Controlled Clinical Investigation of Acute Analgesic Activity of Nimesulide in Pain after Oral Surgery
A double-blind study was conducted to determine the dose-effect relationship of nimesulide and to compare the acute analgesic activity of this agent with that of placebo and niflumic acid.
Patients undergoing extraction of an impacted third molar were randomised into 4 groups (nimesulide 100mg; nimesulide 200mg; niflumic acid 250mg and placebo). They were instructed to take their allocated treatment after the onset of pain, and to record the pain severity and relief during the following 6 hours. 134 patients were evaluated.
There were significant differences between groups for each time of observation/efficacy parameter (Kruskal-Wallis test). Pairwise comparison (Duncan’s test) showed that all 3 active medications were significantly different from the placebo. No substantial differences were found between any of the active treatments. Analogous results were obtained when the amount of rescue drug used (paracetamol) was compared. More positive judgements were reported by patients treated with an active compound than by those taking placebo.
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- Bucci E, Mignogna MD, Scaricabarozzi I, et al. Studio clinico sull’attività terapeutica e la tollerabilità délia nimesulide in formulazione supposte in odontostomatologia. Minerva Stomatologica 39: 13–17, 1990Google Scholar
- Cooper SA. An analgesic relative potency assay comparing ke-toprofen and aspirin in post-operative dental pain. Advances in Therapy 1: 410–418, 1984Google Scholar
- Cornaro G. à new non steroidal anti-inflammatory drug in the treatment of inflammations due to periodontal surgery. Current Therapeutic Research 33: 982–989, 1983Google Scholar
- Salvato A. Sperimentazione clinica di un nuovo antiedemigeno orale: nimesulide. Giornale Stomatologia Ortognatodonzia 3: 184–191, 1984Google Scholar
- Scoren RD. Pain following periodontal surgery: treatment with a nonnarcotic analgesic compared with two codeine combinations. Current Therapeutic Research 42: 463–471, 1987Google Scholar