Danazol in the Treatment of Hereditary Angioedema
Danazol is an effective agent for the prophylaxis of the recurrent attacks of mucocutaneous and visceral swelling which occur in patients with hereditary angioedema (HAE). Danazol apparently increases the synthesis of the inhibitor of the first component of complement which is partially deficient in these heterozygous individuals. The efficacy of danazol in this condition appears to be limited only by the occurrence of adverse effects.
KeywordsAndrogen Fresh Freeze Plasma Danazol Hereditary Angioedema Birth Control Pill
Unable to display preview. Download preview PDF.
- Frank, M.M.: Complement; in Current Concepts. Scope Monograph, The Upjohn Company, pp. 1–48 (1975).Google Scholar
- Hosea, S.W.; Santaella, M. and Frank, M.M.: Long term therapy of hereditary angioedema with danazol. Manuscript in preparation.Google Scholar
- Spaulding, W.B.: Methyltestosterone therapy for hereditary episodal edema. Annals of Internal Medicine 53: 739–745 (1960).Google Scholar