Drug Safety

, Volume 30, Issue 12, pp 1127–1142

Bodyweight Changes Associated with Antihyperglycaemic Agents in Type 2 Diabetes Mellitus

Review Article


The majority of patients with type 2 diabetes mellitus are overweight or obese at the time of diagnosis, and obesity is a recognised risk factor for type 2 diabetes and coronary heart disease (CHD). Conversely, weight loss has been shown to improve glycaemic control in patients with type 2 diabetes, as well as to lower the risk of CHD. The traditional pharmacotherapies for type 2 diabetes can further increase weight and this may undermine the benefits of improved glycaemic control. Furthermore, patients’ desire to avoid weight gain may jeopardise compliance with treatment, thereby limiting treatment success and indirectly increasing the risk of long-term complications. This review evaluates the influences of established and emerging therapies on bodyweight in type 2 diabetes.

Copyright information

© Adis Data Information BV 2007

Authors and Affiliations

  1. 1.Aarhus University HospitalAarhusDenmark
  2. 2.Department of Endocrinology and Metabolism C, Aarhus Sygehus THGAarhus University HospitalAarhus CDenmark

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