Drugs

, Volume 46, Supplement 1, pp 162–167 | Cite as

Controlled Clinical Investigation of Acute Analgesic Activity of Nimesulide in Pain after Oral Surgery

  • J. P. Ragot
  • T. Monti
  • A. Macciocchi
Article

Summary

A double-blind study was conducted to determine the dose-effect relationship of nimesulide and to compare the acute analgesic activity of this agent with that of placebo and niflumic acid.

Patients undergoing extraction of an impacted third molar were randomised into 4 groups (nimesulide 100mg; nimesulide 200mg; niflumic acid 250mg and placebo). They were instructed to take their allocated treatment after the onset of pain, and to record the pain severity and relief during the following 6 hours. 134 patients were evaluated.

There were significant differences between groups for each time of observation/efficacy parameter (Kruskal-Wallis test). Pairwise comparison (Duncan’s test) showed that all 3 active medications were significantly different from the placebo. No substantial differences were found between any of the active treatments. Analogous results were obtained when the amount of rescue drug used (paracetamol) was compared. More positive judgements were reported by patients treated with an active compound than by those taking placebo.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bucci E, Mignogna MD, Scaricabarozzi I, et al. Studio clinico sull’attività terapeutica e la tollerabilità délia nimesulide in formulazione supposte in odontostomatologia. Minerva Stomatologica 39: 13–17, 1990Google Scholar
  2. Bucci E, Mignogna MD, Bucci P. Aulin: una nuova e moderna terapia nel trattamento delle infiammazioni in odontostomatologia. Minerva Stomatologica 36: 101–103, 1987PubMedGoogle Scholar
  3. Cooper SA, Beaver WT. A model to evaluate mild analgesics in oral surgery out-patients. Clinical Pharmacology and Therapeutics 20: 241–250, 1976PubMedGoogle Scholar
  4. Cooper SA. An analgesic relative potency assay comparing ke-toprofen and aspirin in post-operative dental pain. Advances in Therapy 1: 410–418, 1984Google Scholar
  5. Cornaro G. à new non steroidal anti-inflammatory drug in the treatment of inflammations due to periodontal surgery. Current Therapeutic Research 33: 982–989, 1983Google Scholar
  6. Moniaci D, Mozzati M, Anglesio Farina G, et al. Valutazione dell’efficacia e délia tollerabilità della nimesulide in alcune patologie odontostomatologiche. Minerva Stomatologica 37: 291–294, 1988PubMedGoogle Scholar
  7. Pais JM, Rasteiro FM. Nimesulide in the short-term treatment of inflammatory process of dental tissue. A double-blind controlled trial against oxyphenbutazone. Journal of International Medical Research 11: 149–154, 1983PubMedGoogle Scholar
  8. Puigvert Torrent A. Dose-response study of the analgesic study of aceclofenac in odontalgia following extraction of the third molar. Drug Investigation 2: 132–136, 1990CrossRefGoogle Scholar
  9. Salvato A. Sperimentazione clinica di un nuovo antiedemigeno orale: nimesulide. Giornale Stomatologia Ortognatodonzia 3: 184–191, 1984Google Scholar
  10. Scoren RD. Pain following periodontal surgery: treatment with a nonnarcotic analgesic compared with two codeine combinations. Current Therapeutic Research 42: 463–471, 1987Google Scholar
  11. Stefanoni G, Saccomanno F, Scaricabarozzi I, et al. Efficacia clinica della nimesulide in confronta a diclofenac sodico nella prevenzione e nel trattamento della sintomatologia algico-flo-gistica postchirurgica. Minerva Chirurgica 45: 1469–1475, 1990PubMedGoogle Scholar

Copyright information

© ADIS International Limited 1993

Authors and Affiliations

  • J. P. Ragot
    • 1
  • T. Monti
    • 2
  • A. Macciocchi
    • 2
  1. 1.Clinique de Stomatologie et de Chirurgie Maxillo-FacialeHôpital Pitié SalpêtrièreParisFrance
  2. 2.Department of Products DevelopmentHelsinn Healthcare SAChiassoSwitzerland

Personalised recommendations