Drug Safety

, Volume 26, Issue 5, pp 353–362 | Cite as

Lack of Awareness of Community-Acquired Adverse Drug Reactions Upon Hospital Admission

Dimensions and Consequences of a Dilemma
  • Harald DormannEmail author
  • Manfred Criegee-Rieck
  • Antje Neubert
  • Tobias Egger
  • Arnim Geise
  • Sabine Krebs
  • Thomas H. Schneider
  • Micha Levy
  • Eckhart G. Hahn
  • Kay Brune
Original Research Article


Objective: Adverse drug reactions (ADRs) are a well-known cause of hospital admission. Nevertheless a quantitative estimate of the preventability of and physicians’ awareness of these reactions is lacking.

Study Design and Methods: Using intensive bedside and computer-assisted drug surveillance methods a 13-month prospective pharmacoepidemiological survey was carried out on patients admitted to two medical wards of the Erlangen-Nuremberg University Hospital in Erlangen, Germany. This study aimed to define the incidence of preventable and unavoidable ADRs. In addition we investigated the awareness of the physicians to ADRs at the time of admission and the rate of contraindicated pre-admission prescriptions.

Results: In 78 (8.5%) of 915 (10.9%) admissions a total of 102 (42 preventable) community-acquired ADRs were detected on admission. In 45 (3.8%) of the admissions ADRs led directly to hospitalisation. 56.9% of the ADRs were not recognised by the attending physician on admission. Marked correlation was found between the awareness of ADRs and their probability and severity scores (r = 0.85 and r = 0.94, respectively; p < 0.05). The most frequently detected ADRs were due to direct toxicity and secondary pharmacological effects. Idiosyncratic reactions were often missed and 18.6% of all drugs prescribed prior to admission were contraindicated. Leading the list were diuretics, analgesics/NSAIDs and antipsychotics/sedatives.

Conclusions: Awareness of existing ADRs on hospital admission and appropriate prescribing prior to hospital admission require attention. Early detection of ADRs on hospital admission can be achieved by the use of computer support systems. Many ADRs could be prevented by adhering to indications and contraindications.


Staff Physician Idiosyncratic Reaction Chart Note Study Ward Preventable Admission 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This study was supported by grants from BMBF No. EC 9403/7, ELAN No. 98.07.30–1 and Marohnstiftung No. Bru/2001. The authors would like to thank Dr Stephan Rietbrock for his advice and encouragement throughout this study and his statistical analysis. The authors have provided no information on conflicts of interest directly relevant to the content of this study.


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Copyright information

© Adis Data Information BV 2003

Authors and Affiliations

  • Harald Dormann
    • 1
    Email author
  • Manfred Criegee-Rieck
    • 2
  • Antje Neubert
    • 2
  • Tobias Egger
    • 2
  • Arnim Geise
    • 1
  • Sabine Krebs
    • 2
  • Thomas H. Schneider
    • 1
  • Micha Levy
    • 3
  • Eckhart G. Hahn
    • 1
  • Kay Brune
    • 2
  1. 1.Department of Internal Medicine IUniversity of Erlangen-NurembergErlangenGermany
  2. 2.Department of Experimental and Clinical Pharmacology and ToxicologyUniversity of Erlangen-NurembergErlangenGermany
  3. 3.Department of Clinical PharmacologyHadassah-Hebrew University Medical CenterJerusalemIsrael

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