Drugs

, Volume 69, Issue 4, pp 407–419 | Cite as

Pharmacological Treatment Options for Bronchiectasis

Focus on Antimicrobial and Anti-Inflammatory Agents
  • Jonathan Ilowite
  • Peter Spiegler
  • Heather Kessler
Therapy in Practice

Abstract

Patients with bronchiectasis experience tenacious mucus, recurrent infectious exacerbations, and progressive worsening of symptoms and obstruction over time. Treatment is aimed at trying to break the cycle of infection and progressive airway destruction. Antibacterial treatment is targeted towards likely organisms or tailored to the results of sputum culture. Inhaled antibacterial therapy may offer the advantage of increased local concentration of medication, while minimizing systemic adverse effects; however, to date, studies have been equivocal in this disorder. Macrolides, in addition to their antibacterial properties, have unique anti-inflammatory properties, which may make them useful in this disorder. Other mucoactive and anti-inflammatory agents, such as inhaled corticosteroids, mannitol and hypertonic saline, may also prove useful in this disease, but further studies are needed.

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Copyright information

© Adis Data Information BV 2009

Authors and Affiliations

  • Jonathan Ilowite
    • 1
  • Peter Spiegler
    • 1
  • Heather Kessler
    • 1
  1. 1.Winthrop University Hospital, State University Hospital of New York at Stony BrookMineolaUSA

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