Sports Medicine

, Volume 29, Issue 4, pp 221–227 | Cite as

Estrogen and Substrate Metabolism

A Review of Contradictory Research
  • Candi D. Ashley
  • Marianne Leverone Kramer
  • Phillip Bishop
Leading Article

Abstract

The increasing number of females participating in physical activity has heightened our awareness of changes in the menstrual cycle which often accompany physical activity. As such, there has been a considerable amount of research investigating the relationships between menstrual cycle changes and bone mineral density, performance, ventilation and substrate metabolism. A number of researchers have concluded that there may be enhanced fat metabolism in eumenorrhoeic versus amenorrhoeic females, or in the follicular phase versus the luteal phase of the menstrual cycle, due to the theoretical estrogen level in eumenorrhoeic versus amenorrhoeic females or the luteal phase versus the follicular phase. However, a definite relationship between resting estrogen level and substrate metabolism has not been clearly established. In addition, the mechanisms which may be responsible for the effect of estrogen on substrate metabolism have not been addressed. It appears that the effects of estrogen on metabolism may be via the effect of estrogen on glucogenic hormones or lipolytic enzymes. Therefore, the primary purpose of this review is to explore the effects of estrogen on substrate metabolism. Menstrual cycle physiology and possible mechanisms for the effects of estrogen on metabolism, as well as previous research on estrogen and metabolism in rats and humans, will be discussed.

References

  1. 1.
    Hackney AC, McCracken-Compton MA, Ainsworth B. Substrate responses to submaximal exercise in the midfollicular and midluteal phases of the menstrual cycle. Int J Sport Nutr 1994; 4: 299–308PubMedGoogle Scholar
  2. 2.
    Kendrick ZV, Steffen CA, Rumsey WL, et al. Effect of estradiol on tissue glycogen metabolism in exercised oopherectomized rats. J Appl Physiol 1987; 63 (2): 492–6PubMedGoogle Scholar
  3. 3.
    Loucks AB, Mortola JF, Girton L, et al. Alterations in the hypothalamic-pituitary-ovarian and the hypotholamic-pituitary-adrenal axes in athletic women. J Clin Endocrinol Metab 1989; 68 (2): 402–11PubMedCrossRefGoogle Scholar
  4. 4.
    Mandour T, Kissebah AH, Wynn V. Mechanism of oestrogen and progesterone effects on lipid and carbohydrate metabolism: Alteration in the insulin: glucagon molar ratio and hepatic enzyme activity. Eur J Clin Invest 1977; 7: 181–7PubMedCrossRefGoogle Scholar
  5. 5.
    Mature ML, Kalkhoff RK. Sex steroid influence on hepatic gluconeogenesis and glycogen formation. Endocrinology 1973; 92: 762–8CrossRefGoogle Scholar
  6. 6.
    Nicklas BJ, Hackney AC, Sharp RL. The menstrual cycle and exercise: performance, muscle glycogen, and substrate responses. Int J Sports Med 1989; 10: 264–9PubMedCrossRefGoogle Scholar
  7. 7.
    Puhl JL, Brown CH, editors. The menstrual cycle and physical activity. Champaign (IL): Human Kinetics, 1986Google Scholar
  8. 8.
    Wells CL, editor. Women, sport and performance: a physiological perspective. Champaign (IL): Human Kinetics, 1991Google Scholar
  9. 9.
    Bunt J. Metabolic actions of estradiol: significance for acute and chronic exercise responses. Med Sci Sports Exerc 1990; 22: 286–90PubMedGoogle Scholar
  10. 10.
    Reinke U, Ansah B, Voigt KD. Effect of the menstrual cycle on carbohydrate and lipid metabolism in normal females. Acta Endocrinol 1972; 69: 762–8PubMedGoogle Scholar
  11. 11.
    Lebech AM, Kjer A. Lipid metabolism and coagulation during the normal menstrual cycle. Horm Metab Res 1989; 21: 445–8PubMedCrossRefGoogle Scholar
  12. 12.
    Hemer HA, de Bourges VV, Ayala JJ, et al. Variations in serum lipids and lipoproteins throughout the menstrual cycle. Fertil Steril 1985; 44: 80–4Google Scholar
  13. 13.
    Berend J, Brammeier M, Jones N, et al. Effect of the menstrual cycle phase and diet on blood lactate responses to exercise. Biol Sport 1994; 11: 241–8Google Scholar
  14. 14.
    McCracken M, Ainsworth B, Hackney A. Effects of the menstrual cycle phase on the blood lactate responses to exercise. Eur J Appl Physiol 1994; 69: 174–5CrossRefGoogle Scholar
  15. 15.
    Hackney AC. Effects of the menstrual cycle on resting muscle glycogen content. Horm Metab Res 1990; 22: 647PubMedCrossRefGoogle Scholar
  16. 16.
    Hatta H, Atomi Y, Shinohara S, et al. The effects of ovarian hormones on glucose and fatty acid oxidation during exercise in female ovariectomized rats. Horn Metab Res 1988; 20: 609–11CrossRefGoogle Scholar
  17. 17.
    Jurkowski-Hall JE, Jones NL, Toews CJ, et al. Effects of menstrual cycle on blood lactate, O2 delivery, and performance during exercise. J Appl Physiol 1981; 51: 1493–9Google Scholar
  18. 18.
    Bonen A, Haynes F, Watson-Wright W, et al. Effects of menstrual cycle on metabolic responses to exercise. J Appl Physiol 1983; 55: 1506–13PubMedGoogle Scholar
  19. 19.
    Coyle EF, Coggan AR, Hemmert MK, et al. Muscle glycogen utilization during prolonged strenuous exercise when fed carbohydrate. J Appl Physiol 1986; 61: 165–72PubMedGoogle Scholar
  20. 20.
    Dombovy ML, Bonekat HW, Williams TJ, et al. Exercise performance and ventilatory response in the menstrual cycle. Med Sci Sports Exerc 1987; 19: 111–7PubMedGoogle Scholar
  21. 21.
    Hackney AC, Curley CS, Nicklas BJ. Physiological responses to submaximal exercise at the mid-follicular, ovulatory and mid-luteal phases of the menstrual cycle. Scand J Med Sci Sports 1991; 1: 94–8CrossRefGoogle Scholar
  22. 22.
    DeSouza MJ, Maguire MS, Rubin KR, et al. Effects of menstrual phase and amenorrhea on exercise performance in runners. Med Sci Sports Exerc 1990; 22: 575–80CrossRefGoogle Scholar
  23. 23.
    Kanaley JA, Boileau RA, Bahr JA, et al. Substrate oxidation and GH responses to exercise are independent of menstrual phase and status. Med Sci Sports Exerc 1992; 24: 873–80PubMedGoogle Scholar
  24. 24.
    Wilmore JH, Wambsgans KC, Brenner M, et al. Is there energy conservation in amenorrheic compared with eumenorrheic runners? J Appl Physiol 1992; 72 (1): 15–22PubMedGoogle Scholar
  25. 25.
    Lamon-Fava S, Fisher EC, Nelson ME, et al. Effect of exercise and menstrual cycle status on plasma lipids, low density lipoprotein particle size, and apolipoproteins. J Clin Endocrinol Metab 1989; 68 (1): 17–21PubMedCrossRefGoogle Scholar
  26. 26.
    Schaefer EJ, Foster DM, Zech LA, et al. The effects of estrogen administration on plasma lipoprotein metabolism in premenopausal females. J Clin Endocrin Metab 1983; 57 (2): 262–7CrossRefGoogle Scholar
  27. 27.
    Hamosh M, Hamosh P. The effect of estrogen on the lipoprotein lipase activity of rat adipose tissue. J Clin Invest 1975; 55: 1132–5PubMedCrossRefGoogle Scholar
  28. 28.
    Lavoie JM, Dionne N, Helie R, et al. Menstrual cycle phase dissociation of blood glucose homeostasis during exercise. J Appl Physiol 1987; 62 (3): 1084–9PubMedCrossRefGoogle Scholar
  29. 29.
    Thompson DL, Snead DB, Seip RL, et al. Serum lipid levels and steroidal hormones in women runners with irregular menses. Can J Appl Physiol 1997; 22: 66–77PubMedCrossRefGoogle Scholar
  30. 30.
    Schaefer EJ, Lamon-Fava S, Spiegelman D, et al. Changes in plasma lipoprotein concentrations and composition in response to a low-fat, high-fiber diet are associated with changes in serum estrogen concentrations in premenopausal women. Metabolism 1995; 44: 749–56PubMedCrossRefGoogle Scholar
  31. 31.
    Durstine JL, Haskell WL. Effects of exercise training on plasma lipids and lipoproteins. Exerc Sport Sci Rev 1994; 22: 477–521PubMedGoogle Scholar
  32. 32.
    Bemben D, Bolilea R, Bahr J, et al. Effects of oral contraceptives on hormonal and metabolic responses during exercise. Med Sci Sports Exerc 1992; 24: 434–41PubMedGoogle Scholar
  33. 33.
    Bonen A, Haynes F, Graham T. Substrate and hormonal responses to exercise in women using oral contraceptives. J Appl Physiol 1991; 70: 1917–27PubMedGoogle Scholar
  34. 34.
    Briggs M, Briggs M. Oral contraception. Montreal (QC): Eden Press, 1977Google Scholar
  35. 35.
    Heritage AS, Stumpf WE, Sar M, et al. Brainstem catecholamine neurons are target sites for sex steroid hormones. Science 1980; 207: 1377–9PubMedGoogle Scholar
  36. 36.
    Friend KE, Hartman ML, Pezzoli SS, et al. Both oral and transdermal estrogen increase growth hormone release in postmenopausal women: a clinical research center study. J Clin Endocrinol Metab 1996; 81: 2250–6PubMedCrossRefGoogle Scholar
  37. 37.
    Kahn CR, Goldfine ED, Neville DM, et al. Alterations in insulin binding induced by changes in vivo in the levels of glucocorticoids and GH. Endocrinology 1978; 103: 1054–66PubMedCrossRefGoogle Scholar
  38. 38.
    Heiling VJ, Jensen MD. Free fatty acid metabolism in the follicular and luteal phases of the menstrual cycle. J Clin Endocrinol Metab 1992; 74: 806–10PubMedCrossRefGoogle Scholar
  39. 39.
    Chin NW, Frank MD, Dodds WG, et al. Acute effects of exercise on plasma catecholamines in sedentary and athletic women with normal and abnormal menses. Am J Obstet Gynecol 1987; 157: 938–44PubMedGoogle Scholar
  40. 40.
    Sladek C. Gluconeogenesis and hepatic glycogen formation in relation to the rat estrous cycle. Horm Metab Res 1974; 6: 217–21PubMedCrossRefGoogle Scholar
  41. 41.
    Brinkley HJ. Endocrine signaling and female reproduction. Biol Reprod 1981; 24: 22–43PubMedCrossRefGoogle Scholar
  42. 42.
    Tate C, Holtz RW. Gender and fat metabolism. Can J Appl Physiol 1998; 23: 570–82PubMedCrossRefGoogle Scholar
  43. 43.
    Pirke KM, Schweiger U, Lemmel W, et al. The influence of dieting on the menstrual cycle of healthy young women. J Clin Endocrinol Metab 1985; 60: 1174–9PubMedCrossRefGoogle Scholar
  44. 44.
    Brownell KD, Rodin J, Wilmore JH, editors. Eating, body weight, and performance in athletes. Philadelphia (PA): Lea & Febiger, 1992Google Scholar
  45. 45.
    Klimis-Tavantzis DJ, Wolinsky I. Nutrition, cardiovascular disease, and women. In: Klimis-Tavantzis DJ, Wolinsky I, editors. Nutritional concerns of women. Boca Raton (FL): CRC Press, 1996: 135–50Google Scholar
  46. 46.
    Sutton JR. Hormonal and metabolic responses to exercise in subjects of high and low work capacities. Med Sci Sports Exerc 1978; 10: 1–11Google Scholar

Copyright information

© Adis International Limited 2000

Authors and Affiliations

  • Candi D. Ashley
    • 1
  • Marianne Leverone Kramer
    • 2
  • Phillip Bishop
    • 3
  1. 1.School of Physical Education, Wellness, and Sports StudiesUniversity of South FloridaTampaUSA
  2. 2.Department of BiochemistryEast Tennessee State UniversityJohnson CityUSA
  3. 3.College of EducationThe University of AlabamaTuscaloosaUSA

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