, Volume 65, Issue 7, pp 993–1001


In Patients with Rheumatoid Arthritis
Adis Drug Profile

DOI: 10.2165/00003495-200565070-00005

Cite this article as:
Curran, M.P. & Perry, C.M. CNS Drugs (2005) 65: 993. doi:10.2165/00003495-200565070-00005


  • ▴ Tacrolimus, a hydrophobic macrolide with immu-nosuppressant properties, has recently been evaluated as a new treatment for adults with active rheumatoid arthritis.

  • ▴ Oral tacrolimus 3mg once daily was significantly more effective than placebo in patients with rheumatoid arthritis (RA) who were refractory or intolerant to disease-modifying antirheumatic drugs (DMARDs), according to results from a 6-month, phase III trial; American College of Rheumatology 20 (ACR20) response rates were 27% and 10%. Tacrolimus 3mg once daily was effective in the same patient group in a 12-month, open-label trial; the ACR20 response rate was 38%.

  • ▴ Oral tacrolimus 3mg once daily was effective in combination with established methotrexate therapy in patients with RA in a 6-month, open-label trial. The ACR20 response rate was 53%.

  • ▴ Oral tacrolimus 3mg once daily was generally well tolerated by patients with active RA refractory or intolerant to previous DMARD treatment or when administered as combination therapy in patients with RA on established methotrexate therapy.

Copyright information

© Adis Data Information BV 2005

Authors and Affiliations

  1. 1.Adis International LimitedMairangi Bay, AucklandNew Zealand

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