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Pharmacokinetics of Rectal Drug Administration, Part II

Clinical Applications of Peripherally Acting Drugs, and Conclusions

  • Review Article
  • Drug Disposition
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Summary

Part I of this article, which appeared in the previous issue of the Journal, covered general considerations, the physiology of the rectum, spreading of drugs into the colon, rectal absorption, partial avoidance of first-pass elimination, rate-controlled rectal delivery of drugs, irritation of the rectal mucosa and clinical applications of rectal administration, and discussed centrally acting drugs. In Part II, this discussion is extended to drugs which act peripherally and to methods of enhancing rectal drug absorption. The overall summary appeared in Part I.

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  1. Brocades Pharma B.V., Delft, The Netherlands

    Ewoud J. van Hoogdalem, Albertus G. de Boer & Douwe D. Breimer

  2. Center for Biopharmaceutical Sciences, Division of Pharmacology, Sylvius Laboratories, University of Leiden, Leiden, The Netherlands

    Ewoud J. van Hoogdalem, Albertus G. de Boer & Douwe D. Breimer

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van Hoogdalem, E.J., de Boer, A.G. & Breimer, D.D. Pharmacokinetics of Rectal Drug Administration, Part II. Clin. Pharmacokinet. 21, 110–128 (1991). https://doi.org/10.2165/00003088-199121020-00003

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