Sports Medicine

, Volume 18, Issue 4, pp 229–248 | Cite as

Evaluation of the Ergogenic Properties of Ginseng

  • Michael S. Bahrke
  • William P. Morgan
Review Article

Summary

Ginseng has been used for several thousand years in the Orient as a tonic, prophylactic agent and ‘restorative’. However, its efficacy has been established primarily through clinical experience as opposed to scientific verification of its pharmacological effects. Ginseng has been used by athletes as an ergogenic aid for many years, but there is an absence of compelling research evidence in support of its use for this purpose. Indeed, most of the support favouring the use of ginseng to enhance physical performance is of a testimonial nature. While studies with animals show that ginseng or its active components may prolong survival to physical or chemical stress, there is, generally, a lack of controlled research demonstrating the ability of ginseng to improve or prolong performance in fatigued humans.

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References

  1. 1.
    Goldstein B. Ginseng: its history, dispersion, and folk tradition. Am J Chin Med 1975; 3(3): 223–34PubMedCrossRefGoogle Scholar
  2. 2.
    Hu SY. A contribution to our knowledge of ginseng. Am J Chin Med 1977; 5(1): 1–23PubMedCrossRefGoogle Scholar
  3. 3.
    Liu C-X, Xiao P-G. Recent advances on ginseng research in China. J Ethnopharmacol 1992; 36: 27–38PubMedCrossRefGoogle Scholar
  4. 4.
    Brekhman II, Dardymov IV. New substances of plant origin which increase nonspecific resistance. Annu Rev Pharmacol 1969; 9: 419–30PubMedCrossRefGoogle Scholar
  5. 5.
    Cartwright L. Ginseng in pharmacies. Aust J Pharm 1979; 60: 346–9Google Scholar
  6. 6.
    Hu S. Y. The genus Panax (ginseng) in Chinese medicine. Econ Botany 1976; 30: 11–28CrossRefGoogle Scholar
  7. 7.
    Li CP, Li RC. An introductory note to ginseng. Am J Chin Med 1973; 1(2): 249–61PubMedCrossRefGoogle Scholar
  8. 8.
    Perry LM, Metzger J. Medicinal plants of East and Southeast Asia: attributed properties and uses. Cambridge: MIT Press, 1980Google Scholar
  9. 9.
    Baranov A. Recent advances in our knowledge of the morphology, cultivation and uses of ginseng (Panax ginseng C.A. Meyer). Economic Botany 1966; 20: 403–6CrossRefGoogle Scholar
  10. 10.
    Bitties AH, Fulder SJ, Grant EC, et al. The effect of ginseng on lifespan and stress responses in mice. Gerontology 1979; 25: 125–31CrossRefGoogle Scholar
  11. 11.
    Popov IM, Goldwag WJ. A review of the properties and clinical effects of ginseng. Am J Chin Med 1973; 1(2): 263–70PubMedCrossRefGoogle Scholar
  12. 12.
    Liberti LE, Der Marderosian A. Evaluation of commercial ginseng products. J Pharm Sci 1978; 67(10): 1487–9PubMedCrossRefGoogle Scholar
  13. 13.
    Wood HC, La Wall CH, Youngken HW, et al. The dispensatory of the United States of America. Centennial (22nd) ed. Philadelphia: JB Lippincott Co, 1937: 1393Google Scholar
  14. 14.
    Siegel RK. Ginseng abuse syndrome: problems with the panacea. JAMA 1979; 241(15): 1614–5PubMedCrossRefGoogle Scholar
  15. 15.
    Phillipson JD, Anderson LA. Ginseng — quality, safety, and efficacy? Pharmaceut J 1984; 232: 161–5Google Scholar
  16. 16.
    Chong SKF, Oberholzer VG. Ginseng — is there a use in clinical medicine? Postgrad Med J 1988; 64: 841–6PubMedCrossRefGoogle Scholar
  17. 17.
    Editorial. Weekly Pharmacy Report 1977; 35: 1Google Scholar
  18. 18.
    Yamaguchi H, Matsuura H, Kasai R, et al. Analysis of saponins of wild Panax ginseng. Chem Pharm Bull 1988; 36(10): 4177–81PubMedCrossRefGoogle Scholar
  19. 19.
    Dorling E, Kirchdorfer AM, Ruckert KH. Do ginsenosides influence the performance? Notabene Med 1980; 10(5): 241–6Google Scholar
  20. 20.
    Forgo I. Doping control of top-ranking athletes after a 14-day treatment with Ginsana. Report dated February 13. Delray Beach: Ginsana USA Corporation; 1980Google Scholar
  21. 21.
    Forgo I. Effect of drugs on physical performance and hormone system of sportsmen. Meunchener Med Wochenschrift 1983; 125(38): 822–4Google Scholar
  22. 22.
    Forgo I, Kirchdorfer AM. On the question of influencing the performance of top sportsmen by means of biologically active substances. Ärtl Praxis 1981; 33(44): 1784–6Google Scholar
  23. 23.
    Forgo I, Kirchdorfer AM. The effect of different ginsenoside concentrations on physical work capacity. Notabene Med 1982; 12(9): 721–7Google Scholar
  24. 24.
    Forgo I, Schimert G. The duration of effect of the standardized ginseng extract G115 in healthy competitive athletes. Notabene Med 1985; 15(9): 636–40Google Scholar
  25. 25.
    Pietta P, Mauri P, Rava A. Improved high-performance liquid chromatographic method for the analysis of ginsenosides in Panax ginseng extracts and products. J Chromatogr 1986; 356: 212–9PubMedCrossRefGoogle Scholar
  26. 26.
    Soldati F, Sticher O. HPLC separation and quantitative determination of ginsenosides from Panax ginseng, Panax quinquefolium and from ginseng drug preparations. Planta Med 1980; 38: 348–57CrossRefGoogle Scholar
  27. 27.
    Barna P. Food or drug? The case of ginseng [letter]. Lancet 1985; 2: 548PubMedCrossRefGoogle Scholar
  28. 28.
    Court WE. Ginseng — a Chinese folk medicine of current interest. Pharm J 1975; 214: 180–1Google Scholar
  29. 29.
    Williams LO. Ginseng. Econ Botany 1957; 11: 344–8CrossRefGoogle Scholar
  30. 30.
    Baranov AI. Medicinal uses of ginseng and related plants in the Soviet Union: recent trends in the Soviet literature. J Ethnopharmacol 1982; 6: 339–53PubMedCrossRefGoogle Scholar
  31. 31.
    Brekhman II. Eleutherococcus senticosus — a new medicinal herb of the araliaceae family. In: Chen KK, Mukerji B, editors. Pharmacology of oriental plants. New York: Macmillan Company, 1965Google Scholar
  32. 32.
    Hou JP. The chemical constituents of ginseng plants. Comparat Med East West 1977; 5(2): 123–45Google Scholar
  33. 33.
    Iwabuchi H, Yoshikura M, Ikawa Y, et al. Studies on the sesquiterpenoids of Panax ginseng C.A. Meyer. Isolation and structure determination of sesquiterpene alcohols, panasinsanols A and B. Chem Pharm Bull 1987; 35(5): 1975–81PubMedCrossRefGoogle Scholar
  34. 34.
    Iwabuchi H, Yoshikura M, Kamisako W. Studies on the sesquiterpenoids of Panax ginseng C.A. Meyer. II: isolation and structure determination of ginsenol, a novel sesquiterpene alcohol. Chem Pharm Bull 1988; 36(7): 2447–51PubMedCrossRefGoogle Scholar
  35. 35.
    Kasai R, Yamaguchi H, Tanaka O. High-performance liquid chromatography of glycosides on a new type of hydroxyapatite column. J Chromatogr 1987; 407: 205–10PubMedCrossRefGoogle Scholar
  36. 36.
    Shibata S, Fujita M, Itokawa H, et al. Studies on the constituents of Japanese and Chinese crude drugs. XI: panaxadiol, a sapogenin of ginseng roots. Chem Pharm Bull 1963; 11(6): 759–761PubMedCrossRefGoogle Scholar
  37. 37.
    Tanaka O, Nagai M, Shibata S. Chemical studies on the Oriental plant drugs. XVI: the stereochemistry of protopanaxadiol, a genuine sapogenin of ginseng. Chem Pharm Bull 1966; 14(10): 1150–6PubMedCrossRefGoogle Scholar
  38. 38.
    Yamaguchi H, Kasai R, Matsuura H, et al. High-performance liquid chromatographic analysis of acidic saponins of ginseng and related plants. Chem Pharm Bull 1988; 36(9): 3468–73PubMedCrossRefGoogle Scholar
  39. 39.
    Iida Y, Tanaka O, Shibata S. Studies on saponins of ginseng: the structure of ginsenoside-Rg1. Tetrahedron Lett 1968; 52: 5449–53CrossRefGoogle Scholar
  40. 40.
    Shibata S, Tanaka O, Soma K, et al. Studies on saponins and sapogenins of ginseng: the structure of panaxatriol. Tetrahedron Lett 3: 207–13Google Scholar
  41. 41.
    Besso H, Kasai R, Wei J, et al. Further studies on dammarane-saponins of American ginseng, roots of Panax quinquefolium L. Chem Pharm Bull 1982; 30(12): 4534–8CrossRefGoogle Scholar
  42. 42.
    Elyakov GB, Strigina LI, Uvarova NI, et al. Glycosides from ginseng roots. Tetrahedron Lett 1964; 48: 3591–7CrossRefGoogle Scholar
  43. 43.
    Petkov VD, Yinglin C, Todorov I, et al. Behavioral effects of stem-leaves extract from Panax ginseng C.A. Meyer. Acta Physiol Pharmacol Bulg 1992; 18(2): 41–8PubMedGoogle Scholar
  44. 44.
    Matsuda H, Namba K, Fukuda S, et al. Pharmacological study on Panax Ginseng C.A. Meyer. III: effects of red ginseng on experimental disseminated intravascular coagulation. (2). Effects of ginsenosides on blood coagulative and fibrinolytic systems. Chem Pharm Bull 1986; 34(3): 1153–7PubMedCrossRefGoogle Scholar
  45. 45.
    Staba EJ. Ginseng [letter]. Lancet 1985; 2(8467): 1309–10PubMedGoogle Scholar
  46. 46.
    Odani T, Tanizawa H, Takino Y. Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. II: the absorption, distribution and excretion of ginsenoside Rg1 in the rat. Chem Pharm Bull 1983; 31(1): 292–8PubMedCrossRefGoogle Scholar
  47. 47.
    Takino Y, Tanizawa H, Odani T. Studies of the absorption, distribution, excretion and metabolism of genoside Rg1 and Rb1in rats. In: Proceedings of the 4th International Ginseng Symposium. Seoul: Korean Ginseng Research Institute, 1984Google Scholar
  48. 48.
    Karikura M, Tanizawa H, Hirata T, et al. Studies on absorption, distribution, excretion and metabolism of ginseng saponins, VIII: isotope labeling of ginsenoside Rb2. Chem Pharmaceut Bull 1992; 40(9): 2458–60CrossRefGoogle Scholar
  49. 49.
    Cui J, Garle M, Eneroth P, et al. What do commercial ginseng preparations contain? [letter]. Lancet 1994; 344(8915): 134PubMedCrossRefGoogle Scholar
  50. 50.
    Fulder SJ. Ginseng and the hypothalamic-pituitary control of stress. Am J Chin Med 1981; 9(2): 112–8PubMedCrossRefGoogle Scholar
  51. 51.
    Nabata H, Saito H, Takagi K. Pharmacological studies of neutral saponins (GNS) of Panax ginseng root. Jpn J Pharmacol 1973; 23: 29–41PubMedCrossRefGoogle Scholar
  52. 52.
    Petkov V. Über den Wirkungsmechanimus der Panax Ginseng C.A. Meyer. Arzneim Forsch 1961; 11(3): 288–96Google Scholar
  53. 53.
    Takagi K, Saito H, Nabata H. Pharmacological studies of Panax ginseng root: estimation of pharmacological actions of Panax ginseng root. Jpn J Pharmacol 1972; 22: 245–59PubMedCrossRefGoogle Scholar
  54. 54.
    Takagi K, Saito H, Tsuchiya M. Pharmacological studies of Panax ginseng root: pharmacological properties of a crude saponin fraction. Jpn J Pharmacol 1972; 22: 339–46PubMedCrossRefGoogle Scholar
  55. 55.
    Takagi K, Saito H, Tsuchiya M. Effect of Panax ginseng root on spontaneous movement and exercise in mice. Jpn J Pharmacol 1974; 24: 41–8PubMedCrossRefGoogle Scholar
  56. 56.
    Petkov V. Effect of ginseng on the brain biogenic monoamines and 3′,5′-AMP system. Arzneim Forsch 1978; 28(1): 388–93Google Scholar
  57. 57.
    Hiai G, Sasaki S, Oura H. Effect of ginseng saponin on rat adrenal cyclic AMP. Planta Med 1979; 37: 15–9PubMedCrossRefGoogle Scholar
  58. 58.
    Brekhman II, Dardymov IV. Proceedings of the Pacific Scientific Congress 1966; 8: 11Google Scholar
  59. 59.
    Brekhman II, Dardymov IV. Pharmacological investigation of glycosides from ginseng and eleutherococcus. Lloydia 1969; 32: 46–51PubMedGoogle Scholar
  60. 60.
    Kim C, Kim CC, Kim MS, et al. Influence of ginseng on the stress mechanism. Lloydia 1970; 33: 43–8PubMedGoogle Scholar
  61. 61.
    Petkov V, Staneva-Stoicheva D. The effect of an extract of ginseng on the adrenal cortex. In: Chen KK, Mukerji B, editors. Pharmacology of oriential plants. New York: Macmillan Company, 1965Google Scholar
  62. 62.
    Hiai S, Sasayama Y, Oguro C. Chronic effects of ginseng saponin, glycyrrhizin and flavin adenine dinucleotide on adrenal and thymus weight in normal and dexamethasone-treated rats. Chem Pharm Bull 1097; 35(1): 241–8CrossRefGoogle Scholar
  63. 63.
    Sugaya A, Yuzurihara M, Tsuda T, et al. Proliferative effect of ginseng saponin on neurite extension of primary cultured neurons of the rat cerebral cortex. J Ethnopharmacol 1988; 22: 173–81PubMedCrossRefGoogle Scholar
  64. 64.
    Himi T, Saito H, Nishiyama N. Effect of ginseng saponins on the survival of cerebral cortex neurons in cell cultures. Chem Pharm Bull 1989; 37(2): 481–4PubMedCrossRefGoogle Scholar
  65. 65.
    Takeda A, Yonezawa M, Katoh N. Restoration of radiation injury by ginseng. I: responses of X-irradiated mice to ginseng extract. J Radiat Res 1981; 22: 323–35PubMedCrossRefGoogle Scholar
  66. 66.
    Takeda A, Katoh N, Yonezawa M. Restoration of radiation injury by ginseng. III: radioprotective effect of thermostable fraction of ginseng extract on mice, rats and guinea pigs. J Radiat Res 1982; 23: 150–67PubMedCrossRefGoogle Scholar
  67. 67.
    Yonezawa M. Restoration of radiation injury by intraperitoneal injection of ginseng extract in mice. J Radiat Res 1976; 17: 111–3PubMedCrossRefGoogle Scholar
  68. 68.
    Yonezawa M, Katoh N, Takeda A. Restoration of radiation injury by ginseng. II: some properties of the radioprotective substances. J Radiat Res 1981; 22: 336–43PubMedCrossRefGoogle Scholar
  69. 69.
    Yonezawa M, Katoh N, Takeda A. Restoration of radiation injury by ginseng. IV: stimulation of recoveries in CFUs and megakaryocyte counts related to the prevention of occult blood appearance in X-irradiated mice. J Radiat Res 1985; 26: 436–42PubMedCrossRefGoogle Scholar
  70. 70.
    Zhang J-S, Sigdestad CP, Gemmell MA, et al. Modification of radiation response in mice by fractionated extracts of Panax ginseng. Radiat Res 1987; 112: 156–63PubMedCrossRefGoogle Scholar
  71. 71.
    Hallstrom C, Fulder S, Carruthers M. Effects of ginseng on the performance of nurses on night duty. Comparat Med East West 1982; 6(4): 277–82Google Scholar
  72. 72.
    Forgo I, Kayasseh L, Staub JJ. Einfluss eines standardisierten Ginseng-Extraktes auf das Allgemeinbefinden, die Reaktionsfähigkeit, Lungenfunktion und die gonadalen Hormone. Med Welt 1981; 32(19): 751–6PubMedGoogle Scholar
  73. 73.
    von Ardenne M, Klemm W. Measurements of the increase in the difference between the arterial and venous Hb-O2 saturation obtained with daily administration of 200mg standardized ginseng extract Gl 15 for four weeks. Panminerva Med 1987; 29: 143–50Google Scholar
  74. 74.
    Wiklund I, Karlberg J, Lund B. A double-blind comparison of the effect on quality of life of a combination of vital substances including standardized ginseng G115 and placebo. Curr Ther Res 1994; 55(1): 32–42CrossRefGoogle Scholar
  75. 75.
    Jenny E. On the cardiovascular action of the standardized ginseng extract G115 and pure ginsenosides. Report dated September 29. Delray Beach: Ginsana USA Corporation, 1982Google Scholar
  76. 76.
    Lee DC, Lee MO, Kim CY, et al. Effect of ether, ethanol and aqueous extracts of ginseng on cardiovascular functions in dogs. Can J Comparat Med 1981; 45: 182–7Google Scholar
  77. 77.
    Lei X-L, Chiou GCY. Cardiovascular pharmacology of Panax Notoginseng (Burk) F.H. Chen and Salvia miltiorrhiza. Am J Chin Med 1986; 14(3 & 4): 145–52PubMedCrossRefGoogle Scholar
  78. 78.
    Wood WB, Roh BL, White RP. Cardiovascular actions of Panax ginseng in dogs. Jpn J Pharmacol 1964; 14: 284–94PubMedCrossRefGoogle Scholar
  79. 79.
    Kimura Y, Okuda H, Arichi S. Effects of various ginseng saponins on 5-hydroxytryptamine release and aggregation in human platelets. J Pharm Pharmacol 1988; 40: 838–43PubMedCrossRefGoogle Scholar
  80. 80.
    Matsuda H, Namba K, Fukuda S, et al. Pharmacological study on Panax Ginseng C.A. Meyer. IV. Effects of red ginseng on experimental disseminated intravascular coagulation. (3). Effect of ginsenoside-Ro on the blood coagulative and fibrinolytic system. Chem Pharm Bull 1986; 34(5): 2100–4PubMedCrossRefGoogle Scholar
  81. 81.
    Matsuda H, Samukawa K, Fukuda S, et al. Studies on Panax japonicus fibrinolysis. Planta Med 1989; 55: 18–21PubMedCrossRefGoogle Scholar
  82. 82.
    Teng C-M, Kuo S-C, Ko F-N, et al. Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng. Biochim Biophys Acta 1989; 990: 315–20PubMedCrossRefGoogle Scholar
  83. 83.
    Lasarova MB, Mosharrof AH, Petkov VD, et al. Effect of Piracetam and of standardized ginseng extract on the electroconvulsive shock-induced memory disturbances in ‘step-down’ passive avoidance. Acta Physiol Pharmacol Bulg 1987; 13(2): 11–7PubMedGoogle Scholar
  84. 84.
    Petkov VD, Mosharrof AH. Effects of standardized ginseng extract on learning, memory and physical capabilities. Am J Chin Med 1987; 15(1 and 2): 19–29PubMedCrossRefGoogle Scholar
  85. 85.
    Petlov VD, Kehayov R, Belcheva S, et al. Memory effects of standardized extracts of Panax ginseng (G115), Ginkgo biloba(GK501) and their combination (PHL-00701). Planta Med 1993; 59: 106–14CrossRefGoogle Scholar
  86. 86.
    Saito H, Tsuchiya M, Naka S, et al. Effects of Panax ginseng root on conditioned avoidance response in rats. Jpn J Pharmacol 1977; 27: 509–16PubMedCrossRefGoogle Scholar
  87. 87.
    Yoshimura H, Watanabe K, Ogawa N. Psychotropic effects of ginseng saponins on agonistic behaviour between resident and intruder mice. Eur J Pharmacol 1988; 146: 291–7PubMedCrossRefGoogle Scholar
  88. 88.
    Yoshimura H, Watanabe K, Ogawa N. Acute and chronic effects of ginseng saponins on maternal aggression in mice. Eur J Pharmacol 1988; 150: 319–24PubMedCrossRefGoogle Scholar
  89. 89.
    Bhattacharya SK, Mitra SK. Anxiolytic activity of Panax ginseng roots: an experimental study. J Ethnopharmacol 1991; 34: 87–92PubMedCrossRefGoogle Scholar
  90. 90.
    D’Angelo L, Grimaldi R, Caravaggi M, et al. A double-blind, placebo controlled clinical study on the effect of a standardized ginseng extract on psychomotor performance in healthy volunteers. J Ethnopharmacol 1986; 16: 15–22PubMedCrossRefGoogle Scholar
  91. 91.
    Sandberg F. Vitalitet och senilitet — effekten av ginsengglykosi-der pa prestationsformagan. Svensk Farmaceut Tidskrift 1980; 84(13): 499–502Google Scholar
  92. 92.
    Filaretov AA, Bogdanova TS, Podvigina TT, et al. Role of pi-tuitary-adrenocortical system in body adaptation abilities. Exper Clin Endocrinol 1988; 92: 129–36CrossRefGoogle Scholar
  93. 93.
    Savel J. Pharmacological investigation of the standardized ginseng extract G115. Delray Beach: Ginsana USA Corporation, 1971Google Scholar
  94. 94.
    Petkov VD, Getova D, Mosharrof AH. A study of nootropic drugs for anti-anxiety action. Acta Physiol Pharmacol Bulg 1987; 13(4): 25–30PubMedGoogle Scholar
  95. 95.
    Sterner VW, Kirchdorfer AM. Vergleichende Leistungs-prufungen an Mausen mit standardisierten Ginseng-Extrakt und einem ginsenghaltingen Gerotherapeutikum. Zeitschr Gerontol 1970; 3: 307–12Google Scholar
  96. 96.
    Saito H, Yoshida Y, Takagi K. Effect of Panax ginseng root on exhaustive exercise in mice. Jpn J Pharmacol 1974; 24: 119–27PubMedCrossRefGoogle Scholar
  97. 97.
    Avakian EV, Evonuk E. Effect of Panax ginseng extract on tissue glycogen and adrenal cholesterol depletion during prolonged exercise. Planta Med 1979; 36: 43–8PubMedCrossRefGoogle Scholar
  98. 98.
    Martinez B, Staba EJ. The physiological effects of Aralia, Panax, and Eleutherococcus on exercised rats. Jpn J Pharmacol 1984; 35: 79–85PubMedCrossRefGoogle Scholar
  99. 99.
    Avakian EV, Sugimoto RB, Taguchi S, et al. Effect of Panax ginseng extract on energy metabolism during exercise in rats. Planta Med 1984; 50: 151–4PubMedCrossRefGoogle Scholar
  100. 100.
    Fahim MS, Fahim Z, Harman JM, et al. Effect of Panax ginseng on testosterone level and prostate in male rats. Arch Androl 1982; 8: 261–3PubMedCrossRefGoogle Scholar
  101. 101.
    Lewis WH, Zenger VE, Lynch RG. No adaptogen response of mice to ginseng and eleutherococcus infusions. J Ethnopharmacol 1983; 8: 209–14PubMedCrossRefGoogle Scholar
  102. 102.
    Knapik JJ, Wright JE, Welch MJ, et al. The influence of Panax ginseng on indices of substrate utilization during repeated, exhaustive exercise in man [abstract]. Fed Proc 1983; 42: 336Google Scholar
  103. 103.
    Pieralisi G, Ripari P, Vecchiet L. Effects of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals, and trace elements on physical performance during exercise. Clin Ther 1991; 13(3): 373–82PubMedGoogle Scholar
  104. 104.
    Van Schepdael P. Les effects du ginseng G115 sur la capacité physique de sportifs d’endurance. Acta Ther 1993; 19: 337–47Google Scholar
  105. 105.
    Morris AC, Jacobs I, Klugerman TM. No ergogenic effect of ginseng extract ingestion [abstract]. Med Sci Sports Exerc 1994; 26(5): S6Google Scholar
  106. 106.
    Hess FG, Parent RA, Stevens KR, et al. Effects of subchronic feeding of ginseng extract G115 in beagle dogs. Food Chem Toxicol 1983; 21(1): 95–7PubMedCrossRefGoogle Scholar
  107. 107.
    Brunner J. Nasty medicine. New Scientist 1983; 97(1339): 44Google Scholar
  108. 108.
    Dukes MNG. Ginseng and mastalgia [letter]. Br Med J 1978; 1: 1621PubMedCrossRefGoogle Scholar
  109. 109.
    Subiza J, Subiza JL, Escribano PM, et al. Occupational asthma caused by Brazil ginseng dust. J Allergy Clin Immunol 1991; 88: 731–6PubMedCrossRefGoogle Scholar
  110. 110.
    Siegel RK. Ginseng and high blood pressure. JAMA 1980; 243(1): 32PubMedCrossRefGoogle Scholar
  111. 111.
    Koriech OM. Ginseng and mastalgia [letter]. Br Med J 1978; 1: 1556CrossRefGoogle Scholar
  112. 112.
    Palmer BV, Montgomery ACV, Monteiro JCMP. Ginseng and mastalgia [letter]. Br Med J 1978; 1: 1284PubMedCrossRefGoogle Scholar
  113. 113.
    Greenspan EM. Ginseng and vaginal bleeding. JAMA 1983; 249(15): 2018PubMedCrossRefGoogle Scholar
  114. 114.
    Hopkins MP, Androff L, Benninghoff AS. Ginseng face cream and unexplained vaginal bleeding. Am J Obstet Gynaecol 1988; 150(5): 1121–2Google Scholar
  115. 115.
    Punnonen R, Lukola A. Oestrogen-like effect of ginseng. Br Med J 1980; 281: 1110PubMedCrossRefGoogle Scholar
  116. 116.
    Kim C, Choi H, Kim CC, et al. Influence of ginseng on mating behaviour of male rats. Am J Chin Med 1976; 4(2): 163–8PubMedCrossRefGoogle Scholar
  117. 117.
    Hikino H, Takahashi M, Otake K, et al. Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots. J Nat Prod 1986; 49(2): 293–7PubMedCrossRefGoogle Scholar
  118. 118.
    Oshima Y, Sato K, Hikino H. Isolation and hypoglycemic activity of quinquefolans A, B, and C, glycans of Panax quinquefolium roots. J Nat Prod 1987; 50(2): 188–90PubMedCrossRefGoogle Scholar
  119. 119.
    Shader RI, Greenblatt DJ. Phenelzine and the dream machine-ramblings and reflections. J Clin Psychopharmacol 1985; 5(2): 65PubMedCrossRefGoogle Scholar
  120. 120.
    Shader RI, Greenblatt DJ. Bees, ginseng and MAOIs revisited. J Clin Psychopharmacol 1988; 8(4): 235PubMedCrossRefGoogle Scholar
  121. 121.
    Jones BD, Runikis AM. Interaction of ginseng with phenelzine. J Psychopharmacol 1987; 7(3): 201–2CrossRefGoogle Scholar
  122. 122.
    Nikaido T, Ohmoto T, Sankawa U, et al. Inhibitors of cyclic AMP phosphodiesterase in Panax ginseng C.A. Meyer and Panax japonicus C.A. Meyer. Chem Pharm Bull 1984; 32(4): 1477–83PubMedCrossRefGoogle Scholar
  123. 123.
    Tsang D, Yeung HW, Tso WW, et al. Ginseng saponins: influence on neurotransmitter uptake in rat brain synaptosomes. Planta Med 1985; 51(3): 221–4CrossRefGoogle Scholar
  124. 124.
    US Olympic Committee. US Olympic Committee Drug Education Handbook 1989–92 (80909–5760). Colorado Springs: USOC Drug Education Program, 1989Google Scholar
  125. 125.
    Watt J, Bottomley MB, Read MTF. Olympic athletics medical experience, Seoul — personal views. Br J Sports Med 1989; 23(2): 76–9PubMedCrossRefGoogle Scholar

Copyright information

© Adis International Limited 1994

Authors and Affiliations

  • Michael S. Bahrke
    • 1
  • William P. Morgan
    • 1
  1. 1.Sport Psychology Laboratory, Department of KinesiologyUniversity of Wisconsin at MadisonMadisonUSA

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