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Clinical Pharmacokinetics

, Volume 21, Issue 2, pp 110–128 | Cite as

Pharmacokinetics of Rectal Drug Administration, Part II

Clinical Applications of Peripherally Acting Drugs, and Conclusions
  • Ewoud J. van Hoogdalem
  • Albertus G. de Boer
  • Douwe D. Breimer
Review Article Drug Disposition

Summary

Part I of this article, which appeared in the previous issue of the Journal, covered general considerations, the physiology of the rectum, spreading of drugs into the colon, rectal absorption, partial avoidance of first-pass elimination, rate-controlled rectal delivery of drugs, irritation of the rectal mucosa and clinical applications of rectal administration, and discussed centrally acting drugs. In Part II, this discussion is extended to drugs which act peripherally and to methods of enhancing rectal drug absorption. The overall summary appeared in Part I.

Keywords

Mesalazine Rectal Administration Rectal Diazepam Isoxicam Rectal Absorption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Adis International Limited 1991

Authors and Affiliations

  • Ewoud J. van Hoogdalem
    • 1
    • 2
  • Albertus G. de Boer
    • 1
    • 2
  • Douwe D. Breimer
    • 1
    • 2
  1. 1.Brocades Pharma B.V.DelftThe Netherlands
  2. 2.Center for Biopharmaceutical Sciences, Division of Pharmacology, Sylvius LaboratoriesUniversity of LeidenLeidenThe Netherlands

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