Drugs

, Volume 19, Issue 5, pp 370–372 | Cite as

Danazol in the Treatment of Hereditary Angioedema

  • S. W. Hosea
  • M. M. Frank
Evalutions on New Drugs

Summary

Danazol is an effective agent for the prophylaxis of the recurrent attacks of mucocutaneous and visceral swelling which occur in patients with hereditary angioedema (HAE). Danazol apparently increases the synthesis of the inhibitor of the first component of complement which is partially deficient in these heterozygous individuals. The efficacy of danazol in this condition appears to be limited only by the occurrence of adverse effects.

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References

  1. Frank, M.M.: Complement; in Current Concepts. Scope Monograph, The Upjohn Company, pp. 1–48 (1975).Google Scholar
  2. Frank, M.M.; Gelfand, J.A. and Atkinson, J.P.: Hereditary angioedema: the clinical syndrome and its management. Annals of Internal Medicine 84: 580–593 (1976).PubMedGoogle Scholar
  3. Gelfand, J.A.; Sherins, R.J.; Alling, D.W. and Frank, M.M.: Treatment of hereditary angioedema with danazol. Reversal of clinical and biochemical abnormalities. New England Journal of Medicine 295: 1444–1448 (1976).PubMedCrossRefGoogle Scholar
  4. Hosea, S.W.; Santaella, M. and Frank, M.M.: Long term therapy of hereditary angioedema with danazol. Manuscript in preparation.Google Scholar
  5. Jaffe, C.J.; Atkinson, J.P.; Gelfand, J.A. and Frank, M.M.: Hereditary angioedema: The use of fresh frozen plasma for prophylaxis in patients undergoing oral surgery. Journal of Allergy and Clinical Immunology 55: 386–393 (1975).PubMedCrossRefGoogle Scholar
  6. Spaulding, W.B.: Methyltestosterone therapy for hereditary episodal edema. Annals of Internal Medicine 53: 739–745 (1960).Google Scholar

Copyright information

© ADIS Press Australasia Pty Ltd 1980

Authors and Affiliations

  • S. W. Hosea
    • 1
  • M. M. Frank
    • 1
  1. 1.Department of Health, Education and Welfare, Public Health ServiceNational Institutes of HealthBethesdaUSA

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