Drugs & Aging

, Volume 21, Issue 11, pp 711–730

The Impact of Fragility Fracture on Health-Related Quality of Life

The Importance of Antifracture Therapy
  • Ted Xenodemetropoulos
  • Shawn Davison
  • George Ioannidis
  • Jonathan D. Adachi
Review Article


Both general and specific health status instruments can be utilised in evaluating health-related quality of life (HR-QOL) deficits resulting from osteoporotic fractures. Osteoporotic hip, vertebral and wrist fractures significantly decrease HR-QOL in most HR-QOL domains investigated. The presence of multiple vertebral fractures leads to larger decrements in HR-QOL. More research needs to be completed with these HR-QOL tools to better assess the true burden of osteoporotic fractures, particularly in the case of hip fractures, as the burden is surely being underestimated without recognition of HR-QOL. Only when the burden of fragility fractures is understood, inclusive of HR-QOL, will the value of proven antifracture prevention and treatment therapies be appreciated. Information collected by HR-QOL instruments may provide new insight as to how to improve quality of life for patients with fractures and how to properly allocate healthcare spending.


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Copyright information

© Adis Data Information BV 2004

Authors and Affiliations

  • Ted Xenodemetropoulos
    • 1
  • Shawn Davison
    • 1
  • George Ioannidis
    • 1
  • Jonathan D. Adachi
    • 1
  1. 1.St Joseph’s HealthcareMcMaster UniversityHamiltonCanada
  2. 2.St Josephs HospitalMc-Master UniversityHamiltonCanada

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