Sports Medicine

, Volume 13, Issue 1, pp 25–36 | Cite as

Changes in β-Endorphin Levels in Response to Aerobic and Anaerobic Exercise

  • Lothar Schwarz
  • Wilfried Kindermann
Review Article

Summary

Exercise-induced increases in the peripheral β-endorphin concentration are mainly associated both with changes in pain perception and mood state and are possibly of importance in substrate metabolism. A more precise understanding of opioid function during exercise can be achieved by investigating the changes in β-endorphin concentrations dependent upon intensity and duration of physical exercise and in comparison to other stress hormones. Published studies reveal that incremental graded and short term anaerobic exercise lead to an increase in β-endorphin levels, the extent correlating with the lactate concentration. During incremental graded exercise β-endorphin levels increase when the anaerobic threshold has been exceeded or at the point of an overproportionate increase in lactate. In endurance exercise performed at a steady-state between lactate production and elimination, blood β-endorphin levels do not increase until exercise duration exceeds approximately 1 hour, with the increase being exponential thereafter. β-Endorphin and ACTH are secreted simultaneously during exercise, followed by a delayed release of Cortisol. It is not yet clear whether a relationship exists between the catecholamines and β-endorphin.

These results support a possible role of β-endorphin in changes of mood state and pain perception during endurance sports. In predominantly anaerobic exercise the behaviour of β-endorphin depends on the degree of metabolic demand, suggesting an influence of endogenous opioids on anaerobic capacity or acidosis tolerance. Further investigations are necessary to determine the role of β-endorphin in exercise-mediated physiological and psychological events.

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References

  1. Allan EH, Green IC, Titheradge MA. The stimulation of glycogenosis and gluconeogenesis in isolated hepatocytes by opioid peptides. Biochemical Journal 216: 507–510, 1983PubMedGoogle Scholar
  2. Allen M. Activity-generated endorphins: a review of their roles in sports science. Canadian Journal of Applied Sport Sciences 8: 115–133, 1983Google Scholar
  3. Arentz T, Meierleir K, Hollmann W. Die Rolle der endogenen opioiden Peptide während Fahrradergometerarbeit. Deutsche Zeitschrift für Sportmedizin 37: 210–219, 1986Google Scholar
  4. Barron JL, Noakes TD, Levy W, Smith C, Millar RP. Hypothalamic dysfunction in overtrained athletes. Journal of Clinical Endocrinology and Metabolism 60: 803, 1985PubMedCrossRefGoogle Scholar
  5. Berkenbosch F, Vermes I, Binnekade R. Beta-adrenergic stimulation induces an increase of the plasma levels of immunoreactive alpha-MSH, beta-endorphin, ACTH and of corticos-terone. Life Sciences 29: 2249–2256, 1981PubMedCrossRefGoogle Scholar
  6. Bortz WM, Angevin P, Mefford IN, Boarder N, Noyce N, et al. Catecholamines, dopamine, and endorphin levels during extreme exercise. New England Journal of Medicine 305: 466–467, 1981PubMedGoogle Scholar
  7. Brooks S, Burrin J, Cheetham ME, Hall GM, Yeo T, et al. The responses of the catecholamines and β-endorphin to brief maximal exercise in man. European Journal of Applied Physiology 57: 230–234, 1988CrossRefGoogle Scholar
  8. Bullen BA, Skrinar GS, Beitins IZ, Carr DB, Reppert SM, et al. Endurance training effects on plasma hormonal responsiveness and sex hormone excretion. Journal of Applied Physiology 56: 1453–1463, 1984PubMedGoogle Scholar
  9. Buono MJ, Yeager JE, Sucec AA. Effect of aerobic training on plasma ACTH response to exercise. Journal of Applied Physiology 63: 2499–2501, 1987PubMedGoogle Scholar
  10. Carr DB, Bullen BA, Skrinar GS, Arnold MA, Rosenblatt M, et al. Physical conditioning facilitates the exercise-induced secretion of β-endorphin and β-lipotropin in women. New England Journal of Medicine 305: 560–563, 1981PubMedCrossRefGoogle Scholar
  11. Chavkin C, Cox BM, Goldstein A. Stereo-specific opiate binding in the bovine adrenal medulla. Molecular Pharmacology 15: 751–753, 1979PubMedGoogle Scholar
  12. Colt EWD, Wardlaw SL, Frantz AG. The effect of running on plasma β-endorphin. Life Science 28: 1637–1640, 1981CrossRefGoogle Scholar
  13. Dearman J, Francis KT. Plasma levels of catecholamines, Cortisol, and β-endorphins in male athletes after running 26.2, 6 and 2 miles, Journal of Sports Medicine 23: 30–38, 1983Google Scholar
  14. De Meirleir K, Naaktgeboren N, Steirteghem V, Gorus F, Albrecht J, et al. Beta-endorphin and ACTH levels in peripheral blood during and after aerobic and anaerobic exercise. European Journal of Applied Physiology 55: 5–8, 1986CrossRefGoogle Scholar
  15. Dent RRM, Guilleminault C, Albert LH. Diurnal rhythm of plasma immuno-reactive β-endorphin and its relationship to sleep stages and plasma rhythms of Cortisol and prolactin. Journal of Clinical Endocrinology and Metabolism 52: 942–947, 1981PubMedCrossRefGoogle Scholar
  16. Donevan RH, Andrew GM. Plasma β-endorphin immunoreactivity during graded cycle ergometry. Medicine and Science in Sports and Exercise 19: 229–233, 1987Google Scholar
  17. Elias AN, Fairshter R, Pandian MR, Domurat E, Kayaleh R. β-Endorphin/β-lipotropin release and gonadotropin secretion after acute exercise in physicially conditioned males. European Journal of Applied Physiology 58: 522–527, 1989CrossRefGoogle Scholar
  18. Emrich HM, Hollt V, Kissling W, Fischler M, Laspe H, et al. β-Endorphin-like immunoreactivity in cerebrospinal fluid and plasma of patients with schizophrenia and other neuropsychiatric disorders. Pharmakopsychiatrie 12: 269, 1979CrossRefGoogle Scholar
  19. Estilo AE, Cottrell JE. Hemodynamic and catecholamine changes after administration of naloxone. Anesthesia and Analgesia 61: 349–353, 1982PubMedCrossRefGoogle Scholar
  20. Farrell PA, Garthwaite TL, Gustafson AB. Plasma adrenocorti-cotropin and Cortisol responses to submaximal and exhaustive exercise. Journal of Applied Physiology 55: 1441–1444, 1983PubMedGoogle Scholar
  21. Farrell PA, Gates WK, Morgan WP, Maksud MG. Increases in plasma β-endorphin/β-lipotropin immunoreactivity after treadmill running in humans. Journal of Applied Physiology 52: 1245–1249, 1982PubMedGoogle Scholar
  22. Farrell PA, Gustafson AB, Garthwaite TL, Kalkhoff A, Cowley AW, et al. Influence of endogenous opioids on the response of selected hormones to exercise in humans. Journal of Applied Physiology 61: 1051–1057, 1986PubMedGoogle Scholar
  23. Farrell PA, Kjaer M, Bach FW, Galbo H. β-endorphin and adrenocorticotropin response to supramaximal treadmill exercise in trained and untrained males. Acta Physiologica Scandinavica 130: 619–625, 1987PubMedCrossRefGoogle Scholar
  24. Fraioli F, Moretti C, Paolucci D, Alicicco E, Crescenzi F. Physical exercise stimulates marked concomitant release of β-endorphin and ACTH in peripheral blood in man. Experientia 36: 987–989, 1980PubMedCrossRefGoogle Scholar
  25. Fuchs E. Release rates of catecholamines, GABA and β-endorphin in the preoptic area and the mediobasal hypothalamus of the rhesus monkey in push-pull perfusates: correlati-on with blood hormone levels. Experimental Brain Research 65: 224–228, 1986CrossRefGoogle Scholar
  26. Galbo H. Endocrinology and metabolism in exercise. International Journal of Sports Medicine 2: 203–211, 1981CrossRefGoogle Scholar
  27. Gambert SR, Garthwaite TL, Pontzer CH, Cook EE, Tristani FE, et al. Running elevates plasma β-endorphin immunoreactivity and ACTH in un-trained human subjects. Proceedings of the Society for Experimental Biology and Medicine 168: 1–4, 1981PubMedGoogle Scholar
  28. Gerner RH, Sharp B, Catlin DH. Peripherally administered β-endorphin increases cerebrospinal fluid endorphin immunoreactivity. Journal of Clinical Endocrinology and Metabolism 55: 358–360, 1982PubMedCrossRefGoogle Scholar
  29. Gold MS, Redmond DE, Kleber HD. Clonidine blocks acute opiate withdrawal symptoms. Lancet 2: 599–602, 1978PubMedCrossRefGoogle Scholar
  30. Goldfarb AH, Hatfield BD, Armstrong D, Potts J. Plasma betaendorphin concentration: response to intensity and duration of exercise. Medicine and Science in Sports and Exercise 22: 241–244, 1990PubMedGoogle Scholar
  31. Goldfarb AH, Hatfield BD, Sforzo GA, Flynn MG. Serum β-endorphin levels during a graded exercise test to exhaustion. Medicine and Science in Sports and Exercise 19: 78–82, 1987PubMedCrossRefGoogle Scholar
  32. Grossman A. Endorphins: “opiates for the masses”. Medicine and Science in Sports and Exercise 17: 101–105, 1985PubMedGoogle Scholar
  33. Guillemin R, Vargo T, Rossier J, Minick S, Ling N, et al. β-endorphin and adrenocorticotropin are secreted concomitantly by the pituitary gland. Science 197: 1362–1369, 1977CrossRefGoogle Scholar
  34. Haier RJ, Quaid K, Mills JSC. Naloxone alters pain perception after jogging. Psychiatry Research 5: 231–232, 1981PubMedCrossRefGoogle Scholar
  35. Harber VJ, Sutton JR. Endorphins and exercise. Sports Medicine 1: 154–171, 1984PubMedCrossRefGoogle Scholar
  36. Holaday JW. Cardiovascular effects of endogenous opioids. Annual Review of Pharmacology and Toxicology 23: 541–594,1983PubMedCrossRefGoogle Scholar
  37. Hollmann W, De Meirleir K. Gehirn und Sport — hämodynamische und biochemische Aspekte. Deutsche Zeitschrift für Sportmedizin 39: 56–64, 1988Google Scholar
  38. Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan BA, Morris HR. Identification of two related pentapeptides from the brain with potent opiate against activity. Nature 258: 577–579, 1975PubMedCrossRefGoogle Scholar
  39. Janal MN, Colt EWD, Clark WC, Glusman M. Pain sensitivity, mood, and plasma endocrine levels in man following longdistance running: effects of naloxone. Pain 19: 13–25, 1984PubMedCrossRefGoogle Scholar
  40. Jungkunz G. Endogenous opiates increase pain tolerance after stress in humans. Psychiatry Research 8: 13–18, 1983PubMedCrossRefGoogle Scholar
  41. Keizer HA, Platen P, Koppeschaar H, de Vries WR, Vervoorn C, et al. Blunted β-endorphin responses to corticotropin releasing hormone and exercise after exhaustive training. Abstract. International Journal of Sports Medicine 12: 97, 1991Google Scholar
  42. Kelso TB, Herbert WG, Gwazdauskas FC, Goss FL, Hess JL. Exercise — thermoregulatory stress and increased plasma β-endorphin/β-lipotropin in humans. Journal of Applied Physiology 57: 444–449, 1984PubMedGoogle Scholar
  43. Kemppainen P, Pertovaara A, Huopaniemi T, Johansson G, Karonen SL. Modification of dental pain and cutaneous thermal sensitivity by physical exercise in man. Brain Research 360: 33–40, 1985PubMedCrossRefGoogle Scholar
  44. Kindermann W. Das Übertraining — Ausdruck einer vegetativen Fehlsteuerung. Deutsche Zeitschrift für Sportmedizin 37: 238–245, 1986Google Scholar
  45. Kindermann W, Schnabel A, Schmitt WM, Biro G, Hippchen M. Catecholamine, STH, Cortisol, Glucagon, Insulin und Sexu-alhormone bei körperlicher Belastung und Beta1-Blockade. Klinische Wochenschrift 60: 505–512, 1982PubMedCrossRefGoogle Scholar
  46. Kindermann W, Simon G, Keul J. The significance of the aerobic-anaerobic transition for the determination of work load intensities during endurance training. European Journal of Applied Physiology 42: 25–34, 1979CrossRefGoogle Scholar
  47. Kraemer RR, Blair S, Kraemer GR, Castracane VD. Effects of treadmill running on plasma beta-endorphin, corticotropin, and cortisol levels in male and female 10k runners. European Journal of Applied Physiology 58: 845–851, 1989CrossRefGoogle Scholar
  48. Kraemer WJ, Patton JF, Knuttgen HG, Marchitelli LJ, Cruthirds C, et al. Hypothalamic-pituitary-adrenal responses to short-duration high-intensity cycle exercise. Journal of Applied Physiology 66: 161–166, 1989PubMedCrossRefGoogle Scholar
  49. Langenfeld ME, Hart LS, Kao PC. Plasma β-endorphin responses to one-hour bicycling and running at 60% V̇2max. Medicine and Science in Sports and Exercise 19: 83–86, 1987PubMedCrossRefGoogle Scholar
  50. Li CH. β-endorphin: a pituitary peptide with potent morphinelike reactivity. Archives of Biochemistry and Biophysics 183: 595, 1977Google Scholar
  51. Louisy F, Guezennec CY, Lartigue M, Aldigier JC, Galen FX. Influence of endogenous opioids on atrial natriuretic factor release during exercise in man. European Journal of Applied Physiology 59: 34–38, 1989CrossRefGoogle Scholar
  52. Mader A, Liesen H, Heck H, Philippi H, Rost R, et al. Zur Beurteilung der sportartspezifischen Ausdauerleistungs-fähigkeit im Labor. Deutsche Zeitschrift für Sportmedizin 27: 80–112, 1976Google Scholar
  53. Mains RE, Eipper BA, Ling N. Common precursor to corticotropins and endorphins. Proceedings of the National Academy of Sciences of the United States of America 74: 3014–3018, 1977PubMedCrossRefGoogle Scholar
  54. Mannelli M, Maggi M, De Feo ML, Cuomo S, Delitala G, Giusti G, Serio M. Effects of naloxone on catecholamine plasma levels in adult men. A dose-response study. Acta Endocrinologica 106: 357–361, 1984Google Scholar
  55. Matsumura M, Fukushima T, Saito H, Saito S. In vivo and in vitro effects of β-endorphin on glucose metabolism in the rat. Hormone and Metabolic Research 16: 27–31, 1984PubMedCrossRefGoogle Scholar
  56. McDowell J, Kitchen I. Development of opioid systems: peptides, receptors and pharmacology. Brain Research Reviews 12: 397–421, 1987CrossRefGoogle Scholar
  57. McMurray RG, Forsythe WA, Mar MH, Hardy CJ. Exercise intensity-related responses of β-endorphin and catecholamines. Medicine and Science in Sports and Exercise 19: 570–574, 1987PubMedCrossRefGoogle Scholar
  58. Mougin C, Baulay A, Henriet MT, Haton D, Jacquier MC, et al. Assessment of plasma opioid peptides, β-endorphin and metenkephalin at the end of an international nordic ski race. European Journal of Applied Physiology 56: 281–286, 1987CrossRefGoogle Scholar
  59. Olausson R, Eriksson E, Ellmarker L, Rydenhag B, Shyu RC, Andersson SA. Effects of naloxone on dental pain threshold following muscle exercise and low frequency transcutaneous nerve stimulation: a comparative study in man. Acta Physiologica Scandinavica 126: 299–305, 1986PubMedCrossRefGoogle Scholar
  60. Oleshansky MA, Zoltick JM, Herman RH, Mougey EH, Meyerhoff JL. The influence of fitness on neuroendocrine responses to exhaustive treadmill exercise. European Journal of Applied Physiology 59: 405–410, 1990CrossRefGoogle Scholar
  61. Oyama T, Jin T, Yamaya R. Profound analgesic effects of β-endorphin in man. Lancet 1: 122–124, 1980PubMedCrossRefGoogle Scholar
  62. Paulev PE, Thorboll JE, Nielsen U, Kruse P, Jordal R, et al. Opioid involvement in the perception of pain due to endurance exercise in trained man. Japanese Journal of Physiology 39: 67–74, 1989PubMedCrossRefGoogle Scholar
  63. Pertovaara A, Kemppainen P, Johansson G, Karonen SL. Ischemic pain nonsegmentally produces a predominant reduction of pain and thermal sensitivity in man: a selective role for endogenous opioids. Brain Research 251: 83–92, 1982PubMedCrossRefGoogle Scholar
  64. Petraglia F, Barletta C, Faccinetti F, Spinazzola F, Monzani A, et al. Response of circulating adrenocorticotropin, beta-endorphin, beta-lipotropin and Cortisol to athletic competition. Acta Endocrinologica 118: 332–336, 1988PubMedGoogle Scholar
  65. Petraglia F, Facchinetti F, Parrini D, Micieli G, De Luca S, et al. Simultaneous circadian variations of plasma ACTH, beta-lipotropin, beta-endorphin and Cortisol. Hormone Research 17: 147–152, 1983PubMedCrossRefGoogle Scholar
  66. Rahkila P, Hakala E, Alen N, Salminen K, Laatikainen T. Betaendorphin and corticotropin release is dependent on a threshold intensity of running in male endurance athletes. Life Sciences 43: 451–455, 1987aGoogle Scholar
  67. Rahkila P, Hakala E, Salminen K, Laatikainen T. Responses of plasma endorphins to running exercises in male and female endurance athletes. Medicine and Sciences in Sports and Exercise 19: 451–455, 1987bGoogle Scholar
  68. Schwarz L, Kindermann W. β-Endorphin, catecholamines, and Cortisol during exhaustive endurance exercise. International Journal of Sports Medicine 10: 324–328, 1989PubMedCrossRefGoogle Scholar
  69. Schwarz L, Kindermann W. β-Endorphin, adrenocorticotropic hormone, Cortisol and catecholamines during aerobic and anaerobic exercise. European Journal of Applied Physiology 61: 165–171, 1990CrossRefGoogle Scholar
  70. Schwarz L, Kullmer T, Kindermann W. Einfluβ einer chronischen β-selektiven Blockade auf das β-Endorpninverhalten während erschöfender Ausdauerbelastung. In Böning D, et al. (Eds) Sport — Rettung oder Risiko für die Gesundheit?, pp. 166–170, Deutscher Ärzte Verlag, 166–170, Köln, 1989Google Scholar
  71. Sforzo GA. Opioids and exercise: an update. Sports Medicine 7: 109–124, 1988CrossRefGoogle Scholar
  72. Shyu BC, Andersson SA, Thoren P. Endorphin-mediated increase in pain threshold induced by long lasting exercise in rats. Life Science 30: 833–840, 1982CrossRefGoogle Scholar
  73. Sjödin B, Jacobs I. Onset of blood lactate accumulation and marathon running performance. International Journal of Sports Medicine 2: 23–26, 1981PubMedCrossRefGoogle Scholar
  74. Speroff L. Getting high on running. Fertility and Sterility 36: 49–51, 1981Google Scholar
  75. Stegmann H, Kindermann W. Comparison of prolonged exercise tests at the individual anaerobic threshold and the fixed anaerobic threshold of 4 mmol/L. International Journal of Sports Medicine 3: 105–110, 1982PubMedCrossRefGoogle Scholar
  76. Stegmann H, Kindermann W, Schnabel A. Lactate kinetics and individual anaerobic threshold. International Journal of Sports Medicine 2: 160–165, 1981PubMedCrossRefGoogle Scholar
  77. Sutton JR, Brown GM, Keane P, Walker WHC, Jones NL, et al. The role of endorphins in the hormonal control and psychological responses to exercise. International Journal of Sports Medicine 2: 19–24, 1982Google Scholar
  78. Sweep CGJ, Wiegant VM. Release of β-endorphin-immunoreactivity from rat pituitary and hypothalamus in vitro: effects of isoproterenol, dopamine, corticotropin-releasing factor and arginine-vasopressin. Biochemical and Biophysical Research Communications 161: 221–228, 1989PubMedCrossRefGoogle Scholar
  79. raylor T, Dluhy RG, Williams GH. β-Endorphin suppresses ad-renocorticotropin and Cortisol levels in normal human subjects. Journal of Clinical Endocrinology and Metabolism 57: 592–596, 1983CrossRefGoogle Scholar
  80. Tererenius L. Endorphins and modulation of pain. Advances in Neurology 33: 59–64, 1982Google Scholar
  81. Thompson DA, Penicaud L, Welle SL, Jacobs LS. Pharmacological evidence for opioid and adrenergic mechanisms controlling growth hormone, prolactin, pancreatic polypeptide, and catecholamine levels in humans. Metabolism 34: 383–388, 1985PubMedCrossRefGoogle Scholar
  82. Vale W, Rivier C, Yang L, Minick S, Guillemin R. Effects of purified hypothalamic corticotrophin-releasing factor and other substances on the secretion of adrenocorticotropin and β-endorphin-like immunoreactivities in vitro. Endocrinology 103: 1910, 1978PubMedCrossRefGoogle Scholar
  83. Van Loon GR, Appel NM. β-endorphin induced increases in plasma dopamine, norepinephrine, and epinephrine. Research Communications in Chemical Pathology and Pharmacology 27: 607–610, 1980PubMedGoogle Scholar
  84. Vettor R, Manno M, De Carlo E, Federspiel G. Evidence for an involvement of opioid peptides in exercise-induced lipolysis in rats. Hormone and Metabolic Research 19: 282–283, 1987PubMedCrossRefGoogle Scholar
  85. Vuolteenaho O, Leppäluoto J, Männistö P. Rat plasma and hypothalamic β-endorphin levels fluctuate concomitantly with plasma corticosteroids during the day. Acta Physiologica Scandinavica 115: 515–516, 1982PubMedCrossRefGoogle Scholar
  86. Wildmann J, Krüger A, Schmole M, Niemann J, Matthaei H. Increase of circulating β-endorphin-like immunoreactivity correlates with the change in the feeling of pleasantness after running. Life Science 38: 997–1003, 1986CrossRefGoogle Scholar
  87. Wilier JC, Denen H, Cambier J. Stress-induced analgesia in humans: endogenous opioids and naloxone-reversible depression of pain reflexes. Science 212: 689–691, 1981CrossRefGoogle Scholar
  88. Young E, Akil H. Corticotropin-releasing factor stimulation of adrenocorticotropin and β-endorphin release: effects of acute and chronic stress. Endocrinology 117: 23–30, 1985PubMedCrossRefGoogle Scholar

Copyright information

© Adis International Limited 1992

Authors and Affiliations

  • Lothar Schwarz
    • 1
  • Wilfried Kindermann
    • 1
  1. 1.Department of Sports and Performance MedicineUniversity of SaarlandSaarbrückenFederal Republic of Germany

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