhuis JD, Liem AY, South S, et al. Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay. J Clin Endocrinol Metab 1995; 80: 3209–22PubMedGoogle Scholar
  44. 44.
    Rudman D, Feller AG, Nagraj HS, et al. Effects of human growth hormone in men over 60 years old. N Engl J Med 1990; 323: 1–6PubMedGoogle Scholar
  45. 45.
    Holloway L, Butterfield G, Hintz R, et al. Effects of recombinant human growth hormone on metabolic indices, body composition and bone turnover in healthy elderly women. J Clin Endocrinol Metab 1994; 79: 470–9PubMedGoogle Scholar
  46. 46.
    Taaffe DR, Pruitt L, Reim J, et al. Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. J Clin Endocrinol Metab 1994; 79: 1361–6PubMedGoogle Scholar
  47. 47.
    Thompson JL, Butterfield GE, Marcus R, et al. The effects of recombinant human insulin-like growth factor-I and growth hormone on body composition in elderly women. J Clin Endocrinol Metab 1995; 80 (6): 1845–52PubMedGoogle Scholar
  48. 48.
    Yarasheski KE, Zachwieja JJ, Campbell JA, et al. Effect of growth hormone and resistance exercise on muscle growth and strength in older men. Am J Physiol 1995; 268: E268–76Google Scholar
  49. 49.
    Munzer T, Harman SM, Hees P, et al. Effects of GH and/or sex steroid administration on abdominal subcutaneous and visceral fat in healthy aged women and men. J Clin Endocrinol Metab 2001; 86 (8): 3604–10PubMedGoogle Scholar
  50. 50.
    Hartman ML, Weltman JY, Patrie JT, et al. Exercise training for one year does not increase 24-h GH secretion in older adults. 82nd Annual Meeting of the Endocrine Society; 2000 Jun 21–24; Toronto, 396Google Scholar
  51. 51.
    Weltman A, Weltman JY, Wideman L, et al. GH therapy for 1 year does not augment the effects of exercise training on fitness, strength and function in healthy older adults [abstract P435]. 11th International Congress of Endocrinology; 2000 Oct 29-Nov 2; Sydney (NSW), 201Google Scholar
  52. 52.
    Clasey JL, Weltman A, Patrie J, et al. Abdominal visceral fat and fasting insulin are important predictors of 24-hour GH release independent of age, gender and other physiological factors. J Clin Endocrinol Metab 2001; 86: 3845–52PubMedGoogle Scholar
  53. 53.
    Lassarre C, Girard F, Durand J, et al. Kinetics of human growth hormone during submaximal exercise. J Appl Physiol 1974; 37: 826–30PubMedGoogle Scholar
  54. 54.
    Raynaud J, Capderou A, Martineaud J-P, et al. Intersubject variability of growth hormone time course during different types of work. J Appl Physiol 1983; 55: 1682–7PubMedGoogle Scholar
  55. 55.
    Sutton J, Lazarus L. Growth hormone in exercise: comparison of physiological and pharmacological stimuli. J Appl Physiol 1976; 41: 523–7PubMedGoogle Scholar
  56. 56.
    Craig BW, Brown R, Everhart J. Effects of progressive resistance training on growth hormone and testosterone levels in young and elderly subjects. Mech Ageing Dev 1989; 49: 159–69PubMedGoogle Scholar
  57. 57.
    Cappon JP, Brasel J, Mohan S, et al. Effect of brief exercise on circulation insulin-like growth factor I. J Appl Physiol 1994; 76: 2490–6PubMedGoogle Scholar
  58. 58.
    Pritzlaff CJ, Wideman L, Weltman JY, et al. Impact of acute exercise intensity on pulsatile growth hormone (GH) release in men. J Appl Physiol 1999; 87 (2): 498–504PubMedGoogle Scholar
  59. 59.
    Wideman L, Weltman JY, Shah N, et al. The effects of gender on exercise-induced growth hormone release. J Appl Physiol 1999; 87: 1154–62PubMedGoogle Scholar
  60. 60.
    Wideman L, Weltman JY, Patrie JT, et al. Synergy of L-arginine and growth hormone (GH)-releasing peptide-2 (GHRP- 2) stimulation of GH in men and women: modulation by exercise. Am J Physiol Regul Integr Comp Physiol 2000; 279: R1467–77Google Scholar
  61. 61.
    Engstrom BE, Karlsson FA, Wide L. Marked gender differences in ambulatory morning growth hormone values in young adults. Clin Chem 1998; 44 (6): 1289–95PubMedGoogle Scholar
  62. 62.
    Hartman ML, Veldhuis JD, Vance ML, et al. Somatotropin pulse frequency and basal concentrations are increased in acromegaly and are reduced by successful therapy. J Clin Endocrinol Metab 1990; 70: 1375–84PubMedGoogle Scholar
  63. 63.
    Pincus SM, Gevers E, Robinson ICAF, et al. Females secrete growth hormone with more process irregularity than males in both human and rat. Am J Physiol 1996; 270: E107–15Google Scholar
  64. 64.
    Van den Berg G, Veldhuis JD, Frolich M, et al. An amplitude specific divergence in the pulsatile mode of GH secretion underlies the gender difference in mean GH concentrations in men and premenopausal women. J Clin Endocrinol Metab 1996; 81: 2460–6PubMedGoogle Scholar
  65. 65.
    Veldhuis JD. The neuroendocrine regulation and implications of pulsatile GH secretion: gender effects. Endocrinologist 1995; 5: 198–213Google Scholar
  66. 66.
    Bunt JC, Boileau RA, Bahr JM, et al. Sex and training differences in human growth hormone levels during prolonged exercise. J Appl Physiol 1986; 61 (5): 1796–801PubMedGoogle Scholar
  67. 67.
    Pritzlaff-Roy CJ, Wideman L, Weltman JY, et al. Gender governs the relationship between exercise intensity and growth hormone (GH) release. J Appl Physiol 2002; 92: 2053–60PubMedGoogle Scholar
  68. 68.
    Kanaley JA, Weltman JY, Pieper KS, et al. Cortisol and growth hormone responses to exercise at different times of day. J Clin Endocrinol Metab 2001; 86 (6): 2881–9PubMedGoogle Scholar
  69. 69.
    Chang FE, Dodds WG, Sullivan M, et al. The acute effects of exercise on prolactin and growth hormone secretion: comparison between sedentary women and women runners with normal and abnormal menstrual cycle. J Clin Endocrinol Metab 1986; 62: 551–6PubMedGoogle Scholar
  70. 70.
    Felsing N, Brasel J, Cooper DM. Effect of low and high intensity exercise on circulating growth hormone in men. J Clin Endocrinol Metab 1992; 75: 157–62PubMedGoogle Scholar
  71. 71.
    Viru A. Pancreatic hormones and the somatotropin-somatomedian system: hormones in muscular activity. Vol. 1. Boca Raton (FL): CRC Press, 1985: 61–75Google Scholar
  72. 72.
    Clasey JL, Weltman JY, Nass R, et al. Effect of a single bout of exercise on 4-h and 24-h growth hormone (GH) release in young and older subjects. American College of Sports Medicine 45th Annual Meeting; Orlando (FL). Med Sci Sports Exerc 1998; 30 (5 Suppl.): S107Google Scholar
  73. 73.
    Kanaley JA, Weltman JY, Veldhuis JD, et al. Human growth hormone response to repeated bouts of aerobic exercise. J Appl Physiol 1997; 83 (5): 1756–61PubMedGoogle Scholar
  74. 74.
    Kern W, Perras B, Wodick R, et al. Hormonal secretion during nighttime sleep indicating stress of daytime exercise. J Appl Physiol 1995; 79: 1461–8PubMedGoogle Scholar
  75. 75.
    Ronsen O, Haug E, Pedersen BK, et al. Increased neuroendocrine response to a repeated bout of endurance exercise. Med Sci Sports Exerc 2001; 33 (4): 568–75PubMedGoogle Scholar
  76. 76.
    Galliven EA, Singh A, Michelson D, et al. Hormonal and metabolic responses to exercise across time of day andmenstrual cycle phase. J Appl Physiol 1997; 83 (6): 1822–31PubMedGoogle Scholar
  77. 77.
    Scheen AJ, Buxton OM, Jison M, et al. Effects of exercise on neuroendocrine secretions and glucose regulation at different times of day. Am J Physiol Endocrinol Metab 1998; 274: E1040–9Google Scholar
  78. 78.
    Buxton OM, Scheen AJ, L’Hermite-Baleriaux M, et al. Highintensity exercise elicits acute alterations of glucose levels and neuroendocrine secretion that vary with circadian phase of exercise. 83rd Annual Meeting of the Endocrine Society; 2001 Jun 20–23; Denver (CO), OR22–8Google Scholar
  79. 79.
    Galassetti P, Mann S, Tate D, et al. Effect of morning exercise on counter regulatory responses to subsequent, afternoon exercise. J Appl Physiol 2001; 91: 91–9PubMedGoogle Scholar
  80. 80.
    Weltman JY, Frick K, Watson D, et al. Comparison of continuous and intermittent exercise on 24-h growth hormone secretion in obese and non-obese young men. 84th Annual Meeting of the Endocrine Society; 2002 Jun 19–22, San Fransisco (CA)Google Scholar
  81. 81.
    Weltman A, Pritzlaff CJ, Wideman L, et al. The relationship between exercise intensity and growth hormone (GH) release is attenuated in older men. Fourth International Conference of the Growth Horm Res Society; 2000 Sep 7–9, Gothenberg, SwedenGoogle Scholar
  82. 82.
    Weltman A, Anderson SM, Wideman L, et al. Impact of short term estrogen supplementation in postmenopausal women on spontaneous and exercise stimulated pulsatile growth hormone (GH) secretion. 83rd Annual Meeting of the Endocrine Society; 2001 Jun 20–23; Denver (CO), 353Google Scholar
  83. 83.
    Marcell TJ, Wiswell RA, Hawkins SA, et al. Age-related blunting of growth hormone secretion during exercise may not be solely due to increased somatostatin tone. Metabolism 1999; 48 (6): 665–70PubMedGoogle Scholar
  84. 84.
    Zaccaria M, Vanier M, Piazza P, et al. Blunted growth hormone response to maximal exercise in middle-aged versus young subjects and no effect of endurance training. J Clin Endocrinol Metab 1999; 84: 2303–7PubMedGoogle Scholar
  85. 85.
    Gusenoff JA, Harman SM, Veldhuis JD, et al. Cortisol and GH secretory dynamics and their interrelationships, in healthy aged women and men. Am J Physiol Endocrinol Metab 2001; 280: E616–25Google Scholar
  86. 86.
    Weltman A, Weltman JY, Hartman ML, et al. Relationship between age, percentage body fat, fitness, and 24-hour growth hormone release in healthy young adults: effects of gender. J Clin Endocrinol Metab 1994; 78: 543–8PubMedGoogle Scholar
  87. 87.
    Cordido F, Dieguez C, Casanueva FF. Effect of central cholinergic neurotransmission enhancement by pyridostigmine on the growth hormone secretion elicited by clonidine, arginine, or hypoglycemia in normal and obese subjects. J Clin Endocrinol Metab 1990; 70: 1361–70PubMedGoogle Scholar
  88. 88.
    Tanaka K, Inoue S, Numata K, et al. Very-low-calorie diet-induced weight reduction reverses impaired growth hormone secretion responses to growth hormone-releasing hormone, arginine and L-dopa in obesity. Metabolism 1990; 39: 892–6PubMedGoogle Scholar
  89. 89.
    Cordido F, Penalva A, Dieguez C, et al. Massive growth hormone (GH) discharge in obese subjects after the combined administration of GH-releasing hormone and GHRP-6: evidence for a marked somatotroph secretory capability in obesity. J Clin Endocrinol Metab 1993; 76: 819–23PubMedGoogle Scholar
  90. 90.
    Kelijman M, Frohman LA. Enhanced growth hormone (GH) responsiveness to GH-releasing hormone after dietary manipulation in obese and nonobese subjects. J Clin Endocrinol Metab 1988; 66: 489–94PubMedGoogle Scholar
  91. 91.
    Maccario M, Valetto MR, Savio P, et al. Maximal secretory capacity of somatotrope cells in obesity: comparison with GH deficiency. Int J Obes Relat Metab Disord 1997; 21: 27–32PubMedGoogle Scholar
  92. 92.
    Williams T, Berelowitz M, Joffe SN, et al. Impaired growth hormone responses to growth hormone-releasing factor in obesity: a pituitary defect reversed with weight reduction. N Engl J Med 1984; 311: 1403–7PubMedGoogle Scholar
  93. 93.
    Hakkinen K, Pakarinen A. Acute hormonal responses to heavy resistance exercise in men and women at different ages. Int J Sports Med 1995; 16 (8): 507–13PubMedGoogle Scholar
  94. 94.
    Kraemer WJ, Marchitelli L, Gordon SE, et al. Hormonal and growth factor responses to heavy resistance exercise protocols. J Appl Physiol 1990; 69 (4): 1442–50PubMedGoogle Scholar
  95. 95.
    Kraemer RR, Kilgore JL, Kraemer GR, et al. Growth hormone, IGF-1 and testosterone responses to resistive exercise. Med Sci Sports Exerc 1992; 24 (12): 1346–52PubMedGoogle Scholar
  96. 96.
    Kraemer WJ, Gordon SE, Fleck SJ, et al. Endogenous anabolic hormonal and growth factor responses to heavy resistance exercise in males and females. Int J Sports Med 1991; 12 (2): 228–35PubMedGoogle Scholar
  97. 97.
    Kraemer WJ, Fleck SJ, Dziados JE, et al. Changes in hormonal concentrations after different heavy-resistance exercise protocols in women. J Appl Physiol 1993; 75 (2): 594–604PubMedGoogle Scholar
  98. 98.
    Kraemer RR, Heleniak RJ, Tryniecki JL, et al. Follicular and luteal phase hormonal responses to low-volume resistive exercise. Med Sci Sports Exer 1995; 27 (6): 809–17Google Scholar
  99. 99.
    Nindl BC, Hymer WC, Deaver DR, et al. Growth hormone pulsatility profile characteristics following acute heavy resistance exercise. J Appl Physiol 2001; 91: 163–72PubMedGoogle Scholar
  100. 100.
    Raastad T, Bjoro T, Hallen J. Hormonal responses to high- and moderate-intensity strength exercise. Eur J Appl Physiol 2000; 82: 121–8PubMedGoogle Scholar
  101. 101.
    Takarada Y, Nakamura Y, Aruga S, et al. Rapid increase in plasma growth hormone after low-intensity resistance exercise with vascular occlusion. J Appl Physiol 2000; 88: 61–5PubMedGoogle Scholar
  102. 102.
    Vanhelder WP, Radomski MW, Goode RC. Growth hormone responses during intermittent weight lifting exercise in men. Eur J Appl Physiol 1984; 53: 31–4Google Scholar
  103. 103.
    Bosco C, Colli R, Bonomi R, et al. Monitoring strength training: neuromuscular and hormonal profile. Med Sci Sports Exerc 2000; 32 (1): 202–8PubMedGoogle Scholar
  104. 104.
    Mulligan SE, Fleck SJ, Gordon SE, et al. Influence of resistance exercise volume on serum growth hormone and cortisol concentrations in women. J Strength Cond Res 1996; 10 (4): 256–62Google Scholar
  105. 105.
    Chandler RM, Byrne HK, Patterson JG, et al. Dietary supplements affect the anabolic hormones after weight-training exercise. J Appl Physiol 1994; 76: 839–45PubMedGoogle Scholar
  106. 106.
    Eliakim A, Oh Y, Cooper DM. Effect of single wrist exercise on fibroblast growth factor-2, insulin-like growth factor and growth hormone. Am J Physiol Regul Integr Comp Physiol 2000; 279: R548–53Google Scholar
  107. 107.
    Kraemer WJ, Staron RS, Hagerman FC, et al. The effects of short-term resistance training on endocrine function in men and women. Eur J Appl Physiol 1998; 78: 69–76Google Scholar
  108. 108.
    Kraemer WJ, Hakkinen K, Newton RU, et al. Effects of heavy resistance training on hormonal response patterns in younger vs older men. J Appl Physiol 1999; 87 (3): 982–92PubMedGoogle Scholar
  109. 109.
    Nicklas BJ, Ryan AJ, Treuth MM, et al. Testosterone, growth hormone and IGF-1 responses to acute and chronic resistive exercise in men aged 55–70 years. Int J Sports Med 1995; 16 (7): 445–50PubMedGoogle Scholar
  110. 110.
    Pyka G, Wiswell RA, Marcus R. Age-dependent effect of resistance exercise on growth hormone secretion in people. J Clin Endocrinol Metab 1992; 75: 404–7PubMedGoogle Scholar
  111. 111.
    Kraemer WJ, Dudley GA, Tesch PA, et al. The influence of muscle action on the acute growth hormone response to resistance exercise and short-term detraining. Growth Horm IGF Res 2001; 11: 75–83PubMedGoogle Scholar
  112. 112.
    Friedmann B, Kindermann W. Energy metabolism and regulatory hormones in women and men during endurance exercise. Eur J Appl Physiol 1989; 59: 1–9Google Scholar
  113. 113.
    Luger A, Watschinger B, Deuster P, et al. Plasma growth hormone and prolactin responses to graded levels of acute exercise and to a lactate infusion. Neuroendocrinology 1992; 56: 112–7PubMedGoogle Scholar
  114. 114.
    Gray AB, Telford RD, Weidemann MJ. Endocrine response to intense interval exercise. Eur JAppl Physiol 1993; 66: 366–71Google Scholar
  115. 115.
    Weltman A, Weltman JY, Womack CJ, et al. Exercise training decreases the growth hormone (GH) response to acute constant-load exercise. Med Sci Sports Exerc 1997; 29 (5): 669–76PubMedGoogle Scholar
  116. 116.
    Hartley LH, Mason JW, Hogan RP, et al. Multiple hormonal responses to graded exercise in relation to physical training. J Appl Physiol 1972; 33: 602–6PubMedGoogle Scholar
  117. 117.
    Weltman A, Weltman JY, Schurrer R, et al. Endurance training amplifies the pulsatile release of growth hormone: effects of training intensity. J Appl Physiol 1992; 72: 2188–96PubMedGoogle Scholar
  118. 118.
    Deuschle M, Blum WF, Frystyk J, et al. Endurance training and its effect upon the activity of the GH-IGFs system in the elderly. Int J Sports Med 1998; 19 (4): 250–4PubMedGoogle Scholar
  119. 119.
    Pyka G, Taaffe DR, Marcus R. Effect of a sustained program of resistance training on the acute growth hormone response to resistance exercise in older adults. Horm Metab Res 1994; 26: 330–3PubMedGoogle Scholar
  120. 120.
    Marx JO, Ratamess NA, Nindl BC, et al. Low-volume circuit versus high-volume periodized resistance training in women. Med Sci Sports Exerc 2001; 33 (4): 635–43PubMedGoogle Scholar
  121. 121.
    McCall GE, Byrnes WC, Fleck SJ, et al. Acute and chronic hormonal responses to resistance training designed to promote muscle hypertrophy. Can J Appl Physiol 1999; 24 (1): 96–107PubMedGoogle Scholar
  122. 122.
    Mero A, Pitkanen H, Oja SS, et al. Leucine supplementation and serum amino acids, testosterone, cortisol and growth hormone in male power athletes during training. J Sports Med Phys Fitness 1997; 37: 137–45PubMedGoogle Scholar
  123. 123.
    Staron RS, Karapondo DL, Kraemer WJ, et al. Skeletal muscle adaptations during early phase of heavy-resistance training in men and women. J Appl Physiol 1994; 76 (3): 1247–55PubMedGoogle Scholar
  124. 124.
    Hurley RS, Bossetti BM, O’Dorisio TM, et al. The response of serum growth hormone and prolactin to training in weight maintaining healthy males. J Sports Med Phys Fitness 1990; 30: 45–8PubMedGoogle Scholar
  125. 125.
    American Medicine College of Sports Medicine. ACSM’s guidelines for exercise testing and prescription. 6th ed. Baltimore (MD): Lippincott Williams & Wilkins, 2000Google Scholar
  126. 126.
    Bell GJ, Syrotuik D, Martin TP, et al. Effect of concurrent strength and endurance training on skeletal muscle properties and hormone concentrations in humans. Eur J Appl Physiol 2000; 81: 418–27PubMedGoogle Scholar
  127. 127.
    Hakkinen K, Pakarinen A, Kraemer WJ, et al. Basal concentrations and acute responses of serum hormones and strength development during heavy resistance training in middle-aged and elderly men and women. J Gerontol A Biol Sci Med Sci 2000; 55A (2): B95-B105Google Scholar
  128. 128.
    Häkkinen K, Kraemer WJ, Pakarinen A, et al. Effects of heavy resistance/power training on maximal strength, muscle morphology and hormonal response patterns in 60–75-year-old men and women. Can J Appl Physiol 2002; 27 (3): 213–31PubMedGoogle Scholar
  129. 129.
    Weltman A, Pritzlaff CJ, Wideman L, et al. Exercise-dependent growth hormone release is linked to markers of heightened central adrenergic outflow. J Appl Physiol 2000; 89: 629–35PubMedGoogle Scholar
  130. 130.
    Thompson DL, Weltman JY, Rogol AD, et al. Cholinergic and opioid involvement in release of growth hormone during exercise and recovery. J Appl Physiol 1993; 75: 870–8PubMedGoogle Scholar
  131. 131.
    Dall R, Kanaley J, Hansen TK, et al. Plasma ghrelin levels during exercise in healthy subjects and in growth hormone deficient patients. Eur J Endocrinol 2002; 147 (1): 65–70PubMedGoogle Scholar
  132. 132.
    Goodman HM. Growth hormone and metabolism. In: Schreibman MP, Scanes CG, Pang TP, editors. The endocrinology of growth, development and metabolism in vertebrates. San Diego (CA): Academic Press, 1993: 93–115Google Scholar
  133. 133.
    Roupas P, Heringont AC. Cellular mechanisms in the processing of growth hormone and its receptor. Mol Cell Endocrinol 1989; 61: 1–12PubMedGoogle Scholar
  134. 134.
    Kopchick JJ, Bellush LL, Coschigano KT. Transgenic models of growth hormone action. Ann Rev Nutr 1999; 19: 437–61Google Scholar
  135. 135.
    Waxman DJ. Interactions of hepatic cytochrome P-450 with steroid hormones: regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P-450 enzyme expression. Biochem Pharmacol 1988; 37: 71–84PubMedGoogle Scholar
  136. 136.
    Waxman DJ, Pampori NA, Ram PA, et al. Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450. Proc Nat Acad Sci U S A 1991; 88: 6868–72Google Scholar
  137. 137.
    Waxman DJ, Chang TKH. Hormonal regulation of liver cytochrome P450 enzymes. In: Ortiz de Montellano PR, editor. Cytochrome P450: structure, mechanism and biochemistry. New York: Plenum Press, 1995: 319–417Google Scholar

Copyright information

© Adis International Limited 2002

Authors and Affiliations

  • Laurie Wideman
    • 1
  • Judy Y. Weltman
    • 2
  • Mark L. Hartman
    • 3
  • Johannes D. Veldhuis
    • 2
  • Arthur Weltman
    • 2
    • 4
  1. 1.Department of Exercise and Sport ScienceUniversity of North Carolina at GreensboroGreensboroUSA
  2. 2.Department of Medicine, General Clinical Research CenterUniversity of VirginiaCharlottesvilleUSA
  3. 3.Lilly Research LaboratoriesEli Lilly and CompanyIndianapolisUSA
  4. 4.Department of Human ServicesUniversity of VirginiaCharlottesvilleUSA

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