Drugs

, Volume 59, Issue 4, pp 719–743

Resurgent Malaria at the Millennium

Control Strategies in Crisis
  • J. Kevin Baird
Current Opinion

Abstract

Completion of the Panama Canal in 1914 marked the beginning of an era of vector control that achieved conspicuous success against malaria. In 1955 the World Health Organization (WHO) adopted the controversial Global Eradication Campaign emphasising DDT (dichlorodiphenyltrichloroethane) spraying in homes. The incidence of malaria fell sharply where the programme was implemented, but the strategy was not applied in holoendemic Africa. This, along with the failure to achieve eradication in larger tropical regions, contributed to disillusionment with the policy. The World Health Assembly abandoned the eradication strategy in 1969. Aresurgence of malaria began at about that time and today reaches into areas where eradication or control had been achieved. A global malaria crisis looms. In 1993 the WHO adopted a Global Malaria Control Strategy that placed priority in control of disease rather than infection. This formalises a policy that emphasises diagnosis and treatment in a primary healthcare setting, while de-emphasising spraying of residual insecticides. The new policy explicitly stresses malaria in Africa, but expresses the intent to bring control programmes around the world into line with the strategy.

This review raises the argument that a global control strategy conceived to address the extraordinary malaria situation in Africa may not be suitable elsewhere. The basis of argument lies in the accomplishments of the Global Eradication Campaign viewed in an historical and geographical context. Resurgent malaria accompanying declining vector control activities in Asia and the Americas suggests that the abandonment of residual spraying may be premature given the tools now at hand. The inadequacy of vector control as the primary instrument of malaria control in holoendemic Africa does not preclude its utility in Asia and the Americas.

References

  1. 1.
    Harrison G. Mosquitoes, malaria and man: a history of the hostilities since 1880. London: John Murray, 1978: 314Google Scholar
  2. 2.
    Krogstad DJ. Malaria as a reemerging disease. Epidemiol Rev 1996; 18: 77–89PubMedCrossRefGoogle Scholar
  3. 3.
    Mouchet J, Manguin S, Sircoulon J, et al. Evolution of malaria in Africa for the past 40 years: impact of climatic and human factors. J Am Mosquito Control Assoc 1998; 14: 121–30Google Scholar
  4. 4.
    World Health Organization. Implementation of the global malaria control strategy. WHO Technical Report Series no. 839. Geneva: WHO, 1993Google Scholar
  5. 5.
    World Health Organization. Malaria fact sheet no.94. Geneva: WHO, 1998Google Scholar
  6. 6.
    Nye ER, Gibson ME. Ronald Ross: malariologist and polymath. London: Macmillan Press, 1996: 316Google Scholar
  7. 7.
    Boyd MF. Historical review, In: Boyd MF, editor. Malariology. Philadelphia: WB Saunders, 1949: 3–25Google Scholar
  8. 8.
    Ross R. On some peculiar pigmented cells found in two mosquitoes fed on malarial blood. BMJ 1897; ii: 1786–8CrossRefGoogle Scholar
  9. 9.
    Grassi B, Bignami A, Bastianelli G. Ulteriori ricerche sul ciclo dei parassiti malarici umani nel corpo del zanarone. Atti Reale Accademia dei Lincei 1899 S.5; 8: 21Google Scholar
  10. 10.
    James SP. Malaria in Mian Mir. In: Jennings WE, editor. Transactions of the Bombay Medical Conference, 1909. Bombay: Bennett, Coleman, 1909: 84–9Google Scholar
  11. 11.
    McCullough D. The path between the seas: the creation of the Panama Canal, 1870–1914. New York: Simon & Schuster, 1978: 698Google Scholar
  12. 12.
    Reed W, Carroll J, Agramonte A. Experimental yellow fever. Trans Assoc Am Physicians 1901; 16: 45–70Google Scholar
  13. 13.
    Packard RM. Malaria dreams: postwar visions of health and development in the third world. Med Anthropol 1997; 17: 279–96PubMedCrossRefGoogle Scholar
  14. 14.
    Beadle C, Hoffman SL. History of malaria in the United States navalforces atwar: World War I through the Vietnam conflict. Clin Infect Dis 1993; 16: 320–9PubMedCrossRefGoogle Scholar
  15. 15.
    Coatney GR. Pitfalls in a discovery: the chronicle of chloroquine. Am J Trop Med Hyg 1963; 12: 121–8PubMedGoogle Scholar
  16. 16.
    Russel PF. Man’s mastery of malaria. London: Oxford University Press, 1955Google Scholar
  17. 17.
    Zucker JR. Changing patterns of autochthonous malaria transmission in the United States: a review of recent outbreaks. Emerg Infect Dis 1996; 2; 37–43PubMedCrossRefGoogle Scholar
  18. 18.
    Faust EC, Debakey L. Malaria mortality in the Southern United States for the year 1940, with supplementary data on malaria in other states. J Natl Malaria Soc 1942; 1: 125–31Google Scholar
  19. 19.
    MacDonald G. The epidemiology and control of malaria. London: Oxford University Press, 1957Google Scholar
  20. 20.
    United States Agency for International Development. Malaria: meeting the global challenge. AID science & technology in development series. Boston: Oelgeschlager, Gunn, & Hain Publishers, 1985Google Scholar
  21. 21.
    Jukes TH. Insecticides in health, agriculture and the environment. Naturwissenschaften 1974; 61: 6–16PubMedCrossRefGoogle Scholar
  22. 22.
    Sharma VP. Re-emergence of malaria in India. Indian J Med Res 1996; 103; 26–45PubMedGoogle Scholar
  23. 23.
    Atmosoedjono S. Malaria control in Indonesia since World War II. Wageningen Agricultural University Papers 1990; 90-7: 141–54Google Scholar
  24. 24.
    Curtin PD. Malarial immunities in Nineteenth Century West Africa and the Caribbean. Parassitologia 1994; 36: 69–82PubMedGoogle Scholar
  25. 25.
    Baird JK, Sismadi P, Masbar S, et al. Afocus of endemic malaria in Central Java. Am J Trop Med Hyg 1996; 54: 98–104PubMedGoogle Scholar
  26. 26.
    Lepers JP, Fontinille D, Rason MD, et al. Transmission and epidemiology of newly transmitted falciparum malaria in the central highland plateau of Madagascar. Ann Trop Med Parasitai 1991; 85: 297–304Google Scholar
  27. 27.
    Reynolds DJ. The Demerara doctor. Perspectives in Health 1996; 1 (2) [online]. Available from: URL: http://www.paho.org/english/DPImag/Number2/dpi2pdemerara.html [Accessed 2000 Feb 29]
  28. 28.
    Cruz MA. Human migration and the spread of malaria in Brazil. Parasitai Today 1987; 3: 166–70CrossRefGoogle Scholar
  29. 29.
    Trigg PI, Kondrachine AV. Commentary: malaria control in the 1990s. Bull WHO 1998; 76: 11–6PubMedGoogle Scholar
  30. 30.
    Packard RM. ‘No other logical choice’: global malaria eradication and the politics of international health in the post-war era. Parassitologia 1998; 40: 217–29PubMedGoogle Scholar
  31. 31.
    Butler D, Maurice J, O’Brien C. Time to put malaria control on the global agenda. Nature 1997; 386: 535–6PubMedCrossRefGoogle Scholar
  32. 32.
    Campbell CC. Malaria: an emerging and re-emerging global plague. FEMS Immunol Med Microbiol 1997; 18: 325–31PubMedCrossRefGoogle Scholar
  33. 33.
    Kondrachine AV, Trigg PI. Global overview of malaria. Indian J Med Res 1997; 106: 39–52PubMedGoogle Scholar
  34. 34.
    National Academy of Sciences (US). Vaccines Against malaria: hope in a gathering storm. Washington: National Academy Press, 1996Google Scholar
  35. 35.
    Greenberg AE, Lobel HO. Mortality from plasmodium falciparum malaria in travelers from the United States, 1959 to 1987. Ann Intern Med 1990; 113: 326–7PubMedGoogle Scholar
  36. 36.
    World Health Organization. World malaria situation in 1994: Part II, the Americas. Wkly Epidemiol Rec 1997; 72: 277–84Google Scholar
  37. 37.
    World Health Organization. World malaria situation in 1994: Part III. Wkly Epidemiol Rec WHO 1997; 72: 285–90Google Scholar
  38. 38.
    Feighner BH, Pak SI, Novakoski WL, et al. Reemergence of Plasmodium vivax malaria in the Republic of Korea. Emerg Infect Dis 1998; 4: 295–7PubMedCrossRefGoogle Scholar
  39. 39.
    Roberts DR, Laughlin LL, Hsheih P. DDT, global strategies, and a malaria control crisis. Emerg Infect Dis 1997; 3: 295–302PubMedCrossRefGoogle Scholar
  40. 40.
    Sharp BL, le Sueur D. Malaria in South Africa: the past, the present and selected implications for the future. S Afr Med J 1996; 86: 83–9PubMedGoogle Scholar
  41. 41.
    Lepers JP, Deloron P, Andriamagatiana-Rason MD, et al. Newly transmitted plasmodium falciparum malaria in the central highland plateaux of Madagascar: assessment of clinical impact in a rural community. Bull WHO 1990; 68: 217–22PubMedGoogle Scholar
  42. 42.
    Malakooti MA, Biomndo K, Shanks GD. Reemergence of epidemic malaria in the highlands of western Kenya. Emerg Infect Dis 1998; 4: 671–6PubMedCrossRefGoogle Scholar
  43. 43.
    Shukla RP, Pandey AC, Mathur A. Investigation of malaria outbreak in Rajasthan. Indian J Malariol 1995; 32: 119–28PubMedGoogle Scholar
  44. 44.
    Martens WJ, Niessen LW, Rotmans J. Potential impact of global climate change on malaria risk. Environ Health Perspect 1995; 103: 458–64PubMedCrossRefGoogle Scholar
  45. 45.
    Baird JK, Basri H, Jones TR, et al. Resistance to antimalarials in northeastern Irian Jaya, Indonesia. Am J Trop Med Hyg 1991; 44: 640–4PubMedGoogle Scholar
  46. 46.
    Baird JK, Leksana B, Masbar S, et al. Diagnosis of resistance to chloroquine by Plasmodium vivax: timing of recurrence and whole blood chloroquine levels. Am J Trop Med Hyg 1997; 56: 621–6PubMedGoogle Scholar
  47. 47.
    Hogh B, Gamage-Mendis A, Butcher GA, et al. The differing impact of chloroquine and pyrimethamine/sulfadoxine upon the infectivity of malaria species to the mosquito vector. Am J Trop Med Hyg 1998; 58: 176–82PubMedGoogle Scholar
  48. 48.
    Rieckmann KH, Davis DR, Halton DC. Plasmodium vivax resistance to chloroquine? Lancet 1989; II: 1183–4CrossRefGoogle Scholar
  49. 49.
    Schwartz IK, Lackritz EM, Patchen LC. Chloroquine-resistant Plasmodium vivax from Indonesia. N Engl J Med 1991; 324: 927PubMedCrossRefGoogle Scholar
  50. 50.
    Baird JK, Basri H, Subianto B, et al. Treatment of chloroquine resistant Plasmodium vivax with chloroquine and primaquine or halofantrine. J Infect Dis 1995; 171: 1678–82PubMedCrossRefGoogle Scholar
  51. 51.
    Than M, Kyaw MP, Soe AY, et al. Development of resistance to chloroquine by Plasmodium vivax in Myanmar. Trans R Soc Trop Med Hyg 1995; 89: 307–8CrossRefGoogle Scholar
  52. 52.
    Garg M, Gopinathan N, Bodhe P, et al. Vivax malaria resistant to chloroquine: case reports from Bombay. Trans R Soc Trop Med Hyg 1995; 89: 656–7PubMedCrossRefGoogle Scholar
  53. 53.
    Phillips EJ, Keystone JS, Kain KC. Failure of combined chloroquine and high-dose primaquine therapy for Plasmodium vivax acquired in Guyana, South America. Clin Infect Dis 1996; 23: 1171–3PubMedCrossRefGoogle Scholar
  54. 54.
    Baird JK, Wiady I, Fryauff DJ, et al. In vivo resistance to chloroquine by Plasmodium vivax and Plasmodium falciparum at Nabire, Irian Jaya, Indonesia. Am J Trop Med Hyg 1997; 56: 627–31PubMedGoogle Scholar
  55. 55.
    Baird JK, Leksana B, Masbar S, et al. Whole blood chloroquine concentrations with Plasmodium vivax in Irian Jaya, Indonesia. Am J Trop Med Hyg 1997; 56: 618–20PubMedGoogle Scholar
  56. 56.
    Wolff MS, Toniolo PG, Lee EW, et al. Blood levels of organochlorine residues and risk of breast cancer. J Natl Cancer Inst 1993; 85: 648–52PubMedCrossRefGoogle Scholar
  57. 57.
    Krieger N, Wolff MS, Hiatt RA, et al. Breast cancer and serum organochlorines: a prospective study among white, black, and Asian women. J Natl Cancer Inst 1994; 86: 589–99PubMedCrossRefGoogle Scholar
  58. 58.
    Hunter DJ, Hankinson SE, Laden F, et al. Plasma organochlorine levels and risk of breast cancer. N Engl J Med 1997; 337: 1253–8PubMedCrossRefGoogle Scholar
  59. 59.
    Longnecker MP, Rogan WJ, Lucier G. The health effects of DDT and PCBS and an overview of organochlorines in public health. Ann Rev Public Health 1997; 18: 211–44CrossRefGoogle Scholar
  60. 60.
    Institute of Medicine. Malaria: obstacles & opportunities. In: Oaks Jr SC, Mitchell VS, Pearson GW, et al, editors. Washington DC: National Academy Press, 1991Google Scholar
  61. 61.
    World Health Organization. Four international organizations unite to roll back malaria, World Health Organization Press Release WHO/77 of 30 October 1998. Accessed at http: http://www.who.ch/
  62. 62.
    World Health Organization. Multilateral perspective on malaria begins to take shape: tropical diseases newsletter no. 55, February 1998. Geneva: WHO, 1998Google Scholar
  63. 63.
    Fontinille D, Lepers JP, Campbell GH, et al. Malaria transmission and vector biology in Manarintsoa, high plateau of Madagascar. Am J Trop Med Hyg 1990; 43: 107–15Google Scholar
  64. 64.
    Pan American Health Organization. Status of malaria programs in the Americas. XLII Report. Washington, DC: Pan American Health Organization, 1994Google Scholar
  65. 65.
    Pan American Health Organization. Report on the status of malaria programs in the Americas. HCP/HCT/149/99, August 1999Google Scholar
  66. 66.
    Brogdon WG, McAllister JC. Insecticide resistance and vector control. Emerg Infect Dis 1998; 4: 605–14PubMedCrossRefGoogle Scholar
  67. 67.
    Roberts DR, Andre RG. Insecticide resistance issues in vector-borne disease control. Am J Trop Med Hyg 1994; 50 Suppl.: 21–34PubMedGoogle Scholar
  68. 68.
    Bangs MJ. Doctoral dissertation. Bethesda (MD): Uniformed Services University of the Health Sciences, 1998Google Scholar
  69. 69.
    World Wildlife Fund News. WWF urges World Health Assembly delegates to phase out deadly DDT pesticide (May 21 1999) [online]. Available from: URL: http://www.worldwildlife.org [Accessed 2000 Mar 3]
  70. 70.
    Beadle C, McElroy PD, Oster CN, et al. Impact of transmission intensity and age on Plasmodium falciparum density and associated fever: implications for malaria vaccine trial design. J Infect Dis 1995; 172: 1047–54PubMedCrossRefGoogle Scholar
  71. 71.
    Jones TR, Baird JK, Bangs MJ, et al. Malaria vaccine study site in Irian Jaya, Indonesia: plasmodium falciparum incidence measurements, epidemiologic considerations in sample size estimation. Am J Trop Med Hyg 1994; 50: 210–8PubMedGoogle Scholar
  72. 72.
    Pan American Health Organization. Status of malaria programs in the Americas. XLV Report. Washington DC: Pan American Health Organization, 1997Google Scholar
  73. 73.
    Baird JK. Age-dependent characteristics of protection vs. susceptibility to Plasmodium falciparum. Ann Trop Med Parasitol 1998; 92: 367–90CrossRefGoogle Scholar
  74. 74.
    Baird JK. Host age as a determinant of naturally acquired immunity to Plasmodium falciparum. Parasitol Today 1995; 11: 105–11PubMedCrossRefGoogle Scholar
  75. 75.
    Snow RW, Omumbo JA, Lowe B, et al. Relation between severe malaria morbidity in children and level of Plasmodium falciparum transmission in Africa. Lancet 1997; 349: 1650–4PubMedCrossRefGoogle Scholar
  76. 76.
    McElroy PD, Beier JC, Oster CN, et al. Dose- and time-dependent relations between infective Anopheles inoculation and outcomes of Plasmodium falciparum parasitemia among children in Western Kenya. Am J Epidemiol 1997; 145: 945–56PubMedCrossRefGoogle Scholar
  77. 77.
    Baird JK, Hoffman SL. Prevention of malaria in travelers. Med Clin North Am 1999; 83: 923–44PubMedGoogle Scholar
  78. 78.
    White NJ, Nosten F, Looareesuwan S, et al. Averting a malaria disaster. Lancet 1999; 353: 1965–7PubMedCrossRefGoogle Scholar
  79. 79.
    White N. Antimalarial drug resistance and combination chemotherapy. Phil Trans R Soc Lond B Biol Sci 1999; 354: 739–49CrossRefGoogle Scholar
  80. 80.
    Price R, van Vugt M, Phaipun L, et al. Adverse effects in patients with acute falciparum malaria treated with artemisinin derivatives. Am J Trop Med Hyg 1999; 60: 547–55PubMedGoogle Scholar
  81. 81.
    Nosten F, Hien TT, White NJ. Use of artemisinin derivatives for the control of malaria. Med Trop (Mars) 1998; 58 Suppl. 3: 45–9Google Scholar
  82. 82.
    Price RN, Nosten F, Luxemberger C, et al. Artesunate/mefloquine treatment of multi-drug resistant falciparum malaria. Trans R Soc Trop Med Hyg 1997; 91: 574–7PubMedCrossRefGoogle Scholar
  83. 83.
    Van Vugt M, Brockman A, Gemperli B, et al. Randomized comparison of artemether-benflumetol and artesunate-mefloquine in treatment of multi-drug resistant falciparum malaria. Antimicrob Agents Chemother 1998; 42: 135–9PubMedGoogle Scholar

Copyright information

© Adis International Limited 2000

Authors and Affiliations

  • J. Kevin Baird
    • 1
  1. 1.Parasitic Diseases Program, US Naval Medical Research Unit No.2JakartaUSA

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