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Exercise and Male Factor Infertility

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Summary

Recent advances in the study of andrology are unfolding some of the idiopathic components of male factor infertility. The inclusion of exercise training as a component of male factor infertility has been proposed secondary to changes observed in the reproductive hormone and semen profile of some endurance trained male athletes. Evidence exists that a subset of endurance trained men, particularly runners, present with subclinical changes in their reproductive hormone profile. These changes include a reduction in total and free testosterone, alterations in luteinising hormone release and alterations in pituitary responses to gonadotrophin-releasing hormone and other pharmacological perturbations. Less attention has been directed towards identifying changes in spermatogenesis and fertility capacity as a result of endurance training. The semen ejaculate of some endurance trained athletes presents with nonspecific modifications including a low normal sperm count, decreased motility and several morphological changes that may compromise fertility. Thus, although a subset of high mileage endurance trained runners present with subclinical modifications in their reproductive hormone and semen profile, to date there is no evidence that endurance training causes male infertility. Future investigations should focus on the clinical impact these hormone and semen alterations may have on fertility capacity in endurance trained athletes.

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References

  • Abraham SF, Beaumont PW, Frase IS, Llewellyn-Jones D. Body weight, exercise and menstrual status among ballet dancers in training. British Journal of Obstetetrics and Gynaecology 89: 507–510, 1982

    Article  CAS  Google Scholar 

  • Almeida OFX, Nikolarakis KE, Herz A. Evidence for the involvement of endogenous opioids in the inhibition of luteinizing hormone by corticotropin-releasing factor. Endocrinology 122: 1034–1041, 1988

    Article  PubMed  CAS  Google Scholar 

  • Ambrosi B, Gaggini M, Travaglini P, Morisudo P, Elli R, et al. Hypothalamic-pituitary-testicular function in men with PRL-secreting tumors. Journal of Endocrinological Investigation 4: 309–315, 1981

    PubMed  CAS  Google Scholar 

  • Anderson JL. Women’s sports and fitness programmes at the US Military Academy. Physician and Sportsmedicine 7: 72–80, 1980

    Google Scholar 

  • Arce JC, De Souza MJ, Pescatello P, Luciano AA. Subclinical alterations in hormone and semen profile in athletes. Fertility and Sterility 59: 398–404, 1993

    PubMed  CAS  Google Scholar 

  • Ayers WT, Komesu Y, Romani T, Ansbacher R. Anthropomorphic, hormonal, and psychologic correlates of semen quality in endurance-trained male athletes. Fertility and Sterility 43: 917–921, 1985

    PubMed  CAS  Google Scholar 

  • Bagatell CJ, Bremner WJ. Sperm counts and reproductive hormones in male marathoners and lean controls. Fertility and Sterility 53: 688–692, 1990

    PubMed  CAS  Google Scholar 

  • Baker ER, Leuker R, Stumpf PG. Relationship of exercise to semen parameters and fertility success of artificial insemination donors. Fertility and Sterility 41: 107S, 1984

  • Baker HWG, Santen RJ, Burger HG, De Kretser DM, Hudson B, et al. Rhythms in the secretion of gonadotropins and gonadal steroids. Journal of Steroid Biochemistry 6: 793–801, 1975

    Article  PubMed  CAS  Google Scholar 

  • Barbarino A, deMarinis L, Tofani A, Delia Casa S, D’Amico C, et al. Corticotropin-releasing hormone inhibition of gonadotropin release and the effects of opiate blockade. Journal of Clinical Endocrinology and Metabolism 68: 523–528, 1989

    Article  PubMed  CAS  Google Scholar 

  • Blank JL, Desjardins C. Spermatogenesis is modified by food intake in mice. Biology of Reproduction 30: 410–415, 1984

    Article  PubMed  CAS  Google Scholar 

  • Bonen A, Belcastro AN, Ling W, Simpson AA. Profiles of selected hormones during menstrual cycles of teenage athletes. Journal of Applied Physiology 50: 545–548, 1981

    PubMed  CAS  Google Scholar 

  • Bortz WM, II, Angwin P, Mefford IV, Boarder MR, Noyce N, et al. Catecholamines, dopamine, and endorphin levels during extreme exercise. New England Journal of Medicine 305: 466–467, 1981

    PubMed  Google Scholar 

  • Boyden TW, Pamenter RW, Stanforth P, Rotkis T, Wilmore JH. Sex steroids and endurance running in women. Fertility and Sterility 39: 629–632, 1982

    Google Scholar 

  • Braunstein GD. Testes. In Geenspan (Ed.) Basical and Clinical Endocrinology, 3rd ed., pp. 404–441, Appleton & Lange, East Norwalk, 1991

    Google Scholar 

  • Broocks A, Pirke KM, Schweiger U, Tuschl RJ, Laessle RG, et al. Cyclic ovarian function in recreational athletes. Journal of Applied Physiology 68: 2083–2086, 1990

    PubMed  CAS  Google Scholar 

  • Brown BS, Van Huss WD. Exercise and rat brain catecholamines. Journal of Applied Physiology 34: 664–669, 1973

    PubMed  CAS  Google Scholar 

  • Brown BS, Payne T, Kim C, Moore G, Krebs P, et al. Chronic response of rat brain norepinephrine and serotonin levels to endurance training. Journal of Applied Physiology 46: 19–23, 1979

    PubMed  CAS  Google Scholar 

  • Bullen BA, Skrinar GS, Beitins IZ, Carr DB, Reppert SM, et al. Endurance training effects on plasma hormonal responsiveness and sex hormone excretion. Journal of Applied Physiology 56: 1453–1463, 1984

    PubMed  CAS  Google Scholar 

  • Bullen BA, Skrinar, GS, Beitins IZ, Von Mering G, Turnbull BA, et al. Induction of menstrual disorders by strenuous exercise in untrained women. New England Journal of Medicine 312: 1349–1353, 1985

    Article  PubMed  CAS  Google Scholar 

  • Bunt JC, Bahr JM, Bemben DA. Comparison of estradiol and testosterone levels during and immediately following prolonged exercise in moderately active and trained males and females. Endocrine Research 13: 157–172, 1987

    Article  PubMed  CAS  Google Scholar 

  • Cadoux-Hudson TA, Few JD, Imms FJ. The effect of exercise on the production and clearance of testosterone in well trained young men. European Journal of Applied Physiology 54: 321–325, 1985

    Article  CAS  Google Scholar 

  • Calabrese LH, Kirkendall DT, Floyd M, Rapopot S, Williams SW, et al. Menstrual abnormalities, nutritional patterns, and body composition in female classical ballet dancers. Physician and Sportsmedicine 11: 86–98, 1983

    Google Scholar 

  • Cameron JD, Nosbisch C. Suppression of pulsatile luteinizing hormone and testosterone secretion during short term food restriction in the adult male rhesus monkey (Macaca mulatta). Endocrinology 128: 1532–1540, 1991

    Article  PubMed  CAS  Google Scholar 

  • Cameron RDA, Blackshaw AW. The effect of elevated ambient temperature on spermatogenesis in the boar. Journal of Reproduction and Fertility 59: 173, 1980

    Article  PubMed  CAS  Google Scholar 

  • Carlberg KA, Buckman MT, Peake GT, Riedesel ML. Body composition of oligo/amenorrheic athletes. Medicine and Science in Sports and Exercise 15: 215–217, 1983

    Article  PubMed  CAS  Google Scholar 

  • Chaouloff F. Physical exercise and brain monoamines: a review. Acta Physiologica Scandinava 137: 1–13, 1989

    Article  CAS  Google Scholar 

  • Chaouloff F, Laude D, Serrurier B, Merino D, Guezennec Y, et al. Brain serotonin response to exercise in the rat: the influence of training duration. Biogenic Amines 4: 99–126, 1987

    CAS  Google Scholar 

  • Collu R, Gibb W, Ducharme IR. Effects of stress on the gonadal function. Journal of Endocrinological Investigation 7: 529–537, 1984

    PubMed  CAS  Google Scholar 

  • Coltz EWD, Wardlaw SL, Frantz AG. The effect of running on plasma β-endorphin. Life Sciences 28: 1637–1640, 1981

    Article  Google Scholar 

  • Crowley Jr WF, Filicore M, Spratt DI, Santoro N. The physiology of gonadotropin-releasing hormone (GnRH) secretion in men and women. Recent Progress in Hormone Research 41: 473–531, 1985

    PubMed  CAS  Google Scholar 

  • Crowley Jr WF, Whitcomb RW, Jameson JL, Weiss J, Finkelstein JS, et al. Neuroendocrine control of human reproduction in the male. Recent Progress in Hormone Research 47: 27–67, 1991

    PubMed  CAS  Google Scholar 

  • Cumming DC. Physical activity and control of the hypothalamic-pituitary-gonadal axis. Seminars in Reproductive Endocrinology 8: 15–24, 1990

    Article  Google Scholar 

  • Cumming DC, Brunsting LA, III, Strich G, Ries AL, Rebar RW. Reproductive hormone increases in response to acute exercise in men. Medicine and Science in Sports and Exercise 18: 369–373, 1986

    Article  PubMed  CAS  Google Scholar 

  • Cumming DC, Quigley ME, Yen SSC. Acute suppression of circulating testosterone levels by Cortisol in men. Journal of Clinical Endocrinology and Metabolism 57: 671–673, 1983

    Article  PubMed  CAS  Google Scholar 

  • Cumming DC, Wall SR, Quinney HA, Belcastro AN. Decrease in serum testosterone levels with maximal intensity swimming exercise in trained male and female swimmers. Endocrine Research 13: 31–41, 1987

    PubMed  CAS  Google Scholar 

  • Cumming DC, Wheeler GD, McColl EM. The effects of exercise on reproductive function in men. Sports Medicine 7: 1–17, 1989

    Article  PubMed  CAS  Google Scholar 

  • Dale E, Gerlach DH, Wilhite AL. Menstrual dysfunction in distance runners. Obstetrics and Gynecology 54: 47–53, 1979

    Article  PubMed  CAS  Google Scholar 

  • DeLacerda L, Kowarski A, Johanson AJ, Athanasiou R, Migeon CJ. Integrated concentration and circadian variation of plasma testosterone in normal men. Journal of Endocrinology and Metabolism 37: 366–371, 1973

    Article  CAS  Google Scholar 

  • De Souza MJ, Arce JC, Metzger DA. Endocrine bases of exercise-induced amenorrhea. In Costa et al. (Eds) Women in sport, Human Kinetics Publishers, Champaign, in press, 1993

    Google Scholar 

  • De Souza, MJ, Arce JC, Nulsen JC. Effects of exercise training on sex steroids: endocrine profile and clinical implications. Infertility and Reproductive Medicine Clinics of North America 3, 129–148, 1992

    Google Scholar 

  • De Souza MJ, Arce JC, Rubin KR, Loucks AB, Luciano AA. Adrenal gland sensitivity in eumenorrheic and amenorrheic athletes. Medicine and Science in Sports and Exercise 23 (Suppl. 4): S123, 1991

    Google Scholar 

  • De Souza MJ, Metzger DA. Reproductive dysfunction in amenorrheic athletes and anorexic patients. Medicine and Science in Sports and Exercise 23: 995–1007, 1991

    PubMed  Google Scholar 

  • Dessypris A, Kuoppasalmi K, Adlercreutz H. Plasma Cortisol, testosterone, androstenedione and luteinizing hormone (LH) in a non-competitive marathon run. Journal of Steroid Biochemistry 7: 33–37, 1976

    Article  PubMed  CAS  Google Scholar 

  • Dewasmes G, Bothorel B, Hsiung R, Clavert A, Candas V. Human scrotal temperature during heat exposure associated with passive leg heating. In Zorgniotti (Ed.) Temperature and environmental effects on the testis, pp. 187–191, Plenum Press, New York, 1991

    Chapter  Google Scholar 

  • Donevan RH, Andrew GM. Plasma endorphin immunoreactivity during graded cycle ergometry. Medicine and Science in Sports and Exercise 19: 229–233, 1987

    Article  PubMed  CAS  Google Scholar 

  • Elam M, Svensson TH, Thoren P. Brain monoamine metabolism is altered in rats following spontaneous, long-distance running. Acta Physiologica Scandinavica 130: 313–316, 1987

    Article  PubMed  CAS  Google Scholar 

  • Farrell PA., Gates WK, Maksud MG, Morgan WP. Increase in plasma Bendorphin/B-lipotropin immunoreactivity after treadmill running in humans. Journal of Applied Physiology 52: 1245–1249, 1982

    PubMed  CAS  Google Scholar 

  • Feicht CB, Johnson TS, Martin BJ, Sparkes KE, Wagner WW. Secondary amenorrhoea in athletes. Lancet 2: 1145–1146, 1978

    Article  PubMed  CAS  Google Scholar 

  • Fellman N, Coudert J, Jarrige J-F, Bedu M, Denis C, et al. Effects of endurance training on the androgenic response to exercise in man. International Journal of Sports Medicine 6: 215–219, 1985

    Article  Google Scholar 

  • Foresta C, Scanelli G, Tamarin A, Scandellari C. Serotonin but not dopamine is involved in the naloxone-induced luteinizing hormone release in man. Fertility and Sterility 43: 447–450, 1985

    PubMed  CAS  Google Scholar 

  • Frey MAB, Doerr BM, Srivastava LS, Glueck CJ. Exercise training, sex hormones, and lipoprotein relationships in men. Journal of Applied Physiology 54: 757–762, 1983

    PubMed  CAS  Google Scholar 

  • Frisch RE, Gotz-Welbergen AV, McArthur JW, Albright T, Witschi J, et al. Delayed menarche and amenorrhea of college athletes in relation to age of onset of training. Journal of the American Medical Association 246: 1559–1563, 1981

    Article  PubMed  CAS  Google Scholar 

  • Galbo H, Hummer L, Petersen IB, Christensen NJ, Bie N. Thyroid and testicular hormone responses to graded and prolonged exercise in man. European Journal of Applied Physiology 36: 101–106, 1977

    Article  CAS  Google Scholar 

  • Gambert SR, Garthwaite TL, Pontzer CH, Cook EE, Tristani FE, et al. Running elevates plasma endorphin immunoreactivity and ACTH in untrained human subjects. Proceedings of the Society of Experimental Biology and Medicine 168: 1–4, 1981

    CAS  Google Scholar 

  • Goldfarb AH, Hatfield BD, Potts J, Armstrong D. Beta-endorphin time course response to intensity of exercise: effect of training status. International Journal of Sports Medicine 12: 264–268, 1991

    Article  PubMed  CAS  Google Scholar 

  • Goldfarb AH, Hatfield BD, Sforzo GA, Flynn MG. Serum β-endorphin levels during a graded exercise test to exhaustion. Medicine and Science in Sports and Exercise 19: 78–82, 1987

    Article  PubMed  CAS  Google Scholar 

  • Griffith RO, Dressendorfer RH, Fullbright CD, Wade CE. Testicular function during exhaustive endurance training. Physician and Sportsmedicine 18: 54–64, 1990

    Google Scholar 

  • Grossman A. Opiate peptides and reproductive function. Seminars in Reproductive Endocrinology 5: 115–124, 1987

    Article  Google Scholar 

  • Guezennec CY, Ferre P, Serrurier B, Merino D, Aymonod M, et al. Metabolic effects of testosterone during prolonged physical exercise and fasting. European Journal of Applied Physiology 52: 300–304, 1984

    Article  CAS  Google Scholar 

  • Guglielmini C, Paolini AR, Conconi F. Variations of serum testosterone concentrations after physical exercises of different duration. International Journal of Sports Medicine 5: 246–249, 1984.

    Article  PubMed  CAS  Google Scholar 

  • Gutin B, Alejandro D, Duni T, Segal K, Phillips GB. Levels of serum hormones and risk factors for coronary heart disease in exercise-trained men. American Journal of Medicine 79:79–84, 1985

    Article  PubMed  CAS  Google Scholar 

  • Hackney AC. Endurance training and testosterone levels. Sports Medicine 8: 117–127, 1989

    Article  PubMed  CAS  Google Scholar 

  • Hackney AC, Sinning WE, Bruot BC. Reproductive hormonal profiles of endurance-trained and untrained males. Medicine and Science in Sports and Exercise 20: 60–65, 1988

    Article  PubMed  CAS  Google Scholar 

  • Hackney AC, Sinning WE, Bruot BC. Hypothalamic-pituitary-testicular axis function in endurance-trained males. International Journal of Sports Medicine 34: 949–954, 1990

    Google Scholar 

  • Highet R. Athletic amenorrhea: an update on aetiology, complications and management. Sports Medicine 7: 82–108, 1989

    Article  PubMed  CAS  Google Scholar 

  • Jezova D, Vigas M, Tatar P, Kvetnansky R, Nazar K, et al. Plasma testosterone and catecholamine responses to physical exercise of different intensities in men. European Journal of Applied Physiology 54: 62–66, 1985

    Article  CAS  Google Scholar 

  • Judd HL, Parker DC, Rafkoff JS, Hopper BR, Yen SSC. Elucidation of mechanism(s) of the nocturnal rise of testosterone in men. Journal of Clinical Endocrinology and Metabolism 38: 134–141, 1974

    Article  PubMed  CAS  Google Scholar 

  • Kalra PS, Clark JT. Dopamine, hyperprolactinemia, and sexual behavior. In Paulson et al. (Eds) Andrology: male fertility and sterility, pp. 125–147, Academic Press, London, 1986

    Google Scholar 

  • Kandeel FR, Swerdloff RS. Role of temperature in regulation of spermatogenesis and use of heating as a method for contraception. Fertility and Sterility 49: 1–23, 1988

    PubMed  CAS  Google Scholar 

  • Keizer H, Janssen GME, Menheere P, Kranenburg G. Changes in basal plasma testosterone, cortisol, and dehydroepiandrostenerone sulfate in previously untrained males and females preparing for a marathon. International Journal of Sports Medicine 10: S139–S145, 1989

    Article  PubMed  Google Scholar 

  • Kliblanski A, Beitins IZ, Badger T, Little R, McArthur JW. Reproductive function during fasting in men. Journal of Clinical Endocrinology and Metabolism 52: 258–263, 1981

    Article  Google Scholar 

  • Knobil E. The neuroendocrine control of the menstrual cycle. Recent Progress in Hormone Research 36: 53, 1980

    PubMed  CAS  Google Scholar 

  • Kuoppasalmi K. Plasma testosterone and sex-hormone-binding globulin capacity in physical exercise. Scandinavian Journal of Clinical Investigation 40: 411–418, 1980

    Article  CAS  Google Scholar 

  • Kuoppasalmi K, Naveri H, Harkonen M, Adlercreutz H. Plasma Cortisol, androstenedione, testosterone and luteinizing hormone in running exercise of different intensities. Scandinavian Journal of Clinical Investigation 40: 403–409, 1980

    Article  CAS  Google Scholar 

  • Kuoppasalmi K, Naveri H, Rehunen S, Harkonen M, Adlercreutz H. Effect of strenuous anaerobic running exercise on plasma growth hormone, cortisol, luteinizing hormone, testosterone, androstenedione, estrone and estradiol. Journal of Steroid Biochemistry 7: 823–829, 1976

    Article  PubMed  CAS  Google Scholar 

  • Kuusi T, Koistiainen E, Vartiainen E, Pitkanen L, Ehnholm C, et al. Acute effects of marathon running on levels of serum lipoproteins and androgenic hormones in healthy males. Metabolism 33: 527–531, 1984

    Article  PubMed  CAS  Google Scholar 

  • Lamb JC, Foster PMD (Eds). Physiology and toxicology of male reproduction, pp. 1–256, Academic Press, San Diego, 1988

    Google Scholar 

  • Levine RJ, Bordson BL, Mathew RM, Brown MH, Stanley JM, et al. Deterioration of semen quality during summer in New Orleans. Fertility and Sterility 49: 900–907, 1988

    PubMed  CAS  Google Scholar 

  • Levine RJ, Mathew RM, Chenault CB, Brown MH, Hurtt ME, et al. Differences in the quality of semen in outdoor workers during summer and winter. New England Journal of Medicine 323: 12–16, 1990

    Article  PubMed  CAS  Google Scholar 

  • Loosli AR, Gillien DM, Benson J, Bourdet K. Inadequate nutrition and chronic caloric restriction among ballet dancers. Abstract. Medicine and Science in Sports and Exercise 17: 201, 1985

    Article  Google Scholar 

  • Loucks AB, Girton L, Mortola J, Yen SSC. Effect of opioidergic and dopaminergic blockade on LH pulsatility in athletic women. Medicine and Science in Sports and Exercise 23: S123, 1991

    Google Scholar 

  • Loucks AB, Horvath SM. Athletic amenorrhea: a review. Medicine and Science in Sports and Exercise 17: 56–72, 1985

    PubMed  CAS  Google Scholar 

  • Loucks AB, Mola J, Girton L, Yen SSC. Alterations in the hypothalamic-pituitary-ovarian and the hypothalamic-pituitary-adrenal axes in athletic women. Journal of Clinical Endocrinology Metabolism 68: 402–411, 1989

    Article  PubMed  CAS  Google Scholar 

  • Luger A, Deuster PA, Kyle SB, Galluci WT, Montgomerty LC, et al. Acute hypothalamic-pituitary-adrenal responses to the stresses of treadmill exercise: physiologic adaptations to physical training. New England Journal of Medicine 316: 1309–1315, 1987

    Article  PubMed  CAS  Google Scholar 

  • Lutter JM, Cushman S. Menstrual patterns in female runners. Physician and Sportsmedicine 10: 60–72, 1982

    Google Scholar 

  • MacConnie SE, Barkan A, Lampman RM, Schork MA, Beitins IZ. Decreased hypothalamic gonadotropin-releasing hormone secretion in male marathon runners. New England Journal of Medicine 315: 411–417, 1986

    Article  PubMed  CAS  Google Scholar 

  • Manchini-Fabris GF, Volani S, Canale D, Olivieri L. Sperm analysis in the infertile male. In Paulson et al. (Eds) Andrology: male fertility and sterility, pp. 341–357, Academic Press, London, 1986

    Google Scholar 

  • Martini L. The 5 alpha-reduction of testosterone in the neuroendocrine structures. Biochemical and physiological implications. Endocrine Reviews 3: 1–25, 1982

    Article  PubMed  CAS  Google Scholar 

  • Martini L, Zoppi S. Mode of action of androgens in neuroendocrine structures. In Paulson et al. (Eds) Andrology: male fertility and sterility, pp. 149–159, Academic Press, London, 1986

    Google Scholar 

  • Mathur DN, Toriola AL, Dada QA. Serum cortisol and testosterone levels in conditioned male distance runners and non-athletes after maximal exercise. Journal of Sports Medicine Physical Fitness 26: 245–250, 1986

    CAS  Google Scholar 

  • Matsumoto CM, Bremner WJ. Modulation of pulsatile gonadotropin secretion by testosterone in men. Journal of Clinical Endocrinology and Metabolism 58: 609–614, 1984

    Article  PubMed  CAS  Google Scholar 

  • McArthur JW. Endorphins and exercise in females: possible connection with reproductive dysfunction. Medicine and Science in Sports and Exercise 17: 82–88, 1985

    Article  PubMed  CAS  Google Scholar 

  • McColl EM, Wheeler GD, Gomes P, Bhambhani Y, Cumming DC. The effects of acute exercise on pulsatile LH release in high-mileage male runners. Clinical Endocrinology 31: 617–621, 1989

    Article  PubMed  CAS  Google Scholar 

  • Mieusset R. Scrotal hyperthermia, etiologic factors: facts and hypotheses. In Zorgniotti (Ed.) Temperature and environmental effects on the testis, pp. 211–216, Plenum Press, New York, 1991

    Chapter  Google Scholar 

  • Mieusset R, Bujan L, Plantavid M, Mansat A, Grandjean H, et al. Scrotal hyperthermia: frequency in an infertile population and associated alterations in testicular function. In Zorgniotti (Ed.) Temperature and environmental effects on the testis, pp. 203–209, Plenum Press, New York, 1991

    Chapter  Google Scholar 

  • Myerson M, Gutin B, Warren MP, May MT, Contento I, et al. Resting metabolic rate and energy balance in amenorrheic and eumenorrheic runners. Medicine and Science in Sports and Exercise 23: 15–22, 1991

    Article  PubMed  CAS  Google Scholar 

  • Naftolin F, Judd HL, Yen SSC. Pulsatile patterns of gonadotropins and testosterone in man: the effects of clomiphene with and without testosterone. Journal of Clinical Endocrinology and Metabolism 36: 285–288, 1973

    Article  PubMed  CAS  Google Scholar 

  • Negro-Vilar A. LHRH: physiology, pharmacology, and its role in fertility regulation. In Paulson et al. (Eds) Andrology: male fertility and sterility, pp. 3–11, Academic Press, London, 1986

    Google Scholar 

  • Negro-Vilar A, Ojeda SR. Hypophysiotropic hormones of the hypothalamus. In McCann (Ed.) Endocrine physiology III, international review of physiology, pp. 97–156, University Park Press, Baltimore, 1981

    Google Scholar 

  • Negro-Vilar A, Valenca MM. Male neuroendocrinology and endocraine evaluation of reproductive disorders. In Lamb et al. (Eds) Physiology and toxicology of male reproduction, pp. 103–131, Academic Press, San Diego, 1988

    Google Scholar 

  • Peltonen P, Marniemi J, Hietanen E, Vuori I, Enholm C. Changes in serum lipids, lipoproteins and heparin releasable lipolytic enzymes during moderate physical training in man: a longitudinal study. Metabolism 30: 518–526, 1981

    Article  PubMed  CAS  Google Scholar 

  • Perryman RL, Thorner MO. The effects of hyperprolactinemia on sexual and reproductive function in men. Journal of Andrology 2: 233–242, 1981

    Google Scholar 

  • Politoff L, Birkhauser M, Almendral A, Zorn A. New data confirming a circannual rhythm in spermatogenesis. Fertility and Sterility 52: 486–489, 1989

    PubMed  CAS  Google Scholar 

  • Remes K, Kuoppasalmi K, Adlercreutz H. Effect of long-term physical training on plasma testosterone, androstenedione, luteinizing hormone and sex-hormone-binding globulin capacity. Scandinavian Journal of Clinical Investigation 39: 743–749, 1979

    Article  CAS  Google Scholar 

  • Roberts AC, McClure RD, Weiner RI, Brooks GA. The effects of overtraining on reproductive variables in trained men vs controls. Medicine and Science in Sports and Exercise 22: S21, 1990

    Article  Google Scholar 

  • Rogol AD, Veldhuis JD, Williams FA, Johnson ML. Pulsatile secretion of gonadotropins and prolactin in male marathon runners. Journal of Andrology 5: 21–27, 1984

    PubMed  CAS  Google Scholar 

  • Rolandi E, Reggiani E, Francheschini R, Bavastro G, Messina V, et al. Comparison of pituitary responses to physical exercise in athletes and sedentary subjects. Hormone Research 21: 209–213, 1985

    Article  PubMed  CAS  Google Scholar 

  • Russell JB, De Cherney AH, Collins DC. The effect of naloxone and metoclopramide ion the hypothalamic pituitary axis in oligomenorrheic and eumenorrheic swimmers. Fertility and Sterility 52: 583–588, 1989

    PubMed  CAS  Google Scholar 

  • Saint Pol P, Beuscart R, Leroy-Martin B, Hermand E, Jablonski W. Circannual rhythms of sperm of fertile men. Fertility and Sterility 51: 1030–1033, 1989

    Google Scholar 

  • Sanborn CF, Martin BJ, Wagner Jr WW. Is athletic amenorrhea specific to runners? American Journal of Obstetrics and Gynecology 143: 859–861, 1982

    PubMed  CAS  Google Scholar 

  • Schwarz L, Kindermann W. β-endorphin, catecholamines, and cortisol during exhaustive endurance exercise. International Journal of Sports Medicine 10: 324–328, 1989

    Article  PubMed  CAS  Google Scholar 

  • Seidman DS, Dolev E, Deuster PA, Burstein R, Arnon R, et al. Androgenic response to long-term physical training in male subjects. International Journal of Sports Medicine 11: 421–424, 1990

    Article  PubMed  CAS  Google Scholar 

  • Shangold MM, Freeman R, Thyssen B, Mengold G. The relationship between long distance running, plasma progesterone and luteal phase length. Fertility and Sterility 31: 130–133, 1979

    PubMed  CAS  Google Scholar 

  • Shangold MM, Levine HS. The effect of marathon training upon menstrual function. American Journal of Obstetrics and Gynecology 143: 862–869, 1982

    PubMed  CAS  Google Scholar 

  • Smallridge RC, Whorton NE, Burman KD, Ferguson EW. Effects of exercise and physical fitness on the pituitary-thyroid axis and on prolactin secretion in male runners. Metabolism 34: 949–954, 1985

    Article  PubMed  CAS  Google Scholar 

  • Smith SR, Chhreti MK, Johanson J, Radfor J, Migeon J. The pituitary-gonadal axis in men with protein-calorie malnutrition. Journal of Clinical Endocrinology and Metabolism 41: 60–69, 1975

    Article  PubMed  CAS  Google Scholar 

  • Spratt DI, Finkelstein JS, Badger TM, Butter JP, Crowley WF. Bio- and immunoactive luteinizing hormone responses to low dose of gonadotropin-releasing hormone (GnRH): dose-response curves in GnRH deficient men. Jounal of Clinical Endocrinology and Metabolism 63: 143–150, 1986

    Article  CAS  Google Scholar 

  • Spratt DI, Carr DB, Merriam GR, Scully RE, Rao PN, Crowley WF. The spectrum of abnormal patterns of gonadotropin-releasing hormone secretion in men with idiopathic hypergonadotropic hypogonadism: clinical and laboratory correlations. Journal of Clinical Endocrinology and Metabolism 64: 283–291, 1987

    Article  PubMed  CAS  Google Scholar 

  • Spratt DI, O’Dea LStL, Schoenfeld D, Butler J, Rao N, et al. Neuroendocrine-gonadal axis in men: frequent sampling of LH, FSH, and testosterone. American Journal of Physiology 254: E658–E666, 1988

    PubMed  CAS  Google Scholar 

  • Steinberger E, Rodriguez-Rigau LJ, Smith KD. The interaction between the fertility potentials of the two members of an infertile couple. In Frajese et al. (Eds.) Oligozoospermia: recent progress in andrology, pp. 8–16, Raven Press, New York, 1981

    Google Scholar 

  • Tanaka H, Cleroux J, de Champlain J, Ducharme JR, Collu R. Persistent effects of a marathon run on the pituitary-testicular axis. Journal of Endocrinological Investigation 9: 97–101, 1986

    PubMed  CAS  Google Scholar 

  • Urhausen A, Kullmer T, Kindermann W. A 7-week follow-up study of the behaviour of testosterone and cortisol during the competition period in rowers. European Journal of Applied Physiology 56: 528–533, 1987

    Article  CAS  Google Scholar 

  • Veldhuis JD, Evans WS, Demers LM, Thorner MA, Wakat D, et al. Altered neuroendocrine regulation of gonadotropin secretion in women distance runners. Journal of Clinical Endocrinology and Metabolism 61: 557–563, 1985

    Article  PubMed  CAS  Google Scholar 

  • Veldhuis JD, King JC, Urban RJ, Rogol AD, Evans WS, et al. Operati ng characteristics of the male hypothalamo-pituitary-gonadal axis: pulsatile release of testosterone and follicle-stimulating hormone and their temporal coupling with luteinizing hormone. Journal of Clinical Endocrinology and Metabolism 65: 929–941, 1987

    Article  PubMed  CAS  Google Scholar 

  • Villanueva AL, Schlosser C, Hopper B, Liu JH, Hoffman DI, et al. Increased cortisol production in women runners. Journal of Clinical Endocrinology and Metabolism 63: 133–136, 1986

    Article  PubMed  CAS  Google Scholar 

  • Vogel RB, Books CA, Ketchum C, Zauner CW, Murray FT. Increase of free and testosterone during submaximal exercise in normal males. Medicine and Science in Sports and Exercise 17: 119–123, 1985

    Article  PubMed  CAS  Google Scholar 

  • Wakat D, Sweeney KA, Rogol AD. Reproductive system function in women cross-country runners. Medicine and Science in Sports and Exercise 14: 263–269, 1982

    Article  PubMed  CAS  Google Scholar 

  • Warren MP. The effects of exercise on pubertal progression and reproductive function in girls. Journal of Clinical Endocrinology and Metabolism 5: 1150–1157, 1980

    Article  Google Scholar 

  • Webb ML, Wallace JP, Hamill C, Hodgson JL, Mashaly MM. Serum testosterone concentration during two hours of moderate intensity treadmill running in trained men and women. Endocrine Research 10: 27–38, 1984

    PubMed  CAS  Google Scholar 

  • Wheeler GD, Singh M, Pierce WD, Epling WF, Cumming DC. Endurance training decreases serum testosterone levels in men without change in luteinizing hormone pulsatile release. Journal of Clinical Endocrinology and Metabolism 72: 422–425, 1991

    Article  PubMed  CAS  Google Scholar 

  • Wheeler GD, Wall SR, Belcastro AN, Cumming DC. Reduced serum testosterone and prolactin levels in male distance runners. Journal of the American Medical Association 252: 514–516, 1984

    Article  PubMed  CAS  Google Scholar 

  • Wilkerson JE, Horvath SM, Gutin B. Plasma testosterone during treadmill exercise. Journal of Applied Physiology 49: 249–253, 1980

    PubMed  CAS  Google Scholar 

  • Winters SJ. Diurnal rhythm of testosterone and luteinizing hormone in hypogonadal men. Journal of Andrology 12: 185–190, 1991

    PubMed  CAS  Google Scholar 

  • Wolff H, Anderson DJ. Immunohistologic characterization and quantitation of leucocyte subpopulations in human semen. Fertility and Sterility 49: 497–503, 1988

    PubMed  CAS  Google Scholar 

  • World Health Organization. WHO Laboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus Interaction, pp. 27, Cambridge University Press, Cambridge, 1987

    Google Scholar 

  • Zorgniotti AW. Hypothesis to explain subfertile men. In Zorgniotti (Ed.) Temperature and environmental effects on the testis, pp. 221–223, Plenum Press, New York, 1991

    Chapter  Google Scholar 

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Arce, J.C., De Souza, M.J. Exercise and Male Factor Infertility. Sports Medicine 15, 146–169 (1993). https://doi.org/10.2165/00007256-199315030-00002

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