Clinical Pharmacokinetics

, Volume 45, Issue 3, pp 235–252 | Cite as

Clinical Pharmacokinetics of Docetaxel

Recent Developments
Review Article

Abstract

Docetaxel belongs to the class of taxane antineoplastic agents that act by inducing microtubular stability and disrupting the dynamics of the microtubular network. The drug has shown a broad spectrum of antitumour activity in preclinical models as well as clinically, with responses observed in various disease types, including advanced breast cancer and non-small cell lung cancer. The pharmacokinetics and metabolism of docetaxel are extremely complex and have been the subject of intensive investigation in recent years. Docetaxel is subject to extensive metabolic conversion by the cytochrome P450 (CYP) 3A isoenzymes, which results in several pharmacologically inactive oxidation products. Elimination routes of docetaxel are also dependent on the presence of drug-transporting proteins, notably P-glycoprotein, present on the bile canalicular membrane. The various processes mediating drug elimination, either through metabolic breakdown or excretion, impact substantially on interindividual variability in drug handling. Strategies to individualise docetaxel administration schedules based on phenotypic or genotype-dependent differences in CYP3A expression are underway and may ultimately lead to more selective chemotherapeutic use of this agent.

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Copyright information

© Adis Data Information BV 2006

Authors and Affiliations

  • Sharyn D. Baker
    • 1
  • Alex Sparreboom
    • 2
  • Jaap Verweij
    • 3
  1. 1.The Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsBunting-Blaustein Cancer Research BuildingBaltimoreUSA
  2. 2.National Cancer InstituteBethesdaUSA
  3. 3.Erasmus University Medical CenterRotterdamThe Netherlands

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